Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
paper
Cited
Public
- Authors
- Williams, H J; Norton, N; Dwyer, S; Moskvina, V; Nikolov, I; Carroll, L; Georgieva, L; Williams, N M; Morris, D W; Quinn, E M; Giegling, I; Ikeda, M; Wood, J; Lencz, T; Hultman, C; Lichtenstein, P; Thiselton, D; Maher, B S; Molecular Genetics of Schizophrenia Collaboration (MGS) International Schizophrenia Consortium (ISC), SGENE-plus, GROUP; Malhotra, A K; Riley, B; Kendler, K S; Gill, M; Sullivan, P; Sklar, P; Purcell, S; Nimgaonkar, V L; Kirov, G; Holmans, P; Corvin, A; Rujescu, D; Craddock, N; Owen, M J; O'Donovan, M C
- Year
- 2011
- Journal
- Molecular psychiatry
- PMID
- 20368704
- DOI
- 10.1038/mp.2010.36
- PMCID
- PMC3918934
A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10(-9)). In this study we provide additional evidence for association through meta-analysis of a larger data set (schizophrenia/schizoaffective disorder N=18 945, schizophrenia plus bipolar disorder N=21 274 and controls N=38 675). We also sought to better localize the association signal using a combination of de novo polymorphism discovery in exons, pooled de novo polymorphism discovery spanning the genomic sequence of the locus and high-density linkage disequilibrium (LD) mapping. The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P=2.5 × 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P=4.1 × 10(-13), OR 1.11, 95% confidence interval 1.07-1.14). After de novo polymorphism discovery and detailed association analysis, rs1344706 remained the most strongly associated marker in the gene. The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder.
fatSNP1 results for ZNF804AArmitage trend P-values (−log10) for 176 SNPs genotyped during fatSNP phase 1. Dashed lines represent the boundaries of ZNF804A transcript (NM_194250). Solid lines represent the region targeted by genomic resequencing. rs1344706 was the most significant SNP in the earlier GWAS study (O’Donovan et al 2008). Chromosome position based on NCBI build36.
Forest plot of rs1344706 schizophrenia meta analysisOR = Odds Ratio for each individual study. Summary = combined OR for all studies. Squares are drawn proportional to the weight of the sample and lines represent 95% Confidence Intervals.
Relative Allelic Expression data for rs4667001P = results of t-test of mean relative expression. gDNA = relative allelic expression ratio for genomic DNA samples heterozygous for rs4667001. cDNA = relative allelic expression ratio for the corresponding complimentary DNA samples heterozygous for rs4667001. Homo = relative allelic expression ratio for heterozygous rs4667001 cDNA samples stratified for homozygosity at rs1344706. Hetero = relative allelic expression ratio for heterozygous rs4667001 cDNA samples stratified for heterozygosity at rs1344706.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism. | Shen G et al. | — | 2024 | → |
| MicroRNA dysregulation in glutamate and dopamine pathways of schizophrenia: From molecular pathways to diagnostic and therapeutic approaches. | Khosroshahi PA et al. | — | 2024 | → |
| Schizophrenia-Like Deficits and Impaired Glutamate/Gamma-aminobutyric acid Homeostasis in Zfp804a Conditional Knockout Mice. | Zhang QX et al. | — | 2024 | → |
| Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons. | Aabdien A et al. | — | 2024 | → |
| The function of <i>Mef2c</i> toward the development of excitatory and inhibitory cortical neurons. | Ward C et al. | — | 2024 | → |
| Impact of <i>ZNF804A</i> rs1344706 or <i>CACNA1C</i> rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis. | Novaes de Oliveira Roldan AC et al. | — | 2023 | → |
| Polymorphism in the ZNF804A Gene and Variation in D<sub>1</sub> and D<sub>2</sub>/D<sub>3</sub> Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study. | Hegarty CE et al. | — | 2023 | → |
| Psychosis susceptibility zinc finger protein 804A (ZNF804A) gene polymorphism in schizophrenia patients treated with olanzapine in North Indian population. | Maity S et al. | — | 2023 | → |
| Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia. | Hsu YH et al. | — | 2023 | → |
| A functional neuroimaging association study on the interplay between two schizophrenia genome-wide associated genes (CACNA1C and ZNF804A). | Guardiola-Ripoll M et al. | — | 2022 | → |
| Effects of psychosis-associated genetic markers on brain volumetry: a systematic review of replicated findings and an independent validation. | Vouga Ribeiro N et al. | — | 2022 | → |
| Genetic analysis of the ZNF804A gene in Mexican patients with schizophrenia, schizoaffective disorder and bipolar disorder. | Münch-Anguiano L et al. | — | 2022 | → |
| Understanding stigma toward schizophrenia. | Mannarini S et al. | — | 2022 | → |
| Association between rs1344706 Polymorphism in the ZNF804A Gene and the Risk for Schizophrenia. | Esmaeili A et al. | — | 2021 | → |
| Comprehensive Integrative Analyses Identify TIGD5 rs75547282 as a Risk Variant for Autism Spectrum Disorder. | Xie X et al. | — | 2021 | → |
| Ethnicity-dependent effects of Zinc finger 804A variant on schizophrenia: a systematic review and meta-analysis. | Wang D et al. | — | 2021 | → |
| Mapping working memory-specific dysfunction using a transdiagnostic approach. | Yaple ZA et al. | — | 2021 | → |
| Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults. | Bartsch U et al. | — | 2021 | → |
| Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells. | Klockmeier K et al. | — | 2021 | → |
| Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development. | Dong F et al. | — | 2021 | → |
| Towards Understanding the Genetic Nature of Vasovagal Syncope. | Matveeva N et al. | — | 2021 | → |
| ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. | Huang Y et al. | — | 2021 | → |
| Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study. | Krug A et al. | — | 2020 | → |
| Association Analysis Between Common Variants of the <i>TRPM1</i> Gene and Three Mental Disorders in the Han Chinese Population. | Ma C et al. | — | 2020 | → |
| Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia. | Yan Z et al. | — | 2020 | → |
| <i>MIR137</i> polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex. | Liu S et al. | — | 2020 | → |
| <i>ZNF804A</i> Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders. | Calabrò M et al. | — | 2020 | → |
| Proof-of-concept study of a multi-gene risk score in adolescent bipolar disorder. | Dimick MK et al. | — | 2020 | → |
| Schizophrenia‑associated microRNA‑148b‑3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells. | Wu S et al. | — | 2020 | → |
| Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. | Bakshi K et al. | — | 2020 | → |
| Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder. | Van Voorhis AC et al. | — | 2019 | → |
| A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. | Zhang L et al. | — | 2019 | → |
| Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression. | Chapman RM et al. | — | 2019 | → |
| Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population. | Wang Z et al. | — | 2019 | → |
| GWAS of Behavioral Traits. | Mehta D et al. | — | 2019 | → |
| Imaging Genetics Towards a Refined Diagnosis of Schizophrenia. | Jiang W et al. | — | 2019 | → |
| Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms. | Cui L et al. | — | 2019 | → |
| Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review. | Prata DP et al. | — | 2019 | → |
| Control of CNS functions by RNA-binding proteins in neurological diseases. | Zhou Y et al. | — | 2018 | → |
| Convergent analysis of genome-wide genotyping and transcriptomic data suggests association of zinc finger genes with lithium response in bipolar disorder. | Pisanu C et al. | — | 2018 | → |
| Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery. | Kos MZ et al. | — | 2018 | → |
| Genetic analysis of common variants in the ZNF804A gene with schizophrenia and major depressive disorder. | Wang Q et al. | — | 2018 | → |
| Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. | Zhou Y et al. | — | 2018 | → |
| ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults. | Xu Q et al. | — | 2018 | → |
| A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator | Schork AJ et al. | — | 2017 | — |
| A hierarchical causal taxonomy of psychopathology across the life span. | Lahey BB et al. | — | 2017 | → |
| Association between the zinc finger protein 804A (ZNF804A) gene and the risk of schizophrenia and bipolar I disorder across diagnostic boundaries. | Baek JH et al. | — | 2017 | → |
| Bicoronal and metopic craniosynostosis in association with a de novo unbalanced t(2;7) chromosomal translocation. | O'Byrne JJ et al. | — | 2017 | → |
| Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations. | Rao S et al. | — | 2017 | → |
| Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies. | Xiao X et al. | — | 2017 | → |
| Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure. | Deans PJM et al. | — | 2017 | → |
| The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. | Chang H et al. | — | 2017 | → |
| The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. | Ou J et al. | — | 2017 | → |
| A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations. | Huang L et al. | — | 2016 | → |
| Association analysis of ANK3 gene variants with schizophrenia in a northern Chinese Han population. | Guo X et al. | — | 2016 | → |
| Cognitive and neural models of threat appraisal in psychosis: A theoretical integration. | Underwood R et al. | — | 2016 | → |
| Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation. | Butler MG et al. | — | 2016 | → |
| Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity. | Gragnoli C et al. | — | 2016 | → |
| From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia. | Cariaga-Martinez A et al. | — | 2016 | → |
| Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population. | Wen Z et al. | — | 2016 | → |
| Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain. | Duarte RRR et al. | — | 2016 | → |
| High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. | Douglas LN et al. | — | 2016 | → |
| Molecular anatomy of the thalamic complex and the underlying transcription factors. | Nagalski A et al. | — | 2016 | → |
| Neuroimaging Intermediate Phenotypes of Executive Control Dysfunction in Schizophrenia. | Sutcliffe G et al. | — | 2016 | → |
| No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese. | Wang J et al. | — | 2016 | → |
| Shared and divergent neurocognitive impairments in adult patients with schizophrenia and bipolar disorder: Whither the evidence? | Kuswanto C et al. | — | 2016 | → |
| Theory of mind network activity is altered in subjects with familial liability for schizophrenia. | Mohnke S et al. | — | 2016 | → |
| ZNF804A Genetic Variation Confers Risk to Bipolar Disorder. | Zhang C et al. | — | 2016 | → |
| Alterations in neural Theory of Mind processing in euthymic patients with bipolar disorder and unaffected relatives. | Willert A et al. | — | 2015 | → |
| A molecular pathway analysis informs the genetic background at risk for schizophrenia. | Crisafulli C et al. | — | 2015 | → |
| Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis. | Sun Y et al. | — | 2015 | → |
| Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis. | Wickramasinghe A et al. | — | 2015 | → |
| Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder. | Hess JL et al. | — | 2015 | → |
| Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls. | Calabrò M et al. | — | 2015 | → |
| Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. | Hellmich C et al. | — | 2015 | → |
| Genetic studies of schizophrenia: an update. | Chen J et al. | — | 2015 | → |
| Innate immune response is differentially dysregulated between bipolar disease and schizophrenia. | de Baumont A et al. | — | 2015 | → |
| Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene. | Cousijn H et al. | — | 2015 | → |
| Perinatal Risks and Childhood Premorbid Indicators of Later Psychosis: Next Steps for Early Psychosocial Interventions. | Liu CH et al. | — | 2015 | → |
| Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue. | Chang EH et al. | — | 2015 | → |
| Recent genetic findings in schizophrenia and their therapeutic relevance. | Harrison PJ | — | 2015 | → |
| Replication of ZNF804A gene variant associations with risk of heroin addiction. | Hancock DB et al. | — | 2015 | → |
| Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility. | Suárez-Rama JJ et al. | — | 2015 | → |
| Shared and distinct neurocognitive endophenotypes of schizophrenia and psychotic bipolar disorder. | Kim D et al. | — | 2015 | → |
| The current and potential impact of genetics and genomics on neuropsychopharmacology. | Harrison PJ | — | 2015 | → |
| The Rat Homolog of the Schizophrenia Susceptibility Gene ZNF804A Is Highly Expressed during Brain Development, Particularly in Growth Cones. | Hinna KH et al. | — | 2015 | → |
| What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review. | Gurung R et al. | — | 2015 | → |
| Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A. | Guella I et al. | — | 2014 | → |
| Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia. | Perez-Becerril C et al. | — | 2014 | → |
| Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds. | Del Re EC et al. | — | 2014 | → |
| A population-based study of genetic variation and psychotic experiences in adolescents. | Zammit S et al. | — | 2014 | → |
| A schizophrenia risk gene, ZNF804A, is associated with brain white matter microstructure. | Ikuta T et al. | — | 2014 | → |
| Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysis. | Zhu M et al. | — | 2014 | → |
| Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach. | Nicodemus KK et al. | — | 2014 | → |
| Common variant at 16p11.2 conferring risk of psychosis. | Steinberg S et al. | — | 2014 | → |
| Effects of VRK2 (rs2312147) on white matter connectivity in patients with schizophrenia. | Sohn H et al. | — | 2014 | → |
| Effects of ZNF804A on auditory P300 response in schizophrenia. | O'Donoghue T et al. | — | 2014 | → |
| Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. | Guella I et al. | — | 2014 | → |
| Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. | Tao R et al. | — | 2014 | → |
| Further evidence for the impact of a genome-wide-supported psychosis risk variant in ZNF804A on the Theory of Mind Network. | Mohnke S et al. | — | 2014 | → |
| Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder. | Cardno AG et al. | — | 2014 | → |
| Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. | Doherty JL et al. | — | 2014 | → |
| How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis. | Hess JL et al. | — | 2014 | → |
| Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences. | Colonna V et al. | — | 2014 | → |
| Molecular validation of the schizophrenia spectrum. | Bigdeli TB et al. | — | 2014 | → |
| No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. | Cousijn H et al. | — | 2014 | → |
| One gene, many neuropsychiatric disorders: lessons from Mendelian diseases. | Zhu X et al. | — | 2014 | → |
| Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. | Ruderfer DM et al. | — | 2014 | → |
| Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia. | Wang KS et al. | — | 2014 | → |
| Recent advances in understanding schizophrenia. | Haller CS et al. | — | 2014 | → |
| Sequencing of a patient with balanced chromosome abnormalities and neurodevelopmental disease identifies disruption of multiple high risk loci by structural variation. | Blake J et al. | — | 2014 | → |
| Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells. | Hill MJ et al. | — | 2014 | → |
| Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway. | Nicodemus KK et al. | — | 2014 | → |
| Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism. | Anitha A et al. | — | 2014 | → |
| ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies. | Schultz CC et al. | — | 2014 | → |
| A novel conceptual framework for psychiatry: vertically and horizontally integrated approaches to redundancy and pleiotropism that co-exist with a classification of symptom clusters based on DSM-5. | Licinio J et al. | — | 2013 | → |
| Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. | Schwab SG et al. | — | 2013 | → |
| Biomarkers of bipolar disorder: specific or shared with schizophrenia? | Bellivier F et al. | — | 2013 | → |
| Convergent functional genomics of psychiatric disorders. | Niculescu AB | — | 2013 | → |
| Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. | Myles-Worsley M et al. | — | 2013 | → |
| Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients. | Yang Y et al. | — | 2013 | → |
| Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. | Schwab SG et al. | — | 2013 | → |
| Genome-wide association study of atypical psychosis. | Kanazawa T et al. | — | 2013 | → |
| Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. | Greenwood TA et al. | — | 2013 | → |
| Identification of rare copy number variants in high burden schizophrenia families. | Van Den Bossche MJ et al. | — | 2013 | → |
| Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder. | Xu X et al. | — | 2013 | → |
| Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population. | Li M et al. | — | 2013 | → |
| Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia. | Li M et al. | — | 2013 | → |
| MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review. | Forstner AJ et al. | — | 2013 | → |
| Neurocognitive Functioning in Schizophrenia and Bipolar Disorder: Clarifying Concepts of Diagnostic Dichotomy vs. Continuum. | Kuswanto CN et al. | — | 2013 | → |
| Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity. | Paulus FM et al. | — | 2013 | → |
| Personalized medicine in psychiatry: problems and promises. | Ozomaro U et al. | — | 2013 | → |
| Potential roles of zinc in the pathophysiology and treatment of major depressive disorder. | Swardfager W et al. | — | 2013 | → |
| Similar and different gray matter deficits in schizophrenia patients and their unaffected biological relatives. | Xiao Y et al. | — | 2013 | → |
| Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder. | Andreazza AC et al. | — | 2013 | → |
| Synapse-specific contributions in the cortical pathology of schizophrenia. | Seshadri S et al. | — | 2013 | → |
| The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. | Mowry BJ et al. | — | 2013 | → |
| The genomics of schizophrenia: update and implications. | Giusti-Rodríguez P et al. | — | 2013 | → |
| Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neurocognitive performance in a large young male population. | Stefanis NC et al. | — | 2013 | → |
| ZNF804A and cortical thickness in schizophrenia and bipolar disorder. | Bergmann O et al. | — | 2013 | → |
| ZNF804A genotype modulates neural activity during working memory for faces. | Linden DE et al. | — | 2013 | → |
| An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain. | Sprooten E et al. | — | 2012 | → |
| ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. | Yuan A et al. | — | 2012 | → |
| Annual research review: impact of advances in genetics in understanding developmental psychopathology. | Addington AM et al. | — | 2012 | → |
| A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association. | Sazci A et al. | — | 2012 | → |
| A selective review of multimodal fusion methods in schizophrenia. | Sui J et al. | — | 2012 | → |
| Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia. | Wei Q et al. | — | 2012 | → |
| Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. | Li W et al. | — | 2012 | → |
| Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era. | Costain G et al. | — | 2012 | → |
| Connectomic intermediate phenotypes for psychiatric disorders. | Fornito A et al. | — | 2012 | → |
| Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response. | Liou YJ et al. | — | 2012 | → |
| Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients. | Chen M et al. | — | 2012 | → |
| Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. | Hill MJ et al. | — | 2012 | → |
| Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137. | Kim AH et al. | — | 2012 | → |
| Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. | Zhang R et al. | — | 2012 | → |
| Genetic architectures of psychiatric disorders: the emerging picture and its implications. | Sullivan PF et al. | — | 2012 | → |
| Genetics of schizophrenia from a clinicial perspective. | Kukshal P et al. | — | 2012 | → |
| Genome-wide association studies of schizophrenia: does bigger lead to better results? | Bergen SE et al. | — | 2012 | → |
| Genome-wide association study of multiplex schizophrenia pedigrees. | Levinson DF et al. | — | 2012 | → |
| Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia. | Kuswanto CN et al. | — | 2012 | → |
| Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26. | McAuley EZ et al. | — | 2012 | → |
| Increased serum Dickkopf-1 levels in drug-abusing psychotic patients. | Serata D et al. | — | 2012 | → |
| Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. | Wassink TH et al. | — | 2012 | → |
| Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning? | Aas M et al. | — | 2012 | → |
| Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. | Hill MJ et al. | — | 2012 | → |
| Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A. | Van Den Bossche MJ et al. | — | 2012 | → |
| Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. | Li M et al. | — | 2012 | → |
| Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. | Perron H et al. | — | 2012 | → |
| Recent genomic advances in schizophrenia. | Doherty JL et al. | — | 2012 | → |
| Schizophrenia genes: on the matter of their convergence. | Rujescu D | — | 2012 | → |
| Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure: an MRI study in 892 volunteers. | Cousijn H et al. | — | 2012 | → |
| Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis. | Kishi T et al. | — | 2012 | → |
| The future of fMRI and genetics research. | Meyer-Lindenberg A | — | 2012 | → |
| The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms. | Mössner R et al. | — | 2012 | → |
| ZNF804A and schizophrenia susceptibility in Asian populations. | Li M et al. | — | 2012 | → |
| ZNF804A and social cognition in patients with schizophrenia and healthy controls. | Hargreaves A et al. | — | 2012 | → |
| ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2. | Girgenti MJ et al. | — | 2012 | → |
| ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca. | Zaharie A et al. | — | 2012 | → |
| Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. | Li M et al. | — | 2011 | → |
| An integrative functional genomics approach for discovering biomarkers in schizophrenia. | Vawter MP et al. | — | 2011 | → |
| Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. | Williams HJ et al. | — | 2011 | → |
| Brain cortical thickness and surface area correlates of neurocognitive performance in patients with schizophrenia, bipolar disorder, and healthy adults. | Hartberg CB et al. | — | 2011 | → |
| Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases. | Liu C | — | 2011 | → |
| Common variants at VRK2 and TCF4 conferring risk of schizophrenia. | Steinberg S et al. | — | 2011 | → |
| Database of genetic studies of bipolar disorder. | Piletz JE et al. | — | 2011 | → |
| Following the genes: a framework for animal modeling of psychiatric disorders. | Mitchell KJ et al. | — | 2011 | → |
| Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. | Kleinman JE et al. | — | 2011 | → |
| Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. | Zhang R et al. | — | 2011 | → |
| Pharmacogenetic approaches to cognitive enhancement in schizophrenia. | Burdick KE et al. | — | 2011 | → |
| Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. | Hamshere ML et al. | — | 2011 | → |
| Polygenic dissection of the bipolar phenotype. | Hamshere ML et al. | — | 2011 | → |
| Schizophrenia risk genes: Implications for future drug development and discovery. | O'Connell G et al. | — | 2011 | → |
| The shock of the new: progress in schizophrenia genomics. | Moore S et al. | — | 2011 | → |
| The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses. | Voineskos AN et al. | — | 2011 | → |
| Using linkage information to weight a genome-wide association of bipolar disorder. | Howrigan DP et al. | — | 2011 | → |
| A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes. | Lencz T et al. | — | 2010 | → |
| Effects of cis-regulatory variation differ across regions of the adult human brain. | Buonocore F et al. | — | 2010 | → |
| Genome-wide approaches to schizophrenia. | Duan J et al. | — | 2010 | → |
| No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. | Dwyer S et al. | — | 2010 | → |
| [The future of depression research]. | Holsboer F | — | 2010 | → |
| The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. | Hashimoto R et al. | — | 2010 | → |
| The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes. | Donohoe G et al. | — | 2010 | → |