Evidence for a genetic component for substance dependence in Native Americans.
- Authors
- Ehlers, Cindy L; Gizer, Ian R
- Year
- 2013
- Journal
- The American journal of psychiatry
- PMID
- 23377636
- DOI
- 10.1176/appi.ajp.2012.12010113
- PMCID
- PMC3603686
OBJECTIVE: Although tribes differ with regard to the use of alcohol and drugs, substance dependence is one of the primary sources of health problems facing Native Americans. General population studies have demonstrated that substance dependence has a substantially heritable component (approximately 50% of the risk resulting from genetic influences); however, fewer studies have investigated the role of genetics in the risk for substance dependence in Native Americans. METHOD: The authors present a literature review of the evidence for a genetic component in the etiology of substance dependence in Native Americans, including studies of heritability, linkage analyses, and candidate genes. RESULTS: Evidence for the heritability of alcohol and drug dependence was found. Linkage analyses revealed that genes influencing risk for substance dependence and related phenotypes, such as body mass index (BMI), drug tolerance, EEG patterns, and externalizing traits, reside on several chromosome regions identified in other population samples. Overlap in the gene locations for substance dependence and BMI suggests that a common genetic substrate may exist for disorders of consumption. Studies of the genes that code for alcohol-metabolizing enzymes have not revealed any risk variants specific to Native American populations, although most Native Americans lack protective variants seen in other populations. Other candidate genes associated with substance dependence phenotypes in Native Americans include OPRM1, CRN1, COMT, GABRA2, MAOA, and HTR3-B. CONCLUSIONS: Substance dependence has a substantial genetic component in Native Americans, similar in magnitude to that reported for other populations. The high rates of substance dependence seen in some tribes is likely a combination of a lack of genetic protective factors (metabolizing enzyme variants) combined with genetically mediated risk factors (externalizing traits, consumption drive, and drug sensitivity or tolerance) that combine with key environmental factors (trauma exposure, early age at onset of use, and environmental hardship) to produce an elevated risk for the disorder.
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| Beliefs about causal factors for suicide in rural Alaska Native communities and recommendations for prevention. | Skewes MC et al. | — | 2022 | → |
| Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies. | Chang XW et al. | — | 2022 | → |
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| Substance and Behavioral Addictions among American Indian and Alaska Native Populations. | Soto C et al. | — | 2022 | → |
| Trauma, historical trauma, PTSD and suicide in an American Indian community sample. | Ehlers CL et al. | — | 2022 | → |
| "American Indian" as a Racial Category in Public Health: Implications for Communities and Practice. | Gartner DR et al. | — | 2021 | → |
| Belief in the myth of an American Indian/Alaska Native biological vulnerability to alcohol problems among reservation-dwelling participants with a substance use problem. | Gonzalez VM et al. | — | 2021 | → |
| Childhood Experiences and High-Intensity Drinking Among American Indian and Alaska Native Adults: Findings From the 2000-2015 National Alcohol Surveys. | Greenfield TK et al. | — | 2021 | → |
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| Understanding the link between racial trauma and substance use among American Indians. | Skewes MC et al. | — | 2019 | → |
| ANCO-GeneDB: annotations and comprehensive analysis of candidate genes for alcohol, nicotine, cocaine and opioid dependence. | Hu R et al. | — | 2018 | → |
| Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. | Taylor S | — | 2018 | → |
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| The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population. | Blum K et al. | — | 2018 | → |
| The Future of Research on Alcohol-Related Disparities Across U.S. Racial/Ethnic Groups: A Plan of Attack. | Zemore SE et al. | — | 2018 | → |
| Whole genome sequence study of cannabis dependence in two independent cohorts. | Gizer IR et al. | — | 2018 | → |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | — | 2017 | → |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | — | 2017 | → |
| Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. | Peng Q et al. | — | 2017 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Review: Genetic and environmental risk factors for alcohol use disorders in American Indians and Alaskan Natives. | Enoch MA et al. | — | 2017 | → |
| Sleep Quality in an Adult American Indian Community Sample. | Ehlers CL et al. | — | 2017 | → |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | — | 2016 | → |
| Similarities in the Etiology of Alcohol Use Among Native American and Non-Native Young Women. | Komro KA et al. | — | 2016 | → |
| Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample. | Ehlers CL et al. | — | 2016 | → |
| Alcohol Consumption in Healthy OPRM1 G Allele Carriers and Its Association with Impulsive Behavior. | Pfeifer P et al. | — | 2015 | → |
| Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. | Peng Q et al. | — | 2014 | → |
| Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS). | Blum K et al. | — | 2014 | → |
| Improved drug therapy: triangulating phenomics with genomics and metabolomics. | Monte AA et al. | — | 2014 | → |
| Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. | Moeller SJ et al. | — | 2014 | → |
| Molecular and genetic determinants of alcohol dependence. | Awofala AA | — | 2013 | → |