Genome-wide association study of obsessive-compulsive disorder.
paper
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- Authors
- Stewart, S E; Yu, D; Scharf, J M; Neale, B M; Fagerness, J A; Mathews, C A; Arnold, P D; Evans, P D; Gamazon, E R; Davis, L K; Osiecki, L; McGrath, L; Haddad, S; Crane, J; Hezel, D; Illman, C; Mayerfeld, C; Konkashbaev, A; Liu, C; Pluzhnikov, A; Tikhomirov, A; Edlund, C K; Rauch, S L; Moessner, R; Falkai, P; Maier, W; Ruhrmann, S; Grabe, H-J; Lennertz, L; Wagner, M; Bellodi, L; Cavallini, M C; Richter, M A; Cook, E H; Kennedy, J L; Rosenberg, D; Stein, D J; Hemmings, S M J; Lochner, C; Azzam, A; Chavira, D A; Fournier, E; Garrido, H; Sheppard, B; Umaña, P; Murphy, D L; Wendland, J R; Veenstra-VanderWeele, J; Denys, D; Blom, R; Deforce, D; Van Nieuwerburgh, F; Westenberg, H G M; Walitza, S; Egberts, K; Renner, T; Miguel, E C; Cappi, C; Hounie, A G; Conceição do Rosário, M; Sampaio, A S; Vallada, H; Nicolini, H; Lanzagorta, N; Camarena, B; Delorme, R; Leboyer, M; Pato, C N; Pato, M T; Voyiaziakis, E; Heutink, P; Cath, D C; Posthuma, D; Smit, J H; Samuels, J; Bienvenu, O J; Cullen, B; Fyer, A J; Grados, M A; Greenberg, B D; McCracken, J T; Riddle, M A; Wang, Y; Coric, V; Leckman, J F; Bloch, M; Pittenger, C; Eapen, V; Black, D W; Ophoff, R A; Strengman, E; Cusi, D; Turiel, M; Frau, F; Macciardi, F; Gibbs, J R; Cookson, M R; Singleton, A; North American Brain Expression Consortium; Hardy, J; UK Brain Expression Database; Crenshaw, A T; Parkin, M A; Mirel, D B; Conti, D V; Purcell, S; Nestadt, G; Hanna, G L; Jenike, M A; Knowles, J A; Cox, N; Pauls, D L
- Year
- 2013
- Journal
- Molecular psychiatry
- PMID
- 22889921
- DOI
- 10.1038/mp.2012.85
- PMCID
- PMC4218751
Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469,410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10(-6) and P=3.44 × 10(-6)), a member of the neuronal postsynaptic density complex. In the trio analysis, rs6131295, near BTBD3, exceeded the genome-wide significance threshold with a P-value=3.84 × 10(-8). However, when trios were meta-analyzed with the case-control samples, the P-value for this variant was 3.62 × 10(-5), losing genome-wide significance. Although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio-case-control sample, a significant enrichment of methylation QTLs (P<0.001) and frontal lobe expression quantitative trait loci (eQTLs) (P=0.001) was observed within the top-ranked SNPs (P<0.01) from the trio-case-control analysis, suggesting these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD.
Quantile-quantile (QQ) Plots of Observed versus Expected −log(p) Statistics for: (a) Trio samples, (b) Case-Control samples and, (c) Combined Trio-Case-Control SamplesQuantile-quantile (Q-Q) plots of observed versus expected −log (P) test statistics for: (a) trio samples; (b) case-control samples; and (c) combined trio-case-control samples. The 95% confidence interval of expected values is indicated in grey. Corresponding genomic control lambda values are indicated within each plot.
Manhattan Plots for: (a) Trio, (b) Case-Control and, (c) Combined Trio-Case-Control SamplesManhattan plots of all genotyped single-nucleotide polymorphisms (SNPs) for (a) trio samples; (b) case-control samples; and (c) combined trio-case-control samples. Red and blue lines indicate significance thresholds of 5 ×10-8 and 1 × 10-5, respectively.
Locus Plots for SNPs rs6131295 (near BTBD3), rs11081062 (within DLGAP1) and rs297941 (near FAIM2)Regional association plots of the best supported SNPs from the a) Trio, b) Case-Control and c) Trio-Case-Control analyses. Locations and observed -log (p-values) for genotyped SNPs are shown with circles. LD, in r2, to the lowest p-value SNP in each plot is indicated using shading (dark blue, low LD, red-high LD). Light blue lines indicate the estimated recombination rate from HapMap release 22.
Enrichment analyses for Quantitative Trait Loci (QTLs) among GWAS Variants with p<0.01Enrichment of (a) frontal lobe expression QTLs (p=0.001), (b) cerebellum expression QTLs (p=0.033), (c) parietal lobe expression QTLs (p=0.003), and (d) methylation QTLs (p<0.001) among GWAS SNPs with p<0.01 (N=5321). Distribution of the count of QTLs in 1,000 simulations are displayed, each matching the MAF distribution of the OCD–associated SNPs. The black dot identifies the observed eQTL or mQTL count in the OCD susceptibility–associated SNPs.
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| Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders. | Antonyan L et al. | — | 2026 | → |
| Rare Variants in Antisense Long Noncoding RNA-Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder. | Jung S et al. | — | 2026 | → |
| Advancing Obsessive-Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies. | Huang X et al. | — | 2025 | → |
| Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder. | Webb L et al. | — | 2025 | → |
| An Evolutionary Perspective on Dog Behavioral Genetics. | Lord KA et al. | — | 2025 | → |
| Biological, Psychosocial, and Microbial Determinants of Childhood-Onset Obsessive-Compulsive Disorder: A Narrative Review. | Borrego-Ruiz A et al. | — | 2025 | → |
| Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder. | Abdallah SB et al. | — | 2025 | → |
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| Clinical Characteristics of Cognitive Subgroups of Obsessive Compulsive Disorder. | Mısır E et al. | — | 2025 | → |
| DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease. | Chacón T et al. | — | 2025 | → |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | — | 2025 | → |
| Late development of OCD-like phenotypes in Dlgap1 knockout mice. | Minagawa K et al. | — | 2025 | → |
| Pharmacogenetics of obsessive-compulsive disorder: Investigations of intragenic and regulatory region genetic variations. | Zai G et al. | — | 2025 | → |
| Association of rs11081062 polymorphism of <i>DLGAP1</i> gene and levels of SLC1A1 protein with obsessive-compulsive disorder. | Akkuş Eİ et al. | — | 2024 | → |
| Early life stress shifts critical periods and causes precocious visual cortex development. | Poplawski J et al. | — | 2024 | → |
| Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings. | Liu C et al. | — | 2024 | → |
| Forebrain EAAT3 Overexpression Increases Susceptibility to Amphetamine-Induced Repetitive Behaviors. | Kopelman JM et al. | — | 2024 | → |
| Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics. | Dai J et al. | — | 2024 | → |
| Massively parallel disruption of enhancers active in human neural stem cells. | Geller E et al. | — | 2024 | → |
| New horizons for obsessive-compulsive disorder drug discovery: is targeting glutamate receptors the answer? | Grassi G et al. | — | 2024 | → |
| Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder. | Bellia F et al. | — | 2024 | → |
| The genetics of trichotillomania and excoriation disorder: A systematic review. | Reid M et al. | — | 2024 | → |
| Association between <i>ANRIL</i> polymorphisms and risk of obsessive-compulsive disorder. | Akbari M et al. | — | 2023 | → |
| Childhood Obsessive-Compulsive Disorder. | Schuyler M et al. | — | 2023 | → |
| Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics. | Morrill K et al. | — | 2023 | → |
| Distinct Patterns of Abnormal Lateral Orbitofrontal Cortex Activity During Compulsive Grooming and Reversal Learning Normalize After Fluoxetine. | Manning EE et al. | — | 2023 | → |
| Epigenetic modifications and obsessive-compulsive disorder: what do we know? | Mohammadi AH et al. | — | 2023 | → |
| Genetics, sex, and gender. | Reale C et al. | — | 2023 | → |
| Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know. | Crowley JJ | — | 2023 | → |
| Gyrification of the medial and lateral orbitofrontal cortex in first-degree relatives of patients with obsessive-compulsive disorder. | Tomiyama H et al. | — | 2023 | → |
| In search of environmental risk factors for obsessive-compulsive disorder: study protocol for the OCDTWIN project. | Mataix-Cols D et al. | — | 2023 | → |
| Mechanisms of pathogenesis and environmental moderators in preclinical models of compulsive-like behaviours. | Wilson C et al. | — | 2023 | → |
| Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. | Ho EV et al. | — | 2023 | → |
| Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons. | Petroccione MA et al. | — | 2023 | → |
| Pediatric neuropsychiatric disorders with motor and nonmotor phenomena. | Younger DS | — | 2023 | → |
| SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes. | Rajkumar RP | — | 2023 | → |
| Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming. | Morris CW et al. | — | 2023 | → |
| The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS. | Alemany-Navarro M et al. | — | 2023 | → |
| The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. | Vellucci L et al. | — | 2023 | → |
| Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model. | van den Boom BJG et al. | — | 2023 | → |
| Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder. | Domènech L et al. | — | 2022 | → |
| Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. | Chohan MO et al. | — | 2022 | → |
| Dual methylation and hydroxymethylation study of alcohol use disorder. | Clark SL et al. | — | 2022 | → |
| Early intervention in obsessive-compulsive disorder: From theory to practice. | Fontenelle LF et al. | — | 2022 | → |
| Epigenome-wide DNA methylation in obsessive-compulsive disorder. | Schiele MA et al. | — | 2022 | → |
| Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review. | Bandeira ID et al. | — | 2022 | → |
| SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders. | Bai Y et al. | — | 2022 | → |
| The prefrontal cortex and OCD. | Ahmari SE et al. | — | 2022 | → |
| A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. | Takahashi Y et al. | — | 2021 | → |
| A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways. | Varma-Doyle AV et al. | — | 2021 | → |
| Astroglia and Obsessive Compulsive Disorder. | Tanaka K | — | 2021 | → |
| Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. | de Oliveira KC et al. | — | 2021 | → |
| Concurrent and prospective associations of obsessive-compulsive symptoms with suicidality in young adults: A genetically-informative study. | Krebs G et al. | — | 2021 | → |
| Contextualizing genetic risk score for disease screening and rare variant discovery. | Zhou D et al. | — | 2021 | → |
| DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders. | Siu MT et al. | — | 2021 | → |
| Exome sequencing in obsessive-compulsive disorder reveals a burden of rare damaging coding variants. | Halvorsen M et al. | — | 2021 | → |
| Genetic Dissection of Temperament Personality Traits in Italian Isolates. | Concas MP et al. | — | 2021 | → |
| Genetics of obsessive-compulsive disorder. | Mahjani B et al. | — | 2021 | → |
| Genetics of OCD and Related Disorders; Searching for Shared Factors. | Grünblatt E | — | 2021 | → |
| Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder. | Burton CL et al. | — | 2021 | → |
| Genomics of Obsessive-Compulsive Disorder-Toward Personalized Medicine in the Era of Big Data. | Szejko N et al. | — | 2021 | → |
| Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder. | Goodman WK et al. | — | 2021 | → |
| Investigation of gene-environment interactions in relation to tic severity. | Abdulkadir M et al. | — | 2021 | → |
| Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2. | Horner AE et al. | — | 2021 | → |
| Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum in an initial study of subjects with obsessive compulsive disorder. | Piantadosi SC et al. | — | 2021 | → |
| Neurocognitive Endophenotypes of OCD. | Vaghi MM | — | 2021 | → |
| Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions (BHRCS). | Ravagnani Salto AB et al. | — | 2021 | → |
| Oxytocin Receptor Gene DNA Methylation: A Biomarker of Treatment Response in Obsessive-Compulsive Disorder? | Schiele MA et al. | — | 2021 | → |
| Pharmacotherapeutic Strategies and New Targets in OCD. | Pittenger C | — | 2021 | → |
| Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls. | Heinzel S et al. | — | 2021 | → |
| Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder. | Piantadosi SC et al. | — | 2021 | → |
| What Have We Learned About the Genetics of Obsessive-Compulsive and Related Disorders in Recent Years? | Mattheisen M et al. | — | 2021 | → |
| Cutting-edge genetics in obsessive-compulsive disorder. | Saraiva LC et al. | — | 2020 | → |
| De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism. | Cappi C et al. | — | 2020 | → |
| Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder. | Yilmaz Z et al. | — | 2020 | → |
| Exploring genetic variants in obsessive compulsive disorder severity: A GWAS approach. | Alemany-Navarro M et al. | — | 2020 | → |
| Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives. | Karthik S et al. | — | 2020 | → |
| Neurocognitive risk markers in pediatric obsessive-compulsive disorder. | Negreiros J et al. | — | 2020 | → |
| Nordic OCD & Related Disorders Consortium: Rationale, design, and methods. | Mataix-Cols D et al. | — | 2020 | → |
| Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation. | Goodman SJ et al. | — | 2020 | → |
| Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [<sup>11</sup>C]UCB-J PET study in a model of obsessive-compulsive disorder-like behaviour. | Glorie D et al. | — | 2020 | → |
| Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling. | Bralten J et al. | — | 2020 | → |
| The polygenic risk for obsessive-compulsive disorder is associated with the personality trait harm avoidance. | Bey K et al. | — | 2020 | → |
| Association analyses reveal gender-specific associations of DAT1 40-bp VNTR and -839C/T polymorphisms with obsessive-compulsive disorder and obsessive-compulsive symptoms. | Cotrin JC et al. | — | 2019 | → |
| Association study of the PDE4D gene and obsessive-compulsive disorder in a Chinese Han population. | Huang X et al. | — | 2019 | → |
| Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. | Delgado-Acevedo C et al. | — | 2019 | → |
| Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. | Thompson SL et al. | — | 2019 | → |
| Challenges in the diagnosis and treatment of pediatric obsessive-compulsive disorder. | Westwell-Roper C et al. | — | 2019 | → |
| Converging evidence points towards a role of insulin signaling in regulating compulsive behavior. | van de Vondervoort IIGM et al. | — | 2019 | → |
| Do polygenic risk and stressful life events predict pharmacological treatment response in obsessive compulsive disorder? A gene-environment interaction approach. | Alemany-Navarro M et al. | — | 2019 | → |
| Genetic Associations of Serotoninergic and GABAergic Genes in an Extended Collection of Early-Onset Obsessive-Compulsive Disorder Trios. | Boloc D et al. | — | 2019 | → |
| Genetics of obsessive-compulsive disorder. | Purty A et al. | — | 2019 | → |
| Genetic Studies of Tic Disorders and Tourette Syndrome. | Qi Y et al. | — | 2019 | → |
| Glutamate transporter gene polymorphisms and obsessive-compulsive disorder: A case-control association study. | de Salles Andrade JB et al. | — | 2019 | → |
| GWAS of Behavioral Traits. | Mehta D et al. | — | 2019 | → |
| Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder. | Rodriguez N et al. | — | 2019 | → |
| Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study. | Westwell-Roper C et al. | — | 2019 | → |
| Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. | Lisboa BCG et al. | — | 2019 | → |
| Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder | Lei H et al. | — | 2019 | → |
| Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder. | de Oliveira KC et al. | — | 2019 | → |
| Obsessive-compulsive disorder and global mental health. | Stein DJ | — | 2019 | → |
| Obsessive-Compulsive Disorder: Puzzles and Prospects. | Robbins TW et al. | — | 2019 | → |
| OLIG2 gene polymorphisms are associated with nasty, unpleasant and uncontrollable thoughts in obsessive-compulsive disorder. | Vieira-Fonseca T et al. | — | 2019 | → |
| Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder. | Bey K et al. | — | 2019 | → |
| Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms. | Wang YM et al. | — | 2019 | → |
| Sex differences in the genetic architecture of obsessive-compulsive disorder. | Khramtsova EA et al. | — | 2019 | → |
| Systemic autoimmune diseases are associated with an increased risk of obsessive-compulsive disorder: a nationwide population-based cohort study. | Wang LY et al. | — | 2019 | → |
| The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder. | Escobar AP et al. | — | 2019 | → |
| Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis. | Jiang C et al. | — | 2018 | → |
| A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders. | Mataix-Cols D et al. | — | 2018 | → |
| Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder. | Grünblatt E et al. | — | 2018 | → |
| Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. | Coba MP et al. | — | 2018 | → |
| Genetic susceptibility in obsessive-compulsive disorder. | Fernandez TV et al. | — | 2018 | → |
| How can preclinical mouse models be used to gain insight into prefrontal cortex dysfunction in obsessive-compulsive disorder? | Manning EE et al. | — | 2018 | → |
| Imaging and Genetic Approaches to Inform Biomarkers for Anxiety Disorders, Obsessive-Compulsive Disorders, and PSTD. | Maron E et al. | — | 2018 | → |
| Impaired Antisaccades in Obsessive-Compulsive Disorder: Evidence From Meta-Analysis and a Large Empirical Study. | Bey K et al. | — | 2018 | → |
| Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. | Abdulkadir M et al. | — | 2018 | → |
| Kainate Receptors Inhibit Glutamate Release Via Mobilization of Endocannabinoids in Striatal Direct Pathway Spiny Projection Neurons. | Marshall JJ et al. | — | 2018 | → |
| Neuroscientifically Informed Formulation and Treatment Planning for Patients With Obsessive-Compulsive Disorder: A Review. | Dougherty DD et al. | — | 2018 | → |
| PM20D1 is a quantitative trait locus associated with Alzheimer's disease. | Sanchez-Mut JV et al. | — | 2018 | → |
| Polygenic prediction of obsessive compulsive symptoms. | Zilhão NR et al. | — | 2018 | → |
| Prevalence of Cannabis Use Disorder and Associated Factors among Cannabis Young Adult Users at Shashemene Town, Oromia Region, Ethiopia, 2016. | Tullu M et al. | — | 2018 | → |
| Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis. | International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS) | — | 2018 | → |
| Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen. | Hibar DP et al. | — | 2018 | → |
| Symptom dimensions in obsessive-compulsive disorder as predictors of neurobiology and treatment response. | Thorsen AL et al. | — | 2018 | → |
| A review of the role of serotonin system genes in obsessive-compulsive disorder. | Sinopoli VM et al. | — | 2017 | → |
| De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autism | Cappi C et al. | — | 2017 | — |
| Empirically supported psychological treatments and the Research Domain Criteria (RDoC). | McKay D et al. | — | 2017 | → |
| GLANET: genomic loci annotation and enrichment tool. | Otlu B et al. | — | 2017 | → |
| Glutamate-Modulating Drugs as a Potential Therapeutic Strategy in Obsessive-Compulsive Disorder. | Marinova Z et al. | — | 2017 | → |
| GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer. | Song X et al. | — | 2017 | → |
| High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder. | Grünblatt E et al. | — | 2017 | → |
| Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. | Noh HJ et al. | — | 2017 | → |
| Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study. | Rutrick D et al. | — | 2017 | → |
| Preliminary investigation of the role of BTB domain-containing 3 gene in the proliferation and metastasis of hepatocellular carcinoma. | Xiao W et al. | — | 2017 | → |
| Progress in Genetic Studies of Tourette's Syndrome. | Qi Y et al. | — | 2017 | → |
| Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder. | Song M et al. | — | 2017 | → |
| Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology. | Zike I et al. | — | 2017 | → |
| Self-domestication in Homo sapiens: Insights from comparative genomics. | Theofanopoulou C et al. | — | 2017 | → |
| Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. | Zhu J et al. | — | 2017 | → |
| Volitional saccade performance in a large sample of patients with obsessive-compulsive disorder and unaffected first-degree relatives. | Bey K et al. | — | 2017 | → |
| A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function. | Zeng M et al. | — | 2016 | → |
| A current snapshot of common genomic variants contribution in psychiatric disorders. | Santoro ML et al. | — | 2016 | → |
| An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder. | van de Vondervoort I et al. | — | 2016 | → |
| Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics. | Bandelow B et al. | — | 2016 | → |
| Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation. | Glatt CE et al. | — | 2016 | → |
| Decoding the non-coding genome: elucidating genetic risk outside the coding genome. | Barr CL et al. | — | 2016 | → |
| DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD. | Nissen JB et al. | — | 2016 | → |
| Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder. | Cappi C et al. | — | 2016 | → |
| Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia. | Costas J et al. | — | 2016 | → |
| Genome-wide association mapping of heritable temperament variation in the Tennessee Walking Horse. | Staiger EA et al. | — | 2016 | → |
| Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers. | Borné Y et al. | — | 2016 | → |
| Genome-wide DNA methylation analysis in obsessive-compulsive disorder patients. | Yue W et al. | — | 2016 | → |
| Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. | Bøttger P et al. | — | 2016 | → |
| Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. | Ade KK et al. | — | 2016 | → |
| Learning From Animal Models of Obsessive-Compulsive Disorder. | Monteiro P et al. | — | 2016 | → |
| Meta-analysis of genome-wide association studies of anxiety disorders. | Otowa T et al. | — | 2016 | → |
| Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge. | Gonzalez-Pena D et al. | — | 2016 | → |
| Neuropsychiatric genomics in precision medicine: diagnostics, gene discovery, and translation. | Need AC et al. | — | 2016 | → |
| No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population. | Umehara H et al. | — | 2016 | → |
| "Not Just Right Experiences" as a psychological endophenotype for obsessive-compulsive disorder: Evidence from an Italian family study. | Sica C et al. | — | 2016 | → |
| Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs. | den Braber A et al. | — | 2016 | → |
| OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. | Pittenger C et al. | — | 2016 | → |
| Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. | Fernandez TV et al. | — | 2016 | → |
| Systematic review of environmental risk factors for Obsessive-Compulsive Disorder: A proposed roadmap from association to causation. | Brander G et al. | — | 2016 | → |
| The need for inclusion of sex and age of onset variables in genetic association studies of obsessive-compulsive disorder: Overview. | Mattina GF et al. | — | 2016 | → |
| Treatment-refractory obsessive compulsive disorder. | Atmaca M | — | 2016 | → |
| TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. | Forde NJ et al. | — | 2016 | → |
| Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation. | Gazzellone MJ et al. | — | 2016 | → |
| Using mice to model Obsessive Compulsive Disorder: From genes to circuits. | Ahmari SE | — | 2016 | → |
| Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. | Cappi C et al. | — | 2016 | → |
| Whole-genome association analysis of treatment response in obsessive-compulsive disorder. | Qin H et al. | — | 2016 | → |
| Advances in Tourette syndrome: diagnoses and treatment. | Serajee FJ et al. | — | 2015 | → |
| An Adaptive Association Test for Multiple Phenotypes with GWAS Summary Statistics. | Kim J et al. | — | 2015 | → |
| An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive-compulsive disorder in a Chinese Han population. | Li J et al. | — | 2015 | → |
| Are stressful life events causally related to the severity of obsessive-compulsive symptoms? A monozygotic twin difference study. | Vidal-Ribas P et al. | — | 2015 | → |
| COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study. | Sampaio AS et al. | — | 2015 | → |
| Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. | Yu D et al. | — | 2015 | → |
| DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS. | Ahmari SE et al. | — | 2015 | → |
| GDNF gene is associated with tourette syndrome in a family study. | Huertas-Fernández I et al. | — | 2015 | → |
| Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. | Peprah E et al. | — | 2015 | → |
| Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. | Mattheisen M et al. | — | 2015 | → |
| Genomic research in Zambia: confronting the ethics, policy and regulatory frontiers in the 21st Century. | Chanda-Kapata P et al. | — | 2015 | → |
| Glutamate modulators in the treatment of obsessive-compulsive disorder. | Pittenger C | — | 2015 | → |
| Glutamatergic agents for OCD and related disorders. | Pittenger C | — | 2015 | → |
| MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. | Hommers L et al. | — | 2015 | → |
| No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population. | Umehara H et al. | — | 2015 | → |
| Obsessive-compulsive disorder in children and adolescents. | Krebs G et al. | — | 2015 | → |
| Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study. | Cederlöf M et al. | — | 2015 | → |
| Striatal circuits, habits, and implications for obsessive-compulsive disorder. | Burguière E et al. | — | 2015 | → |
| Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder. | Shaw P et al. | — | 2015 | → |
| The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study. | Sharp ME et al. | — | 2015 | → |
| An inherited small microdeletion at 15q13.3 in a patient with early-onset obsessive-compulsive disorder. | Cappi C et al. | — | 2014 | → |
| Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. | Tang R et al. | — | 2014 | → |
| Clinical practice: Obsessive-compulsive disorder. | Grant JE | — | 2014 | → |
| Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. | McGrath LM et al. | — | 2014 | → |
| Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development. | Grados M et al. | — | 2014 | → |
| Genetic neuropathology of obsessive psychiatric syndromes. | Jaffe AE et al. | — | 2014 | → |
| Genetics of obsessive-compulsive disorder and related disorders. | Browne HA et al. | — | 2014 | → |
| Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | Otowa T et al. | — | 2014 | → |
| GWAS is going to the dogs. | Machiela MJ et al. | — | 2014 | → |
| Horizons of psychiatric genetics and epigenetics: where are we and where are we heading? | Mostafavi Abdolmaleky H | — | 2014 | → |
| Imaging genetics in obsessive-compulsive disorder: linking genetic variations to alterations in neuroimaging. | Grünblatt E et al. | — | 2014 | → |
| Obsessive compulsive disorder and the glutamatergic system. | Kariuki-Nyuthe C et al. | — | 2014 | → |
| Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. | Pauls DL et al. | — | 2014 | → |
| Pharmacogenetics of antidepressant treatment in obsessive-compulsive disorder: an update and implications for clinicians. | Zai G et al. | — | 2014 | → |
| Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity. | Pallanti S et al. | — | 2014 | → |
| Searching for the immune basis of obsessive-compulsive disorder. | Teixeira AL et al. | — | 2014 | → |
| The Inheritance of Tourette Disorder: A review. | Pauls DL et al. | — | 2014 | → |
| The neurobiological link between OCD and ADHD. | Brem S et al. | — | 2014 | → |
| Top associated SNPs in prostate cancer are significantly enriched in cis-expression quantitative trait loci and at transcription factor binding sites. | Jiang J et al. | — | 2014 | → |
| Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index. | Simonson MA et al. | — | 2014 | → |
| Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. | Murphy DL et al. | — | 2013 | → |
| Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. | Karlsson EK et al. | — | 2013 | → |
| Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. | Wu K et al. | — | 2013 | → |
| Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. | Stewart SE et al. | — | 2013 | → |
| Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. | Davis LK et al. | — | 2013 | → |
| The genetic basis of Gilles de la Tourette Syndrome. | Paschou P | — | 2013 | → |