The incentive salience of alcohol: translating the effects of genetic variant in CNR1.
paper
Cited
Public
- Authors
- Hutchison, Kent E; Haughey, Heather; Niculescu, Michelle; Schacht, Joe; Kaiser, Alan; Stitzel, Jerry; Horton, William J; Filbey, Francesca
- Year
- 2008
- Journal
- Archives of general psychiatry
- PMID
- 18606956
- DOI
- 10.1001/archpsyc.65.7.841
- PMCID
- PMC2856651
CONTEXT: The gene that codes for cannabinoid receptor 1 (CNR1) represents an important target for investigations designed to elucidate individual differences in the etiology of alcohol dependence. OBJECTIVE: To achieve a better understanding of the role of the CNR1 gene in the etiology and treatment of alcohol dependence. DESIGN: The present investigation spans multiple levels of analysis, including receptor binding in postmortem brain tissue, neuroimaging, human laboratory models, and analyses of treatment outcome data. RESULTS: Findings indicate that the C allele of rs2023239 is associated with greater CB1 binding in the prefrontal cortex, greater alcohol cue-elicited brain activation in the midbrain and prefrontal cortex, greater subjective reward when consuming alcohol, and more positive outcomes after treatment with a medication that targets the mesocorticolimbic neurocircuitry. In addition, there were strong correlations between cue-elicited brain activation and alcohol consumption measures in individuals with the C allele. CONCLUSION: Individuals with the C allele may be more susceptible to changes in the mesocorticolimbic neurocircuitry that is involved in the attribution of incentive salience after repeated exposure to alcohol.
No figures extracted from this document.
1β20 of 37
Next β
| Name | Type |
|---|---|
| 0.1X buffer local | drug |
| Active medication local | drug |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcohol-related problems | phenotype |
| Alcohol reward | phenotype |
| Alcohol urge questionnaire | phenotype |
| Alcohol Urge Questionnaire score local | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| Alcohol Use Disorder Identification Test score local | phenotype |
| Alcohol Use Disorders Identification Test | phenotype |
| anorexia nervosa | phenotype |
| antipsychotics | drug |
| AUDIT | phenotype |
| behavioral phenotypes | phenotype |
| bipolar disorder | phenotype |
| bovine serum albumin | drug |
| brain activation to rewarding stimuli local | phenotype |
| Breath alcohol level | phenotype |
| Brodmann area 10 | anatomy |
| Brodmann area 9 | anatomy |
| bulimia nervosa | phenotype |
| calcium chloride | drug |
| CB1 receptor | drug |
| CB1 receptor binding local | phenotype |
| CB1 receptor levels local | phenotype |
| CC genotype local | variant |
| clinical phenotypes | phenotype |
| Cnr1 | gene |
| CNR1 CT genotype local | variant |
| CNR1 TT genotype local | variant |
| control | cohort |
| CP55,940 local | drug |
| craving | phenotype |
| CT genotype local | variant |
| CT genotype individuals local | cohort |
| CT group local | cohort |
| Cue-elicited craving local | phenotype |
| cue reactivity | phenotype |
| Cyproheptadine hydrochloride local | drug |
| DRD4 | gene |
| DRD4 VNTR | variant |
| drink 1 local | drug |
| drink 2 local | drug |
| drink 3 local | drug |
| drinking | phenotype |
| drinks per week | phenotype |
| drug dependence | phenotype |
| drugs | drug |
| drug-seeking behavior | phenotype |
| Fluorocarbon resin local | drug |
| Gatorade local | drug |
| genetic variants | cohort |
| Greater reward local | phenotype |
| heavy drinking | phenotype |
| HEPES | drug |
| high | phenotype |
| hypotonic buffer local | drug |
| illicit drugs | phenotype |
| incentive salience | phenotype |
| Inotech Biosystems local | cohort |
| Juice local | drug |
| Litchi juice local | drug |
| male white alcoholics local | cohort |
| marijuana | phenotype |
| matched controls | cohort |
| medication | drug |
| Mesocorticolimbic system | anatomy |
| MgSO4 | drug |
| moderate to heavy drinkers local | phenotype |
| Moderate to heavy nonβtreatmentβseeking drinkers local | cohort |
| mood disorders | phenotype |
| Motivation for change local | phenotype |
| NAcc | anatomy |
| NAcc/ventral striatum local | anatomy |
| neuroimaging phenotypes local | phenotype |
| neuronal activation after alcohol cue challenge local | phenotype |
| nonspecific binding local | phenotype |
| nucleus accumbens | anatomy |
| Olanzapine trial local | cohort |
| OPRM1 | cohort |
| OPRM1 A/G SNP local | variant |
| orbitofrontal cortex | anatomy |
| Orbitofrontal Cortex (left) local | anatomy |
| participants | cohort |
| Perkin Elmer local | cohort |
| PFC | anatomy |
| placebo beverage | drug |
| positive affect | phenotype |
| potassium chloride | drug |
| prefrontal cortex | anatomy |
| previous clinical trial local | cohort |
| Psychosocial treatment local | drug |
| race/ethnicity | phenotype |
| reward | phenotype |
| reward and positive affect local | phenotype |
| Reward from alcoholic beverages local | phenotype |
| right orbitofrontal cortex | anatomy |
| rs2023239 | variant |
| schizophrenia | phenotype |
| Self-reported high local | phenotype |
| sex | phenotype |
| subjective craving local | phenotype |
| subjective effects of alcohol consumption local | phenotype |
| substance abuse | phenotype |
| tobacco use | phenotype |
| treatment outcome differences local | phenotype |
| Trial participants local | cohort |
| tritium-labeled CP55,940 local | drug |
| TT genotype | variant |
| TT group local | cohort |
| urge to drink | phenotype |
| ventral tegmental area | anatomy |
| ventromedial prefrontal cortex | anatomy |
| volunteers | cohort |
| VTA | anatomy |
| whites | cohort |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| PET Molecular Imaging of the Endocannabinoid System in Psychiatric Disorders. | Cui C et al. | β | 2026 | β |
| Pharmacogenetic association study of cannabis use in chronic pain. | Beauchesne W et al. | β | 2026 | β |
| Polymorphisms in GPCR genes: Their role in schizophrenia, autism diseases and response to antipsychotic treatment - A systematic review. | DelaCuesta-Barrutia J et al. | β | 2026 | β |
| Pharmacogenetic association study of cannabis use in chronic pain | Beauchesne W et al. | β | 2025 | β |
| Examining the Impact of Simultaneous Alcohol and Cannabis Use on Alcohol Consumption and Consequences: Protocol for an Observational Ambulatory Assessment Study in Young Adults. | Gunn RL et al. | β | 2024 | β |
| Acute and chronic ethanol administration: A potential model of behavioral sensitization using wheel-running in male CD1 mice. | Niculescu M et al. | β | 2022 | β |
| Behavioral response bias and event-related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol. | CofresΓ RU et al. | β | 2022 | β |
| Biomarkers of the Endocannabinoid System in Substance Use Disorders. | Navarrete F et al. | β | 2022 | β |
| Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities. | MacKenzie A et al. | β | 2022 | β |
| The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use. | Bornscheuer L et al. | β | 2022 | β |
| Associations of CB1 cannabinoid receptor (CNR1) gene polymorphisms with risk for alcohol dependence: Evidence from meta-analyses of genetic and genome-wide association studies. | Pabalan N et al. | β | 2021 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Endocannabinoid Gene Γ Gene Interaction Association to Alcohol Use Disorder in Two Adolescent Cohorts. | Elkrief L et al. | β | 2021 | β |
| Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis. | Murphy T et al. | β | 2021 | β |
| The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers. | Chukwueke CC et al. | β | 2021 | β |
| The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli. | Filbey FM et al. | β | 2021 | β |
| Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence. | Fleming KA et al. | β | 2021 | β |
| Disease-associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue-specific activity of the cannabinoid-1 receptor gene promoter; implications for cannabinoid pharmacogenetics. | Hay EA et al. | β | 2020 | β |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | β | 2020 | β |
| Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour. | Hay EA et al. | β | 2019 | β |
| Distinct functions of endogenous cannabinoid system in alcohol abuse disorders. | Basavarajappa BS et al. | β | 2019 | β |
| DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity. | Bidwell LC et al. | β | 2019 | β |
| Endocannabinoid System and Alcohol Abuse Disorders. | Basavarajappa BS | β | 2019 | β |
| Cannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density. | Ketcherside A et al. | β | 2017 | β |
| Cross-Cultural Effects of Cannabis Use Disorder: Evidence to Support a Cultural Neuroscience Approach. | Prashad S et al. | β | 2017 | β |
| A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. | King AC et al. | β | 2016 | β |
| Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research. | Bujarski S et al. | β | 2016 | β |
| Liking, wanting, and the incentive-sensitization theory of addiction. | Berridge KC et al. | β | 2016 | β |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | β | 2016 | β |
| Roles for the endocannabinoid system in ethanol-motivated behavior. | Henderson-Redmond AN et al. | β | 2016 | β |
| The role of the cannabinoid receptor in adolescents' processing of facial expressions. | Ewald A et al. | β | 2016 | β |
| A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients. | Icick R et al. | β | 2015 | β |
| Altered CB1 receptor coupling to G-proteins in the post-mortem caudate nucleus and cerebellum of alcoholic subjects. | Erdozain AM et al. | β | 2015 | β |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | β | 2015 | β |
| Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior. | Colizzi M et al. | β | 2015 | β |
| Pharmacotherapy for alcohol use disorder: current and emerging therapies. | Swift RM et al. | β | 2015 | β |
| The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. | Erdozain AM et al. | β | 2015 | β |
| Cannabis controversies: how genetics can inform the study of comorbidity. | Agrawal A et al. | β | 2014 | β |
| Preliminary functional MRI results from a combined stop-signal alcohol-cue task. | Karoly HC et al. | β | 2014 | β |
| Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students. | Krebs MO et al. | β | 2014 | β |
| Craving and subjective responses to alcohol administration: validation of the desires for alcohol questionnaire in the human laboratory. | Courtney KE et al. | β | 2013 | β |
| Evaluating an Integrative Theoretical Framework for HIV Sexual Risk among Juvenile Justice involved Adolescents. | Magnan RE et al. | β | 2013 | β |
| Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues. | Wilcox CE et al. | β | 2013 | β |
| Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems. | Bidwell LC et al. | β | 2013 | β |
| Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. | Schacht JP et al. | β | 2013 | β |
| Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls. | Falcone M et al. | β | 2013 | β |
| Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. | Hirvonen J et al. | β | 2013 | β |
| Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. | Karoly HC et al. | β | 2013 | β |
| Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses. | Hill MN et al. | β | 2013 | β |
| Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus. | Nicoll G et al. | β | 2012 | β |
| A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. | Pava MJ et al. | β | 2012 | β |
| Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. | Schacht JP et al. | β | 2012 | β |
| Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia. | Jenko KJ et al. | β | 2012 | β |
| Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. | Hillard CJ et al. | β | 2012 | β |
| Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use. | Barson JR et al. | β | 2012 | β |
| The genetic basis of the endocannabinoid system and drug addiction in humans. | LΓ³pez-Moreno JA et al. | β | 2012 | β |
| Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. | Ho BC et al. | β | 2011 | β |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | β | 2011 | β |
| How psychosocial alcohol interventions work: a preliminary look at what FMRI can tell us. | Feldstein Ewing SW et al. | β | 2011 | β |
| Identifying neurobiological phenotypes associated with alcohol use disorder severity. | Claus ED et al. | β | 2011 | β |
| Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence. | Erdozain AM et al. | β | 2011 | β |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | β | 2011 | β |
| Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. | Chakrabarti B et al. | β | 2011 | β |
| A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. | Tiwari AK et al. | β | 2010 | β |
| A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ). | Kramer JR et al. | β | 2010 | β |
| Consilient research approaches in studying gene x environment interactions in alcohol research. | Sher KJ et al. | β | 2010 | β |
| Exploring the relationship between depressive and anxiety symptoms and neuronal response to alcohol cues. | Feldstein Ewing SW et al. | β | 2010 | β |
| Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. | Filbey FM et al. | β | 2010 | β |
| Substance use disorders: realizing the promise of pharmacogenomics and personalized medicine. | Hutchison KE | β | 2010 | β |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | β | 2009 | β |
| Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. | Onaivi ES | β | 2009 | β |
| Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample. | Feldstein Ewing SW et al. | β | 2009 | β |
| Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. | Agrawal A et al. | β | 2009 | β |
| Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. | Zuo L et al. | β | 2009 | β |
| Alcohol dependence: neuroimaging and the development of translational phenotypes. | Hutchison KE | β | 2008 | β |
| Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. | Filbey FM et al. | β | 2008 | β |