Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
paper
Cited
Public
- Authors
- Demontis, Ditte; Walters, G Bragi; Athanasiadis, Georgios; Walters, Raymond; Therrien, Karen; Nielsen, Trine Tollerup; Farajzadeh, Leila; Voloudakis, Georgios; Bendl, Jaroslav; Zeng, Biau; Zhang, Wen; Grove, Jakob; Als, Thomas D; Duan, Jinjie; Satterstrom, F Kyle; Bybjerg-Grauholm, Jonas; Bækved-Hansen, Marie; Gudmundsson, Olafur O; Magnusson, Sigurdur H; Baldursson, Gisli; Davidsdottir, Katrin; Haraldsdottir, Gyda S; Agerbo, Esben; Hoffman, Gabriel E; Dalsgaard, Søren; Martin, Joanna; Ribasés, Marta; Boomsma, Dorret I; Soler Artigas, Maria; Roth Mota, Nina; Howrigan, Daniel; Medland, Sarah E; Zayats, Tetyana; Rajagopal, Veera M; ADHD Working Group of the Psychiatric Genomics Consortium; iPSYCH-Broad Consortium; Nordentoft, Merete; Mors, Ole; Hougaard, David M; Mortensen, Preben Bo; Daly, Mark J; Faraone, Stephen V; Stefansson, Hreinn; Roussos, Panos; Franke, Barbara; Werge, Thomas; Neale, Benjamin M; Stefansson, Kari; Børglum, Anders D
- Year
- 2023
- Journal
- Nature genetics
- PMID
- 36702997
- DOI
- 10.1038/s41588-022-01285-8
- PMCID
- PMC10914347
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84-98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.
Results from GWAS meta-analysis of iPSYCH, deCODE and PGC cohorts including 38,899 cases and 186,843 controls in total.The y-axis represents βlog10(two-sided P-values) from meta-analysis using an inverse-variance weighted fixed effects model. Index variants in each of the genome-wide significant loci are marked as a green diamond (note that two loci on chromosome 3, index variants rs7613360 and rs2311059, are located in close proximity and therefore appear as one diamond in the plot). The red horizontal line represents the threshold for genome-wide significant association (P = 5 Γ 10β8).
Venn diagrams showing MiXeR results of the estimated number of variants shared between ADHD and psychiatric disorders (with significant genetic correlations with ADHD) and phenotypes representing other domains with high genetic correlation with ADHD.Circles represent shared variants (gray), unique to ADHD (light blue) and unique to the other phenotype of interest (orange). The number of shared variants (and standard deviations) is shown in thousands. The size of the circles reflects the polygenicity of each phenotype, with larger circles corresponding to greater polygenicity. The estimated genetic correlation (rg) between ADHD and each phenotype from LDSC is shown below the corresponding Venn diagram, with an accompanying scale (β1 to +1) with blue and red representing negative and positive genetic correlations, respectively. Bivariate results for ADHD, autism spectrum disorder (ASD), major depressive disorder (MDD), schizophrenia (SCZ), body mass index (BMI), smoking initiation (SmoIni), insomnia, educational attainment (EA) and age at first birth (AFB) are shown (see also Supplementary Table 17).
Association of ADHD-PGS with measures of cognitive abilities in the PNC cohort (n = 4,973).Beta values (represented as a dot and standard errors indicated as horizontal bars) from linear regression testing for the association of ADHD-PGS with the 15 neurocognitive measures listed on the y-axis (Wide Range Achievement Test-4 (WRAT). The color bar at the right indicates the βlog10(Bonferroni adjusted two-sided P-value) and P-value thresholds are indicated by stars (*P = 0.05; **P = 0.01, ***P = 0.001).
1β20 of 69
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| Aguilar-LacasanaS Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children. Psychol Med. 52, 1356β1364 (2022).32924895 10.1017/S0033291720003189PMC9157306 | β | β | β |
| AkaikeH A new look at the statistical model identification. IEE Transactions on Automatic Controls 19, 716β723 (1974). | β | β | β |
| AlsTD Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities. medRxiv (2022). | β | β | β |
| AraujoDJ FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev 29, 2081β96 (2015).26494785 10.1101/gad.267989.115PMC4617974 | β | β | β |
| BabinskiDE, NeelyKA, BaDM & LiuG Depression and Suicidal Behavior in Young Adult Men and Women With ADHD: Evidence From Claims Data. J Clin Psychiatry 81, 19m13130 (2020).10.4088/JCP.19m13130PMC754020632965804 | β | β | β |
| BahmaniZ Prefrontal Contributions to Attention and Working Memory. Curr Top Behav Neurosci 41, 129β153 (2019).30739308 10.1007/7854_2018_74PMC6689265 | β | β | β |
| BataillonT The effective size of the Icelandic population and the prospects for LD mapping: inference from unphased microsatellite markers. Eur J Hum Genet 14, 1044β53 (2006).16736029 10.1038/sj.ejhg.5201669 | β | β | β |
| BennerC FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics 32, 1493β501 (2016).26773131 10.1093/bioinformatics/btw018PMC4866522 | β | β | β |
| BoomsmaDI, van BeijsterveldtT, OdintsovaVV, NealeMC & DolanCV Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults. Behav Genet 51, 250β263 (2021).33259025 10.1007/s10519-020-10025-9PMC8093158 | β | β | β |
| Bulik-SullivanBK LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47, 291β5 (2015).25642630 10.1038/ng.3211PMC4495769 | β | β | β |
| Bybjerg-GrauholmJ The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders. medRxiv (2020).10.1038/mp.2017.196PMC575446628924187 | β | β | β |
| CalkinsME The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. J Child Psychol Psychiatry 56, 1356β1369 (2015).25858255 10.1111/jcpp.12416PMC4598260 | β | β | β |
| CapusanAJ, BendtsenP, MarteinsdottirI & LarssonH Comorbidity of Adult ADHD and Its Subtypes With Substance Use Disorder in a Large Population-Based Epidemiological Study. J Atten Disord 23, 1416β1426 (2019).26838558 10.1177/1087054715626511 | β | β | β |
| ChangCC Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).25722852 10.1186/s13742-015-0047-8PMC4342193 | β | β | β |
| ChangS, YangL, WangY & FaraoneSV Shared polygenic risk for ADHD, executive dysfunction and other psychiatric disorders. Transl Psychiatry 10, 182 (2020).32518222 10.1038/s41398-020-00872-9PMC7283259 | β | β | β |
| ChangZ, LichtensteinP, DβOnofrioBM, SjolanderA & LarssonH Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study. JAMA Psychiatry 71, 319β25 (2014).24477798 10.1001/jamapsychiatry.2013.4174PMC3949159 | β | β | β |
| ChenQ Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: A population-based cross-sectional study. PLoS One 13, e0204516 (2018).30256837 10.1371/journal.pone.0204516PMC6157884 | β | β | β |
| ChenW Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics. Genetics 200, 719β36 (2015).25948564 10.1534/genetics.115.176107PMC4512539 | β | β | β |
| CorcesMR Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimerβs and Parkinsonβs diseases. Nat Genet 52, 1158β1168 (2020).33106633 10.1038/s41588-020-00721-xPMC7606627 | β | β | β |
| Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 179, 1469β1482.e11 (2019).31835028 10.1016/j.cell.2019.11.020PMC7077032 | β | β | β |
| DalsgaardS, LeckmanJF, MortensenPB, NielsenHS & SimonsenM Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. Lancet Psychiatry 2, 702β9 (2015).26249301 10.1016/S2215-0366(15)00271-0 | β | β | β |
| DalsgaardS, OstergaardSD, LeckmanJF, MortensenPB & PedersenMG Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet 385, 2190β6 (2015).25726514 10.1016/S0140-6736(14)61684-6 | β | β | β |
| DasS Next-generation genotype imputation service and methods. Nat Genet 48, 1284β1287 (2016).27571263 10.1038/ng.3656PMC5157836 | β | β | β |
| de LeeuwCA, MooijJM, HeskesT & PosthumaD MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol 11, e1004219 (2015).25885710 10.1371/journal.pcbi.1004219PMC4401657 | β | β | β |
| DemontisD Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet 51, 63β75 (2019).30478444 10.1038/s41588-018-0269-7PMC6481311 | β | β | β |
| FaraoneSV & LarssonH Genetics of attention deficit hyperactivity disorder. Mol Psychiatry 24, 562β575 (2019).29892054 10.1038/s41380-018-0070-0PMC6477889 | β | β | β |
| FaraoneSV Attention-deficit/hyperactivity disorder. Nature Reviews Disease Primers, 15020 (2015).10.1038/nrdp.2015.2027189265 | β | β | β |
| FinucaneHK Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat Genet 50, 621β629 (2018).29632380 10.1038/s41588-018-0081-4PMC5896795 | β | β | β |
| FinucaneHK Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet 47, 1228β35 (2015).26414678 10.1038/ng.3404PMC4626285 | β | β | β |
| FongWL, KuoHY, WuHL, ChenSY & LiuFC Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain. Neuroscience 388, 214β223 (2018).30031127 10.1016/j.neuroscience.2018.07.017 | β | β | β |
| FrankeB Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan. Eur Neuropsychopharmacol 28, 1059β1088 (2018).30195575 10.1016/j.euroneuro.2018.08.001PMC6379245 | β | β | β |
| FrankeB The genetics of attention deficit/hyperactivity disorder in adults, a review. Mol Psychiatry 17, 960β87 (2012).22105624 10.1038/mp.2011.138PMC3449233 | β | β | β |
| FreiO Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nat Commun 10, 2417 (2019).31160569 10.1038/s41467-019-10310-0PMC6547727 | β | β | β |
| GandalMJ Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362, eaat8127 (2018).30545856 10.1126/science.aat8127PMC6443102 | β | β | β |
| GazalS Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection. Nat Genet 49, 1421β1427 (2017).28892061 10.1038/ng.3954PMC6133304 | β | β | β |
| GeT, ChenCY, NiY, FengYA & SmollerJW Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat Commun 10, 1776 (2019).30992449 10.1038/s41467-019-09718-5PMC6467998 | β | β | β |
| GreenbaumJ & DengHW A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density. J Bone Miner Res 32, 1651β1658 (2017).28425624 10.1002/jbmr.3154PMC5550336 | β | β | β |
| GroveJ Identification of common genetic risk variants for autism spectrum disorder. Nat Genet 51, 431β444 (2019).30804558 10.1038/s41588-019-0344-8PMC6454898 | β | β | β |
| GurRC Age group and sex differences in performance on a computerized neurocognitive battery in children age 8β21. Neuropsychology 26, 251β265 (2012).22251308 10.1037/a0026712PMC3295891 | β | β | β |
| HindleyG The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis. Am J Med Genet B Neuropsychiatr Genet 189, 207β218 (2022).35841185 10.1002/ajmg.b.32907PMC9541703 | β | β | β |
| HowardDM Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci 22, 343β352 (2019).30718901 10.1038/s41593-018-0326-7PMC6522363 | β | β | β |
| JangmoA Attention-deficit/hyperactivity disorder and occupational outcomes: The role of educational attainment, comorbid developmental disorders, and intellectual disability. PLoS One 16, e0247724 (2021).33730071 10.1371/journal.pone.0247724PMC7968636 | β | β | β |
| JensenCM & SteinhausenHC Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Atten Defic Hyperact Disord 7, 27β38 (2015).24942707 10.1007/s12402-014-0142-1 | β | β | β |
| JohnsonEC A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry 7, 1032β1045 (2020).33096046 10.1016/S2215-0366(20)30339-4PMC7674631 | β | β | β |
| KoopmansF SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron 103, 217β234 e4 (2019).31171447 10.1016/j.neuron.2019.05.002PMC6764089 | β | β | β |
| KuleshovMV Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44, W90β7 (2016).27141961 10.1093/nar/gkw377PMC4987924 | β | β | β |
| La MannoG Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells. Cell 167, 566β580.e19 (2016).27716510 10.1016/j.cell.2016.09.027PMC5055122 | β | β | β |
| LeeJJ Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet 50, 1112β1121 (2018).30038396 10.1038/s41588-018-0147-3PMC6393768 | β | β | β |
| LeHH Economic impact of childhood/adolescent ADHD in a European setting: the Netherlands as a reference case. Eur Child Adolesc Psychiatry 23, 587β98 (2014).24166532 10.1007/s00787-013-0477-8PMC4077218 | β | β | β |
| LibutzkiB Direct medical costs of ADHD and its comorbid conditions on basis of a claims data analysis. Eur Psychiatry 58, 38β44 (2019).30802682 10.1016/j.eurpsy.2019.01.019 | β | β | β |
| LiuM Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat Genet 51, 237β244 (2019).30643251 10.1038/s41588-018-0307-5PMC6358542 | β | β | β |
| LyngeE, SandegaardJL & ReboljM The Danish National Patient Register. Scand J Public Health 39, 30β3 (2011).21775347 10.1177/1403494811401482 | β | β | β |
| MartinJ, HamshereML, StergiakouliE, OβDonovanMC & ThaparA Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. J Child Psychol Psychiatry 56, 648β56 (2015).25280069 10.1111/jcpp.12336PMC4431584 | β | β | β |
| MattheisenM Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nat. Genet. 54, 1470β1478 (2022).36163277 10.1038/s41588-022-01171-3PMC10848300 | β | β | β |
| McCarthyS A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet 48, 1279β83 (2016).27548312 10.1038/ng.3643PMC5388176 | β | β | β |
| MeulemanW Index and biological spectrum of human DNase I hypersensitive sites. Nature 584, 244β251 (2020).32728217 10.1038/s41586-020-2559-3PMC7422677 | β | β | β |
| MillsMC Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nat Hum Behav 5, 1717β1730 (2021).34211149 10.1038/s41562-021-01135-3PMC7612120 | β | β | β |
| MoralesM & MargolisEB Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nat Rev Neurosci 18, 73β85 (2017).28053327 10.1038/nrn.2016.165 | β | β | β |
| MorsO, PertoGP & MortensenPB The Danish Psychiatric Central Research Register. Scand J Public Health 39, 54β7 (2011).21775352 10.1177/1403494810395825 | β | β | β |
| MostafaviH, SpenceJP, NaqviS & PritchardJK Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery. bioRxiv (2022). | β | β | β |
| MullinsN Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet 53, 817β829 (2021).34002096 10.1038/s41588-021-00857-4PMC8192451 | β | β | β |
| NiggJT Working Memory and Vigilance as Multivariate Endophenotypes Related to Common Genetic Risk for Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry 57, 175β182 (2018).29496126 10.1016/j.jaac.2017.12.013PMC6547382 | β | β | β |
| OkbayA Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals. Nat Genet 54, 437β449 (2022).35361970 10.1038/s41588-022-01016-zPMC9005349 | β | β | β |
| PardinasAF Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet 50, 381β389 (2018).29483656 10.1038/s41588-018-0059-2PMC5918692 | β | β | β |
| PedersenCB The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Mol Psychiatry 23, 6β14 (2018).28924187 10.1038/mp.2017.196PMC5754466 | β | β | β |
| Plana-RipollO Exploring Comorbidity Within Mental Disorders Among a Danish National Population. JAMA Psychiatry 76, 259β270 (2019).30649197 10.1001/jamapsychiatry.2018.3658PMC6439836 | β | β | β |
| PriceAL The impact of divergence time on the nature of population structure: an example from Iceland. PLoS Genet 5, e1000505 (2009).19503599 10.1371/journal.pgen.1000505PMC2684636 | β | β | β |
| Roadmap Epigenomics Consortium Integrative analysis of 111 reference human epigenomes. Nature 518, 317β30 (2015).25693563 10.1038/nature14248PMC4530010 | β | β | β |
| SatterstromFK Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. Nat Neurosci 22, 1961β1965 (2019).31768057 10.1038/s41593-019-0527-8PMC6884695 | β | β | β |
| SatterstromFK Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism. Cell 180, 568β584.e23 (2020).31981491 10.1016/j.cell.2019.12.036PMC7250485 | β | β | β |
| SatterthwaiteTD Neuroimaging of the Philadelphia neurodevelopmental cohort. Neuroimage 86, 544β53 (2014).23921101 10.1016/j.neuroimage.2013.07.064PMC3947233 | β | β | β |
| SazonovsA Large-scale sequencing identifies multiple genes and rare variants associated with Crohnβs disease susceptibility. Nat. Genet. 54, 1275β1283 (2021).10.1038/s41588-022-01156-2PMC970043836038634 | β | β | β |
| SinghT Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 604, 509β516 (2022).35396579 10.1038/s41586-022-04556-wPMC9805802 | β | β | β |
| SollisE Equivalent missense variant in the FOXP2 and FOXP1 transcription factors causes distinct neurodevelopmental disorders. Hum Mutat 38, 1542β1554 (2017).28741757 10.1002/humu.23303 | β | β | β |
| SonneJ, ReddyV & BeatoMR Neuroanatomy, Substantia Nigra. in StatPearls (Treasure Island (FL), 2021).30725680 | β | β | β |
| TrubetskoyV Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 604, 502β508 (2022).35396580 10.1038/s41586-022-04434-5PMC9392466 | β | β | β |
| TrzaskowskiM Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 180, 439β447 (2019).30708398 10.1002/ajmg.b.32713PMC6675638 | β | β | β |
| UffelmannE Genome-wide association studies. Nature Reviews Methods Primers 1, 59 (2021). | β | β | β |
| WangD Comprehensive functional genomic resource and integrative model for the human brain. Science 362, eaat8464 (2018).30545857 10.1126/science.aat8464PMC6413328 | β | β | β |
| WangJ CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. Nucleic Acids Res 48, D807βD816 (2020).31691819 10.1093/nar/gkz1026PMC7145620 | β | β | β |
| WatanabeK Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nat. Genet. 54, 1125β1132 (2022).35835914 10.1038/s41588-022-01124-w | β | β | β |
| WatanabeK, TaskesenE, van BochovenA & PosthumaD Functional mapping and annotation of genetic associations with FUMA. Nat Commun 8, 1826 (2017).29184056 10.1038/s41467-017-01261-5PMC5705698 | β | β | β |
| WatanabeK, Umicevic MirkovM, de LeeuwCA, van den HeuvelMP & PosthumaD Genetic mapping of cell type specificity for complex traits. Nat Commun 10, 3222 (2019).31324783 10.1038/s41467-019-11181-1PMC6642112 | β | β | β |
| WilkinsonGS & RobertsonGJ Wide range achievement test (WRAT4). Lutz, FL: Psychological Assessment Resources (2006). | β | β | β |
| WillerCJ, LiY & AbecasisGR METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190β1 (2010).20616382 10.1093/bioinformatics/btq340PMC2922887 | β | β | β |
| XieZ Gene Set Knowledge Discovery with Enrichr. Curr Protoc 1, e90 (2021).33780170 10.1002/cpz1.90PMC8152575 | β | β | β |
| YangJ, LeeSH, GoddardME & VisscherPM GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88, 76β82 (2011).21167468 10.1016/j.ajhg.2010.11.011PMC3014363 | β | β | β |
| YaoX Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders. Transl Psychiatry 11, 69 (2021).33479212 10.1038/s41398-020-01195-5PMC7820351 | β | β | β |
| YengoL Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry. Hum Mol Genet 27, 3641β3649 (2018).30124842 10.1093/hmg/ddy271PMC6488973 | β | β | β |
| ZablotskyB, BramlettMD & BlumbergSJ The Co-Occurrence of Autism Spectrum Disorder in Children With ADHD. J Atten Disord 24, 94β103 (2020).28614965 10.1177/1087054717713638PMC5711626 | β | β | β |
| ZhangW Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits. Nat Commun 10, 3834 (2019).31444360 10.1038/s41467-019-11874-7PMC6707297 | β | β | β |
| ZhaoX Family Burden of Raising a Child with ADHD. J Abnorm Child Psychol 47, 1327β1338 (2019).30796648 10.1007/s10802-019-00518-5 | β | β | β |
| ZhengJ LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33, 272β279 (2017).27663502 10.1093/bioinformatics/btw613PMC5542030 | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| ADHD polygenic risk predicts neural signatures of cognitive control: Evidence from midfrontal theta dynamics. | Aydin Γ et al. | β | 2026 | β |
| Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style. | Kranz TM et al. | β | 2026 | β |
| A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions. | Kiltschewskij DJ et al. | β | 2026 | β |
| A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity. | Kaas M et al. | β | 2026 | β |
| A multi-cohort assessment of the polygenic prediction in ADHD treatment response. | Rovaris DL et al. | β | 2026 | β |
| Aniracetam restores the excitation-inhibition balance of neurotransmitters in the prefrontal cortex of mice with ADHD. | Cui J et al. | β | 2026 | β |
| An update on the comorbidity of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) and its clinical management. | Petruzzelli MG et al. | β | 2026 | β |
| Assessing the effects of methylphenidate in proliferation and Wnt activity of neuronal stem cells from attention deficit/hyperactivity disorder patients. | Yde Ohki CM et al. | β | 2026 | β |
| Association between genetic polymorphisms in circadian cycle genes (<i>PER2, PER3</i>, and <i>HCRTR2</i>) and Attention Deficit Hyperactivity Disorder (ADHD). | Alves RB et al. | β | 2026 | β |
| Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study. | Zhang R et al. | β | 2026 | β |
| Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample. | Chatzigeorgiou C et al. | β | 2026 | β |
| Bazedoxifene reverses sexually dimorphic autistic-like abnormalities in biallelic MDGA1-mutant mice. | Kim S et al. | β | 2026 | β |
| Brain structures mediate the causal effects of socioeconomic status on mental disorders: A multi-stage Mendelian randomization study. | Pan S et al. | β | 2026 | β |
| Causal relationships between ADHD, ASD and brain structure: A mendelian randomization study. | Zhao Y et al. | β | 2026 | β |
| Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment. | Mallard TT et al. | β | 2026 | β |
| Common and rare variant contributions to discontinuation of stimulant treatment in ADHD. | Thirstrup JP et al. | β | 2026 | β |
| Computation and resource efficient genome-wide association analysis for large-scale imaging studies. | Jiang Z et al. | β | 2026 | β |
| Detection of pleiotropic genetic factors and critical brain cell types linking insomnia with psychiatric disorders. | Xue B et al. | β | 2026 | β |
| Dietary inflammatory index (DII) and attention deficit hyperactivity disorder: a cross-sectional study in US children and adolescents and Mendelian randomization study. | Hu J et al. | β | 2026 | β |
| Dissecting gene regulatory networks governing human cortical cell fate. | Ding JW et al. | β | 2026 | β |
| Dissecting the Mediating Role of Cortical Structures in the Pathogenesis of Socioeconomic Status to ADHD: A Mendelian Randomization Study and Mediation Analysis. | Xie W et al. | β | 2026 | β |
| Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis. | Nishioka M et al. | β | 2026 | β |
| Enduring Mental Health in Childhood and Adolescence: Prevalence, Prediction, and Genetic Architecture. | Alrouh H et al. | β | 2026 | β |
| Exploration of the relationship between autoimmune neurologic diseases and mental disorders: evidence from Mendelian randomization study. | Shen Y et al. | β | 2026 | β |
| Exploring the Behavioral and Emotional Manifestation of Polygenic Risk for Psychiatric Disorders Among Schoolchildren. | Alemany S et al. | β | 2026 | β |
| Exploring the genetic overlap between substance use disorder and educational attainment. | Cabana-DomΓnguez J et al. | β | 2026 | β |
| Gene-Environment Correlation Across Trauma Subtypes and Developmental Timing: Evidence From the EU-GEI and ALSPAC. | Trotta G et al. | β | 2026 | β |
| Genetic exploration of the relationship between liability to psychiatric disorders and acne vulgaris. | Mitchell BL et al. | β | 2026 | β |
| Genetic Susceptibility to Schizophrenia and the Onset of Brain Developmental Change During Adolescence. | Xu B et al. | β | 2026 | β |
| Genome-wide cross-trait analyses reveal shared genetic architecture and causal links between attention-deficit/hyperactivity disorder and cardiovascular diseases. | Liu HY et al. | β | 2026 | β |
| Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies. | Koch E et al. | β | 2026 | β |
| Growth Hormone and IGF-1 Actions in the Brain and Neuropsychiatric Diseases. | Aguiar-Oliveira MH et al. | β | 2026 | β |
| Heterogeneity in the longitudinal course of depressive symptomatology in adults with a history of recurrent major depressive disorder. | Weavers B et al. | β | 2026 | β |
| hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development. | McNeill RV et al. | β | 2026 | β |
| Identification of Mediating Pathways Between Attention Deficit/Hyperactivity Disorder and Coronary Artery Disease and Heart Failure: A Two-Step Multivariable Mendelian Randomization Study. | Lin J et al. | β | 2026 | β |
| Immunogenetic Variants in Major Mental and Neurodevelopmental Disorders. | Le Clerc S et al. | β | 2026 | β |
| Impact of SNAP-25 MnlI polymorphism on brain activity patterns in children with ADHD: Insights from fractional amplitude of low-frequency fluctuation analysis. | Fang D et al. | β | 2026 | β |
| Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases. | Ma Y et al. | β | 2026 | β |
| Interplay between attention-deficit/hyperactivity disorder, educational attainment, and vascular risk factors: Insights from Mendelian randomization analyses. | Song J et al. | β | 2026 | β |
| Intra-familial dynamics of mental distress during the Covid-19 lockdown. | Pettersen JH et al. | β | 2026 | β |
| Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds. | Parker N et al. | β | 2026 | β |
| Limbic System White Matter in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Diffusion Magnetic Resonance Imaging Analysis. | Connaughton M et al. | β | 2026 | β |
| Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. | Shakeshaft A et al. | β | 2026 | β |
| Mapping the genetic landscape across 14 psychiatric disorders. | Grotzinger AD et al. | β | 2026 | β |
| Maternal migraine and offspring ADHD: triangulating the evidence. | Luo Y et al. | β | 2026 | β |
| Microbiome dynamics in attention-deficit hyperactivity disorder: A systematic review and meta-analysis decoding the role of gut dysbiosis and potential dietary interventions. | Ghosh S et al. | β | 2026 | β |
| Neonatal gut Bifidobacterium associates with indole-3-lactic acid levels in blood and risk of ADHD at age 10. | Widdowson M et al. | β | 2026 | β |
| Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study. | Byg LM et al. | β | 2026 | β |
| Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study. | Ho AM et al. | β | 2026 | β |
| Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders. | Antonyan L et al. | β | 2026 | β |
| Polygenic risk scores reveal genetic underpinnings of comorbidity between substance use disorders and ADHD. | Horstman LI et al. | β | 2026 | β |
| Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders. | Xue H et al. | β | 2026 | β |
| Proteome-wide multi-trait association analyses prioritize candidate proteins and therapeutic targets for psychiatric disorders. | Yao S et al. | β | 2026 | β |
| Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. | Demontis D et al. | β | 2026 | β |
| Shared and disorder-specific prenatal and perinatal risk factors for neurodevelopmental disorders: a nationwide cohort study. | Peyre H et al. | β | 2026 | β |
| Shared genetic etiology between specific phobia and other psychiatric disorders. | Ueda K et al. | β | 2026 | β |
| Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus. | Mulvey B et al. | β | 2026 | β |
| Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk. | Keser E et al. | β | 2026 | β |
| Sulcal Depth and Genetic Susceptibility Influence Initial Treatment Response in Adults With Attention-Deficit/Hyperactivity Disorder. | Laatsch J et al. | β | 2026 | β |
| The effects of stimulant medications on the sleepiness curve of young men with Attention-Deficit Hyperactivity Disorder (ADHD). | Haimov I et al. | β | 2026 | β |
| The gene expression landscape of disease genes. | GarcΓa-GonzΓ‘lez J et al. | β | 2026 | β |
| Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders. | Werwath KE et al. | β | 2026 | β |
| Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders. | Giacomel A et al. | β | 2026 | β |
| Transformer-based InsightGWAS improves GERD genetic discovery via pretraining on GWAS for major depressive disorder. | Wei Y et al. | β | 2026 | β |
| Unique and shared internalizing and externalizing genetic factors associated with suicidal thoughts and behaviors: Findings from the adolescent brain cognitive development study. | Thomas NS et al. | β | 2026 | β |
| Unraveling ADHD for the pediatrician. | Casella EB et al. | β | 2026 | β |
| Untangling the connection between dopamine and ADHD. | Madhusoodanan J | β | 2026 | β |
| Unveiling the hidden genetic conundrum linking pulmonary diseases and neuropsychiatric disorders: Novel insights from advanced omics-based analyses of the lung-brain axis. | Ding S et al. | β | 2026 | β |
| Abnormal Association Between Neural Activity and Genetic Expressions of Impulsivity in Attention-Deficit/Hyperactivity Disorder: An Adolescent Brain Cognitive Development Study. | Jeon S et al. | β | 2025 | β |
| A common neural signature between genetic and environmental risk for mental illness. | Vedechkina M et al. | β | 2025 | β |
| ADHD and Differences in Brain Function as Measured by EEG: Cause or Effect? | Ahn K et al. | β | 2025 | β |
| ADHD remote technology and ADHD transition: predicting and preventing negative outcomes (ART-transition) - an adolescent prospective cohort study protocol. | Bowler A et al. | β | 2025 | β |
| A Genetic Atlas of Relationships Between Circulating Metabolites and Liability to Psychiatric Conditions | Kiltschewskij DJ et al. | β | 2025 | β |
| A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders. | Antonatos C et al. | β | 2025 | β |
| Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. | Malone SG et al. | β | 2025 | β |
| A microglia-containing cerebral organoid model to study early life immune challenges. | Buonfiglioli A et al. | β | 2025 | β |
| A narrative review of research advances in gut microbiota and microecological agents in children with attention deficit hyperactivity disorder (ADHD). | Liu Y et al. | β | 2025 | β |
| An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus. | Thompson JR et al. | β | 2025 | β |
| Antisocial personality disorder:Failure to balance excitation/inhibition? | Lesch KP et al. | β | 2025 | β |
| An Update on the Psychiatric Genomics of Posttraumatic Stress Disorder (PTSD). | Norrholm SD | β | 2025 | β |
| A plasma proteome-mediated Mendelian randomization study reveals the impact of rheumatoid arthritis on mental disorders in a European population. | Wang J et al. | β | 2025 | β |
| Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study. | Ge Q et al. | β | 2025 | β |
| Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study. | Leffa DT et al. | β | 2025 | β |
| Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization. | Zhang Z et al. | β | 2025 | β |
| Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren. | Zubizarreta-Arruti U et al. | β | 2025 | β |
| A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling. | Dalby A et al. | β | 2025 | β |
| Attention-Deficit Hyperactivity Disorder (ADHD): A Comprehensive Overview of the Mechanistic Insights from Human Studies to Animal Models. | Yacoub MW et al. | β | 2025 | β |
| Attention-deficit/hyperactivity disorder (ADHD) in adults: evidence base, uncertainties and controversies. | Cortese S et al. | β | 2025 | β |
| Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. | Horstmann L et al. | β | 2025 | β |
| Beneath the Phenotypic Surface: Pleiotropy Shapes the Co-Occurrence of Alcohol Use Disorder and Psychopathology. | Mallard TT et al. | β | 2025 | β |
| Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth. | Xu B et al. | β | 2025 | β |
| Bidirectional genetic overlap between psychiatric disorders and high-density lipoprotein cholesterol levels. | Li X et al. | β | 2025 | β |
| Blunted cortisol as a biomarker of depression based on the attenuation hypothesis: A Mendelian randomization analysis using depression as exposure. | Chan II | β | 2025 | β |
| Brain region and cell type-specific DNA methylation profiles in association with ADHD. | Meijer M et al. | β | 2025 | β |
| Causal association between mental disorders and cerebrovascular diseases: Evidence from Mendelian randomization study. | Xiang W et al. | β | 2025 | β |
| Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis. | Li Y et al. | β | 2025 | β |
| Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study. | Du W et al. | β | 2025 | β |
| CAUSALdb2: an updated database for causal variants of complex traits. | Wang J et al. | β | 2025 | β |
| Causal relationship between graves' disease and mental disorders: A bidirectional Mendelian randomization study. | Deng Y et al. | β | 2025 | β |
| Characterizing selection on complex traits through conditional frequency spectra. | Patel RA et al. | β | 2025 | β |
| Childhood trauma and subclinical hypomania in early adulthood: A genetically informative study. | Gonzalez-Calvo I et al. | β | 2025 | β |
| Chromatic pupillometry findings in attention deficit hyperactivity disorder: Sex differences. | Duque-Chica GL et al. | β | 2025 | β |
| Circulating MicroRNAs in Cord Blood to Predict Attention-Deficit/Hyperactivity Disorder Diagnosis. | DypΓ₯s LB et al. | β | 2025 | β |
| Common and rare genetic variants explain distinct diagnostic variance in pediatric attention deficit hyperactivity disorder. | Arnett AB et al. | β | 2025 | β |
| Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD. | Zhong Y et al. | β | 2025 | β |
| Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate. | Rammos A et al. | β | 2025 | β |
| Could Maladaptive Daydreaming Delay ADHD Diagnosis Until Adulthood? Clinical Characteristics of Adults With ADHD Based on Diagnosis Age. | KandeΔer A et al. | β | 2025 | β |
| Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression. | Ouellet-Morin I et al. | β | 2025 | β |
| Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit. | Zhao Y et al. | β | 2025 | β |
| Differences and similarities between the genetic architecture of lifetime substance use across different substances. | Bright U et al. | β | 2025 | β |
| Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations. | Liu JJ et al. | β | 2025 | β |
| Direct and indirect genetic effects on early neurodevelopmental traits. | Hegemann L et al. | β | 2025 | β |
| Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR. | Shadrin AA et al. | β | 2025 | β |
| Distinguishing specific from broad genetic associations between external correlates and common factors. | de la Fuente J et al. | β | 2025 | β |
| Effects of micronutrients on neurodevelopmental disorders through the mediation of brain structure and function: A two-step Mendelian randomization analysis. | Li C et al. | β | 2025 | β |
| Electrophysiological indices of reward anticipation as ADHD risk and prognostic biomarkers. | Bunford N et al. | β | 2025 | β |
| Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders. | Weekley BH et al. | β | 2025 | β |
| Emotion regulation as a transdiagnostic link between ADHD and depression symptoms: evidence from a network analysis of youth in the ABCD study. | Tharaud JB et al. | β | 2025 | β |
| Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design. | Duarte I et al. | β | 2025 | β |
| Epigenetic age across development in children and adolescents with ADHD. | Wrigglesworth J et al. | β | 2025 | β |
| Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. | Pathak GA et al. | β | 2025 | β |
| Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium. | Neumann A et al. | β | 2025 | β |
| Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders. | Breunig S et al. | β | 2025 | β |
| Excess Wnt in neurological disease. | Pascual DM et al. | β | 2025 | β |
| Exploring causal associations between plasma metabolites and attention-deficit/hyperactivity disorder. | Shi S et al. | β | 2025 | β |
| Exploring Copy Number Variants in a Cohort of Children Affected by ADHD: Clinical Investigation and Translational Insights. | Mirabella F et al. | β | 2025 | β |
| Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach. | Prapiadou S et al. | β | 2025 | β |
| Exploring the complex relationship between attention deficit hyperactivity disorder and the immune system: A bidirectional Mendelian randomization analysis. | Du J et al. | β | 2025 | β |
| Exploring the genetic architecture of brain structure and ADHD using polygenic neuroimaging-derived scores. | van der Es T et al. | β | 2025 | β |
| Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders. | Song Q et al. | β | 2025 | β |
| Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference. | Luque-GarcΓa L et al. | β | 2025 | β |
| Exploring the shared genetic basis of attention-deficit/hyperactivity disorder and obstructive sleep apnea: A multi-omics analysis. | Huang Y et al. | β | 2025 | β |
| Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children. | Deng WQ et al. | β | 2025 | β |
| Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes. | Baranova A et al. | β | 2025 | β |
| From Clinic to Mechanisms: Multi-Omics Provide New Insights into Cerebrospinal Fluid Metabolites and the Spectrum of Psychiatric Disorders. | Wen J et al. | β | 2025 | β |
| Gene-Environment Interplay Between Perceived Stress and ADHD Symptoms in Adults. | Hur YM | β | 2025 | β |
| Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19. | Monistrol-Mula A et al. | β | 2025 | β |
| Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses. | Nielsen TT et al. | β | 2025 | β |
| Genetic Association Between Attention-Deficit/Hyperactivity Disorder and Sarcopenia: A Bidirectional Two-Sample, Two-Step Mendelian Randomized Study. | Zhao X et al. | β | 2025 | β |
| Genetic association of attention-deficit/hyperactivity disorder with thirteen ocular disorders. | Chen XN et al. | β | 2025 | β |
| [Genetic diagnostics of mental health disorders in adulthood]. | Kilarski LL et al. | β | 2025 | β |
| Genetic influence and neural pathways underlying the dose-response relationships between wearable-measured physical activity and mental health in adolescence. | Yu G et al. | β | 2025 | β |
| Genetic insights into the role of mitochondria-related genes in mental disorders: An integrative multi-omics analysis. | Lu Y et al. | β | 2025 | β |
| Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk. | Ciochetti NP et al. | β | 2025 | β |
| Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults. | Shi Y et al. | β | 2025 | β |
| Genetic neurodevelopmental clustering and dyslexia. | Ciulkinyte A et al. | β | 2025 | β |
| Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study. | Skelton M et al. | β | 2025 | β |
| Genetic overlap between household income and psychiatric disorders. | Zhang J et al. | β | 2025 | β |
| Genetic predisposition to digital device use and the risk of five psychiatric disorders. | Liu Q et al. | β | 2025 | β |
| Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis. | Abudusalamu R et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
| Genome-wide analysis of screen behaviors among adolescents identifies novel loci and overlap with educational attainment and mental disorders. | Frei E et al. | β | 2025 | β |
| Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry. | Gui A et al. | β | 2025 | β |
| Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. | van der Laan CM et al. | β | 2025 | β |
| Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study. | Deng WQ et al. | β | 2025 | β |
| Genome-wide DNA methylation analysis of hippocampal tissue in a murine model of attention deficit-hyperactivity disorder. | Vidal R et al. | β | 2025 | β |
| GenomicSEM Modelling of Diverse Executive Function GWAS Improves Gene Discovery. | Perry LC et al. | β | 2025 | β |
| Genomics yields biological and phenotypic insights into bipolar disorder. | O'Connell KS et al. | β | 2025 | β |
| High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD. | Borbye-Lorenzen N et al. | β | 2025 | β |
| Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice. | Zhang Y et al. | β | 2025 | β |
| Identification and validation of postpartum depression subtypes: a population-based cohort study. | Bauer AE et al. | β | 2025 | β |
| Identification of Risk Genes for Attention-Deficit/Hyperactivity Disorder During Early Human Brain Development. | Deng MG et al. | β | 2025 | β |
| Identifying novel protein biomarkers with cross-psychiatric disorders effects and potential intervention targets: Evidence from proteomic-Mendelian randomization. | Zhang R et al. | β | 2025 | β |
| Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions. | Dardani C et al. | β | 2025 | β |
| Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study. | Xiang L et al. | β | 2025 | β |
| Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers. | Zou X et al. | β | 2025 | β |
| Improving Outcomes in Mental Health (IOMH)-an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile. | Galligan DE et al. | β | 2025 | β |
| Improving polygenic risk prediction performance by integrating electronic health records through phenotype embedding. | Xu L et al. | β | 2025 | β |
| Increasing specificity in ADHD genetic association studies during childhood: use of the oxytocin-vasopressin pathway in attentional processes suggests specific mechanism for endophenotypes in the 2004 Pelotas birth (Brazil) cohort. | Camerini L et al. | β | 2025 | β |
| Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits. | Wang L et al. | β | 2025 | β |
| Integrating Genetic and Single-Cell Genomic Data to Reveal Brain Cell-Specific Regulation of Attention-Deficit/Hyperactivity Disorder Risk in the Prefrontal Cortex. | Gui J et al. | β | 2025 | β |
| Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders. | Ding H et al. | β | 2025 | β |
| Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology. | Davis CN et al. | β | 2025 | β |
| Integrative genetic analysis: cornerstone of precision psychiatry. | Vorstman J et al. | β | 2025 | β |
| Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder. | Jiao S et al. | β | 2025 | β |
| Intersectionality in a sociogenomic world: How do race, disability, socioeconomic status, and polygenic prediction interact to affect perceptions of educational trajectories? | Matthews LJ et al. | β | 2025 | β |
| Investigating the impact of omega-3 fatty acids on oxidative stress and pro-inflammatory cytokine release in iPSC-derived forebrain cortical neurons from ADHD patients. | Walter NM et al. | β | 2025 | β |
| Investigation of brain structures and potential mechanisms associated with ADHD: Insights from Mendelian randomization and genetic analysis. | Hu X et al. | β | 2025 | β |
| Linking Genome-Wide Association Studies to Pharmacological Treatments for Psychiatric Disorders. | Arnatkeviciute A et al. | β | 2025 | β |
| Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset. | van der Meer D et al. | β | 2025 | β |
| Maternal exacerbating and protective factors that shape the prevalence and severity of child attention-deficit hyperactivity disorder: a narrative review. | Thorsheim C et al. | β | 2025 | β |
| Maternal Inflammatory Proteins in Pregnancy and Neurodevelopmental Disorders at Age 10 Years. | Wang T et al. | β | 2025 | β |
| Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews. | Sheikh J et al. | β | 2025 | β |
| Measures of General Intelligence and Risk for Alcohol Use Disorder. | Capusan AJ et al. | β | 2025 | β |
| Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach. | Liu D et al. | β | 2025 | β |
| Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. | Johnson EC et al. | β | 2025 | β |
| Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions. | Wingo AP et al. | β | 2025 | β |
| Multi-ancestry investigation of the genomics of erectile dysfunction. | Bright U et al. | β | 2025 | β |
| Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery. | Mountford HS et al. | β | 2025 | β |
| Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. | Wen J et al. | β | 2025 | β |
| Neuropsychiatric polygenic scores are weak predictors of professional categories. | Voloudakis G et al. | β | 2025 | β |
| Not just old wine in new bottles: Polygenic liability for ADHD is associated with electrophysiological affective-motivational processing beyond anxiety, depression, and ODD. | Γgrez K et al. | β | 2025 | β |
| Parental preconceptual Ξ±-cypermethrin exposure alters embryonic brain transcriptomics in mice: Implications for autism spectrum disorder and stress vulnerability. | Hing B et al. | β | 2025 | β |
| Paternal valproate use and impact of shared genetic susceptibility on child neurodevelopment. | Olstad EW et al. | β | 2025 | β |
| Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood. | Heumann J et al. | β | 2025 | β |
| Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank. | Wang LH et al. | β | 2025 | β |
| Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations. | Al-Soufi L et al. | β | 2025 | β |
| Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des rΓ©sultats du traitement antidΓ©presseur Γ l'aide des scores de risque polygΓ©niques : Rapport sur l'Γ©tude CAN-BIND-1. | Magarbeh L et al. | β | 2025 | β |
| Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology. | Freeman K et al. | β | 2025 | β |
| Precision Medicine in Pediatric Attention-deficit/Hyperactivity Disorder: A Systematic Review of Behavioral, Neurobiological and Genetic Diagnostic Biomarkers. | PranjiΔ M et al. | β | 2025 | β |
| Prospective study on the impact of parental anxiety on academic performance in children with attention deficit. | Jin Y et al. | β | 2025 | β |
| Proteome-wide association studies have predicted that the protein abundance of LSM6, GMPPB, ICA1L, and CISD2 is associated with attention-deficit/hyperactivity disorder. | Liu J | β | 2025 | β |
| Psychiatric genetics in the diverse landscape of Latin American populations. | Bruxel EM et al. | β | 2025 | β |
| Psychiatric Polygenic Risk Scores and Week-by-Week Symptomatic Status in Youth with Bipolar Disorder: An Exploratory Study. | Jiang X et al. | β | 2025 | β |
| PsyRiskMR: A Comprehensive Resource for Identifying Psychiatric Disorder Risk Factors Through Mendelian Randomization. | Li X et al. | β | 2025 | β |
| PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity. | Li FJ et al. | β | 2025 | β |
| Refining Criteria for a Neurodevelopmental Subphenotype of Bipolar Disorders: AΒ FondaMental Advanced Centers of Expertise for Bipolar Disorders Study. | Lefrere A et al. | β | 2025 | β |
| Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies. | Solomon MB et al. | β | 2025 | β |
| Rodent research of attention-deficit/hyperactivity disorder: insights into widely used animal models. | Corona JC | β | 2025 | β |
| Role of serotonin in the neurobiology of attention-deficit/hyperactivity disorder: a systematic literature review. | Faraone SV et al. | β | 2025 | β |
| Serotonin dysfunction in ADHD. | Jackson EF et al. | β | 2025 | β |
| Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors. | Ramos JKN et al. | β | 2025 | β |
| Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus. | Guo X et al. | β | 2025 | β |
| Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders. | Sun R et al. | β | 2025 | β |
| Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease. | Liu A et al. | β | 2025 | β |
| Sleep and circadian disturbances in children with neurodevelopmental disorders. | Bruni O et al. | β | 2025 | β |
| Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity. | Jia Y et al. | β | 2025 | β |
| Systematic review: Biopsychosocial factors related to attention-deficit/hyperactivity disorder in children/adolescents with Neurofibromatosis type 1. | Hou Y et al. | β | 2025 | β |
| The association between temperament and polygenic score for psychopathology from infancy to middle childhood. | Freitag E et al. | β | 2025 | β |
| The causal association between psychiatric disorders and gynecological cancer: a bidirectional Mendelian randomization study. | Wang Y et al. | β | 2025 | β |
| The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis. | Zhao L et al. | β | 2025 | β |
| The disruptive effects of methylphenidate treatment on circadian rhythm in adult female zebrafish and epigenetic transmission of its negative effects to offspring. | Kutan BaΕΓ§Δ± AR et al. | β | 2025 | β |
| The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities. | Arruda AL et al. | β | 2025 | β |
| The Genetic Architecture of the Human Corpus Callosum and its Subregions. | Bhatt RR et al. | β | 2025 | β |
| The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis. | Tong Y et al. | β | 2025 | β |
| The importance of genetic counselling for turner syndrome transition. | Villarreal EML et al. | β | 2025 | β |
| The Psychiatric Genomics Consortium: discoveries and directions. | Agrawal A et al. | β | 2025 | β |
| The role of astrocytes in attention-deficit hyperactivity disorder: An update. | Dury LC et al. | β | 2025 | β |
| The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder. | Christiansen GB et al. | β | 2025 | β |
| The Role of Empathy in ADHD Children: Neuropsychological Assessment and Possible Rehabilitation Suggestions-A Narrative Review. | Casula A et al. | β | 2025 | β |
| The role of inflammation in the development of tic symptoms in subjects with ADHD. | Takahashi N et al. | β | 2025 | β |
| The Role of Mitochondrial DNA Copy Number in Neurodevelopmental Disorders: A Bidirectional Two-Sample Mendelian Randomization Study. | Qiu X et al. | β | 2025 | β |
| Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms. | Van Horn S et al. | β | 2025 | β |
| Transdiagnostic and Diagnosis-Specific Morphological Similarity Related Transcriptional Profile in Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder. | Zhang F et al. | β | 2025 | β |
| Transformer-based deep learning enhances discovery in migraine GWAS. | Meng Z et al. | β | 2025 | β |
| Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. | Qiu D et al. | β | 2025 | β |
| Unraveling ADHD: genes, co-occurring traits, and developmental dynamics. | Miller CJ et al. | β | 2025 | β |
| Unraveling the Genetic Link Between Endocrine Hormones and Psychiatric Disorders: An Atlas of Genetic Correlations. | Li JL | β | 2025 | β |
| Unraveling the shared genetic foundations of neurodevelopmental and psychiatric disorders: Insights from comprehensive genome-wide analyses. | Maimaiti A et al. | β | 2025 | β |
| Unveiling causal relationship between white matter tracts and psychiatric disorders. | Yu Y et al. | β | 2025 | β |
| Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders. | Liwayiding A et al. | β | 2025 | β |
| Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records. | Γorsteinsson H et al. | β | 2025 | β |
| Wearables in ADHD: Monitoring and Intervention-Where Are We Now? | Olinic MS et al. | β | 2025 | β |
| What clinicians should know about the contribution of modern behavioral genetics to psychiatric problems. | Plomin R et al. | β | 2025 | β |
| Absence of Causal Relationship Between Levels of Unsaturated Fatty Acids and ADHD: Evidence From Mendelian Randomization Study. | Wang Z et al. | β | 2024 | β |
| Adult ADHD: it is old and new at the same timeΒ - what is it? | Custodio RJP et al. | β | 2024 | β |
| Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder. | Shen F et al. | β | 2024 | β |
| A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. | Lin YP et al. | β | 2024 | β |
| A multi-omics study of brain tissue transcription and DNA methylation revealing the genetic pathogenesis of ADHD. | Wang J et al. | β | 2024 | β |
| An investigation on the alterations in Wnt signaling in ADHD across developmental stages. | Walter NM et al. | β | 2024 | β |
| Association among attention-deficit hyperactivity disorder, restless legs syndrome, and peripheral iron status: a two-sample Mendelian randomization study. | Xiao G et al. | β | 2024 | β |
| Association between human herpesviruses infections and childhood neurodevelopmental disorders: insights from two-sample mendelian randomization analyses and systematic review with meta-analysis. | Fang L et al. | β | 2024 | β |
| Association of air pollutants with psychiatric disorders: a two-sample Mendelian randomization. | Ma YY et al. | β | 2024 | β |
| Association of Chronic Obstructive Pulmonary Disease with Risk of Psychiatric Disorders: A Two-Sample Mendelian Randomization Study. | Zhang Q et al. | β | 2024 | β |
| Association of mental disorders with sepsis: a bidirectional Mendelian randomization study. | Hu Y et al. | β | 2024 | β |
| Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study. | Haan E et al. | β | 2024 | β |
| A state-of-the-art overview of candidate diagnostic biomarkers for Attention-deficit/hyperactivity disorder (ADHD). | Parlatini V et al. | β | 2024 | β |
| Attention-deficit/hyperactivity disorder. | Faraone SV et al. | β | 2024 | β |
| Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs. | Garcia-Argibay M et al. | β | 2024 | β |
| Attention-Deficit/Hyperactivity Disorder as a Potential Risk Factor for Dementia and Other Neurocognitive Disorders: A Systematic Review. | Carr RH et al. | β | 2024 | β |
| Attention deficit hyperactivity disorder diagnoses and prescriptions in UK primary care, 2000-2018: population-based cohort study. | Philipsen A | β | 2024 | β |
| Attention-deficit/hyperactivity disorder in Mozambique: an epidemiological investigation in a primary school sample. | Daniel HMC et al. | β | 2024 | β |
| Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder. | Song Y et al. | β | 2024 | β |
| Causal effects of PM<sub>2.5</sub> exposure on neuropsychiatric disorders and the mediation via gut microbiota: A Mendelian randomization study. | Li C et al. | β | 2024 | β |
| Causal influences of neuropsychiatric disorders on Alzheimer's disease. | Baranova A et al. | β | 2024 | β |
| Causality between six psychiatric disorders and digestive tract cancers risk: a two-sample Mendelian randomization study. | Fu Q et al. | β | 2024 | β |
| Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis. | Chen J et al. | β | 2024 | β |
| Clinical associations with treatment resistance in depression: An electronic health record study. | Coombes BJ et al. | β | 2024 | β |
| Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes. | Li M et al. | β | 2024 | β |
| Common Genetic Influence on the Relationship Between Gaming Addiction and Attention Deficit Hyperactivity Disorder in Young Adults: A Twin Study. | Lee SA et al. | β | 2024 | β |
| Comparative Efficacy of Neurofeedback Interventions for Attention-Deficit/Hyperactivity Disorder in Children: A Network Meta-Analysis. | Wu G et al. | β | 2024 | β |
| Compensation between FOXP transcription factors maintains proper striatal function. | Ahmed NI et al. | β | 2024 | β |
| Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study. | Li Z et al. | β | 2024 | β |
| Connecting clinical and genetic heterogeneity in ADHD. | Yap CX et al. | β | 2024 | β |
| Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter-, cell type-specific and chromosome- transcriptomic signatures. | Chen Z et al. | β | 2024 | β |
| Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder. | Shastri GG et al. | β | 2024 | β |
| Critical reasoning on the co-expression module QTL in the dorsolateral prefrontal cortex. | Cote AC et al. | β | 2024 | β |
| Developmental language disorder - heritability and genetic correlations with other disorders affecting language. | Nudel R et al. | β | 2024 | β |
| Dissecting the genetic and causal relationship between sleep-related traits and common brain disorders. | Xue B et al. | β | 2024 | β |
| Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment. | Cabana-DomΓnguez J et al. | β | 2024 | β |
| Distinct impact modes of polygenic disposition to dyslexia in the adult brain. | Soheili-Nezhad S et al. | β | 2024 | β |
| DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study. | Schuurmans IK et al. | β | 2024 | β |
| Dopaminergic system and neurons: Role in multiple neurological diseases. | Chen H et al. | β | 2024 | β |
| Epilepsy and childhood psychiatric disorders: a two-sample bidirectional Mendelian randomization study. | Wu Y et al. | β | 2024 | β |
| Estimating causality between smoking and abdominal obesity by Mendelian randomization. | Carrasquilla GD et al. | β | 2024 | β |
| Evaluating the link between immune characteristics and attention deficit hyperactivity disorder through a bi-directional Mendelian randomization study. | Jue H et al. | β | 2024 | β |
| Evaluating the regulatory function of non-coding autism-associated single nucleotide polymorphisms on gene expression in human brain tissue. | Pugsley K et al. | β | 2024 | β |
| Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood. | Breunig S et al. | β | 2024 | β |
| Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study. | Frach L et al. | β | 2024 | β |
| Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium. | LΓ³pez-Vicente M et al. | β | 2024 | β |
| Examining the role of common variants in rare neurodevelopmental conditions. | Huang QQ et al. | β | 2024 | β |
| Exploring causal associations of antioxidants from supplements and diet with attention deficit/hyperactivity disorder in European populations: a Mendelian randomization analysis. | Chen J et al. | β | 2024 | β |
| Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization. | Wang Y et al. | β | 2024 | β |
| Exploring Neuroimaging Association Scores in adulthood ADHD and middle-age trajectories. | Bandeira CE et al. | β | 2024 | β |
| Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study. | JΓ‘come-Ferrer P et al. | β | 2024 | β |
| Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization. | Deng X et al. | β | 2024 | β |
| Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study. | Breinbjerg A et al. | β | 2024 | β |
| Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts. | GarzΓ³n RodrΓguez N et al. | β | 2024 | β |
| From neurons to brain networks, pharmacodynamics of stimulant medication for ADHD. | Parlatini V et al. | β | 2024 | β |
| Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. | Friligkou E et al. | β | 2024 | β |
| Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study. | Xu WM et al. | β | 2024 | β |
| Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study. | Hegemann L et al. | β | 2024 | β |
| Genetic architecture of the structural connectome. | Wainberg M et al. | β | 2024 | β |
| Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts. | Grimes PZ et al. | β | 2024 | β |
| Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Attention Deficit Hyperactivity Disorder. | Guo D et al. | β | 2024 | β |
| Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. | Koller D et al. | β | 2024 | β |
| Genetic correlation and causal associations between psychiatric disorders and lung cancer risk. | Shi J et al. | β | 2024 | β |
| Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we? | Iakunchykova O et al. | β | 2024 | β |
| Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study. | Gao X et al. | β | 2024 | β |
| Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia. | Cameron D et al. | β | 2024 | β |
| Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia. | Tume CE et al. | β | 2024 | β |
| Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. | Nievergelt CM et al. | β | 2024 | β |
| Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age. | Egeskov-Cavling AM et al. | β | 2024 | β |
| Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome. | AkΓ§imen F et al. | β | 2024 | β |
| Identification of immune traits associated with neurodevelopmental disorders by two-sample Mendelian randomization analysis. | Chen J et al. | β | 2024 | β |
| Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders. | Tesfaye M et al. | β | 2024 | β |
| Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis. | Sun W et al. | β | 2024 | β |
| Impact of working memory training on brain network plasticity and genetic associations: insights from individual differences. | Wu H et al. | β | 2024 | β |
| Individual differences in adolescent self-control: The role of gene-environment interplay. | Willems YE et al. | β | 2024 | β |
| Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder. | Hubers N et al. | β | 2024 | β |
| Interference of default mode on attention networks in adults with attention-deficit/hyperactivity disorder and its association with genetic variants and treatment outcomes. | Liu L et al. | β | 2024 | β |
| Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture? | Voronin I et al. | β | 2024 | β |
| Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization. | Marchi M et al. | β | 2024 | β |
| Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis. | Chen Y et al. | β | 2024 | β |
| Major depressive disorder elevates the risk of dentofacial deformity: a bidirectional two-sample Mendelian randomization study. | Nie J et al. | β | 2024 | β |
| Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study. | Zhang J et al. | β | 2024 | β |
| Mendelian randomization analysis of the brain, cerebrospinal fluid, and plasma proteome identifies potential drug targets for attention deficit hyperactivity disorder. | Zhang C et al. | β | 2024 | β |
| Method for Testing Etiologic Heterogeneity Among Noncompeting Diagnoses, Applied to Impact of Perinatal Exposures on Autism and Attention Deficit Hyperactivity Disorder. | Kalkbrenner AE et al. | β | 2024 | β |
| mFusion: a multiscale fusion method bridging neuroimages to genes through neurotransmissions in mental health disorders. | Cao L et al. | β | 2024 | β |
| Mitochondrial related Mendelian randomization identifies causal associations between metabolic disorders and childhood neurodevelopmental disorders. | Hu C et al. | β | 2024 | β |
| More than just a number: the gut microbiota and brain function across the extremes of life. | Nuzum ND et al. | β | 2024 | β |
| Multi-polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives. | Shi Y et al. | β | 2024 | β |
| Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans. | Chakrabarty A et al. | β | 2024 | β |
| Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers. | Koirala S et al. | β | 2024 | β |
| Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies. | Wu X et al. | β | 2024 | β |
| Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis. | You Z et al. | β | 2024 | β |
| No evidence for a causal contribution of bioavailable testosterone to ADHD in sex-combined and sex-specific two-sample Mendelian randomization studies. | Dinkelbach L et al. | β | 2024 | β |
| No gene by stressful life events interaction on individual differences in adults' self-control. | Willems YE et al. | β | 2024 | β |
| Novel pharmacological targets for GABAergic dysfunction in ADHD. | Ferranti AS et al. | β | 2024 | β |
| Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study. | Liu H et al. | β | 2024 | β |
| Parental education and children's depression, anxiety, and ADHD traits, a within-family study in MoBa. | Hughes AM et al. | β | 2024 | β |
| Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling. | Horwitz TB et al. | β | 2024 | β |
| Persistent thinness and anorexia nervosa differ on a genomic level. | HΓΌbel C et al. | β | 2024 | β |
| Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation. | Zhou K et al. | β | 2024 | β |
| Polygenic scores for psychiatric disorders associate with year of first bipolar disorder diagnosis: A register-based study between 1972 and 2016. | Jonsson L et al. | β | 2024 | β |
| Polygenic Variation Underlying Educational Attainment and Attention-Deficit/Hyperactivity Disorder Indexes Behavior Ratings of Executive Functions in Child Psychiatry Outpatients. | Capawana MR et al. | β | 2024 | β |
| Population Neuroscience: Principles and Advances. | Paus T | β | 2024 | β |
| Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD. | Patel KHS et al. | β | 2024 | β |
| Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health. | Lv Y et al. | β | 2024 | β |
| Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects. | Ahlqvist VH et al. | β | 2024 | β |
| Psychiatric Polygenic Risk Scores Across Youth With Bipolar Disorder, Youth at High Risk for Bipolar Disorder, and Controls. | Jiang X et al. | β | 2024 | β |
| Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. | Olfson E et al. | β | 2024 | β |
| Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study. | Meng Z et al. | β | 2024 | β |
| Relative Age Effects on Attention-Deficit/Hyperactivity Disorder Symptoms and Educational Achievement: A Longitudinal UK Cohort Study. | Deng Q et al. | β | 2024 | β |
| Seven psychiatric traits and the risk of increased carotid intima-media thickness: a Mendelian randomization study. | He K et al. | β | 2024 | β |
| Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study. | Wimberley T et al. | β | 2024 | β |
| Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders. | Xiu Z et al. | β | 2024 | β |
| The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study. | Du Rietz E et al. | β | 2024 | β |
| The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models. | MacDonald HJ et al. | β | 2024 | β |
| The known and unknown about attention deficit hyperactivity disorder (ADHD) genetics: a special emphasis on Arab population. | Mahrous NN et al. | β | 2024 | β |
| The neural and genetic underpinnings of different developmental trajectories of Attention-Deficit/Hyperactivity Symptoms in children and adolescents. | Wang Y et al. | β | 2024 | β |
| The shared genetic etiology of antisocial behavior and psychiatric disorders: Insights from pleiotropy and causality analysis. | Wang S et al. | β | 2024 | β |
| Transcriptomic Evaluation of a Stress Vulnerability Network Using Single-Cell RNA Sequencing in Mouse Prefrontal Cortex. | Hing B et al. | β | 2024 | β |
| Transcutaneous auricular vagus nerve stimulation as a potential therapy for attention deficit hyperactivity disorder: modulation of the noradrenergic pathway in the prefrontal lobe. | Zhi J et al. | β | 2024 | β |
| Trends in Body Mass Index Among Individuals With Neurodevelopmental Disorders. | Garcia-Argibay M et al. | β | 2024 | β |
| Understanding Environmental Exposures and ADHD: a Pathway Forward. | Faraone SV | β | 2024 | β |
| Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence. | Liu Z et al. | β | 2024 | β |
| Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder. | HΓΈberg A et al. | β | 2024 | β |
| Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum. | Michelini G et al. | β | 2024 | β |
| Whole exome sequencing and polygenic assessment of a Swedish cohort with severe developmental language disorder. | Yahia A et al. | β | 2024 | β |
| Why are females less likely to be diagnosed with ADHD in childhood than males? | Martin J | β | 2024 | β |
| xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data. | Luo L et al. | β | 2024 | β |
| A bidirectional Mendelian randomization study about the role of morning plasma cortisol in attention deficit hyperactivity disorder. | Jue H et al. | β | 2023 | β |
| A cross-species proteomic map reveals neoteny of human synapse development. | Wang L et al. | β | 2023 | β |
| ADuLT: An efficient and robust time-to-event GWAS. | Pedersen EM et al. | β | 2023 | β |
| Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause. | Sonuga-Barke EJS et al. | β | 2023 | β |
| An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder. | da Silva BS et al. | β | 2023 | β |
| Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity. | Ugarte G et al. | β | 2023 | β |
| Attention-deficit/hyperactivity disorder symptoms and subsequent cardiometabolic disorders in adults: investigating underlying mechanisms using a longitudinal twin study. | Dobrosavljevic M et al. | β | 2023 | β |
| Blood miRNA levels associated with ADHD traits in children across six European birth cohorts. | DypΓ₯s LB et al. | β | 2023 | β |
| Causal associations between COVID-19 and childhood mental disorders. | Chen F et al. | β | 2023 | β |
| Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD. | Chaumette B et al. | β | 2023 | β |
| Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. | Als TD et al. | β | 2023 | β |
| Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population? | Xie T et al. | β | 2023 | β |
| Epidemiology of ADHD coming of age and a plea for prospective research on causes and consequences of ADHD throughout the lifespan in multidisciplinary team science. | Hartman CA | β | 2023 | β |
| Examining the shared etiology of psychopathology with genome-wide association studies. | Mallard TT et al. | β | 2023 | β |
| Fifty years of executive control research in attention-deficit/hyperactivity disorder:What we have learned and still need to know. | Schachar RJ | β | 2023 | β |
| From attention-deficit hyperactivity disorder to sporadic Alzheimer's disease-Wnt/mTOR pathways hypothesis. | GrΓΌnblatt E et al. | β | 2023 | β |
| Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes. | RibasΓ©s M et al. | β | 2023 | β |
| Genome-wide association studies: utility and limitations for research in physiology. | Pereira Ciochetti N et al. | β | 2023 | β |
| Genomic findings in schizophrenia and their implications. | Owen MJ et al. | β | 2023 | β |
| Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. | Yang ZH et al. | β | 2023 | β |
| Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders. | Karadag N et al. | β | 2023 | β |
| Identification of region-specific splicing QTLs in human hippocampal tissue and its distinctive role in brain disorders. | Li X et al. | β | 2023 | β |
| Independent Associated SNPs at SORCS3 and Its Protein Interactors for Multiple Brain-Related Disorders and Traits. | Kamran M et al. | β | 2023 | β |
| Integration of xeno-free single-cell cloning in CRISPR-mediated DNA editing ofΒ human iPSCs improves homogeneity and methodological efficiency ofΒ cellular disease modeling. | Namipashaki A et al. | β | 2023 | β |
| Joint polygenic and environmental risks for childhood attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom dimensions. | Mooney MA et al. | β | 2023 | β |
| Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults. | Deng WQ et al. | β | 2023 | β |
| Machine learning in attention-deficit/hyperactivity disorder: new approaches toward understanding the neural mechanisms. | Cao M et al. | β | 2023 | β |
| Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. | Zhou H et al. | β | 2023 | β |
| Multiple psychiatric polygenic risk scores predict associations between childhood adversity and bipolar disorder. | Yao K et al. | β | 2023 | β |
| Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts. | Farhat LC et al. | β | 2023 | β |
| Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort. | He Q et al. | β | 2023 | β |
| New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications. | Andreassen OA et al. | β | 2023 | β |
| Pediatric attention deficit hyperactivity disorder (ADHD): 2022 updates on pharmacological management. | O'Connor L et al. | β | 2023 | β |
| Rare copy number variants in males and females with childhood attention-deficit/hyperactivity disorder. | Jung B et al. | β | 2023 | β |
| Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder. | Baranova A et al. | β | 2023 | β |
| The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings. | Berg LM et al. | β | 2023 | β |
| Transcriptomic risk scores for attention deficit/hyperactivity disorder. | Cabana-DomΓnguez J et al. | β | 2023 | β |
| ADHD and its neurocognitive substrates: A two sample Mendelian randomization study. | Ahn K et al. | β | 2022 | β |
| Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD). | Cabana-DomΓnguez J et al. | β | 2022 | β |
| Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample. | Moses M et al. | β | 2022 | β |