Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability.

paper Cited Public

Authors: Button, Tanya M M; Stallings, Michael C; Rhee, Soo Hyun; Corley, Robin P; Boardman, Jason D; Hewitt, John K
Year: 2009
Journal: Drug and alcohol dependence
PMID: 19008053
DOI: 10.1016/j.drugalcdep.2008.08.014
PMCID: PMC2663024

#	Section	Preview
20	2. Method — 2.2 Measures — 2.2.1 Dependence Vulnerability	1998; Stallings et al., 2003; Stallings et al., 2005; Young et al., 2000; Young et al., 2006).…
21	2. Method — 2.2 Measures — 2.2.2 Perceived Peer Delinquency	Perceived Peer Delinquency (PPD) was measured using the Exposure to Delinquent Peers Measure from…
22	2. Method — 2.2 Measures — 2.2.2 Perceived Peer Delinquency	the PPD score provides information regarding the individuals’ perceptions of the relative…
23	2. Method — 2.3 Analyses	There were significant correlations between age and both DV (r = 0.366) and PPD (0.485). Therefore,…
24	2. Method — 2.3 Analyses	Twin data were analyzed with Mx (Neale, 2004) using structural equation modeling. This method…
25	2. Method — 2.3 Analyses	MZ twin pairs are less than twice as similar as the DZ twin pairs, shared environment influence is…
26	2. Method — 2.3 Analyses	Many of the studies of contextual moderation of the variance components of substance use problems…
27	2. Method — 2.3 Analyses	To test for a moderating effect of PPD on the variance components of DV (GxM), a moderation term is…
28	2. Method — 2.3 Analyses	where the C and U subscript refers to common and unique effects, respectively.
29	2. Method — 2.3 Analyses	The total variance of DV is potentially attributable to genetic, shared environment and non-shared…
30	2. Method — 2.3 Analyses	The significance of moderations was tested by first dropping all moderation terms, then testing all…
31	2. Method — 2.3 Analyses	Moderation terms that could be dropped without a significant change in χ2 were dropped from the…
32	3. Results — 3.1 Descriptive and univariate results	The PPD scores ranged from 13 to 58, with a mean PPD score of 18.24 and a standard deviation of…
33	3. Results — 3.1 Descriptive and univariate results	analysis only included those aged 13 years and older), resulting in slightly different standardized…
34	3. Results — 3.2 Genetic and environmental moderation	Results of model fitting are presented in Table 1. Dropping the interaction terms on the pathways…
35	3. Results — 3.2 Genetic and environmental moderation	Although some moderating effects could be dropped, indicating a non-significant effect, this may be…
36	3. Results — 3.3 Results of a follow-up analysis	To assess the reliability of the results obtained from the complex model used here, we also…
37	3. Results — 3.3 Results of a follow-up analysis	EDV showed similar patterns to those reported for the full model described above. The ADV was…
38	3. Results — 3.4 Moderation of the covariance between PPD and DV	In addition, we estimated the extent to which the genetic, shared environmental, and non-shared…
39	4. Discussion	The primary goal of the current study was to investigate whether the magnitude of the variance…

Name	Type
additive genetic influences	cohort
adolescents	cohort
adolescent substance use	phenotype
adolescent vulnerability to develop substance dependence local	phenotype
ADV local	drug
ADV local	phenotype
affiliation with deviant peers	phenotype
alcohol	phenotype
alcohol dependence	phenotype
alcoholism	phenotype
Alcohol Use	phenotype
amphetamines	drug
antisocial personality disorder	phenotype
Birth cohort 1910-1924 local	cohort
Birth cohort 1925-1939 local	cohort
Birth cohort 1940-1958 local	cohort
CDV local	drug
CDV local	phenotype
Center on Antisocial Drug Dependence	cohort
cocaine	phenotype
Colorado Longitudinal Twin Sample local	cohort
Colorado Twin Registry	cohort
Community Twin Sample local	cohort
conduct disorder	phenotype
current study	cohort
CxM local	phenotype
daily smoking	phenotype
delinquency	phenotype
dependence vulnerability local	phenotype
deviant peers	phenotype
drug dependence	phenotype
drugs	drug
Drug Vulnerability local	phenotype
DSM dependence criteria local	phenotype
DV	phenotype
DZ local	phenotype
early cohort	cohort
EDV local	drug
EDV local	phenotype
ExM local	phenotype
Exposure to Delinquent Peers Measure local	phenotype
externalizing disorders	phenotype
family dysfunction	phenotype
Generalized dependence vulnerability local	phenotype
general population	cohort
genetic risk	cohort
genetic vulnerability	phenotype
GxM local	phenotype
hallucinogens	drug
illicit drugs	phenotype
illicit drug use	phenotype
inhalants	drug
later cohort	cohort
legal substances local	drug
marijuana	phenotype
marijuana dependence	phenotype
marital status	phenotype
Multiple substance dependence vulnerability local	phenotype
MZ local	phenotype
National Youth Survey local	cohort
negative behaviors local	phenotype
non-additive genetic effects	cohort
non-shared environment	phenotype
non-shared environmental risk local	phenotype
nonspecific substance dependence local	phenotype
opiates	drug
peer delinquency	phenotype
Perceived Peer Delinquency (PPD) local	phenotype
phencyclidine	drug
phenotype	phenotype
phenotypic variance	phenotype
PPD	phenotype
problem behavior	phenotype
regular smoking	phenotype
religiosity	phenotype
rural communities local	cohort
Rural community local	cohort
rural environment local	phenotype
same sex twin pairs local	cohort
sedatives	drug
sex	phenotype
shared environmental influence	phenotype
shared environmental risk local	phenotype
short tandem repeat polymorphisms local	variant
smoking	phenotype
smoking initiation	phenotype
Social network control local	phenotype
substance abuse	phenotype
substance dependence vulnerability local	phenotype
substances	phenotype
substance use	phenotype
tobacco use	phenotype
total variance	phenotype
Twin cohort	cohort
unmarried status local	phenotype
unmarried women	phenotype
urban communities local	cohort
Urban community local	cohort
urban environment	phenotype

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In this knowledge base

Title	Year	PMID
Association of substance dependence phenotypes in the COGA sample.	2015	24832863
Candidate gene-environment interaction research: reflections and recommendations.	2015	25620996
Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.	2014	23692184
The co-occurring use and misuse of cannabis and tobacco: a review.	2012	22300456
Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.	2010	20840187
Peer substance involvement modifies genetic influences on regular substance involvement in young women.	2010	20569232
The moderating effect of religiosity on the genetic variance of problem alcohol use.	2010	20569244

External

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Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use.	Elam KK et al.	—	2022	→
Delinquent Behavior: Systematic Review of Genetic and Environmental Risk Factors.	Azeredo A et al.	—	2019	→
The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.	Iacono WG et al.	—	2018	→
ALDH2*2 and peer drinking in East Asian college students.	O'Shea T et al.	—	2017	→
Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction.	Samek DR et al.	—	2017	→
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Association of substance dependence phenotypes in the COGA sample.	Wetherill L et al.	—	2015	→
Candidate gene-environment interaction research: reflections and recommendations.	Dick DM et al.	—	2015	→
Genetic and environmental influences on affiliation with deviant peers during adolescence and early adulthood.	Tarantino N et al.	—	2014	→
Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.	Dick DM et al.	—	2014	→
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The co-occurring use and misuse of cannabis and tobacco: a review.	Agrawal A et al.	—	2012	→
The genetics of addiction-a translational perspective.	Agrawal A et al.	—	2012	→
Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.	Johnson EO et al.	—	2010	→
Peer substance involvement modifies genetic influences on regular substance involvement in young women.	Agrawal A et al.	—	2010	→
The moderating effect of religiosity on the genetic variance of problem alcohol use.	Button TM et al.	—	2010	→