An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
paper
Cited
Public
- Authors
- van den Heuvel, Odile A; Boedhoe, Premika S W; Bertolin, Sara; Bruin, Willem B; Francks, Clyde; Ivanov, Iliyan; Jahanshad, Neda; Kong, Xiang-Zhen; Kwon, Jun Soo; O'Neill, Joseph; Paus, Tomas; Patel, Yash; Piras, Fabrizio; Schmaal, Lianne; Soriano-Mas, Carles; Spalletta, Gianfranco; van Wingen, Guido A; Yun, Je-Yeon; Vriend, Chris; Simpson, H Blair; van Rooij, Daan; Hoexter, Marcelo Q; Hoogman, Martine; Buitelaar, Jan K; Arnold, Paul; Beucke, Jan C; Benedetti, Francesco; Bollettini, Irene; Bose, Anushree; Brennan, Brian P; De Nadai, Alessandro S; Fitzgerald, Kate; Gruner, Patricia; Grünblatt, Edna; Hirano, Yoshiyuki; Huyser, Chaim; James, Anthony; Koch, Kathrin; Kvale, Gerd; Lazaro, Luisa; Lochner, Christine; Marsh, Rachel; Mataix-Cols, David; Morgado, Pedro; Nakamae, Takashi; Nakao, Tomohiro; Narayanaswamy, Janardhanan C; Nurmi, Erika; Pittenger, Christopher; Reddy, Y C Janardhan; Sato, João R; Soreni, Noam; Stewart, S Evelyn; Taylor, Stephan F; Tolin, David; Thomopoulos, Sophia I; Veltman, Dick J; Venkatasubramanian, Ganesan; Walitza, Susanne; Wang, Zhen; Thompson, Paul M; Stein, Dan J; ENIGMA-OCD working group
- Year
- 2022
- Journal
- Human brain mapping
- PMID
- 32154629
- DOI
- 10.1002/hbm.24972
- PMCID
- PMC8675414
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.
World map showing the 34 institutes participating in the ENIGMA‐OCD consortium
Summary of the subcortical volume effects in ENIGMA‐OCD (based on Boedhoe et al., 2017Am J Psychiatry)
Summary of the cortical thickness effects in adult OCD patients compared to healthy controls in ENIGMA‐OCD, in relation to medication status (based on Boedhoe et al., 2018Am J Psychiatry). Negative effect sizes d (ranging from light orange d = −0.05 to dark red d = −0.15) indicate thinner cortex in OCD compared to controls
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| Adhikari, B. M. , Jahanshad, N. , Shukla, D. , Glahn, D. C. , Blangero, J. , Fox, P. T. , … Kochunov, P. (2018). Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline. Human Brain Mapping, 39, 4893–4902.3005231810.1002/hbm.24331PMC6218292 | — | — | — |
| Adhikari, B. M. , Jahanshad, N. , Shukla, D. , Turner, J. , Grotegerd, D. , Dannlowski, U. , … Kochunov, P. (2019). A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: An ENIGMA rs‐fMRI protocol. Brain Imaging and Behavior, 13, 1453–1467.3019151410.1007/s11682-018-9941-xPMC6401353 | — | — | — |
| Ashburner, J. , & Friston, K. J. (2000). Voxel‐based morphometry, the methods. NeuroImage, 11, 805–821.1086080410.1006/nimg.2000.0582 | — | — | — |
| Behar, D. , Rapoport, J. , Berg, C. J. , Denckla, M. B. , Mann, L. , Cox, C. , … Wolfman, M. G. (1984). Computerized tomography and neuropsychological test measures in adolescents with obsessive‐compulsive disorder. The American Journal of Psychiatry, 141, 363–369.670309910.1176/ajp.141.3.363 | — | — | — |
| Behrens, T. E. , Johansen‐Berg, H. , Woolrich, M. W. , Smith, S. M. , Wheeler‐Kingshott, C. A. , Boulby, P. A. , … Matthews, P. M. (2003). Non‐invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neuroscience, 7, 750–757.10.1038/nn107512808459 | — | — | — |
| Bertolin, S. , Martinez‐Zalacain, I. , Boedhoe, P.S.W. , Alonso, P. , ENIGMA‐OCD working group ,…, Soriano‐Mas, C. (2019). Prefrontal cortical thickness is associated with response to cognitive‐behavioral therapy in children with OCD. Poster presented at the 32nd European College of Neuropsychopharmacology (ECNP) Congress. | — | — | — |
| Boedhoe, P. S. W. , Heymans, M. W. , Schmaal, L. , Abe, Y. , Alonso, P. , Ameis, S. H. , … Twisk, J. W. R. (2019). An empirical comparison of meta‐ and mega‐analysis with data from the ENIGMA obsessive‐compulsive disorder working group. Frontiers in Neuroinformatics, 12, 102.3067095910.3389/fninf.2018.00102PMC6331928 | — | — | — |
| Boedhoe, P. S. W. , Schmaal, L. , Abe, Y. , Ameis, S. H. , Antecevic, A. , Arnold, P. D. , … van den Heuvel, O. A. (2018). Cortical abnormalities associated with pediatric and adult obsessive‐compulsive disorder: Findings from the ENIGMA obsessive‐compulsive disorder working group. The American Journal of Psychiatry, 175, 453–462.2937773310.1176/appi.ajp.2017.17050485PMC7106947 | — | — | — |
| Boedhoe, P. S. W. , Schmaal, L. , Abe, Y. , Ameis, S. H. , Arnold, P. D. , Batistuzzo, M. C. , … van den Heuvel, O. A. (2017). Distinct subcortical volume alterations in pediatric and adult OCD; a worldwide meta‐ and mega‐analysis. The American Journal of Psychiatry, 174, 60–70.2760924110.1176/appi.ajp.2016.16020201PMC5344782 | — | — | — |
| Boedhoe, P.S.W. , van Rooij, D. , Hoogman, M. , Twisk, J.W.R. , Lianne Schmaal , Yoshinari Abe , …, van den Heuvel, O.A. (2019). Subcortical brain volume, regional cortical thickness and cortical surface areas across ADHD, ASD, and OCD: findings from the ENIGMA‐ADHD, ‐ASD, and –OCD working groups. The American Journal of Psychiatry (revision)/or BioRXiv, 673012. 10.1101/673012 PMC829607032539527 | — | — | — |
| Bruin, W. B. , Taylor, L. , Thomas, R. M. , Shock, J. P. , Zhutovsky, P. , ENIGMA‐OCD consortium , … van Wingen, G. A. (2019). Structural neuroimaging biomarkers for obsessive‐compulsive disorder in the ENIGMA‐OCD consortium: Medication matters. MedRxiv. 10.1101/19012567 PMC759894233033241 | — | — | — |
| Cummings, J. L. (1995). Anatomic and behavioral aspects of frontal‐subcortical circuits. Annals of the new York Academy of Sciences, 769, 1–13.10.1111/j.1749-6632.1995.tb38127.x8595019 | — | — | — |
| Cummings, J. L. , & Cunningham, K. (1992). Obsessive‐compulsive disorder in Huntington's disease. Biological Psychiatry, 31, 263–270.153213210.1016/0006-3223(92)90049-6 | — | — | — |
| De Vries, F. E. , de Wit, S. J. , Cath, D. C. , van der Werf, Y. D. , van der Borden, V. , van Rossum, T. B. , … van den Heuvel, O. A. (2014). Compensatory fronto‐parietal activity during working memory: An endophenotype of obsessive‐compulsive disorder. Biological Psychiatry, 76, 878–887.2436548410.1016/j.biopsych.2013.11.021 | — | — | — |
| De Wit, S. J. , Alonso, P. , Schweren, L. , Mataix‐Col, D. , Lochner, C. , Menchon, J. M. , … van den Heuvel, O. A. (2014). Multi‐center voxel‐based morphometry mega‐analysis of structural brain scans in obsessive‐compulsive disorder. The American Journal of Psychiatry, 171, 340–349.2422066710.1176/appi.ajp.2013.13040574 | — | — | — |
| Desikan, R. S. , Ségonne, F. , Fischl, B. , Quinn, B. T. , Dickerson, B. C. , Blacker, D. , … Hyman, B. T. (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage, 31, 968–980.1653043010.1016/j.neuroimage.2006.01.021 | — | — | — |
| Douw, L. , Quaak, M. , Fitzsimmons, S. M. D. D. , de Wit, S. J. , van der Werf, Y. D. , van den Heuvel, O. A. , & Vriend, C. (2019). Static and dynamic network properties of the repetitive transcranial magnetic stimulation target predict changes in emotion regulation in obsessive‐compulsive disorder. Brain Stimulation, 2020, 13(2), 318–326.10.1016/j.brs.2019.10.01731679906 | — | — | — |
| Eslinger, P. L. , & Damasio, A. R. (1985). Severe disturbance of higher cognition after bilateral frontal lobe ablation: Patient EVR. Neurology, 35, 1731–1741.406936510.1212/wnl.35.12.1731 | — | — | — |
| Esteban, O. , Markiewicz, C. J. , Blair, R. W. , Moodie, C. A. , Isik, A. I. , Erramuzpe, A. , … Gorgolewski, K. J. (2019). fMRIPrep: A robust preprocessing pipeline for functional MRI. Nature Methods, 16, 111–116.3053208010.1038/s41592-018-0235-4PMC6319393 | — | — | — |
| Eyler, L. T. , Prom‐Wormley, E. , Panizzon, M. S. , Kaup, A. R. , Fennema‐Notestine, C. , Neale, M. C. , … Kremen, W. S. (2011). Genetic and environmental contributions to regional cortical surface area in humand: A magnetic resonance imaging twin study. Cerebral Cortex, 21, 2313–2321.2137811210.1093/cercor/bhr013PMC3169660 | — | — | — |
| Fischl, B. , & Dale, A. M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 97, 11050–11055.1098451710.1073/pnas.200033797PMC27146 | — | — | — |
| Fouche, J. P. , du Plessis, S. , Hattingh, C. , Roos, A. , Lochner, C. , Soriano‐Mas, C. , … van den Heuvel, O. A. (2017). Cortical thickness in obsessive‐compulsive disorder: Multisite mega‐analysis of 780 brain scans from six centers. The British Journal of Psychiatry, 210, 67–74.2719848510.1192/bjp.bp.115.164020 | — | — | — |
| Frye, R. E. , Liederman, J. , Malmberg, B. , McLean, J. , Strickland, D. , & Beauchamp, M. S. (2010). Surface area accounts for the relation of gray matter volume to reading‐related skills and history of dyslexia. Cerebral Cortex, 20, 2625–2635.2015401110.1093/cercor/bhq010PMC2981021 | — | — | — |
| Fullana, M. A. , Cardoner, N. , Alonso, P. , Subira, M. , Lopez‐Sola, C. , Pujol, J. , … Soriano‐Mas, C. (2014). Brain regions related to fear extinction in obsessive‐ compulsive disorder and its relation to exposure therapy outcome: A morphometric study. Psychological Medicine, 44, 845–856.2377347910.1017/S0033291713001128 | — | — | — |
| Fullana, M. A. , Zhu, X. , Alonso, P. , Cardoner, N. , Real, E. , Lopes‐Sola, C. , … Soriano‐Mas, C. (2017). Basolateral amygdala‐ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive‐compulsive disorder. Journal of Psychiatry and Neuroscience, 42, 378–385.2863212010.1503/jpn.160215PMC5662459 | — | — | — |
| Glasser, M. F. , Coalson, T. S. , Robinson, E. C. , Hacker, C. D. , Harwell, J. , Yacoubs, E. , … van Essen, D. C. (2016). A multi‐modal parcellation of human cerebral cortex. Nature, 536, 171–178.2743757910.1038/nature18933PMC4990127 | — | — | — |
| Goodkind, M. , Eickhoff, S. B. , Oathes, D. J. , Jiang, Y. , Chang, A. , Jones‐Hagata, L. B. , … Etkin, A. (2015). Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry, 72, 305–315.2565106410.1001/jamapsychiatry.2014.2206PMC4791058 | — | — | — |
| Gursel, D. A. , Avram, M. , Sorg, C. , Brandl, F. , & Koch, K. (2018). Frontoparietal areas link impairments of large‐scale intrinsic brain networks with aberrant fronto‐striatal interactions in OCD: A meta‐analysis of resting‐state functional connectivity. Neuroscience and Biobehavioural Reviews, 87, 151–160.10.1016/j.neubiorev.2018.01.01629410103 | — | — | — |
| Göttlich, M. , Krämer, U. M. , Kordon, A. , Hohagen, F. , & Zurowski, B. (2015). Resting‐state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive‐compulsive disorder. Biological Psychology, 111, 100–109.2638825710.1016/j.biopsycho.2015.09.004 | — | — | — |
| Hawrylycz, M. J. , Lein, E. S. , Guillozet‐Bongaarts, A. L. , Shen, E. H. , Ng, L. , Miller, J. A. , … Riley, Z. L. (2012). An anatomically comprehensive atlas of the adult human brain transcriptome. Nature, 489, 391–399.2299655310.1038/nature11405PMC4243026 | — | — | — |
| Hibar, D. P. , Cheung, J. W. , Medland, S. E. , Mufford, M. S. , Jahanshad, N. , Dalvie, S. , … Thompson, P. M. (2018). Significant concordance of genetic variation that increases both the risk for obsessive‐compulsive disorder and the volumes of the nucleus accumbens and putamen. British Journal of Psychiatry, 213, 430–436.10.1192/bjp.2018.62PMC605327129947313 | — | — | — |
| Hibar, D. P. , Westlye, L. T. , van Erp, T. G. , Rasmussen, J. , Leonardo, C. D. , Faskowitz, J. , … Andreassen, O. A. (2016). Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry, 21, 1710–1716.2685759610.1038/mp.2015.227PMC5116479 | — | — | — |
| Hoexter, M. Q. , Dougherty, D. D. , Shavitt, R. G. , D'Alcante, C. C. , Duran, F. L. , Lopes, A. C. , … Miguel, E. C. (2013). Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive‐behavioral therapy in obsessive‐ compulsive disorder. European Neuropsychopharmacology, 23, 569–580.2284113110.1016/j.euroneuro.2012.06.014 | — | — | — |
| Hunt, B. A. , Tewarie, P. K. , Mougin, O. E. , Geades, N. , Jones, D. K. , Singh, K. D. , … Brooks, M. J. (2016). Relationships between cortical myeloarchitecture and electrophysiological networks. Proceedings of the National Academy of Sciences of the United States of America, 113, 13510–13515.2783065010.1073/pnas.1608587113PMC5127325 | — | — | — |
| Iglesias, J. E. , Insausti, R. , Lerma‐Usabiaga, G. , Bocchetta, M. , van Leemput, K. , Greve, D. N. , … Paz‐Alonso, P. M. (2018). A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology. NeuroImage, 183, 314–326.3012133710.1016/j.neuroimage.2018.08.012PMC6215335 | — | — | — |
| Ivanov, I. , Boedhoe, P.S.W. , Stein, D.J. , Thompson, P.M. , van den Heuvel O.A. , O'Neill, J. , ENIGMA‐OCD working group (2019). Psychopharmaccological treatment for OCD on brain morphometry across the lifespan. Presentation at symposium ‘the structure of the OCD brain: Effects of medication, chronicity and disease‐specificity’ at the Society of Biological Psychiatry 74th Annual Meeting, Chicago. | — | — | — |
| Jaddoe, V. W. , van Duijn, C. M. , van der Heijden, A. J. , Mackenbach, J. P. , Moll, H. A. , Steegers, E. A. , … Hofman, A. (2010). The generation R study: Design and cohort update 2010. European Journal of Epidemiology, 25, 823–841.2096756310.1007/s10654-010-9516-7PMC2991548 | — | — | — |
| Jaspers‐Fayer, F. , Lin, S. Y. , Chan, E. , Ellwyn, R. , Lim, R. , Best, J. , … Stewart, S. E. (2019). Neural correlates of symptom provocation in pediatric obsessive‐compulsive disorder. Neuroimage Clinical, 24, 102034.3173453310.1016/j.nicl.2019.102034PMC6861668 | — | — | — |
| Kong, X. Z. , Boedhoe, P. S. W. , Abe, Y. , Alonso, P. , Ameis, S. H. , Arnold, P. D. , … Francks, C. (2019). Mapping cortical and subcortical asymmetry in obsessive‐compulsive disorder: Findings from the ENIGMA consortium. Biological Psychiatry, S0006‐3223(19)31292‐2. 10.1016/j.biopsych.2019.04.022 PMC709480231178097 | — | — | — |
| Laplane, D. , Levasseur, M. , Pillon, B. , Baulac, M. , Mazoyer, B. , … Baron, J. C. (1989). Obsessive‐compulsive and other behavioural changes with bilateral basal ganglia lesions: A neuropsychological, magnetic resonance imaging and positron tomography study. Brain, 112, 699–725.278644010.1093/brain/112.3.699 | — | — | — |
| Logue, M. W. , van Rooij, S. J. H. , Dennis, E. L. , Davis, S. L. , Hayes, J. P. , Stevens, J. S. , … Marey, R. A. (2018). Smaller hippocampal volume in posttraumatic stress disorder: A multisite ENIGMA‐PGC study: Subcortical volumetry results from posttraumativ stress disorder consortia. Biological Psychiatry, 83, 244–253.2921729610.1016/j.biopsych.2017.09.006PMC5951719 | — | — | — |
| Luxenberg, J. S. , Swedo, S. E. , Flamant, M. F. , Friedland, R. P. , Rapoport, J. , & Rapoport, S. I. (1988). Neuroanatomical abnormalities in obsessive‐compulsive disorder detected with quantitative X‐ray computed tomography. American Journal of Psychiatry, 145, 1089–1093.10.1176/ajp.145.9.10893414851 | — | — | — |
| Mangin, J. F. , Jouvent, E. , & Cachia, A. (2010). In‐vivo measurement of cortical morphology: Emans and meanings. Current Opinion in Neurology, 23, 359–367.2048961710.1097/WCO.0b013e32833a0afc | — | — | — |
| Milad, M. R. , Furtak, S. C. , Greenberg, J. L. , Keshaviah, A. , Im, J. J. , Falkenstein, M. J. , … Wilhelm, S. (2013). Defecits in conditioned fear extinction in obsessive‐compulsive disorder and neurobiological changes in the fear circuit. JAMA Psychiatry, 70, 608–618.2374004910.1001/jamapsychiatry.2013.914 | — | — | — |
| Norman, L. J. , Taylor, S. F. , Liu, Y. , Radua, J. , Chye, Y. , de Wit, S. J. , … Fitzgerald, K. (2019). Error processing and inhibitory control in obsessive‐compulsive disorder: A meta‐analysis using statistical parametric maps. Biological Psychiatry, 85, 713–725.3059523110.1016/j.biopsych.2018.11.010PMC6474799 | — | — | — |
| Olatunji, B. O. , Ferreira‐Garcia, R. , Caseras, X. , Fullana, M. A. , Wooderson, S. , Speckens, A. , … Mataix‐Cols, D. (2014). Predicting response to cognitive behavioral therapy in contamination‐based obsessive‐compulsive disorder from functional magnetic resonance imaging. Psychological Medicine, 44, 2125–2137.2422947410.1017/S0033291713002766 | — | — | — |
| Patel, Y. , Shin, J. , Gowland, P. , Pausova, Z. , & Paus, T. (2018). Maturation of the human cerebral cortex during adolescence: Myelin or dendritic arbor? Cerebral Cortex, 29, 3351–3362. 10.1093/cercor/bhy204 PMC664485730169567 | — | — | — |
| Peng, Z. , Lui, S. S. , Cheung, E. F. , Jin, Z. , Miso, G. , Jing, J. , & Chan, R. C. (2012). Brain structural abnormalities in obsessive‐compulsive disorder: Converging evidence from white matter and grey matter. Asian Journal of Psychiatry, 5, 290–296.2317443510.1016/j.ajp.2012.07.004 | — | — | — |
| Piras, F. , Piras, F. , Abe, Y. , Agarwal, S. M. , Anticevic, A. , Ameis, S. , … Spalletta, G. (2019). White matter microstructure and its relation to clinical features of obsessive‐compulsive disorder: Findings from the ENIGMA OCD working group. bioRxiv, 855916. 10.1101/855916 PMC796974433731673 | — | — | — |
| Piras, F. , Piras, F. , Caltagirone, C. , & Spalletta, G. (2013). Brain circuitries of obsessive‐compulsive disorder: A systematic review and meta‐analysis of diffusion tensor imaging studies. Neuroscience and Biobehavioural Reviews, 37, 2856–2877.10.1016/j.neubiorev.2013.10.00824177038 | — | — | — |
| Pujol, J. , Soriano‐Mas, C. , Alonso, P. , Cardoner, N. , Menchon, J. M. , Deus, J. , & Vallejo, J. (2004). Mapping structural brain alterations in obsessive‐compulsive disorder. Archives of General Psychiatry, 61, 720–730.1523708410.1001/archpsyc.61.7.720 | — | — | — |
| Radua, J. , & Mataix‐Cols, D. (2009). Voxel‐wise meta‐analysis of grey matter changes in obsessive‐compulsive disorder. British Journal of Psychiatry, 195, 393–402.10.1192/bjp.bp.108.05504619880927 | — | — | — |
| Radua, J. , Grau, M. , van den Heuvel, O. A. , Thiebaut de Schotten, M. , Stein, D. J. , Rodriguez, E. J. , … Mataix‐Cols, D. (2014). Multimodal voxel‐based meta‐analysis of white matter abnormalities in obsessive‐compulsive disorder. Neuropsychopharmacology, 39, 1547–1557.2440726510.1038/npp.2014.5PMC4023155 | — | — | — |
| Radua, J. , van den Heuvel, O. A. , Surguladze, S. , & Mataix‐Cols, D. (2010). Meta‐analytical comparison of coxel‐based morpometry studies in obsessive‐compulsive disorder versus other anxiety disorders. Archives of General Psychiatry, 67, 701–711.2060345110.1001/archgenpsychiatry.2010.70 | — | — | — |
| Reggente, N. , Moody, T. D. , Morfini, F. , Sheen, C. , Rissman, J. , O'Neill, J. , & Feusner, J. D. (2018). Multivariate resting‐state functional connectivity predicts response to cognitive behavioral therapy in obsessive‐compulsive disorder. Proceedings of the National Academy of Sciences of the United States of America, 115, 2222–2227.2944040410.1073/pnas.1716686115PMC5834692 | — | — | — |
| Remijnse, P. L. , Nielen, M. M. , van Balkom, A. J. , Cath, D. C. , van Oppen, P. , Uylings, H. B. , & Veltman, D. J. (2006). Reduced orbitofrontal‐striatal activity on a reversal learning task in obsessive‐compulsive disorder. Archives of General Psychiatry, 63, 1225–1236.1708850310.1001/archpsyc.63.11.1225 | — | — | — |
| Rotge, J. Y. , Langbour, N. , Guehl, D. , Bioulac, B. , Jaafari, N. , Allard, M. , … Burbaud, P. (2010). Gray matter alterations in obsessive‐compulsive disorder: An anatomic likelihood estimation meta‐analysis. Neuropsychopharmacology, 35, 686–691.1989026010.1038/npp.2009.175PMC3055616 | — | — | — |
| Rubin, R. T. , Anath, J. , Villanueva‐Meyer, J. , Trajmar, P. G. , & Mena, I. (1995). Regional 133xenon cerebral blood flow and cerebal 99mTc‐HMPAO uptake in patients with obsessive‐compulsive disorder before and during treatment. Biological Psychiatry, 38, 429–437.867260310.1016/0006-3223(94)00305-m | — | — | — |
| Satizabal, C. L. , Adams, H. H. H. , Hibar, D. P. , White, C. C. , Knol, M. J. , Stein, J. L. , … Ikram, M. A. (2019). Genetic architecture of subcortical brain structures in 38.851 individuals. Nature Genetics, 51, 1624–1636.3163645210.1038/s41588-019-0511-yPMC7055269 | — | — | — |
| Schmaal, L. , Veltman, D. J. , van Erp, T. G. , Sämann, P. G. , Frodl, T. , Jahanshad, N. , … Hibar, D. P. (2016). Subcortical brain alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group. Molecular Psychiatry, 21, 806–812.2612258610.1038/mp.2015.69PMC4879183 | — | — | — |
| Shaw, P. , Sharp, W. , Sudre, G. , Wharton, A. , Greenstein, D. , Raznahan, A. , … Rapaport, J. (2015). Subcortical and cortical morphological anamolies as an endophenotype in obsessive‐compulsive disorder. Molecular Psychiatry, 20, 224–231.2451456810.1038/mp.2014.3PMC5912882 | — | — | — |
| Shin, J. , French, L. , Xu, T. , Leonard, G. , Perron, M. , Pike, G. B. , … Paus, T. (2018). Cell‐specific gene‐expression profiles and cortical thickness in the human brain. Cerebral Cortex, 28, 3267–3277.2896883510.1093/cercor/bhx197 | — | — | — |
| Simpson, H. B. , van den Heuvel, O. A. , Miguel, E. C. , Reddy, Y. C. J. , Stein, D. J. , Lewis‐Fernández, R. , … Wall, M. (2020). Toward identifying reproducible brain signatures of obsessive‐compulsive profiles: Rationale and methods for a new global initiative. BMC Psychiatry, 20, 68.3205969610.1186/s12888-020-2439-2PMC7023814 | — | — | — |
| Stein, D. J. , Costa, D. L. C. , Lochner, C. , Miguel, E. C. , Reddy, Y. C. J. , Shavitt, R. G. , … Simpson, H. B. (2019). Obsessive‐compulsive disorder. Nature Reviews Disease Primers, 5, 52.10.1038/s41572-019-0102-3PMC737084431371720 | — | — | — |
| Subira, M. , Cano, M. , de Wit, S. J. , Alonso, P. , Cardoner, N. , Hoexter, M. Q. , … Soriano‐Mas, C. (2016). Structural covariance of neostriatal and limbic regions in patients with obsessive‐compulsive disorder. Journal of Psychiatry and Neuroscience, 41, 115–123.2650514210.1503/jpn.150012PMC4764480 | — | — | — |
| Swedo, S. E. , Rapoport, J. L. , Cheslow, D. L. , Leonard, H. L. , & Ayoub, E. M. (1989). High‐prevalence of obsessive‐compulsive symptoms in patients with Sydenham's chorea. The American Journal of Psychiatry, 146, 246–249.291226710.1176/ajp.146.2.246 | — | — | — |
| Thompson, P. M. , Jahanshad, N. , Ching, C. R. K. , Salminen, L. , Thomopoulos, S. I. , Bright, J. , … Zelman, V. (2019). ENIGMA and global neuroscience: A decade of large‐scale studies of the brain in halth and disease across more than 40 countries. PsyArXiv. 10.31234/osf.io/qnsh7 PMC708392332198361 | — | — | — |
| Thorsen, A. L. , Hagland, P. , Radua, J. , Mataix‐Cols, D. , Kvale, G. , Hansen, B. , & van den Heuvel, O. A. (2018). Emotional processing in obsessive‐compulsive disorder: A systematic review and meta‐analysis of 25 functional neuroimaging studies. Biological Psychiatry, Cognitive Neuroscience Neuroimaging, 3, 563–571.2955045910.1016/j.bpsc.2018.01.009PMC5994188 | — | — | — |
| Van den Heuvel, O. A. , Remijnse, P. L. , Mataix‐Cols, D. , Vrenken, H. , Groenewegen, H. J. , Uylings, H. B. , … Veltman, D. J. (2009). The major symptom dimensions of obsessive‐compulsive disorder are mediated by partially distinct neural systems. Brain, 132, 853–868.1895267510.1093/brain/awn267 | — | — | — |
| Van den Heuvel, O. A. , van Wingen, G. , Soriano‐Mas, C. , Alonso, P. , Chamberlain, S. R. , Nakamae, T. , … Veltman, D. J. (2016). Brain circuitry of compulsivity. European Neuropsychopharmacology, 26, 810–827.2671168710.1016/j.euroneuro.2015.12.005 | — | — | — |
| Van den Heuvel, O. A. , Veltman, D. J. , Groenewegen, H. J. , Cath, D. C. , van Balkom, A. J. , van Hartskamp, J. , … van Dyck, R. (2005). Frontal‐striatal dysfunction during planning in obsessive‐compulsive disorder. Archives of General Psychiatry, 62, 301–309.1575324310.1001/archpsyc.62.3.301 | — | — | — |
| Van Erp, T. G. , Hibar, D. P. , Rasmussen, J. M. , Glahn, D. C. , Pearlson, G. D. , Andreassen, O. A. , … Turner, J. A. (2016). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry, 21, 547–553.2603324310.1038/mp.2015.63PMC4668237 | — | — | — |
| Writing Committee for the ENIGMA‐CNV Working Group , van der Meer, D., Sønderby, I. E., Kaufmann, T., Walters, G. B., … Andreassen O. A. (2019). Association of copy number variation of the 15q11.2 BP1‐BP2 region with cortical and subcortical morphology and cognition. JAMA Psychiatry. 10.1001/jamapsychiatry.2019.3779. [Epub ahead of print].PMC682209631665216 | — | — | — |
| Yan, C. G. , Chen, X. , Li, L. , Castellanos, F. X. , Bai, T. J. , Bo, Q. J. , … Zang, Y. F. (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proceedings of the National Academy of Sciences of the United States of America, 116, 9078–9083.3097980110.1073/pnas.1900390116PMC6500168 | — | — | — |
| Yun, J. Y. , Boedhoe, P. S. W. , Vriend, C. , Jahanshad, N. , Yoshinari, A. , Ameis, S. H. , … Kwon, J. S. (2020). Brain structural covariance networks in obsessive‐compulsive disorder: A graph analysis from the ENIGMA consortium. Brain, 143(2), 684–700.3204056110.1093/brain/awaa001PMC7009583 | — | — | — |
| Zeisel, A. , Muñoz‐Manchado, A. B. , Codeluppi, S. , Lönnerberg, P. , La Manno, G. , Juréus, A. , … Betsholtz, C. (2015). Cell types in the mouse cortex and hippocampus revealed by single‐cell RNA‐seq. Science, 347, 1138–1142.2570017410.1126/science.aaa1934 | — | — | — |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | 2025 | 40360802 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Altered brain activity and connectivity in adolescent obsessive-compulsive disorder and their correlations with perceived parental rearing patterns: A resting-state fMRI study. | Li K et al. | — | 2026 | → |
| Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis. | Thorsen AL et al. | — | 2026 | → |
| Executive Function in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium. | Džinalija N et al. | — | 2026 | → |
| Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis. | Bas-Hoogendam JM et al. | — | 2026 | → |
| Clinical and Neuroimaging Effects of Mindfulness-Based Cognitive Therapy for Symptomatic Obsessive-Compulsive Disorder Patients after First-Line Treatments: A Randomised Controlled Trial. | Serra-Blasco M et al. | — | 2025 | → |
| Decoding Obsessive-Compulsive Disorder: The Regional Vulnerability Index and Its Association With Clinical Symptoms. | Koch K et al. | — | 2025 | → |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | — | 2025 | → |
| Hippocampal and amygdala subfield volumes in obsessive-compulsive disorder by medication status. | Ntwatwa Z et al. | — | 2025 | → |
| Innovative treatment approaches for paediatric obsessive-compulsive disorder. | Marazziti D et al. | — | 2025 | → |
| "It's All Under Control" - Description of the Dissociation Between Psychological Symptoms and Autonomic Arousal in People With Obsessive-compulsive Symptoms: A Case-control Study. | Guidotti S et al. | — | 2025 | → |
| Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium. | Dzinalija N et al. | — | 2025 | → |
| Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights. | Alturaiqi NA et al. | — | 2025 | → |
| Obsessive-compulsive disorder in the World Mental Health surveys | Stein DJ et al. | — | 2025 | — |
| Obsessive-compulsive disorder in the World Mental Health surveys. | Stein DJ et al. | — | 2025 | → |
| Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study. | Ikemizu Y et al. | — | 2025 | → |
| Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor. | Bianco MG et al. | — | 2025 | → |
| Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder. | Masjoodi S et al. | — | 2024 | → |
| A systematic review of structural neuroimaging markers of psychotherapeutic and pharmacological treatment for obsessive-compulsive disorder. | Moreau AL et al. | — | 2024 | → |
| Behavioral Activation and Brain Network Changes in Depression. | Jung M et al. | — | 2024 | → |
| Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder. | Kato K et al. | — | 2024 | → |
| Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review. | Lochner C et al. | — | 2024 | → |
| A comprehensive review for machine learning on neuroimaging in obsessive-compulsive disorder. | Li X et al. | — | 2023 | → |
| Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder. | Ding Z et al. | — | 2023 | → |
| Decreased intrinsic neural timescales in obsessive compulsive disorder and two distinct subtypes revealed by heterogeneity through discriminative analysis. | Xu Y et al. | — | 2023 | → |
| Early Identification and Intervention in Pediatric Obsessive-Compulsive Disorder. | Liu X et al. | — | 2023 | → |
| Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications. | Lefebvre A et al. | — | 2023 | → |
| Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms. | Pouwels PJW et al. | — | 2023 | → |
| Measurement fidelity of clinical assessment methods in a global study on identifying reproducible brain signatures of obsessive-compulsive disorder. | Shavitt RG et al. | — | 2023 | → |
| New Challenges for Anatomists in the Era of Omics. | Stabile AM et al. | — | 2023 | → |
| Phenomenological Considerations of the World of the Obsessive Patient. | Demaria F et al. | — | 2023 | → |
| White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies. | Haghshomar M et al. | — | 2023 | → |
| A longitudinal multi-scanner multimodal human neuroimaging dataset. | Hawco C et al. | — | 2022 | → |
| An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder. | Jaspers-Fayer F et al. | — | 2022 | → |
| An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration. | van den Heuvel OA et al. | — | 2022 | → |
| Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group. | Walton E et al. | — | 2022 | → |
| Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings. | Cheon EJ et al. | — | 2022 | → |
| Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration. | Paschou P et al. | — | 2022 | → |
| ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data. | Waller L et al. | — | 2022 | → |
| OCD at the Advent of Fahr's Disease and Small-World Connectomics: A Case Report. | Garg S et al. | — | 2022 | → |
| Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder. | Saraiva LC et al. | — | 2022 | → |
| Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression. | Larivière S et al. | — | 2022 | → |
| Symptom-Based Profiling and Multimodal Neuroimaging of a Large Preteenage Population Identifies Distinct Obsessive-Compulsive Disorder-like Subtypes With Neurocognitive Differences. | Wu X et al. | — | 2022 | → |
| The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping. | Thompson PM et al. | — | 2022 | → |
| Altered Resting-State Brain Activity in Schizophrenia and Obsessive-Compulsive Disorder Compared With Non-psychiatric Controls: Commonalities and Distinctions Across Disorders. | Zhang Y et al. | — | 2021 | → |
| A Systematic Review of a Polyvagal Perspective on Embodied Contemplative Practices as Promoters of Cardiorespiratory Coupling and Traumatic Stress Recovery for PTSD and OCD: Research Methodologies and State of the Art. | Poli A et al. | — | 2021 | → |
| Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study. | Maziero MP et al. | — | 2021 | → |
| Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis. | Klugah-Brown B et al. | — | 2021 | → |
| Editorial: Neurobiological Substrates of Subclinical Obsessive-Compulsive Disorder in Children. | MacMaster FP et al. | — | 2021 | → |
| ENIGMA-Sleep: Challenges, opportunities, and the road map. | Tahmasian M et al. | — | 2021 | → |
| Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review. | Cooper SE et al. | — | 2021 | → |
| General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study. | Patel Y et al. | — | 2021 | → |
| Genetics of obsessive-compulsive disorder. | Mahjani B et al. | — | 2021 | → |
| Network-based functional connectivity predicts response to exposure therapy in unmedicated adults with obsessive-compulsive disorder. | Shi TC et al. | — | 2021 | → |
| Plasticity-Related Activity in the Hippocampus, Anterior Cingulate, Orbitofrontal, and Prefrontal Cortex Following a Repeated Treatment with D<sub>2</sub>/D<sub>3</sub> Agonist Quinpirole. | Brozka H et al. | — | 2021 | → |
| Structural Imaging in OCD. | Veltman DJ | — | 2021 | → |
| Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder. | Shephard E et al. | — | 2021 | → |
| Chimpanzee brain morphometry utilizing standardized MRI preprocessing and macroanatomical annotations. | Vickery S et al. | — | 2020 | → |