Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?".

paper Primary Public

Authors: Dick, Danielle M
Year: 2018
Journal: Prevention science : the official journal of the Society for Prevention Research
PMID: 28735446
DOI: 10.1007/s11121-017-0828-7
PMCID: PMC5754264

#	Section	Preview
0	Introduction	The number of studies devoted to understanding how genetic and environmental influences operate…
1	Overview of the Special Issue	This special issue contains a collection of papers that address different aspects of incorporating…
2	Overview of the Special Issue	Other papers in this issue focus on the need to ensure that the incorporation of genetic information…
3	Overview of the Special Issue	The importance of incorporating a developmental perspective into studies of gene by intervention…
4	Overview of the Special Issue	Finally, in this issue, Beach et al.(Beach, Lei, Brody, & Philibert, 2016) report an epigenetic…
5	Overview of this Commentary	Accordingly, with growing attention focused on the incorporation of genetic information into…
6	Why the growing interest in incorporating genetics into prevention studies?	There are probably numerous reasons for the growing number of psychological studies incorporating…
7	Opportunities and Challenges	The papers in this special issue provide illustrations of places where developmental psychologists…
8	Opportunities and Challenges	However, the selection of genetic information for incorporation into a prevention study is not…
9	Opportunities and Challenges	truth, we are only studying genetic variation, not genetic “risk”, and though an allele may be…
10	Opportunities and Challenges	The fact that the incorporation of single variants from theoretically-based biological candidate…
11	Opportunities and Challenges	Some prevention studies are now incorporating polygenic risk scores (PRS)(Musci et al., 2016), in…
12	Opportunities and Challenges	liability(Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014). A similar story…
13	Opportunities and Challenges	However, there are several challenges that the strategy of including GPSs in prevention studies will…
14	Opportunities and Challenges	such as aggression, conduct problems, depressive affect, or anxiety, there has been far less…
15	Opportunities and Challenges	multiple studies, with related, but distinct, phenotypes (Turley et al., 2017). Accordingly, it is…
16	Opportunities and Challenges	A third major challenge with the inclusion of GPS in prevention studies is that many of these…
17	Opportunities and Challenges	Finally, it is possible that some genetically influenced outcomes of interest to prevention…
18	Opportunities and Challenges	A construct of deep interest to prevention science – the idea that there may be a predisposition…
19	Practical and Ethical Implications Associated with Genotyping in Prevention Science	The rationale often provided for including genetic information in prevention science is that it…

Citation	PMID	DOI	Status
Albert, D et al., J Policy Anal Manage, 2015, Can genetics predict response to complex behavioral interventions? Evidence from a genetic analysis of the fast track randomized control trial	26106668	10.1002/pam.21811	Cited
Bakermans-Kranenburg, MJ et al., Dev Psychol, 2008, Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers’ externalizing behavior in a randomized controlled trial	18194028	10.1037/0012-1649.44.1.293	Cited
Bakermans-Kranenburg, MJ et al., Dev Psychopathol, 2011, Differential susceptibility to rearing environment depending on dopamine-related genes: New evidence and a meta-analysis	21262038	10.1017/s0954579410000635	Cited
Bates, JE et al., Dev Psychol, 1998, Interaction of temperamental resistance to control and restrictive parenting in the development of externalizing behavior	9779744	10.1037//0012-1649.34.5.982	Cited
Beach, SRH et al., Prevention Science, 2016, Prevention of early substance use mediates, and variation at SLC6A4 moderates, SAAF intervention effects on OXTR methylation	27655391	10.1007/s11121-016-0709-5	Cited
Belsky, J et al., Current directions in psychological science, 2007, For better and for worse: Differential susceptibility to environmental influences	—	—	—
Belsky, J et al., Mol Psychiatry, 2009, Vulnerability genes or plasticity genes?	19455150	10.1038/mp.2009.44	Cited
Belsky, J, Child Dev, 1997, Theory testing, effect-size evaluation, and differential susceptibility to rearing influence: the case of mothering and attachment	9306638	—	Cited
Brody, GH et al., Am J Public Health, 2013, Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology	23927515	10.2105/ajph.2012.301080	Cited
Brody, GH et al., Child Dev, 2009, Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design	19489894	10.1111/j.1467-8624.2009.01288.x	Cited
Brody, GH et al., Health Psychol, 2014, Differential sensitivity to prevention programming: a dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use	23379386	10.1037/a0031253	Cited
Brody, GH et al., Pediatrics, 2009, Participation in a family-centered prevention program decreases genetic risk for adolescents’ risky behaviors	19706565	10.1542/peds.2008-3464	Cited
Bronfenbrenner, U, Readings on the development of children, 1994, Ecological models of human development	—	—	—
Bujak, R et al., J Pharm Biomed Anal, 2015, Metabolomics for laboratory diagnostics	25577715	10.1016/j.jpba.2014.12.017	Cited
Burke, W et al., Jama, 2007, Personalized medicine in the era of genomics	17925520	10.1001/jama.298.14.1682	Cited
Carlson, CS et al., Am J Hum Genet, 2004, Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium	14681826	10.1086/381000	Cited
Caspi, A et al., Science, 2002, Role of genotype in the cycle of violence in maltreated children	12161658	10.1126/science.1072290	Cited
Caspi, A et al., Science, 2003, Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene	12869766	10.1126/science.1083968	Cited
Christenhusz, GM et al., Eur J Hum Genet, 2013, To tell or not to tell? A systematic review of ethical reflections on incidental findings arising in genetics contexts	22739341	10.1038/ejhg.2012.130	Cited
Cleveland, HH et al., Prev Sci, 2017, Transactions between substance use intervention, the oxytocin receptor (OXTR) gene, and peer substance use predicting youth alcohol use	28150062	10.1007/s11121-017-0749-5	Cited
Collins, FS et al., N Engl J Med, 2015, A new initiative on precision medicine	25635347	10.1056/NEJMp1500523	Cited
Dick, DM et al., Behav Genet, 2006, The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages	16557364	10.1007/s10519-005-9041-8	Primary
Dick, DM et al., Biol Psychiatry, 2008, A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9	18163977	10.1016/j.biopsych.2007.11.005	Primary
Dick, DM et al., Frontiers in Psychiatry, 2011, Incorporating genetics into your studies: A guide for social scientists	21629842	10.3389/fpsyt.2011.00017	Cited
Dick, DM et al., J Abnorm Child Psychol, 2005, Understanding the covariation among childhood externalizing symptoms: genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms	15839499	10.1007/s10802-005-1829-8	Cited
Dick, DM et al., Mol Psychiatry, 2004, A genome-wide screen for genes influencing conduct disorder	14699444	10.1038/sj.mp.4001368	Primary
Dick, DM et al., Twin Res Hum Genet, 2007, Changing environmental influences on substance use across development	17564520	10.1375/twin.10.2.315	Cited
Dick, DM et al., Under review, 2017, Post-GWAS in psychiatric genetics: A developmental perspective on the “other” next steps	29227573	10.1111/gbb.12447	Primary
Dishion, TJ et al., J Abnorm Child Psychol, 2014, Prevention of problem behavior through annual family check-ups in early childhood: intervention effects from home to early elementary school	24022677	10.1007/s10802-013-9768-2	Cited
Farrell, MS et al., Mol Psychiatry, 2015, Evaluating historical candidate genes for schizophrenia	25754081	10.1038/mp.2015.16	Cited
Feero, WG et al., Acad Pediatr, 2014, Genomics, personalized medicine, and pediatrics	24369865	10.1016/j.acap.2013.06.008	Cited
Friedman, N et al., Genome Res, 2015, Epigenomics and the structure of the living genome	26430158	10.1101/gr.190165.115	Cited
Glenn, AL et al., Prev Sci, 2017, Oxytocin receptor gene variant interacts with intervention delivery format in predicting intervention outcomes for youth with conduct problems	28303421	10.1007/s11121-017-0777-1	Cited
Green, RC et al., Genet Med, 2013, ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing	23788249	10.1038/gim.2013.73	Cited
Guo, G et al., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007, Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes	17440951	10.1002/ajmg.b.30340	Cited
Guttmacher, AE et al., N Engl J Med, 2003, Welcome to the genomic era	12954750	10.1056/NEJMe038132	Cited
Guttmacher, AE et al., Nat Rev Genet, 2007, Educating health-care professionals about genetics and genomics	17230201	10.1038/nrg2007	Cited
Hendrickson, BC et al., J Med Genet, 2009, Differences in SMN1 allele frequencies among ethnic groups within North America	19625283	10.1136/jmg.2009.066969	Cited
Hettema, JM et al., Am J Psychiatry, 2001, A review and meta-analysis of the genetic epidemiology of anxiety disorders	11578982	10.1176/appi.ajp.158.10.1568	Cited
Humphery-Smith, I, Proteomics, 2015, The 20th anniversary of proteomics and some of its origins	25689367	10.1002/pmic.201400582	Cited
Irons, DE et al., Alcohol Clin Exp Res, 2012, Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use	22563891	10.1111/j.1530-0277.2012.01809.x	Cited
Kessler, RC et al., Arch Gen Psychiatry, 1997, Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey	9107147	10.1001/archpsyc.1997.01830160031005	Cited
Latendresse, SJ et al., Prev Sci, 2017, Critical issues in the inclusion of genetic and epigenetic information in prevention and intervention trials	28409280	10.1007/s11121-017-0785-1	Cited
Leve, LD et al., Prev Sci, 2017, Naturalistic experimental designs as tools for understanding the role of genes and the environment in prevention research	28093649	10.1007/s11121-017-0746-8	Cited
Li, JJ et al., Alcohol Clin Exp Res, 2017, The impact of peer substance use and polygenic risk on trajectories of heavy episodic drinking across adolescence and emerging adulthood	27991676	10.1111/acer.13282	Primary
Maher, BS et al., Prevention Science, 2016, Informing prevention and intervention policy using genetic studies of resistance	27943075	10.1007/s11121-016-0730-8	Cited
McCarthy, S et al., Nat Genet, 2016, A reference panel of 64,976 haplotypes for genotype imputation	27548312	10.1038/ng.3643	Cited
McDonald, D et al., Microbiome, 2015, Context and the human microbiome	26530830	10.1186/s40168-015-0117-2	Cited
Musci, RJ et al., Prevention Science, 2016, Polygenic score × intervention moderation: An application of discrete-time survival analysis to model the timing of first marijuana use among urban youth	27817095	10.1007/s11121-016-0729-1	Cited
Nature Genetics, 2011, Genome-wide association study identifies five new schizophrenia loci	21926974	10.1038/ng.940	Cited
Nature, 2014, Biological insights from 108 schizophrenia-associated genetic loci	25056061	10.1038/nature13595	Cited
Okbay, A et al., Nature, 2016, Genome-wide association study identifies 74 loci associated with educational attainment	27225129	10.1038/nature17671	Cited
O’Donovan, MC, World Psychiatry, 2015, What have we learned from the Psychiatric Genomics Consortium	26407777	10.1002/wps.20270	Cited
Pappa, I et al., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016, A genome-wide approach to children’s aggressive behavior: the EAGLE consortium	26087016	10.1002/ajmg.b.32333	Cited
Ripke, S et al., Mol Psychiatry, 2013, A mega-analysis of genome-wide association studies for major depressive disorder	22472876	10.1038/mp.2012.21	Cited
Russell, MA et al., Prev Sci, 2017, PROSPER intervention effects on adolescents’ alcohol misuse vary by GABRA2 genotype and age	28185103	10.1007/s11121-017-0751-y	Cited
Salvatore, JE et al., Clin Psychol Sci, 2015, Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults	25821660	10.1177/2167702614534211	Primary
Salvatore, JE et al., Genes (Basel), 2014, Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment	24727307	10.3390/genes5020330	Cited
Schlaepfer, IR et al., Biol Psychiatry, 2008, The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults	18163978	10.1016/j.biopsych.2007.10.024	Cited
Turley, P et al., bioRxiv, 2017, MTAG: multi-trait analysis of GWAS	—	—	—
Walsh, CG et al., Clinical Psychological Science, 2017, Predicting risk of suicide attempts over time through machine learning	—	—	—
Webb, BT et al., Front Genet, 2017, Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students	28360924	10.3389/fgene.2017.00030	Cited
Wolf, SM et al., J Law Med Ethics, 2008, Managing incidental findings in human subjects research: analysis and recommendations	18547191	10.1111/j.1748-720X.2008.00266.x	Cited
Wood, AR et al., Nat Genet, 2014, Defining the role of common variation in the genomic and biological architecture of adult human height	25282103	10.1038/ng.3097	Cited
Zheng, Y et al., Prevention Science, 2016, Glucocorticoid receptor (NR3C1) gene polymorphism moderate intervention effects on the developmental trajectory of African-American adolescent alcohol abuse	27817096	10.1007/s11121-016-0726-4	Cited

In this knowledge base

Title	Year	PMID
Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.	2018	29227573

External

Title	Authors	Journal	Year	Link
Protocol for a new family history of addiction density score to aid in the treatment of alcohol and substance use disorders.	Bourdon JL et al.	—	2025	→
Theory of Mind: A Brief Review of Candidate Genes.	Silvestri C et al.	—	2024	→
Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.	Thomas T et al.	—	2023	→
Building causal knowledge in behavior genetics.	Madole JW et al.	—	2022	→
Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.	Dick DM et al.	—	2022	→
Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies.	Goldberg LR et al.	—	2022	→
Parenting in the Context of the Child: Genetic and Social Processes.	Reiss D et al.	—	2022	→
Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way.	Bourdon JL et al.	—	2021	→
Early childhood psychosocial family risks and cumulative dopaminergic sensitizing score: Links to behavior problems in U.S. 9-year-olds.	Mullola S et al.	—	2021	→
Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review.	Bourdon JL et al.	—	2020	→
Intergenerational congruence in adolescent onset of alcohol, tobacco, and marijuana use.	Kerr DCR et al.	—	2020	→
Contributions of an Internalizing Symptoms Polygenic Risk Score and Contextual Factors to Alcohol-Related Disorders in African American Young Adults.	Rabinowitz JA et al.	—	2019	→
The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.	Trucco EM et al.	—	2019	→
Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.	Dick DM et al.	—	2018	→
The Implications of Genetics for Prevention and Intervention Programming.	Musci RJ et al.	—	2018	→