Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.

paper Cited Public

Authors: Chen, Xiangning; Chen, Jingchun; Williamson, Vernell S; An, Seon-Sook; Hettema, John M; Aggen, Steven H; Neale, Michael C; Kendler, Kenneth S
Year: 2009
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 19132693
DOI: 10.1002/ajmg.b.30919
PMCID: PMC3081884

#	Section	Preview
20	Discussion	We also found significant association with symptoms of alcohol abuse and dependence in our combined…
21	Discussion	the two substances: nicotine is a stimulant whereas alcohol is a depressant. So, for example, if…
22	Discussion	To summarize, there were two main findings of this study. First, in two large samples, we verified…

Name	Type
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
anxiety	phenotype
cannabis dependence	phenotype
cannabis use	phenotype
Caucasian dataset of the HapMap project local	cohort
central nervous system	anatomy
Chrna3	gene
CHRNA5	gene
Chrnb4	gene
combined sample	cohort
drinking	phenotype
FAM local	drug
FTND	phenotype
FTND score	phenotype
FTQ local	phenotype
genomic DNA	drug
haplotype 2-2-1 local	variant
haplotype A-A-T local	variant
HapMap	cohort
heavy smoking	phenotype
high nicotine dependence	phenotype
IANGF local	phenotype
IANGF score local	phenotype
internalizing anxiety and neuroticism genetic factor (IANGF) score local	phenotype
low nicotine dependence local	phenotype
lung cancer	phenotype
mesolimbic dopamine system	drug
nAChR genes local	gene
neuroticism	phenotype
nicotine	drug
nicotine dependence	phenotype
nicotinic acetylcholine receptor	drug
number of cigarettes smoked per day	phenotype
number of maximal cigarettes smoked daily local	phenotype
psychoactive substances	drug
regular smoking	phenotype
rs1051730	variant
rs16969968	variant
rs2869546 local	variant
rs578776	variant
rs6495038 local	variant
rs6495308 local	variant
rs8192475	variant
smoking initiation	phenotype
substance abuse	phenotype
substance use/abuse/dependence local	phenotype
SymAlcAD local	phenotype
SymCanAD local	phenotype
TaqMan assay mix local	drug
TaqMan Universal PCR Master Mix	drug
tobacco use	phenotype
Twin study (Kendler et al., 2007) local	cohort
VAANX-ND local	cohort
VAANX-ND local	phenotype
VAANX-ND sample local	cohort
VAANX panel local	cohort
VAFTND local	cohort
VAFTND local	phenotype
VAND panel local	cohort
VIC	drug
Virginia Adult Twin Study of Psychiatric and Substance Use Disorder local	cohort
Virginia study of anxiety and neuroticism local	cohort
Virginia study of nicotine dependence local	cohort

Citation	PMID	DOI	Status
Amos, CI et al., Nat Genet, 2008, Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1	18385676	10.1038/ng.109	Cited
Barrett, JC et al., Bioinformatics, 2005, Haploview: Analysis and visualization of LD and haplotype maps	15297300	10.1093/bioinformatics/bth457	Cited
Bergen, AW et al., Genet Epidemiol, 1999, A genome-wide search for loci contributing to smoking and alcoholism	10597412	10.1002/gepi.1370170710	Cited
Berrettini, W et al., Mol Psychiatry, 2008, Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking	18227835	10.1038/sj.mp.4002154	Cited
Bierut, LJ et al., Am J Med Genet Part A, 2004, A genomic scan for habitual smoking in families of alcoholics: Common and specific genetic factors in substance dependence	14679582	10.1002/ajmg.a.20329	Primary
Bierut, LJ et al., Am J Med Genet, 2000, Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking	10710227	10.1002/(sici)1096-8628(20000214)90:4<299::aid-ajmg7>3.0.co;2-y	Primary
Bierut, LJ et al., Am J Psychiatry, 2008, Variants in nicotinic receptors and risk for nicotine dependence	18519524	10.1176/appi.ajp.2008.07111711	Primary
Caporaso, NE et al., Cancer Epidemiol Biomarkers Prev, 2001, Nicotine metabolism and CYP2D6 phenotype in smokers	11303596	—	Cited
Chen, X et al., Am J Med Genet Part B, 2004, Association study of the Epac gene and tobacco smoking and nicotine dependence	15274052	10.1002/ajmg.b.30040	Cited
Chen, X et al., Arch Gen Psychiatry, 2008, The cannabinoid receptor 1 (CNR1) gene association with nicotine dependence	18606954	10.1001/archpsyc.65.7.816	Cited
Chen, X et al., Genes Brain Behav, 2007, RhoA, encoding a Rho GTPase, is associated with smoking initiation	17284169	10.1111/j.1601-183X.2006.00296.x	Cited
Daeppen, JB et al., Alcohol Alcohol, 2000, Clinical correlates of cigarette smoking and nicotine dependence in alcohol-dependent men and women. The Collaborative Study Group on the Genetics of Alcoholism	10787393	10.1093/alcalc/35.2.171	Primary
Dani, JA et al., Nat Neurosci, 2005, Nicotine addiction and comorbidity with alcohol abuse and mental illness	16251989	10.1038/nn1580	Cited
Degenhardt, L et al., Drug Alcohol Depend, 2007, Epidemiological patterns of extra-medical drug use in the United States: Evidence from the National Comorbidity Survey Replication, 2001-2003	17481828	10.1016/j.drugalcdep.2007.03.007	Cited
Dudbridge, F, Hum Hered, 2008, Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data	18382088	10.1159/000119108	Cited
Duggirala, R et al., Genet Epidemiol, 1999, Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q	10597426	10.1002/gepi.1370170724	Cited
Fagerström, KO et al., J Behav Med, 1989, Measuring nicotine dependence: A review of the Fagerström Tolerance Questionnaire	2668531	10.1007/BF00846549	Cited
Falk, DE et al., Alcohol Res Health, 2006, An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions	17373404	—	Cited
Feng, Y et al., Am J Hum Genet, 2004, A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men	15154117	10.1086/422194	Cited
Grucza, RA et al., Biol Psychiatry, 2008, A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence	18519132	10.1016/j.biopsych.2008.04.018	Primary
Heatherton, TF et al., Br J Addict, 1991, The Fagerström test for nicotine dependence: A revision of the Fagerström Tolerance Questionnaire	1932883	10.1111/j.1360-0443.1991.tb01879.x	Cited
Hettema, JM et al., Mol Psychiatry, 2006, Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism	16718280	10.1038/sj.mp.4001845	Cited
Hung, RJ et al., Nature, 2008, A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25	18385738	10.1038/nature06885	Cited
Ishikawa, H et al., Cancer Epidemiol Biomarkers Prev, 1999, Association between serotonin transporter gene polymorphism and smoking among Japanese males	10498403	—	Cited
John, U et al., Alcohol Alcohol, 2003, Strength of the relationship between tobacco smoking, nicotine dependence and the severity of alcohol dependence syndrome criteria in a population-based sample	14633650	10.1093/alcalc/agg122	Cited
Kendler, KS et al., Arch Gen Psychiatry, 2007, Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence	17984400	10.1001/archpsyc.64.11.1313	Cited
Kendler, KS et al., Genes, environment, and psychopathology: Understanding the causes of psychiatric and substance use disorders, 2007	22688232	10.1176/appi.ajp.2007.07081262	Cited
Kendler, KS et al., Psychol Med, 1999, A population-based twin study in women of smoking initiation and nicotine dependence	10218922	10.1017/s0033291798008022	Cited
Lerman, C et al., Health Psychol, 1999, Evidence suggesting the role of specific genetic factors in cigarette smoking	9925041	10.1037//0278-6133.18.1.14	Cited
Li, MD et al., Addiction, 2003, A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins	12492752	10.1046/j.1360-0443.2003.00295.x	Cited
Li, MD et al., Am J Hum Genet, 2006, A genomewide search finds major susceptibility Loci for nicotine dependence on chromosome 10 in african americans	16960812	10.1086/508208	Cited
Li, MD et al., Hum Mol Genet, 2005, Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence	15790597	10.1093/hmg/ddi132	Cited
Li, MD et al., Mol Psychiatry, 2007, Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence	17179996	10.1038/sj.mp.4001933	Cited
Ling, D et al., J Hum Genet, 2004, Association between polymorphism of the dopamine transporter gene and early smoking onset: An interaction risk on nicotine dependence	14685824	10.1007/s10038-003-0104-5	Cited
Livak, KJ, Genet Anal, 1999, Allelic discrimination using fluorogenic probes and the 5′ nuclease assay	10084106	10.1016/s1050-3862(98)00019-9	Cited
Mineur, YS et al., Biochem Pharmacol, 2008, Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction	17632086	10.1016/j.bcp.2007.06.010	Cited
MMWR Morb Mortal Wkly Rep, 2004, State-specific prevalence of current cigarette smoking among adults - United States, 2002	14712175	—	Cited
Munafo, M et al., Nicotine Tob Res, 2004, The genetic basis for smoking behavior: A systematic review and meta-analysis	15370155	10.1080/14622200410001734030	Cited
Nussbaum, J et al., Hum Mol Genet, 2008, Significant association of the neurexin 1 gene (NRXN1) with nicotine dependence in European and African American smokers	18270208	10.1093/hmg/ddn044	Cited
Nyholt, DR, Am J Hum Genet, 2004, A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other	14997420	10.1086/383251	Cited
Prescott, CA et al., Am J Psychiatry, 1999, Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins	9892295	10.1176/ajp.156.1.34	Cited
Saccone, SF et al., Hum Mol Genet, 2007, Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs	17135278	10.1093/hmg/ddl438	Cited
Schlaepfer, IR et al., Biol Psychiatry, 2008, The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults	18163978	10.1016/j.biopsych.2007.10.024	Cited
Silverman, MA et al., Am J Med Genet, 2000, Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence	11054772	—	Cited
Straub, RE et al., Mol Psychiatry, 1999, Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study	10208445	10.1038/sj.mp.4000518	Cited
Sullivan, PF et al., Am J Med Genet, 2001, Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence	11449402	10.1002/ajmg.1433	Cited
Sullivan, PF et al., Nicotine Tob Res, 1999, The genetic epidemiology of smoking	11768187	10.1080/14622299050011811	Cited
Swan, GE et al., Am J Med Genet Part B, 2006, A genome-wide screen for nicotine dependence susceptibility loci	16671072	10.1002/ajmg.b.30315	Cited
Thorgeirsson, TE et al., Nature, 2008, A variant associated with nicotine dependence, lung cancer and peripheral arterial disease	18385739	10.1038/nature06846	Cited
True, WR et al., Addiction, 1997, Genetic and environmental contributions to smoking	9489045	—	Cited
True, WR et al., Arch Gen Psychiatry, 1999, Common genetic vulnerability for nicotine and alcohol dependence in men	10401514	10.1001/archpsyc.56.7.655	Cited
van den Oord, EJ et al., Biotechniques, 2003, FP-TDI SNP scoring by manual and statistical procedures: A study of error rates and types	12661166	10.2144/03343dd04	Cited
Vink, JM et al., Pharmacogenomics J, 2004, Linkage analysis of smoking initiation and quantity in Dutch sibling pairs	15170444	10.1038/sj.tpj.6500255	Cited
Wang, JC et al., Mol Psychiatry, 2008, Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence	18414406	10.1038/mp.2008.42	Primary
Weiss, RB et al., PLoS Genet, 2008, A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction	18618000	10.1371/journal.pgen.1000125	Cited
Winterer, G et al., Hum Mol Genet, 2007, Association of attentional network function with exon 5 variations of the CHRNA4 gene	17613539	10.1093/hmg/ddm168	Cited

In this knowledge base

Title	Year	PMID
Human Genetics of Addiction: New Insights and Future Directions.	2018	29504045
The genetic epidemiology of substance use disorder: A review.	2017	28938182
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	2016	27166759
Narrative review of genes, environment, and cigarettes.	2016	27124093
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.	2013	23249876
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.	2012	22534784
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders.	2012	22281715
The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.	2012	22382757
Genetic vulnerability and susceptibility to substance dependence.	2011	21338875
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.	2011	21168125
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.	2010	19859904
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.	2010	20808433
Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.	2010	20624154
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	2010	20584212
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.	2010	20700436
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.	2009	19706762

External

Title	Authors	Journal	Year	Link
<i>chrna3</i> Modulates Alcohol Response.	Raine J et al.	—	2025	→
The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans.	de Chaumont F et al.	—	2025	→
Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.	Tochon L et al.	—	2024	→
<i>chrna3</i> modulates alcohol response	Raine J et al.	—	2024	—
Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia.	Almahasneh F et al.	—	2024	→
Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.	Venkatesh SK et al.	—	2024	→
Candidate gene-environment interactions in substance abuse: A systematic review.	Jiang Z et al.	—	2023	→
<i>CHRNA5</i> rs16969968 and <i>CHRNA3</i> rs578776 polymorphisms are associated with multiple nicotine dependence phenotypes in Bangladeshi smokers.	Chaity NI et al.	—	2022	→
Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms.	Brynildsen JK et al.	—	2021	→
Nicotine addiction: Translational insights from circuit neuroscience.	Scarlata MJ et al.	—	2021	→
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.	Wittenberg RE et al.	—	2020	→
Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling.	Papke RL et al.	—	2020	→
Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models.	Gipson CD et al.	—	2020	→
Chronic Menthol Does Not Change Stoichiometry or Functional Plasma Membrane Levels of Mouse <i>α</i>3<i>β</i>4-Containing Nicotinic Acetylcholine Receptors.	Bavan S et al.	—	2019	→
Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.	Besson M et al.	—	2019	→
Human Genetics of Addiction: New Insights and Future Directions.	Hancock DB et al.	—	2018	→
Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.	Melroy-Greif WE et al.	—	2017	→
Isoform-specific mechanisms of α3β4*-nicotinic acetylcholine receptor modulation by the prototoxin lynx1.	George AA et al.	—	2017	→
Neuropeptide systems and new treatments for nicotine addiction.	Bruijnzeel AW	—	2017	→
The genetic epidemiology of substance use disorder: A review.	Prom-Wormley EC et al.	—	2017	→
Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.	Kita-Milczarska K et al.	—	2016	→
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	Yang J et al.	—	2016	→
Narrative review of genes, environment, and cigarettes.	Do E et al.	—	2016	→
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.	Melroy-Greif WE et al.	—	2016	→
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.	Jensen KP et al.	—	2015	→
A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.	Hawkins EG et al.	—	2015	→
Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.	Buczkowski K et al.	—	2015	→
CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.	Wu XY et al.	—	2015	→
Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood.	Bares CB et al.	—	2015	→
Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis.	Leung T et al.	—	2015	→
Exon sequencing identifies a novel CHRNA3-CHRNA5-CHRNB4 variant that increases the risk for chronic obstructive pulmonary disease.	Zhao Z et al.	—	2015	→
Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers.	Chen X et al.	—	2015	→
New mechanisms and perspectives in nicotine withdrawal.	Jackson KJ et al.	—	2015	→
Nicotinic receptor contributions to smoking: insights from human studies and animal models.	Brunzell DH et al.	—	2015	→
Pharmacogenetics of nicotine and associated smoking behaviors.	Tanner JA et al.	—	2015	→
Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region.	Sarginson JE et al.	—	2015	→
ADHD diagnosis may influence the association between polymorphisms in nicotinic acetylcholine receptor genes and tobacco smoking.	Polina ER et al.	—	2014	→
CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.	Criado JR et al.	—	2014	→
Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.	Cui K et al.	—	2014	→
Merging old and new perspectives on nicotinic acetylcholine receptors.	Papke RL	—	2014	→
The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke.	Pedneault M et al.	—	2014	→
Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content.	Macqueen DA et al.	—	2014	→
A Comparison of Factor Score Estimation Methods in the Presence of Missing Data: Reliability and an Application to Nicotine Dependence.	Estabrook R et al.	—	2013	→
A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.	Zayats T et al.	—	2013	→
Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression.	Gallego X et al.	—	2013	→
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.	Bergen AW et al.	—	2013	→
Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.	Hällfors J et al.	—	2013	→
The Mid-Atlantic Twin Registry, revisited.	Lilley EC et al.	—	2013	→
Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.	Bousman CA et al.	—	2012	→
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.	Broms U et al.	—	2012	→
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.	Munafò MR et al.	—	2012	→
Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966.	Kaakinen M et al.	—	2012	→
Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.	Stephens SH et al.	—	2012	→
From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.	Ware JJ et al.	—	2012	→
Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.	Tammimäki A et al.	—	2012	→
Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.	Budulac SE et al.	—	2012	→
Parent of origin effects.	Guilmatre A et al.	—	2012	→
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders.	Kendler KS et al.	—	2012	→
The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.	Lubke GH et al.	—	2012	→
The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis.	Zhang T et al.	—	2012	→
Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.	Gallego X et al.	—	2012	→
Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.	Stokes C et al.	—	2012	→
A CHRNA5 allele related to nicotine addiction and schizophrenia.	Hong LE et al.	—	2011	→
Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis.	Ware JJ et al.	—	2011	→
A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.	Maes HH et al.	—	2011	→
Epidemiology, radiology, and genetics of nicotine dependence in COPD.	Kim DK et al.	—	2011	→
Genetic vulnerability and susceptibility to substance dependence.	Bierut LJ	—	2011	→
Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.	Sarginson JE et al.	—	2011	→
Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety.	Edwards AC et al.	—	2011	→
Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats.	Chatterjee S et al.	—	2011	→
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.	Ducci F et al.	—	2011	→
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.	Hong LE et al.	—	2010	→
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.	Li MD et al.	—	2010	→
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.	Li MD et al.	—	2010	→
Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients.	De Ruyck K et al.	—	2010	→
Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.	Grucza RA et al.	—	2010	→
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	Saccone NL et al.	—	2010	→
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.	Saccone NL et al.	—	2010	→
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.	Chatterjee S et al.	—	2010	→
Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment.	Khokhar JY et al.	—	2010	→
Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.	Wessel J et al.	—	2010	→
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.	Improgo MR et al.	—	2010	→
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.	Saccone NL et al.	—	2009	→