nicotine dependence phenotype
Evidence from:
primary |
all sources
Related entities (5)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| cases | associated_with | nicotine dependence | — | 1 |
| DNA methylation | associated_with | nicotine dependence | — | 1 |
| nicotine dependence | associated_with | Virginia Twin Registry | — | 1 |
| pack-years | associated_with | nicotine dependence | 0.0001 | 1 |
| time to first cigarette | associated_with | nicotine dependence | — | 1 |
Mentioned in (133)
Papers in which this entity is mentioned.
- Mapping the genetic landscape across 14 psychiatric disorders. (2026)
- Trajectories of genetic risk across dimensions of alcohol use behaviors. (2025)
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. (2024)
- Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish. (2022)
- Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. (2021)
- Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. (2021)
- Genetics of substance use disorders in the era of big data. (2021)
- Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. (2020)
- Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. (2020)
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. (2020)
- Image processing and analysis methods for the Adolescent Brain Cognitive Development Study. (2019)
- Comparison of the 4-Digit Code, Canadian 2015, Australian 2016 and Hoyme 2016 fetal alcohol spectrum disorder diagnostic guidelines. (2019)
- Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. (2019)
- Reliability and validity of an internalizing symptom scale based on the adolescent and adult Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). (2019)
- A randomized controlled trial of screening and brief interventions for substance misuse in reproductive health. (2018)
- Genome-wide association study identifies a novel locus for cannabis dependence. (2018)
- Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2018)
- DNA methylation as a predictor of fetal alcohol spectrum disorder. (2018)
- Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. (2018)
- Human Genetics of Addiction: New Insights and Future Directions. (2018)
- Hemispheric brain asymmetry differences in youths with attention-deficit/hyperactivity disorder. (2018)
- Smoking during pregnancy in the United States, 2005-2014: The role of depression. (2017)
- Review: Prevalence and co-occurrence of addictions in US ethnic/racial groups: Implications for genetic research. (2017)
- Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. (2017)
- Gene-environment interactions in development and disease. (2017)
- CHN2 Promoter Methylation Change May Be Associated With Methamphetamine Dependence. (2017)
- Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users. (2017)
- Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. (2016)
- The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks. (2016)
- KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. (2016)
- Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis. (2016)
- Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures. (2016)
- Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. (2015)
- Age-varying associations between substance use behaviors and depressive symptoms during adolescence and young adulthood. (2015)
- Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. (2015)
- Dissecting ancestry genomic background in substance dependence genome-wide association studies. (2015)
- Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. (2015)
- A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015)
- Candidate gene-environment interaction research: reflections and recommendations. (2015)
- Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial. (2015)
- Investigating the psychosocial determinants of child health in Africa: The Drakenstein Child Health Study. (2015)
- Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015)
- Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015)
- The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. (2014)
- MBASED: allele-specific expression detection in cancer tissues and cell lines. (2014)
- Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development. (2014)
- Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. (2014)
- Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (2014)
- Pharmacogenetics of OPRM1. (2014)
- Genetic variability in the regulation of gene expression in ten regions of the human brain. (2014)
- Identification of CHRNA5 rare variants in African-American heavy smokers. (2014)
- Increased cigarette tax is associated with reductions in alcohol consumption in a longitudinal U.S. sample. (2014)
- Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. (2014)
- Polygenic risk scores for smoking: predictors for alcohol and cannabis use? (2014)
- A survey of synthetic cannabinoid consumption by current cannabis users. (2014)
- A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. (2013)
- Nominal association with CHRNA4 variants and nicotine dependence. (2013)
- Comorbidity of posttraumatic stress disorder with alcohol dependence among US adults: results from National Epidemiological Survey on Alcohol and Related Conditions. (2013)
- Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. (2013)
- A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. (2013)
- The Finnish Twin Cohort Study: an update. (2013)
- Maturation of the adolescent brain. (2013)
- ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (2013)
- Childhood sexual abuse and early substance use in adolescent girls: the role of familial influences. (2013)
- Central precocious puberty caused by mutations in the imprinted gene MKRN3. (2013)
- Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. (2013)
- A Practical Guide to Calculating Cohen's f(2), a Measure of Local Effect Size, from PROC MIXED. (2012)
- Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. (2012)
- Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. (2012)
- Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects? (2012)
- Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: preliminary results using an aggregate genetic risk score. (2012)
- The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. (2012)
- The co-occurring use and misuse of cannabis and tobacco: a review. (2012)
- Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. (2012)
- Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans. (2012)
- Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (2012)
- The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. (2012)
- The genetic basis of addictive disorders. (2012)
- Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (2012)
- Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012)
- Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. (2012)
- Association of CHRNA4 polymorphisms with smoking behavior in two populations. (2011)
- Sex differences amongst dependent heroin users: histories, clinical characteristics and predictors of other substance dependence. (2011)
- TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011)
- Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. (2011)
- Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. (2011)
- A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. (2011)
- Opioid dependence latent structure: two classes with differing severity? (2011)
- The serotonin transporter gene and startle response during nicotine deprivation. (2011)
- Clinical practice. Treating smokers in the health care setting. (2011)
- Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. (2011)
- Transcriptional and epigenetic mechanisms of addiction. (2011)
- Adolescent initiation of licit and illicit substance use: Impact of intrauterine exposures and post-natal exposure to violence. (2011)
- Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. (2011)
- Genome wide association for addiction: replicated results and comparisons of two analytic approaches. (2010)
- Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (2010)
- Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. (2010)
- Longitudinal characterization of white matter maturation during adolescence. (2010)
- Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related Conditions. (2010)
- Neurocognitive correlates of white matter quality in adolescent substance users. (2010)
- Mothers' maximum drinks ever consumed in 24 hours predicts mental health problems in adolescent offspring. (2010)
- Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010)
- Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers. (2010)
- Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: likelihood, expression and course. (2010)
- Common genetic contributions to alcohol and cannabis use and dependence symptomatology. (2010)
- Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (2009)
- Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. (2009)
- Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. (2009)
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (2009)
- Environmental adversity and increasing genetic risk for externalizing disorders. (2009)
- A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. (2009)
- Brain stress systems in the amygdala and addiction. (2009)
- Genome-wide association studies in ADHD. (2009)
- Long-term effects of minimum drinking age laws on past-year alcohol and drug use disorders. (2009)
- Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. (2009)
- New insights into the genetics of addiction. (2009)
- Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. (2009)
- Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. (2009)
- The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology. (2009)
- Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009)
- Ethanol's molecular targets. (2008)
- Strengthening the case: prenatal alcohol exposure is associated with increased risk for conduct disorder. (2008)
- Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (2008)
- Real-time craving and mood assessments before and after smoking. (2008)
- Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology. (2008)
- Rate of nicotine metabolism and withdrawal symptoms in adolescent light smokers. (2008)
- One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility. (2008)
- Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. (2008)
- Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. (2006)
- Structural abnormalities in the brains of human subjects who use methamphetamine. (2004)
- A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. (2003)
- Sociocultural influences on smoking and drinking. (2000)
- Event-Related Potentials and Cognitive Function in Alcoholism. (1995)
Merged raw entities (30)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| nicotine dependence | phenotype | 120 | 494 |
| nd | phenotype | 14 | 35 |
| ndn | gene | 5 | 7 |
| nicotine dependence symptoms | phenotype | 4 | 4 |
| nicotine dependency | phenotype | 4 | 5 |
| cigarette-based nd | phenotype | 1 | 3 |
| nicotine dependent | phenotype | 1 | 1 |
| case–control status for nicotine dependence | phenotype | — | — |
| current nicotine dependence | phenotype | — | — |
| dichotomous nicotine dependence phenotype | phenotype | — | — |
| dsm‑iv nd | phenotype | — | — |
| dsm nicotine dependence | phenotype | — | — |
| fagerström nicotine tolerance score | phenotype | — | — |
| fagerstrom score | phenotype | — | — |
| fagerstrom scores | phenotype | — | — |
| ftnd≤1 | phenotype | — | — |
| ftnd≥4 | phenotype | — | — |
| ftnd-defined nicotine dependence | phenotype | — | — |
| ftnd dependence on nicotine | phenotype | — | — |
| lifetime nicotine dependence symptoms | phenotype | — | — |
| nd-related behaviors | phenotype | — | — |
| negative difference | phenotype | — | — |
| nicotine dependence etiology | phenotype | — | — |
| nicotine dependence (honc) | phenotype | — | — |
| nicotine dependence measures | phenotype | — | — |
| nicotine dependence (mftq) | phenotype | — | — |
| nicotine dependence phenotype | phenotype | — | — |
| nicotine dependence risk | phenotype | — | — |
| nicotine dependent cases | phenotype | — | — |
| nicotine dependent individuals | phenotype | — | — |