Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.
- Authors
- Johnson, Catherine; Drgon, Tomas; Liu, Qing-Rong; Zhang, Ping-Wu; Walther, Donna; Li, Chuan-Yun; Anthony, James C; Ding, Yulan; Eaton, William W; Uhl, George R
- Year
- 2008
- Journal
- BMC medical genetics
- PMID
- 19094236
- DOI
- 10.1186/1471-2350-9-113
- PMCID
- PMC2637238
BACKGROUND: Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers. RESULTS: We identify substantial overlap between the home address zip codes reported by members of these two samples. We find overlapping clusters of SNPs whose allele frequencies differ with nominal significance between substance dependent vs control individuals in both samples. These overlapping clusters of nominally-positive SNPs identify 172 genes in ways that are never found by chance in Monte Carlo simulation studies. Comparison with data from human expressed sequence tags suggests that these genes are expressed in brain, especially in hippocampus and amygdala, to extents that are greater than chance. CONCLUSION: The convergent results from these probability sample and research volunteer sample datasets support prior genome wide association results. They fail to support the idea that large portions of the molecular genetic results for vulnerability to substance dependence derive from factors that are limited to research volunteers.
Substantial overlaps of the zip codes in which subjects reported their residences. Fractional distributions (X axis) of zip codes (Y axis) in which ECA (solid blue bars) or MNB (dotted purple bars) subjects reported their residence. Areas from which NIDA and ECA recruitment efforts were dissimilar include 21214; Lauraville and surrounding areas and 21222, Dundalk and surrounding areas. Zip codes from which fewer than 3 individuals were recruited are not indicated.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D. | Uhl GR | — | 2023 | → |
| Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum. | Wu Y et al. | — | 2022 | → |
| Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. | Sun Y et al. | — | 2021 | → |
| LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain. | Cornejo F et al. | — | 2021 | → |
| Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality. | Soler Artigas M et al. | — | 2020 | → |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | — | 2020 | → |
| Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry. | Brick LA et al. | — | 2019 | → |
| The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction. | Muskiewicz DE et al. | — | 2018 | → |
| Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions. | Akbar MA et al. | — | 2017 | → |
| A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors. | Urquhart KR et al. | — | 2016 | → |
| Cadherin 13: human <i>cis</i>-regulation and selectively-altered addiction phenotypes and cerebral cortical dopamine in knockout mice. | Drgonova J et al. | — | 2016 | → |
| FRMD4A: A potential therapeutic target for the treatment of tongue squamous cell carcinoma. | Zheng X et al. | — | 2016 | → |
| Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer. | Fan Y et al. | — | 2016 | → |
| Reward Sensitivity of ACC as an Intermediate Phenotype between DRD4-521T and Substance Misuse. | Baker TE et al. | — | 2016 | → |
| Activity dependent CAM cleavage and neurotransmission. | Conant K et al. | — | 2015 | → |
| Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models. | Drgonova J et al. | — | 2015 | → |
| Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes. | Zhong X et al. | — | 2015 | → |
| Mouse Model for Protein Tyrosine Phosphatase D (<i>PTPRD</i>) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference. | Drgonova J et al. | — | 2015 | → |
| A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes. | Li M et al. | — | 2014 | → |
| Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. | Markunas CA et al. | — | 2014 | → |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | — | 2013 | → |
| Individual differences in rhesus monkeys' demand for drugs of abuse. | Koffarnus MN et al. | — | 2012 | → |
| Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. | Yoon D et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes. | Mozhui K et al. | — | 2011 | → |
| Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. | Baik I et al. | — | 2011 | → |
| Genome-wide association studies of alcohol dependence and substance use disorders. | Treutlein J et al. | — | 2011 | → |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | — | 2011 | → |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | — | 2011 | → |
| Are adolescents with ADHD interested in genetic testing for nicotine addiction susceptibility? | Herbert LJ et al. | — | 2010 | → |
| Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. | Chalasani N et al. | — | 2010 | → |
| Novel phenotype issues raised in cross-national epidemiological research on drug dependence. | Anthony JC | — | 2010 | → |
| Parental consanguinity and susceptibility to drug abuse among offspring, a case-control study. | Saadat M et al. | — | 2010 | → |
| Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. | David SP et al. | — | 2010 | → |
| Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs. | Sora I et al. | — | 2010 | → |
| Function and regulation of TRP family channels in C. elegans. | Xiao R et al. | — | 2009 | → |