Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

paper Cited Public

Authors: Stephens, Sarah H; Hartz, Sarah M; Hoft, Nicole R; Saccone, Nancy L; Corley, Robin C; Hewitt, John K; Hopfer, Christian J; Breslau, Naomi; Coon, Hilary; Chen, Xiangning; Ducci, Francesca; Dueker, Nicole; Franceschini, Nora; Frank, Josef; Han, Younghun; Hansel, Nadia N; Jiang, Chenhui; Korhonen, Tellervo; Lind, Penelope A; Liu, Jason; Lyytikäinen, Leo-Pekka; Michel, Martha; Shaffer, John R; Short, Susan E; Sun, Juzhong; Teumer, Alexander; Thompson, John R; Vogelzangs, Nicole; Vink, Jacqueline M; Wenzlaff, Angela; Wheeler, William; Yang, Bao-Zhu; Aggen, Steven H; Balmforth, Anthony J; Baumeister, Sebastian E; Beaty, Terri H; Benjamin, Daniel J; Bergen, Andrew W; Broms, Ulla; Cesarini, David; Chatterjee, Nilanjan; Chen, Jingchun; Cheng, Yu-Ching; Cichon, Sven; Couper, David; Cucca, Francesco; Dick, Danielle; Foroud, Tatiana; Furberg, Helena; Giegling, Ina; Gillespie, Nathan A; Gu, Fangyi; Hall, Alistair S; Hällfors, Jenni; Han, Shizhong; Hartmann, Annette M; Heikkilä, Kauko; Hickie, Ian B; Hottenga, Jouke Jan; Jousilahti, Pekka; Kaakinen, Marika; Kähönen, Mika; Koellinger, Philipp D; Kittner, Stephen; Konte, Bettina; Landi, Maria-Teresa; Laatikainen, Tiina; Leppert, Mark; Levy, Steven M; Mathias, Rasika A; McNeil, Daniel W; Medland, Sarah E; Montgomery, Grant W; Murray, Tanda; Nauck, Matthias; North, Kari E; Paré, Peter D; Pergadia, Michele; Ruczinski, Ingo; Salomaa, Veikko; Viikari, Jorma; Willemsen, Gonneke; Barnes, Kathleen C; Boerwinkle, Eric; Boomsma, Dorret I; Caporaso, Neil; Edenberg, Howard J; Francks, Clyde; Gelernter, Joel; Grabe, Hans Jörgen; Hops, Hyman; Jarvelin, Marjo-Riitta; Johannesson, Magnus; Kendler, Kenneth S; Lehtimäki, Terho; Magnusson, Patrik K E; Marazita, Mary L; Marchini, Jonathan; Mitchell, Braxton D; Nöthen, Markus M; Penninx, Brenda W; Raitakari, Olli; Rietschel, Marcella; Rujescu, Dan; Samani, Nilesh J; Schwartz, Ann G; Shete, Sanjay; Spitz, Margaret; Swan, Gary E; Völzke, Henry; Veijola, Juha; Wei, Qingyi; Amos, Chris; Cannon, Dale S; Grucza, Richard; Hatsukami, Dorothy; Heath, Andrew; Johnson, Eric O; Kaprio, Jaakko; Madden, Pamela; Martin, Nicholas G; Stevens, Victoria L; Weiss, Robert B; Kraft, Peter; Bierut, Laura J; Ehringer, Marissa A
Year: 2013
Journal: Genetic epidemiology
PMID: 24186853
DOI: 10.1002/gepi.21760
PMCID: PMC3947535

#	Section	Preview
20	Results — Single SNP Analysis for AOI and AOS Phenotypes	Tables 4 and 5 show PLINK meta-analysis results for each single locus and the AOI and AOS…
21	Results — Single SNP Analysis for AOI and AOS Phenotypes	Table 5 shows the corresponding results of AOS meta-analyses. Locus rs578776 was significantly…
22	Results — Single SNP Analysis for AOI and AOS Phenotypes	Cochrane’s Q statistic P-values (column six of Tables 4 and 5) indicate that there was one…
23	Discussion	This meta-analysis was designed to examine the relationship of SNPs in the CHRNA5/CHRNA3/CHRNB4 gene…
24	Discussion	Results revealed evidence for association between AOS and three of the five target SNPs.…
25	Discussion	In the current report, the strongest evidence for association with AOS was detected with SNP…
26	Discussion	In contrast to the AOS findings, there was no evidence for association between AOI and any of the…
27	Discussion	age. A social explanation was proposed for these findings in that early initiators were said to face…
28	Discussion	underlying behaviors, such as novelty-seeking and conduct disorder. Future studies aimed at…
29	Discussion	These findings corroborate and strengthen certain previous reports. Rs578776 (CHRNA3) has been…
30	Discussion	locus. SNP rs1948 was recently associated with the tolerance factor of the Nicotine Dependence…
31	Discussion	The PLINK meta-option reports the Cochrane’s Q statistic as a measure of heterogeneity for each…
32	Discussion	Q P-value = 0.01) suggesting the NTR1 rs588765 T allele frequency is not the cause of observed…
33	Discussion	There are several limitations to this study. First, given the involvement of many groups across…
34	Discussion	This study also features several strengths. First, this study was built on strong existing support…
35	Discussion	The most significant finding (rs578776) has been associated with nicotine dependence in multiple…
36	Discussion	behaviors are related to, but different from nicotine dependence. It also demonstrates the value in…

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