Overview and findings from the rush Memory and Aging Project.
paper
Cited
Public
- Authors
- Bennett, David A; Schneider, Julie A; Buchman, Aron S; Barnes, Lisa L; Boyle, Patricia A; Wilson, Robert S
- Year
- 2012
- Journal
- Current Alzheimer research
- PMID
- 22471867
- DOI
- 10.2174/156720512801322663
- PMCID
- PMC3439198
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: (1) the relation of motor function to cognition, disability, and death; (2) the relation of risk factors to cognitive and motor outcomes, disability and death; (3) the relation of neuropathologic indices to cognitive outcomes; (4) the relation of risk factors to neuropathologic indices; and (5) additional study findings. The findings are discussed and contextualized.
Major locations of Memory and Aging Project participants in Northeastern Illinois.**Alden of Waterford, Aurora; Beacon Hill, Lombard; Bethlehem Woods, La Grange Park; Clare Oaks Retirement Community, Bartlett; Covenant Village, Northbrook; Elgin Housing Authority, Elgin; Fairview Village, Downer's Grove; Frances Manor, Des Plaines; Franciscan Village, Lemont; Friendship Village, Schaumburg; Garden House, Calumet City; Green Castle, Arlington Heights; Holland Home, South Holland; King-Bruwaert House, Burr Ridge; Kingston Manor, Chicago; Lawrence Manor, Matteson; Luther Village, Arlington Heights; Marian Village, Homer Glen; Mayslake Village, Oak Brook; Peace Village, Palos Park; Renaissance, Hillside; Victorian Village, Tinley Park; St. Andrew's Manor, Phoenix; St. Paul Home, Chicago; The Breakers of Edgewater, Chicago; The Birches, Clarendon Hills; The Holmstad, Batavia; The Imperial, Chicago; The Mills, Oak Park; The Moorings, Arlington Heights; The Oaks, Oak Park; Trinity United Church Of Christ, Chicago; Victory Lakes, Lindenhurst; Village Woods, Crete; Washington Jane Smith, Chicago; Windsor Park Manor, Carol Stream; Wyndemere, Wheaton.
LLM interpretation
This figure is a geographic map showing the distribution of Memory and Aging Project participant locations across several counties in Northeastern Illinois. Black dots represent specific sites distributed across Lake, Cook, Du Page, Kane, and Will Counties, bordering Lake Michigan. The map illustrates a higher density of participant locations within Cook County compared to the surrounding counties.
Overall study design of the Rush Memory and Aging Project**Through November, 2011, the baseline evaluation was completed on 1,489 persons. There have been 343 cases of incident MCI and 250 cases of incident dementia, and 424 autopsies.
LLM interpretation
This figure is a schematic diagram illustrating the longitudinal study design of the Rush Memory and Aging Project. It shows a progression from a baseline evaluation through multiple follow-up evaluations (F/U 1, F/U 2... F/U X), tracking the emergence of motor decline, incident MCI, and incident AD over time. The diagram also indicates that participants who are deceased undergo autopsy to assess neuropathology, such as AD, CVD, and Lewy bodies.
Overview of clinical pathologic relationships reported in the Rush Memory and Aging Project through November 2010.
LLM interpretation
This figure is a conceptual diagram illustrating the clinical pathologic relationships reported in the Rush Memory and Aging Project. It maps the flow from genetic and psychosocial factors (e.g., *APOE*, social networks) to neuropathological markers (e.g., Amyloid Tangles, Lewy bodies), which then link to outcomes such as Cognitive Decline and Clinical AD. Additional associations are shown between these pathologies and physical health markers, decision making, and odor identification.
| # | Section | Preview |
|---|---|---|
| 40 | FINDINGS β Relation of Motor Function to Cognition, Disability and Death | In longitudinal analyses, level of physical frailty and change in physical frailty over time wereβ¦ |
| 41 | FINDINGS β Relation of Motor Function to Cognition, Disability and Death | Further, change over time in cognition, an overall measure of motor function, physical frailty,β¦ |
| 42 | FINDINGS β Relation of Motor Function to Cognition, Disability and Death | We also conducted change point models to determine the timing of onset of cognitive decline prior toβ¦ |
| 43 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Cognitive, Physical Activities, Social Engagement, Loneliness and Life Space | Participation in cognitively stimulating activities across the life course was associated with levelβ¦ |
| 44 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Cognitive, Physical Activities, Social Engagement, Loneliness and Life Space | Physical activity by self report was associated with a slower rate of decline in motor functionβ¦ |
| 45 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Cognitive, Physical Activities, Social Engagement, Loneliness and Life Space | Social engagement, specifically social activity and social support, though not social networks, wasβ¦ |
| 46 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Cognitive, Physical Activities, Social Engagement, Loneliness and Life Space | Finally, greater life space was associated with better cognitive and motor function [123], and itβ¦ |
| 47 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Anxiety-Related Traits: Neuroticism, Anxiety, Childhood Adversity, and Harm Avoidance | Neuroticism was associated with an increased risk of AD and with a more rapid rate of cognitiveβ¦ |
| 48 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Anxiety-Related Traits: Neuroticism, Anxiety, Childhood Adversity, and Harm Avoidance | Harm avoidance, a trait associated with apprehensiveness and behavioral inhibition, was associatedβ¦ |
| 49 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Medical Conditions | In cross-sectional analyses, low hemoglobin was associated with lower cognition [132], and inβ¦ |
| 50 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Apolipoprotein E Allele Status (APOE) and Other Genetic Variants | The APOE Ξ΅4 allele was associated with a greater rate of decline in motor function [83]. CR1 andβ¦ |
| 51 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Well-Being (Purpose in Life) | Purpose in life was associated with a reduced risk of incident AD, incident MCI and a slower rate ofβ¦ |
| 52 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Odor Identification | Loss of odor identification was associated with a greater rate of cognitive decline and an increasedβ¦ |
| 53 | FINDINGS β Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death β Respiratory Muscle Strength and Pulmonary Function | Respiratory muscle strength was associated with the rate of change in mobility even afterβ¦ |
| 54 | FINDINGS β Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition β Alzheimer's Disease Pathology | About 90% of persons meeting clinical criteria for AD also met pathologic criteria for the diseaseβ¦ |
| 55 | FINDINGS β Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition β Cerebrovascular Disease | Persons with dementia were most likely to have had cerebral infarcts and those with MCI had anβ¦ |
| 56 | FINDINGS β Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition β Lewy Bodies | Lewy bodies were most common in persons with dementia and intermediate among those with MCI [33]. Inβ¦ |
| 57 | FINDINGS β Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition β Mixed Pathologies | The combination of AD pathology with cerebral infarcts or Lewy bodies is so common that mixedβ¦ |
| 58 | FINDINGS β Relation of Common Neuropathologic Indices to Motor Function and Odor Identification | Parkinsonian signs were related to AD pathology, cerebrovascular disease, Lewy bodies and nigralβ¦ |
| 59 | FINDINGS β Relation of Risk Factors to Neuropathologic Indices (Table 3) | The APOE Ξ΅4 allele was associated with greater AD pathology and the Ξ΅2 allele was associated withβ¦ |
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| Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer disease. | Ramcharitar J et al. | β | 2013 | β |
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