Environmental influences predominate in remission from alcohol use disorder in young adult twins.
- Authors
- McCutcheon, V V; Grant, J D; Heath, A C; Bucholz, K K; Sartor, C E; Nelson, E C; Madden, P A F; Martin, N G
- Year
- 2012
- Journal
- Psychological medicine
- PMID
- 22423619
- DOI
- 10.1017/S003329171200044X
- PMCID
- PMC3752317
BACKGROUND: Familial influences on remission from alcohol use disorder (AUD) have been studied using family history of AUD rather than family history of remission. The current study used a remission phenotype in a twin sample to examine the relative contributions of genetic and environmental influences to remission. METHOD: The sample comprised 6183 twins with an average age of 30 years from the Australian Twin Registry. Lifetime history of alcohol abuse and dependence symptoms and symptom recency were assessed with a structured telephone interview. AUD was defined broadly and narrowly as history of two or more or three or more abuse or dependence symptoms. Remission was defined as absence of symptoms at time of interview among individuals with lifetime AUD. Standard bivariate genetic analyses were conducted to derive estimates of genetic and environmental influences on AUD and remission. RESULTS: Environmental influences alone accounted for remission in males and for 89% of influences on remission in females, with 11% due to genetic influences shared with AUD, which decreased the likelihood of remission. For women, more than 80% of influences on remission were distinct from influences on AUD, and environmental influences were from individual experiences only. For men, just over 50% of influences on remission were distinct from those on AUD, and the influence of environments shared with the co-twin were substantial. The results for the broad and narrow phenotypes were similar. CONCLUSIONS: The current study establishes young adult remission as a phenotype distinct from AUD and highlights the importance of environmental influences on remission.
(a) Frequency of drinking and (b) usual number of drinks per drinking occasion during the heaviest 12-month period of drinking and past 12 months, for individuals with two or more alcohol use disorder (AUD) symptoms, by remission status.
| Name | Type |
|---|---|
| 175 Patients Cohort local | cohort |
| abstinence | phenotype |
| abstinent recovery | phenotype |
| AD symptom count | phenotype |
| age ≥30 years local | cohort |
| Age ≥30 years local | phenotype |
| age at initiation | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| Alcohol abuse symptoms local | phenotype |
| alcohol dependence | phenotype |
| Alcohol Dependence Symptoms | phenotype |
| Alcohol Initiation | phenotype |
| alcoholism | phenotype |
| Alcohol Problems | phenotype |
| Alcohol problems in parents local | phenotype |
| alcohol-related phenotypes | phenotype |
| Alcohol treatment | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| American Indians | cohort |
| AUD | phenotype |
| AUD phenotype local | phenotype |
| Australian Twin Registry | cohort |
| Australian Twin Registry Older Cohort local | cohort |
| Australian Twin Registry Young Adult Cohort local | cohort |
| behavioral dyscontrol local | phenotype |
| Childhood physical or sexual abuse local | phenotype |
| childhood physical/sexual abuse local | phenotype |
| clinical cohort | cohort |
| clinical samples | cohort |
| Clinical study (175 patients) local | cohort |
| close relationship with parents (age 6-13) local | phenotype |
| cognitive efficiency | phenotype |
| co-twin early remission local | phenotype |
| co-twin sustained remission local | phenotype |
| Danish Longitudinal Study on Alcoholism local | cohort |
| drinking | phenotype |
| drug | drug |
| Duration of Alcohol Use Disorder local | phenotype |
| DZM twins local | cohort |
| early remission local | phenotype |
| Early remission local | phenotype |
| education | phenotype |
| environmental influences | phenotype |
| failure to remit local | phenotype |
| familial alcohol problems local | phenotype |
| familial history of AUD local | phenotype |
| familial risk | cohort |
| family history of alcoholism | phenotype |
| Family history of remission local | phenotype |
| female pairs local | cohort |
| frequency of alcohol use | phenotype |
| Having one child local | phenotype |
| heavy drinking | phenotype |
| High-Risk Family Study Cohort local | cohort |
| high-risk sample | cohort |
| High-Risk Samples Cohort local | cohort |
| Hospitalization for alcoholism local | phenotype |
| Individuals with three or more AUD symptoms local | cohort |
| Individuals with two or more AUD symptoms local | cohort |
| Knop 2003 study local | cohort |
| life crises at age 19–20 local | phenotype |
| lifetime alcohol use | phenotype |
| lifetime AUD symptom count local | phenotype |
| lifetime pregnancy status local | phenotype |
| lifetime treatment for alcohol problems local | phenotype |
| Life transitions local | phenotype |
| male pairs local | cohort |
| marital status | phenotype |
| Maximum number of drinks consumed in a 24-h period local | phenotype |
| medication | drug |
| men | cohort |
| Mission Indians Cohort local | cohort |
| MZ female twins local | cohort |
| MZ male twins local | cohort |
| MZM twins local | cohort |
| NESARC | cohort |
| non-abstinent recovery | phenotype |
| number of biological children local | phenotype |
| Onset of first AUD symptom local | phenotype |
| OS pairs local | cohort |
| parental alcoholism | phenotype |
| parental psychiatric problems local | phenotype |
| parents | cohort |
| paternal alcohol use disorder | phenotype |
| Penick 2010 study local | cohort |
| Periods of Abstinence local | phenotype |
| Population-Based Cohort local | cohort |
| population-based sample | cohort |
| Probands Cohort local | cohort |
| problematic alcohol use | phenotype |
| relapse | phenotype |
| religion local | phenotype |
| remission | phenotype |
| Remission from Alcohol Use Disorder local | phenotype |
| remission from three or more AUD symptoms local | phenotype |
| remission from two or more AUD symptoms local | phenotype |
| Remission in males local | phenotype |
| severe physical assault local | phenotype |
| sex | phenotype |
| shared environment local | drug |
| socio-economic status of family at birth local | phenotype |
| stable relationships local | phenotype |
| Stable relationships local | phenotype |
| substance use | phenotype |
| sustained remission local | phenotype |
| Sustained remission local | phenotype |
| Symptom clustering measure local | phenotype |
| tension between parents (age 6-13) local | phenotype |
| Tension between parents (aged 6 to 13) local | phenotype |
| three or more AUD symptoms local | phenotype |
| three-symptom phenotype local | phenotype |
| trauma history local | phenotype |
| Twin cohort | cohort |
| twin early remission local | phenotype |
| twin sustained remission local | phenotype |
| two or more AUD symptoms local | phenotype |
| Untreated remission from AUD local | phenotype |
| US twins local | cohort |
| witnessing injury/killing local | phenotype |
| women | cohort |
| work status local | phenotype |
| Years of abstinence local | phenotype |
| Young adult cohort | cohort |
| young adult remission local | phenotype |
| Young adult twins local | cohort |
| Young Sample Cohort local | cohort |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Familial association of abstinent remission from alcohol use disorder in first-degree relatives of alcohol-dependent treatment-seeking probands. | 2017 | 28556494 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| [Factors influencing the achievement of remission in patients with alcohol dependence and concomitant psychological disorders]. | Kardashian RA et al. | — | 2025 | → |
| Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank. | Lai D et al. | — | 2024 | → |
| Promoter Specific Methylation of <i>SSTR4</i> is Associated With Alcohol Dependence in Han Chinese Males. | Zhao R et al. | — | 2022 | → |
| Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples. | Johnson EC et al. | — | 2021 | → |
| Transitions in alcohol use over time: a survival analysis. | Koenig LB et al. | — | 2020 | → |
| Alcohol use disorder relapse factors: A systematic review. | Sliedrecht W et al. | — | 2019 | → |
| Remission from Alcohol Use Disorder among Males in the Lundby Cohort during 1947-1997. | Mattisson C et al. | — | 2018 | → |
| Familial association of abstinent remission from alcohol use disorder in first-degree relatives of alcohol-dependent treatment-seeking probands. | McCutcheon VV et al. | — | 2017 | → |
| Reduced Social Network Drinking is Associated with Improved Response Inhibition in Women During Early Recovery from Alcohol Use Disorders: A Pilot Study. | McCutcheon VV et al. | — | 2016 | → |
| Risk and resistance perspectives in translation-oriented etiology research. | Vanyukov MM et al. | — | 2016 | → |
| Behavioral genetics and population health interventions for alcohol problems: at odds or oddly in agreement? | Cunningham JA et al. | — | 2013 | → |