An atlas of genetic correlations across human diseases and traits.
paper
Cited
Public
- Authors
- Bulik-Sullivan, Brendan; Finucane, Hilary K; Anttila, Verneri; Gusev, Alexander; Day, Felix R; Loh, Po-Ru; ReproGen Consortium; Psychiatric Genomics Consortium; Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3; Duncan, Laramie; Perry, John R B; Patterson, Nick; Robinson, Elise B; Daly, Mark J; Price, Alkes L; Neale, Benjamin M
- Year
- 2015
- Journal
- Nature genetics
- PMID
- 26414676
- DOI
- 10.1038/ng.3406
- PMCID
- PMC4797329
Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation from genome-wide association study (GWAS) data with current methods are the lack of availability of individual-level genotype data and widespread sample overlap among meta-analyses. We circumvent these difficulties by introducing a technique-cross-trait LD Score regression-for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap. We use this method to estimate 276 genetic correlations among 24 traits. The results include genetic correlations between anorexia nervosa and schizophrenia, anorexia and obesity, and educational attainment and several diseases. These results highlight the power of genome-wide analyses, as there currently are no significantly associated SNPs for anorexia nervosa and only three for educational attainment.
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|---|---|---|---|---|
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| Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease. | Kuzovenkova D et al. | β | 2025 | β |
| Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution. | Baya NA et al. | β | 2025 | β |
| Common genetic basis and causality between central nervous system disease and cancer. | Tan S et al. | β | 2025 | β |
| Common genetic variation influencing the human lung imaging phenotypes. | Zhu M et al. | β | 2025 | β |
| Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. | Lee DSM et al. | β | 2025 | β |
| Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex. | Schwaba T et al. | β | 2025 | β |
| Comprehensive genetic analysis based on multi - omics reveals novel therapeutic targets for mitral valve prolapse and drug molecular dynamics simulation. | Chen B et al. | β | 2025 | β |
| Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine. | Niu Y et al. | β | 2025 | β |
| Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers. | Zhang X et al. | β | 2025 | β |
| Comprehensive Profiling of Genetic and Nongenetic Factors that Influence Skin Traits in Asian Women from 4 Countries. | Moon H et al. | β | 2025 | β |
| Computationally efficient methods for estimating phenome-wide coheritability of multi-type phenotypes using biobank data. | Deng Y et al. | β | 2025 | β |
| Confounding fuels misinterpretation in human genetics. | Benning JW et al. | β | 2025 | β |
| Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity. | Yao S et al. | β | 2025 | β |
| Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies. | Cao X et al. | β | 2025 | β |
| Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects. | Wu XR et al. | β | 2025 | β |
| Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates. | van Alten S et al. | β | 2025 | β |
| COVID-19 infection and longevity: an observational and mendelian randomization study. | Qiu S et al. | β | 2025 | β |
| Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression. | Li Y et al. | β | 2025 | β |
| Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis. | Luo Y et al. | β | 2025 | β |
| Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization. | Xia C et al. | β | 2025 | β |
| Deciphering the shared genetic architecture between bipolar disorder and body mass index. | Ma H et al. | β | 2025 | β |
| Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density. | Zhou J et al. | β | 2025 | β |
| Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization. | Chang KJ et al. | β | 2025 | β |
| Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank. | Xu W et al. | β | 2025 | β |
| Determinants of Brain Aging in the Brazilian Longitudinal Study of Adult Health: Study Design, Neuroimaging Protocol, and Baseline Characteristics. | Goulart AC et al. | β | 2025 | β |
| Disentangling horizontal and vertical Pleiotropy in genetic correlation estimation: introducing the HVP model. | Amente LD et al. | β | 2025 | β |
| Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization. | Chatterjee A et al. | β | 2025 | β |
| Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. | Lin BD et al. | β | 2025 | β |
| Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization. | Hong Y et al. | β | 2025 | β |
| Dissecting Shared Genetic Architecture of Thoracic Aortic Aneurysm and Aortic Related Traits and Identifying SplA/Ryanodine Receptor Domain and SOCS Box Containing 1 Involved in Smooth Muscle Phenotype Switching and Cell Senescence Through Alternative Splicing. | Song Q et al. | β | 2025 | β |
| Dissecting the genetic basis and mechanisms underlying the associations between multiple extrahepatic factors and autoimmune liver diseases. | Zhang Z et al. | β | 2025 | β |
| Dissecting the genetic basis of agronomic traits by multi-trait GWAS and genetic networks in maize (<i>Zea mays</i> L.). | Zhou Y et al. | β | 2025 | β |
| Dissecting the Genetic Correlations and Causal Effects of Gut Microbiota on Pan-Cancer Phenotype: Driven by Common Dietary Preferences. | Zhou Y et al. | β | 2025 | β |
| Distinct explanations underlie gene-environment interactions in the UK Biobank. | Durvasula A et al. | β | 2025 | β |
| Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease. | Trenkwalder T et al. | β | 2025 | β |
| Does the Influence of Low Body Mass Index on Diagnosis Complicate Genetic Studies of the Role of Cardiometabolic Traits in Liability to Anorexia Nervosa? | Reay WR et al. | β | 2025 | β |
| DrFARM: identification of pleiotropic genetic variants in genome-wide association studies. | Chan LS et al. | β | 2025 | β |
| Early detection of Parkinson's disease through multiplex blood and urine biomarkers prior to clinical diagnosis. | Gao S et al. | β | 2025 | β |
| Early lipid genetics: identification of common and rare genetic variants for lipid traits in Indian adolescents. | Nair JM et al. | β | 2025 | β |
| Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans. | Xiang Y et al. | β | 2025 | β |
| Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms. | Wang F et al. | β | 2025 | β |
| Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank. | Richards AL et al. | β | 2025 | β |
| Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects. | Zhang L et al. | β | 2025 | β |
| Elucidating shared genetic association between female body mass index and preeclampsia. | Yang F et al. | β | 2025 | β |
| Endometriosis-Related Genetic Factors and Their Role in Preterm Birth: A Two-Sample Mendelian Randomisation Study. | Flatley C et al. | β | 2025 | β |
| EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma. | Kharitonova EV et al. | β | 2025 | β |
| Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson's disease. | Zhang H et al. | β | 2025 | β |
| Evaluating the effects of coffee consumption on the structure and function of the heart from multiple perspectives. | Ma XB et al. | β | 2025 | β |
| Evaluation of a bidirectional causal association between cardiovascular diseases and pneumonia: a Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Evaluation of the two-way associations between mental disorders and menstrual irregularities: A Mendelian randomization study from both directions. | Dong F et al. | β | 2025 | β |
| Evidence supporting the role of hypertension in the onset of migraine. | Xiao G et al. | β | 2025 | β |
| Evidence to shared genetic correlation of ischemic stroke and intracerebral hemorrhage and cardiovascular related traits. | He W et al. | β | 2025 | β |
| Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders. | Breunig S et al. | β | 2025 | β |
| Examining the genetic relationship between Alzheimer's disease, schizophrenia and their shared risk factors using genomic structural equation modelling. | Almeida E Sousa I et al. | β | 2025 | β |
| Exome sequencing identifies protein-coding variants associated with loneliness and social isolation. | Wang YX et al. | β | 2025 | β |
| Expanding scope of genetic studies in the era of biobanks. | Dutta D et al. | β | 2025 | β |
| Exploiting pleiotropy to enhance variant discovery with functional false discovery rates. | Bass AJ et al. | β | 2025 | β |
| Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights. | Wu X et al. | β | 2025 | β |
| Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study. | Huang Z et al. | β | 2025 | β |
| Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses. | Meng Z et al. | β | 2025 | β |
| Exploring genetic structures and shared sites between alcohol, cheese intake, and inflammatory bowel disease. | Huang Z et al. | β | 2025 | β |
| Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy. | Yang W et al. | β | 2025 | β |
| Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions. | Darlay R et al. | β | 2025 | β |
| Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota. | Li X et al. | β | 2025 | β |
| Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis. | Cheng Z et al. | β | 2025 | β |
| Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism. | Wu Y et al. | β | 2025 | β |
| Exploring the genetic causal inference between plasma lipidome and hemorrhagic stroke. | Yu Z et al. | β | 2025 | β |
| Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization. | Ding L et al. | β | 2025 | β |
| Exploring the genetic intersection of dried fruit intake and breast cancer risk: a multi-trait genomic analysis with epidemiological context. | Zou K et al. | β | 2025 | β |
| Exploring the Genetic Underpinnings of Diffusion Tensor Image Analysis Along the Perivascular Space: A Genome-Wide Correlation Study and Implications for Brain Health. | Wu J et al. | β | 2025 | β |
| Exploring the Link Between C-Reactive Protein Change and Stroke Risk: Insights From a Prospective Cohort Study and Genetic Evidence. | Ling Y et al. | β | 2025 | β |
| Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits. | Fusco D et al. | β | 2025 | β |
| Exploring the relationship and shared mechanisms of major depressive disorder and diabetic kidney disease: a comprehensive clinical and genetic analysis. | Liu HX et al. | β | 2025 | β |
| Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study. | He H et al. | β | 2025 | β |
| Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies. | Lu J et al. | β | 2025 | β |
| Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis. | Wang L et al. | β | 2025 | β |
| Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density. | Feng X et al. | β | 2025 | β |
| Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain. | Aman AM et al. | β | 2025 | β |
| Exploring the shared genetic basis of attention-deficit/hyperactivity disorder and obstructive sleep apnea: A multi-omics analysis. | Huang Y et al. | β | 2025 | β |
| Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications. | Lee H et al. | β | 2025 | β |
| Family-based genome-wide association study designs for increased power and robustness. | Guan J et al. | β | 2025 | β |
| Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes. | Baranova A et al. | β | 2025 | β |
| Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. | Dang X et al. | β | 2025 | β |
| Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. | Qi P et al. | β | 2025 | β |
| Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases. | JordΓ P et al. | β | 2025 | β |
| Genetic analysis of alcohol use disorder: GWAS of alcohol use disorders identification test (AUDIT) and polygenic risk scores in an east slavic population. | Trofimov M et al. | β | 2025 | β |
| Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation. | Yang Y et al. | β | 2025 | β |
| Genetic and immune regulatory links between inflammatory bowel disease and breast cancer involving the JAK STAT PD L1 axis. | Zeng L et al. | β | 2025 | β |
| Genetic and neural mechanisms shared by schizophrenia and depression. | Xie Y et al. | β | 2025 | β |
| Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics. | Chen Y et al. | β | 2025 | β |
| Genetic approach uncovering the pathways between childhood maltreatment and suicide attempt. | Qu D et al. | β | 2025 | β |
| Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis. | Hua Y et al. | β | 2025 | β |
| Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies. | Gu Y et al. | β | 2025 | β |
| Genetic architecture of plasma metabolome in 254,825 individuals. | Qiang YX et al. | β | 2025 | β |
| Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood. | Chen TT et al. | β | 2025 | β |
| Genetic association between human skin microbiota with vaginitis: aΒ two-sample Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Genetic association of attention-deficit/hyperactivity disorder with thirteen ocular disorders. | Chen XN et al. | β | 2025 | β |
| Genetic Association of Mood Swings with Lung Function and Respiratory Diseases. | Ku Y et al. | β | 2025 | β |
| Genetic Associations between Obesity and Brain Cortical Thickness: Combined Genetic Correlation, Multi-Trait Meta-Analysis, and Mendelian Randomization. | Chen J et al. | β | 2025 | β |
| Genetic association studies using disease liabilities from deep neural networks. | Yang L et al. | β | 2025 | β |
| Genetic basis and causal relationship between atrial fibrillation and sinus node dysfunction: Evidence from comprehensive genetic analysis. | Yan Z et al. | β | 2025 | β |
| Genetic Commonalities Between Metabolic Syndrome and Rheumatic Diseases Through Disease Interactome Modules. | Shi Y et al. | β | 2025 | β |
| Genetic Comorbidity of Psoriasis and Four Cardiovascular Diseases: Uncovering Shared Mechanisms and Potential Therapeutic Targets. | Li X et al. | β | 2025 | β |
| Genetic correlation analysis between sepsis and hematological traits: Identifying shared genomic regions. | Zhang J et al. | β | 2025 | β |
| Genetic correlation and causation of craniofacial microsomia with 33 diseases in Asian populations: insights from large-scale genome-wide cross-trait analysis. | Luo P et al. | β | 2025 | β |
| Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant Coffee and Age-Related Macular Degeneration. | Jia Q et al. | β | 2025 | β |
| Genetic Correlation and Mendelian Randomization Analysis Revealed an Unidirectional Causal Relationship Between Left Caudal Middle Frontal Surface Area and Cigarette Consumption. | Xie H et al. | β | 2025 | β |
| Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disorders. | Zhou S et al. | β | 2025 | β |
| Genetic correlations and causal associations between BMI, HDL-C, and postoperative infections: a two-sample Mendelian randomization study. | Yang T et al. | β | 2025 | β |
| Genetic Correlations and Causalities between Alzheimer's Disease and 35 Biomarkers in Blood and Urine. | Zhang S et al. | β | 2025 | β |
| Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males. | Waller TC et al. | β | 2025 | β |
| Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies. | Mishra BH et al. | β | 2025 | β |
| Genetic Crosstalk Between Type 1 Diabetes and SjΓΆgren's Syndrome: A Systematic Exploration of Risk Genes and Common Pathways. | Fahira A et al. | β | 2025 | β |
| Genetic determinants of proteomic aging. | MΓΆrseburg A et al. | β | 2025 | β |
| Genetic Estimates of Correlation and Causality Between Keratoconus and Osteoarthritis. | Han T et al. | β | 2025 | β |
| Genetic evidence for causal effects of inflammatory protein factors on breast cancer. | Liu X et al. | β | 2025 | β |
| Genetic evidence for causal links between type 1 diabetes and autoimmune liver diseases. | Liang C et al. | β | 2025 | β |
| Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study. | Li C et al. | β | 2025 | β |
| Genetic Insights Into the Link Between Restless Legs Syndrome and Diabetic Nephropathy Risk. | Lin Y et al. | β | 2025 | β |
| Genetic insights of waist-to-height ratio on the risk of steatotic and advanced liver diseases: genome-wide association study and polygenic risk score-based analyses. | Chen H et al. | β | 2025 | β |
| Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk. | Ciochetti NP et al. | β | 2025 | β |
| Genetic liability to psoriasis predicts severe disease outcomes. | Saklatvala JR et al. | β | 2025 | β |
| Genetic links between multimorbidity and human aging. | Dinh PA et al. | β | 2025 | β |
| Genetic neurodevelopmental clustering and dyslexia. | Ciulkinyte A et al. | β | 2025 | β |
| Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study. | Skelton M et al. | β | 2025 | β |
| Genetic overlap between multi-site chronic pain and cognition: a large-scale genome-wide cross-trait analysis. | Chen Y et al. | β | 2025 | β |
| Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis. | Lin W et al. | β | 2025 | β |
| Genetic overlap between schizophrenia and constipation: insights from a genome-wide association study in a European population. | Luo Q et al. | β | 2025 | β |
| Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma: An Integrated Proteogenomic Investigation. | Chen L et al. | β | 2025 | β |
| Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. | Jiang X et al. | β | 2025 | β |
| Genetic regulation of lncRNA expression in whole human brain and their contribution to CNS disorders. | He Y et al. | β | 2025 | β |
| Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease. | Khan A et al. | β | 2025 | β |
| Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia. | Aicoboaie S et al. | β | 2025 | β |
| Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies. | Xu J et al. | β | 2025 | β |
| Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study. | Liu H et al. | β | 2025 | β |
| Genetic, Transcriptomic, and Epigenomic Insights into SjΓΆgren's Disease: An Integrative Network Investigation and Immune Diseases Comparison. | Enduru N et al. | β | 2025 | β |
| Genetic variants predisposing to an increased risk of kidney stone disease. | Lovegrove CE et al. | β | 2025 | β |
| Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis. | Chen H et al. | β | 2025 | β |
| Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma. | Qiu K et al. | β | 2025 | β |
| Genome-wide analysis identifies novel shared loci between depression and white matter microstructure. | Zhao Q et al. | β | 2025 | β |
| Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. | Jawinski P et al. | β | 2025 | β |
| Genome-wide analysis of screen behaviors among adolescents identifies novel loci and overlap with educational attainment and mental disorders. | Frei E et al. | β | 2025 | β |
| Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression. | Xiong Y et al. | β | 2025 | β |
| Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry. | Gui A et al. | β | 2025 | β |
| Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. | van der Laan CM et al. | β | 2025 | β |
| Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants. | FΓΆrster F et al. | β | 2025 | β |
| Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures. | Jee YH et al. | β | 2025 | β |
| Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. | Henry A et al. | β | 2025 | β |
| Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics. | Andersson NW et al. | β | 2025 | β |
| Genome-wide association study of pulpal and apical diseases. | Salminen A et al. | β | 2025 | β |
| Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. | Cole JB et al. | β | 2025 | β |
| Genome-wide association study provides novel insight into the genetic architecture of severe obesity. | Krishnan M et al. | β | 2025 | β |
| Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy. | Sun Y et al. | β | 2025 | β |
| Genome-wide association study unravels mechanisms of brain glymphatic activity. | Huang SY et al. | β | 2025 | β |
| Genome-wide copy number variation association study in anorexia nervosa. | Walker A et al. | β | 2025 | β |
| Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density. | Lei B et al. | β | 2025 | β |
| Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. | Kang M et al. | β | 2025 | β |
| Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss. | Chen L et al. | β | 2025 | β |
| Genomic Correlations, Shared Loci, and Drug Targets Between Polycystic Ovary Syndrome and Asthma: Insights From Genome-wide Association Analysis. | Ji E et al. | β | 2025 | β |
| Genomic determinants of biological age estimated by deep learning applied to retinal images. | Huang Y et al. | β | 2025 | β |
| Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies. | Borges VM et al. | β | 2025 | β |
| Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa. | Broadaway KA et al. | β | 2025 | β |
| GenomicSEM Modelling of Diverse Executive Function GWAS Improves Gene Discovery. | Perry LC et al. | β | 2025 | β |
| Genomics of chronic dry cough unravels neurological pathways. | Coley K et al. | β | 2025 | β |
| Gut microbiome and diabetic kidney disease: Insights from Mendelian randomization and genetic correlations. | Yang K et al. | β | 2025 | β |
| Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis. | Zhou J et al. | β | 2025 | β |
| GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids. | Sun Y et al. | β | 2025 | β |
| GWASBrewer: An R Package for Simulating Realistic GWAS Summary Statistics. | Morrison J | β | 2025 | β |
| GWAS by Subtraction to Disentangle RBD Genetic Background from Ξ±-Synucleinopathies. | Gaudio A et al. | β | 2025 | β |
| GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density. | Conery M et al. | β | 2025 | β |
| GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. | Dand N et al. | β | 2025 | β |
| Heritability and genetic correlations of obesity indices and cardiometabolic traits in the Northern Chinese families. | Lin B et al. | β | 2025 | β |
| High rates of Parkinson's disease diagnosis in the autistic population: True co-occurrence or a product of overlapping traits? | Hickman LJ et al. | β | 2025 | β |
| Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice. | Zhang Y et al. | β | 2025 | β |
| Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses. | Guo X et al. | β | 2025 | β |
| Identification of genetic architecture shared between schizophrenia and Alzheimer's disease. | Liu H et al. | β | 2025 | β |
| Identification of immune cells and circulating inflammatory factors associated with neurodevelopmental disorders by bidirectional Mendelian randomization and mediation analysis. | Liu Z et al. | β | 2025 | β |
| Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning. | Li T et al. | β | 2025 | β |
| Identification of <i>TMEM106B</i> as a Shared Potential Drug Target for Depression and Stroke Through Comprehensive Genetic Analyses. | Zhang W et al. | β | 2025 | β |
| Identification of pathogenic cell types and shared genetic loci and genes for Alzheimer's disease and inflammatory bowel disease. | Zhang J et al. | β | 2025 | β |
| Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. | Icick R et al. | β | 2025 | β |
| Identification of Shared Genetic Loci Associated With Inflammatory Bowel Disease, Ischemic Heart Disease, and Atrial Fibrillation and Flutter. | Chen G et al. | β | 2025 | β |
| Identification of shared genetic loci for asthma, allergic rhinitis, and pollinosis in East Asians. | Wang D et al. | β | 2025 | β |
| Identifying associations between short tandem repeat sequences and gene expression in yeast reveals specific repeated motifs encoding transcriptional regulatory proteins. | Yu Z et al. | β | 2025 | β |
| Identifying causal genes for prostatitis through drug-targeted Mendelian randomization. | Yan K et al. | β | 2025 | β |
| Identifying common genetic etiologies between iridocyclitis and related immune-mediated diseases. | Liu Z et al. | β | 2025 | β |
| Identifying Four Obesity Axes Through Integrative Multiomics and Imaging Analysis. | Odoemelam CS et al. | β | 2025 | β |
| Identifying genes and traits associated with pre-eclampsia using summary statistics. | Zhu W et al. | β | 2025 | β |
| Identifying genetic variants associated with sugar intake and appraising the genetic correlations with cardiovascular outcomes. | Janzi S et al. | β | 2025 | β |
| Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis. | Lei S et al. | β | 2025 | β |
| IL7R<sup>+</sup> T Cell-Macrophage Crosstalk Links Asthma to Alzheimer's Pathogenesis: Integrating Mendelian Randomization and CellChat Analysis. | Yang J et al. | β | 2025 | β |
| Immune cells, inflammatory proteins, and sepsis: A mediation Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study. | Chen JH et al. | β | 2025 | β |
| Improved genetic discovery and fine-mapping resolution through multivariate latent factor analysis of high-dimensional traits. | Zhou F et al. | β | 2025 | β |
| Improving Machine Learning Prediction of ADHD Using Gene Set Polygenic Risk Scores and Risk Scores From Genetically Correlated Phenotypes. | Barnett EJ et al. | β | 2025 | β |
| Improving polygenic risk prediction performance by integrating electronic health records through phenotype embedding. | Xu L et al. | β | 2025 | β |
| Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE. | Dong Z et al. | β | 2025 | β |
| Inflammatory proteins and hidradenitis suppurativa: Insights from genetic correlation and Mendelian randomization. | Luo H et al. | β | 2025 | β |
| Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study. | Ni X et al. | β | 2025 | β |
| Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease. | Pan L et al. | β | 2025 | β |
| Integrated Retrospective and Post-GWAS Analyses Reveal Mechanisms Linking Nightly Short Sleep to Asthma. | Fu C et al. | β | 2025 | β |
| Integrating a multi-omics strategy framework to screen potential targets in cognitive impairment-related epilepsy. | Xu C et al. | β | 2025 | β |
| Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia. | Fu W et al. | β | 2025 | β |
| Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders. | Ding H et al. | β | 2025 | β |
| Integrative genetic analysis of shared genetic architecture of stroke and coronary artery disease: implications for pharmacist-led precision medicine. | Shi W et al. | β | 2025 | β |
| Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential. | Chen H et al. | β | 2025 | β |
| Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes. | Du Y et al. | β | 2025 | β |
| Integrative genomic analysis reveals shared loci for reproduction and production traits in Yorkshire pigs. | Wei R et al. | β | 2025 | β |
| Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study. | Wei S et al. | β | 2025 | β |
| Investigating shared genetic architecture between major depressive disorder and central obesity. | Zhan Y et al. | β | 2025 | β |
| Investigating shared risk variants and genetic etiology between Alzheimer's disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis. | Dang W et al. | β | 2025 | β |
| Investigating the causal and genetic relationship between migraine and Parkinson's disease. | Deng MG et al. | β | 2025 | β |
| Investigating the Relationships Between Neurodegenerative Diseases and Cancer Types: A Computational Approach. | Cava C et al. | β | 2025 | β |
| Investigating the Sexual Dimorphism of Waist-to-Hip Ratio and Its Associations with Complex Traits. | Li H et al. | β | 2025 | β |
| Investigating the shared genetic architecture between anxiety and stroke. | Zhang Y et al. | β | 2025 | β |
| Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer. | Li Z et al. | β | 2025 | β |
| Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis. | Tian W et al. | β | 2025 | β |
| Investigating the shared genetic structure between rheumatoid arthritis and stroke. | Qin Q et al. | β | 2025 | β |
| Lack of genetic correlation and causal association between specific gut microbiota and osteoporosis. | Chen D et al. | β | 2025 | β |
| Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension. | Gurholt TP et al. | β | 2025 | β |
| Large-scale genome-wide analyses of stuttering. | Polikowsky HG et al. | β | 2025 | β |
| Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy. | Tadros R et al. | β | 2025 | β |
| Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. | He W et al. | β | 2025 | β |
| Leisure-Time Physical Activity, Sedentary Behavior, and Biological Aging: Evidence From Genetic Correlation and Mendelian Randomization Analyses. | Zhao X et al. | β | 2025 | β |
| Lessons in adjusting for genetic confounding in population research on education and health. | Zacher M et al. | β | 2025 | β |
| Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies. | Tang B et al. | β | 2025 | β |
| Leveraging pleiotropy for the improved treatment of psychiatric disorders. | Woodward DJ et al. | β | 2025 | β |
| Liability threshold model-based disease risk prediction based on electronic health record phenotypes. | Lee CH et al. | β | 2025 | β |
| Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA. | Abdellaoui A et al. | β | 2025 | β |
| Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort. | Mihov M et al. | β | 2025 | β |
| Local Genetic Correlations and Pleiotropy Reveal Shared Genetic Architecture Between COVID-19 Phenotypes and Prostate Cancer in European Populations. | Xiang R et al. | β | 2025 | β |
| Local genetic sex differences in quantitative traits. | Uffelmann E et al. | β | 2025 | β |
| Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions. | Fanelli G et al. | β | 2025 | β |
| <i>TMEM14A</i> Gene Affects Hippocampal Sclerosis in Mesial Temporal Lobe Epilepsy. | Kim J et al. | β | 2025 | β |
| Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset. | van der Meer D et al. | β | 2025 | β |
| Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school-going children. | Nair JM et al. | β | 2025 | β |
| Maternal Immune Activation and Autism in Offspring: What Is the Evidence for Causation? | Gardner RM et al. | β | 2025 | β |
| Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI. | FΓΌrtjes AE et al. | β | 2025 | β |
| Mediating factors between autoimmune thyroiditis and breast cancer: a bidirectional Mendelian randomization study. | Xin P et al. | β | 2025 | β |
| Mediation analysis of gut microbiota and plasma metabolites in asthma pathogenesis using Mendelian randomization. | Zheng X et al. | β | 2025 | β |
| Mendelian randomization analysis to identify potential drug targets for osteoarthritis. | Lu C et al. | β | 2025 | β |
| Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity. | Villaplana-Velasco A et al. | β | 2025 | β |
| Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes. | Jumentier B et al. | β | 2025 | β |
| metaGE: Investigating genotype x environment interactions through GWAS meta-analysis. | De Walsche A et al. | β | 2025 | β |
| Modeling the genomic architecture of adiposity and anthropometrics across the lifespan. | Arehart CH et al. | β | 2025 | β |
| MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites. | Ahmed A et al. | β | 2025 | β |
| Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. | Johnson EC et al. | β | 2025 | β |
| Multi-ancestry genome-wide association meta-analysis identifies novel associations and informs genetic risk prediction for Hirschsprung disease. | Zhong Y et al. | β | 2025 | β |
| Multi-domain rule-based phenotyping algorithms enable improved GWAS signal. | Newbury A et al. | β | 2025 | β |
| Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction. | Yang W et al. | β | 2025 | β |
| Multi-omic dissection of clinically diagnosed and self-reported major depressive disorder reveals phenotype-specific genetic and proteomic architecture in East Asian populations. | Wang W et al. | β | 2025 | β |
| Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function. | Gunter-Rahman F et al. | β | 2025 | β |
| Multi-omic spatial effects on high-resolution AI-derived retinal thickness. | Jackson VE et al. | β | 2025 | β |
| Multi-omic underpinnings of heterogeneous aging across multiple organ systems. | Xiong J et al. | β | 2025 | β |
| Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk. | MULTI consortium et al. | β | 2025 | β |
| Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer's disease. | Fu M et al. | β | 2025 | β |
| Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes. | Chaar DL et al. | β | 2025 | β |
| Multitrait Genetic Analysis Identifies Novel Pleiotropic Loci for Depression and Schizophrenia in East Asians. | Song Y et al. | β | 2025 | β |
| Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank. | Ran S et al. | β | 2025 | β |
| Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations. | Chen X et al. | β | 2025 | β |
| Multitrait GWAS of non-suicidal self-injury and the polygenetic effects on child psychopathology and brain structures. | Sun Y et al. | β | 2025 | β |
| Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases. | Yang F et al. | β | 2025 | β |
| Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities. | Chen H et al. | β | 2025 | β |
| MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics. | Boquet-Pujadas A et al. | β | 2025 | β |
| Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. | Wen J et al. | β | 2025 | β |
| New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping. | Lu C et al. | β | 2025 | β |
| No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation. | Qi J et al. | β | 2025 | β |
| Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. | Bradley J et al. | β | 2025 | β |
| Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index. | Park K et al. | β | 2025 | β |
| Novel Insights Into the Genetic Basis Between Cholelithiasis and Four Dietary Patterns. | Zheng E et al. | β | 2025 | β |
| Observational, causal relationship and shared genetic basis between cholelithiasis and gastroesophageal reflux disease: evidence from a cohort study and comprehensive genetic analysis. | Lyu Y et al. | β | 2025 | β |
| ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets. | Shen Y et al. | β | 2025 | β |
| Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects. | Karczewski KJ et al. | β | 2025 | β |
| Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer. | Rosenthal EA et al. | β | 2025 | β |
| PIGEON: a statistical framework for estimating gene-environment interaction for polygenic traits. | Miao J et al. | β | 2025 | β |
| Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults. | Kang J et al. | β | 2025 | β |
| Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers. | van der Meer D et al. | β | 2025 | β |
| Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study. | Kasela S et al. | β | 2025 | β |
| Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank. | Wang LH et al. | β | 2025 | β |
| Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations. | Al-Soufi L et al. | β | 2025 | β |
| Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank. | Akimova ET et al. | β | 2025 | β |
| Polygenic predisposition to transdiagnostic symptom dimensions and treatment outcomes across psychiatric disorders. | Abondio P et al. | β | 2025 | β |
| Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population. | Gu Y et al. | β | 2025 | β |
| Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility. | Hubers N et al. | β | 2025 | β |
| Population-specific polygenic risk scores for people of Han Chinese ancestry. | Chen HH et al. | β | 2025 | β |
| Post-genome-wide association study dissects genetic vulnerability and risk gene expression of SjΓΆgren's disease for cardiovascular disease. | Yi X et al. | β | 2025 | β |
| Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility. | Blay N et al. | β | 2025 | β |
| Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. | Caro I et al. | β | 2025 | β |
| Proteomic landscape of multidimensional aging phenotypes. | Cao Z et al. | β | 2025 | β |
| Protocol for finding genetic variation associated with unmeasured traits through GenomicSEM common-factor GWAS. | Johnston KJA et al. | β | 2025 | β |
| Protocol for genetic analysis of population-scale ultra-low-depth sequencing data. | Zeng J et al. | β | 2025 | β |
| PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity. | Li FJ et al. | β | 2025 | β |
| Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks. | Wen J | β | 2025 | β |
| Relationship Between Chronic Pain and Breast Cancer: Insight From Genetic Correlation Analyses and 2-Sample Mendelian Randomization. | Yang H et al. | β | 2025 | β |
| Relationship Between Maternal Serum Level of Bilirubin with Sporadic and Recurrent Miscarriage: A Bidirectional 2-Sample Mendelian Randomization Study. | Kong S et al. | β | 2025 | β |
| Repurposing piroxicam as an SLC7A5 antagonist to ameliorate prothrombotic state in Diane-35-treated polycystic ovary syndrome patients. | Jiang S et al. | β | 2025 | β |
| Revealing the genetic and immunological crosstalk between SLE and ccRCC: An integrative genomic analysis approach. | Lin F et al. | β | 2025 | β |
| Rheumatoid arthritis and risk of hearing impairment: A genetic correlation and bidirectional Mendelian randomization study. | Liu Z et al. | β | 2025 | β |
| Roles of Gut Microbiota and Associated Metabolites in <i>Clostridioides difficile</i> Infection. | Gao Y et al. | β | 2025 | β |
| Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization. | Jiang C et al. | β | 2025 | β |
| Sex-stratified genome-wide association meta-analysis of major depressive disorder. | Thomas JT et al. | β | 2025 | β |
| Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors. | Ramos JKN et al. | β | 2025 | β |
| Shared genetic architecture and causal relationship between frailty and schizophrenia. | Deng MG et al. | β | 2025 | β |
| Shared Genetic Architecture and Causal Relationship Between Serum 25-Hydroxyvitamin D and Bone Mineral Density. | Sha L et al. | β | 2025 | β |
| Shared genetic architecture between anxiety, depression and erectile dysfunction: a genome-wide cross-trait analysis. | Xie L et al. | β | 2025 | β |
| Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases. | Lazanas P et al. | β | 2025 | β |
| Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis. | Liu H et al. | β | 2025 | β |
| Shared genetic architecture between leukocyte telomere length and Alzheimer's disease. | Cao Z et al. | β | 2025 | β |
| Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis. | Li G et al. | β | 2025 | β |
| Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis. | Bai W et al. | β | 2025 | β |
| Shared genetic architecture contributes to risk of major cardiovascular diseases. | Qiao J et al. | β | 2025 | β |
| Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes. | Liu W et al. | β | 2025 | β |
| Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis. | Feng K et al. | β | 2025 | β |
| Shared genetic associations between CHA<sub>2</sub>DS<sub>2</sub>-VASc score and cardio-embolic stroke: Insights from mendelian randomization based bioinformatics analysis. | Yuan K et al. | β | 2025 | β |
| Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations. | Zhong P et al. | β | 2025 | β |
| Shared genetics and causal relationship between sociability and the brain's default mode network. | Fanelli G et al. | β | 2025 | β |
| Shared genetics of lung cancer and type 2 diabetes: a large-scale genome-wide cross-trait analysis. | Wang Z et al. | β | 2025 | β |
| Simple scaling laws control the genetic architectures of human complex traits. | Simons YB et al. | β | 2025 | β |
| Socio-economic status is a social construct with heritable components and genetic consequences. | Abdellaoui A et al. | β | 2025 | β |
| Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components. | Omdahl AR et al. | β | 2025 | β |
| Spatially resolved mapping of cells associated with human complex traits. | Song L et al. | β | 2025 | β |
| Spatiotemporal dynamics of RERE in schizophrenia pathogenesis: insights from multi-omics and single-cell sequencing. | Shen J et al. | β | 2025 | β |
| Statistical construction of calibrated prediction intervals for polygenic score-based phenotype prediction. | Xu C et al. | β | 2025 | β |
| Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers. | Blechter B et al. | β | 2025 | β |
| STREAM-PRS: a multi-tool pipeline for streamlining polygenic risk score computation. | Becelaere S et al. | β | 2025 | β |
| SUDEP risk is influenced by longevity genomics: a polygenic risk score study. | Martins H et al. | β | 2025 | β |
| Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases. | Ma Y et al. | β | 2025 | β |
| Testing for differences in polygenic scores in the presence of confounding. | Blanc J et al. | β | 2025 | β |
| The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study. | Hu Y et al. | β | 2025 | β |
| The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study. | Wu C et al. | β | 2025 | β |
| The causal effect of folate on major depressive disorder: Mendelian randomization, LDSC, and colocalization analysis. | Liu D et al. | β | 2025 | β |
| The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data. | Wilcox N et al. | β | 2025 | β |
| The genetic architecture of brainstem structures. | Xue H et al. | β | 2025 | β |
| The genetic architecture of cervical length is shared with spontaneous preterm birth risk. | Wolf HM et al. | β | 2025 | β |
| The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life. | Askelund AD et al. | β | 2025 | β |
| The Genetic Architecture of the Human Corpus Callosum and its Subregions. | Bhatt RR et al. | β | 2025 | β |
| The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension. | Zhou LT et al. | β | 2025 | β |
| The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis. | Tong Y et al. | β | 2025 | β |
| The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6. | WistrΓΆm ED et al. | β | 2025 | β |
| The genetics of low and high birthweight and their relationship with cardiometabolic disease. | Moen GH et al. | β | 2025 | β |
| The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases. | Konieczny MJ et al. | β | 2025 | β |
| The impact of common and rare genetic variants on bradyarrhythmia development. | Weng LC et al. | β | 2025 | β |
| The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation. | Schoeler T et al. | β | 2025 | β |
| The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources. | Dilliott AA et al. | β | 2025 | β |
| The phenotypic and genetic association between endometriosis and immunological diseases. | Shigesi N et al. | β | 2025 | β |
| Therapeutic potential of GLP-1RAs in sleep apnea with genetic associations to type 2 diabetes. | Cheng F et al. | β | 2025 | β |
| The relationship between kidney health and neurodegenerative diseases. | Zuo M et al. | β | 2025 | β |
| The relationship between vitamin D levels and depression: a genetically informed study. | Lyu H et al. | β | 2025 | β |
| The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis. | Zhu W et al. | β | 2025 | β |
| The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis. | Zheng X et al. | β | 2025 | β |
| The shared genetic etiology of autoimmune disorders and interstitial lung disease: insights from large-scale genome-wide cross-trait analysis. | Zhou F et al. | β | 2025 | β |
| The Trait Coding Rule in Phenotype Space. | Wang J et al. | β | 2025 | β |
| Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects. | Downie CG et al. | β | 2025 | β |
| Uncovering pleiotropic loci in allergic rhinitis and leukocyte traits through multi-trait GWAS. | Yang L et al. | β | 2025 | β |
| Uncovering Potential Susceptibility Genes for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization Analysis. | Xu Y et al. | β | 2025 | β |
| Uncovering potential therapeutic targets for autoimmune hepatitis using proteome-wide Mendelian randomization. | Li C et al. | β | 2025 | β |
| Uncovering shared genetic features between inflammatory bowel disease and systemic lupus erythematosus. | Shaw VR et al. | β | 2025 | β |
| Unraveling shared genetics across asthma subtypes and 81 asthma-related traits. | Vernet R et al. | β | 2025 | β |
| Unraveling the Causal Relationship Between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study. | Li M et al. | β | 2025 | β |
| Unraveling the causal role of sleep traits in development of diabetic retinopathy: A UK Biobank observational study and Mendelian randomization. | Huang Y et al. | β | 2025 | β |
| Unraveling the Genetic Link Between Endocrine Hormones and Psychiatric Disorders: An Atlas of Genetic Correlations. | Li JL | β | 2025 | β |
| Unraveling the genetic links between depression and type 2 diabetes. | Baranova A et al. | β | 2025 | β |
| Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845Β 492 individuals: a diagnostic study. | Huang W et al. | β | 2025 | β |
| 'Unravelling the shared genetic architecture between suicidality and subcortical brain volume: a genome-wide association study'. | Defo J et al. | β | 2025 | β |
| Unsupervised Learning-Derived ComplexΒ Metabolic Signatures RefineΒ Cardiometabolic Risk. | Zhou Y et al. | β | 2025 | β |
| Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma. | Zhang Y et al. | β | 2025 | β |
| Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis. | Lin H et al. | β | 2025 | β |
| Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study. | Xu J et al. | β | 2025 | β |
| Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor. | Liang X et al. | β | 2025 | β |
| Using human genetics to understand the epidemiological association between neuroticism and lung cancer. | Wu D et al. | β | 2025 | β |
| Visual impairment and frailty: insights from genetic correlation and Mendelian randomization. | Deng Z et al. | β | 2025 | β |
| Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese. | Wang M et al. | β | 2025 | β |
| Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. | Xu H et al. | β | 2025 | β |
| Woolf et al's "GWAS by subtraction" is not useful for cross-generational Mendelian randomization studies. | Evans DM et al. | β | 2025 | β |
| Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation. | Zheng S et al. | β | 2024 | β |
| A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study. | Liu H et al. | β | 2024 | β |
| Accelerated biological aging as a potential risk factor for rheumatoid arthritis. | Dan YL et al. | β | 2024 | β |
| A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma. | Wu X et al. | β | 2024 | β |
| A cross-trait study of lung cancer and its related respiratory diseases based on large-scale exome sequencing population. | Jiang Y et al. | β | 2024 | β |
| A framework for conducting GWAS using repeated measures data with an application to childhood BMI. | Burrows K et al. | β | 2024 | β |
| A Genetic Analysis of Current Medication Use in the UK Biobank. | Rohde PD | β | 2024 | β |
| A genome-wide association meta-analysis of all-cause and vascular dementia. | Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium | β | 2024 | β |
| A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits. | Zhu Y et al. | β | 2024 | β |
| A genome-wide association study of occupational creativity and its relations with well-being and career success. | Li WD et al. | β | 2024 | β |
| A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans. | Moksnes MR et al. | β | 2024 | β |
| A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing. | Bhatt IS et al. | β | 2024 | β |
| A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis. | Wu Y et al. | β | 2024 | β |
| A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. | Gupta P et al. | β | 2024 | β |
| A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait. | Abbondanza F et al. | β | 2024 | β |
| A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer. | Wu D et al. | β | 2024 | β |
| An Atlas Characterizing the Shared Genetic Architecture of Inflammatory Bowel Disease with Clinical and Behavioral Traits. | Shaw VR et al. | β | 2024 | β |
| A New Method for Conditional Gene-Based Analysis Effectively Accounts for the Regional Polygenic Background. | Svishcheva GR et al. | β | 2024 | β |
| A novel method for multiple phenotype association studies based on genotype and phenotype network. | Cao X et al. | β | 2024 | β |
| A novel multivariable Mendelian randomization framework to disentangle highly correlated exposures with application to metabolomics. | Chan LS et al. | β | 2024 | β |
| A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically determined protein-protein networks. | Tsai YT et al. | β | 2024 | β |
| A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders. | Pan YJ et al. | β | 2024 | β |
| A review of the advances in understanding the genetic basis of spondylarthritis and emerging clinical benefit. | Stadler M et al. | β | 2024 | β |
| Association among attention-deficit hyperactivity disorder, restless legs syndrome, and peripheral iron status: a two-sample Mendelian randomization study. | Xiao G et al. | β | 2024 | β |
| Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality. | Yu XH et al. | β | 2024 | β |
| Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality. | Rong GW et al. | β | 2024 | β |
| Association between endometriosis and arthritis: results from NHANES 1999-2006, genetic correlation analysis, and Mendelian randomization study. | Xu H et al. | β | 2024 | β |
| Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations. | Liu D et al. | β | 2024 | β |
| Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture. | Kang J et al. | β | 2024 | β |
| Association between Kidney Stones and CKD: A Bidirectional Mendelian Randomization Study. | Zhou LT et al. | β | 2024 | β |
| Association between levels of sex hormones and risk of multiple sclerosis: a mendelian randomization study. | Geng C et al. | β | 2024 | β |
| Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study. | Wu XP et al. | β | 2024 | β |
| Association between oxidative stress and chronic orofacial pain and potential druggable targets: Evidence from a Mendelian randomization study. | Zhang SH et al. | β | 2024 | β |
| Association between proton pump inhibitors and dementia risk: a Mendelian randomization study. | Xie K et al. | β | 2024 | β |
| Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. | Domenighetti C et al. | β | 2024 | β |
| Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis. | Warren TL et al. | β | 2024 | β |
| Association of obstructive sleep apnea syndrome with polycystic ovary syndrome through bidirectional Mendelian randomization. | Liu P et al. | β | 2024 | β |
| Associations Between Temporomandibular Disorders and Brain Imaging-Derived Phenotypes. | Lin J et al. | β | 2024 | β |
| Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study. | Liu J et al. | β | 2024 | β |
| Bidirectional Mendelian randomization to explore the causal relationships between schizophrenia and narcolepsy. | Geng C et al. | β | 2024 | β |
| Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol. | Sullivan EL et al. | β | 2024 | β |
| Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels. | Hahn J et al. | β | 2024 | β |
| Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways. | Guo J et al. | β | 2024 | β |
| Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis. | Meena D et al. | β | 2024 | β |
| Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. | Ojima T et al. | β | 2024 | β |
| Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk. | Xu H et al. | β | 2024 | β |
| Canadian COVID-19 host genetics cohort replicates known severity associations. | Garg E et al. | β | 2024 | β |
| Causal association among glaucoma, cerebral cortical structures, and Alzheimer's disease: insights from genetic correlation and Mendelian randomization. | Chen J et al. | β | 2024 | β |
| Causal association and shared genetics between telomere length and COVID-19 outcomes: New evidence from the latest large-scale summary statistics. | Zhang J et al. | β | 2024 | β |
| Causal association between blood metabolites and vertigo: A Mendelian randomization study. | Zhang B et al. | β | 2024 | β |
| Causal association between frailty and chronic obstructive pulmonary disease: insights from bidirectional Mendelian randomization and mediation analysisΒ | Cheng Z et al. | β | 2024 | β |
| Causal associations between 45 dietary intake habits and urolithiasis: insights from genetic studies. | Yang L et al. | β | 2024 | β |
| Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study. | Liang Y et al. | β | 2024 | β |
| Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. | Li L et al. | β | 2024 | β |
| Causal relationship between narcolepsy and anxiety: A two-sample Mendelian randomization study. | Geng C et al. | β | 2024 | β |
| Causal relationship between primary biliary cholangitis and inflammatory bowel disease: a Mendelian randomization study. | Zhu Q et al. | β | 2024 | β |
| Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes. | Sun Z et al. | β | 2024 | β |
| Causal Relationships Between Epilepsy, Anti-Epileptic Drugs, and Serum Vitamin D and Vitamin D Binding Protein: A Bidirectional and Drug Target Mendelian Randomization Study. | Cheng Z et al. | β | 2024 | β |
| Causal role of peripheral immune cells in epilepsy: A large-scale genetic correlation study. | Zhao T et al. | β | 2024 | β |
| Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records. | Venkatesh SS et al. | β | 2024 | β |
| Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis. | Schaffer LS et al. | β | 2024 | β |
| Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development. | Jaholkowski P et al. | β | 2024 | β |
| Childhood Reading Ability and Pain in Childhood Through to Midlife. | Bridges EC et al. | β | 2024 | β |
| Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes. | Li M et al. | β | 2024 | β |
| Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization. | Wang P et al. | β | 2024 | β |
| Comorbidity Between Inflammatory Bowel Disease and Asthma and Allergic Diseases: A Genetically Informed Study. | Gong T et al. | β | 2024 | β |
| Complex trait susceptibilities and population diversity in a sample of 4,145 Russians. | Usoltsev D et al. | β | 2024 | β |
| Controlling for polygenic genetic confounding in epidemiologic association studies. | Zhao Z et al. | β | 2024 | β |
| CoPheScan: phenome-wide association studies accounting for linkage disequilibrium. | Manipur I et al. | β | 2024 | β |
| Correlation between benign prostatic hyperplasia and comorbidities: a systematic analysis integrating global burden of disease and mendelian randomization study. | Song Z et al. | β | 2024 | β |
| Cross-ancestry genetic architecture and prediction for cholesterol traits. | Momin MM et al. | β | 2024 | β |
| Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. | Johnson EC et al. | β | 2024 | β |
| Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization. | Liu Y et al. | β | 2024 | β |
| Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence. | Zhao P et al. | β | 2024 | β |
| Deciphering the lipid-cancer nexus: comprehensive Mendelian randomization analysis of the associations between lipid profiles and digestive system cancer susceptibility. | Jin Y et al. | β | 2024 | β |
| Deep learning of left atrial structure and function provides link to atrial fibrillation risk. | Pirruccello JP et al. | β | 2024 | β |
| Depression and hepatobiliary diseases: a bidirectional Mendelian randomization study. | Kong Y et al. | β | 2024 | β |
| Developmental language disorder - heritability and genetic correlations with other disorders affecting language. | Nudel R et al. | β | 2024 | β |
| DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits. | Hwang LD et al. | β | 2024 | β |
| Discovering non-additive heritability using additive GWAS summary statistics. | Pattillo Smith S et al. | β | 2024 | β |
| Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan. | Chen HL et al. | β | 2024 | β |
| Disentangling the genetic overlap between ischemic stroke and obesity. | Yang R et al. | β | 2024 | β |
| Dissecting loci that underpin the genetic correlations between production, fertility, and urea traits in Australian Holstein cattle. | Olasege BS et al. | β | 2024 | β |
| Dissecting shared genetic architecture between depression and body mass index. | Zhang H et al. | β | 2024 | β |
| Dissecting the biology of feeding and eating disorders. | Huckins LM et al. | β | 2024 | β |
| Dissecting the genetic and causal relationship between sleep-related traits and common brain disorders. | Xue B et al. | β | 2024 | β |
| Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets. | Pisanu C et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between anti-MΓΌllerian hormone and age at menopause based on genome-wide association study. | Long P et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between endometriosis and polycystic ovary syndrome. | Tan H et al. | β | 2024 | β |
| Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia. | Tao Y et al. | β | 2024 | β |
| Distinct impact modes of polygenic disposition to dyslexia in the adult brain. | Soheili-Nezhad S et al. | β | 2024 | β |
| Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. | Verma A et al. | β | 2024 | β |
| DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms. | Kong Y et al. | β | 2024 | β |
| Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization. | Ruigrok YM et al. | β | 2024 | β |
| Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics. | Feng X et al. | β | 2024 | β |
| Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance. | Bao J et al. | β | 2024 | β |
| Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits. | Xiao X et al. | β | 2024 | β |
| Environmental risk factors for schizophrenia and bipolar disorder from childhood to diagnosis: a Swedish nested case-control study. | Robinson N et al. | β | 2024 | β |
| Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer. | Tang M et al. | β | 2024 | β |
| Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases. | Qian Q et al. | β | 2024 | β |
| Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients. | Geng C et al. | β | 2024 | β |
| Estimating trans-ancestry genetic correlation with unbalanced data resources. | Zhao B et al. | β | 2024 | β |
| Estimation of a genetic Gaussian network using GWAS summary data. | Yang Y et al. | β | 2024 | β |
| Evaluation and comparison of nine growth and development-based measures of pubertal timing. | Elhakeem A et al. | β | 2024 | β |
| Evaluation of Bayesian Linear Regression derived gene set test methods. | Bai Z et al. | β | 2024 | β |
| Evaluation of behavioral variance/covariance explained by the neuroimaging data through a pattern-based regression. | Chen D et al. | β | 2024 | β |
| Evaluation of bi-directional causal association between obstructive sleep apnoea syndrome and diabetic microangiopathy: a Mendelian randomization study. | Liu Q et al. | β | 2024 | β |
| Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety. | Zhang X et al. | β | 2024 | β |
| Examination of the shared genetic architecture between multiple sclerosis and systemic lupus erythematosus facilitates discovery of novel lupus risk loci. | Kerns S et al. | β | 2024 | β |
| Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood. | Breunig S et al. | β | 2024 | β |
| Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex. | Voorhies K et al. | β | 2024 | β |
| Exploration of the potential causative genes for inflammatory bowel disease: Transcriptome-wide association analysis, Mendelian randomization analysis and Bayesian colocalisation. | Luo Q et al. | β | 2024 | β |
| Exploring the Common Genetic Underpinnings of Chronic Pulmonary Disease and Esophageal Carcinoma Susceptibility. | Zhang D et al. | β | 2024 | β |
| Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer. | Yang Y et al. | β | 2024 | β |
| Exploring the Genetic Relationship Between Type 2 Diabetes and Cardiovascular Disease: A Large-Scale Genetic Association and Polygenic Risk Score Study. | Yao Z et al. | β | 2024 | β |
| Exploring the Germline Genetics of In Situ and Invasive Cutaneous Melanoma: A Genome-Wide Association Study Meta-Analysis. | Ingold N et al. | β | 2024 | β |
| Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis. | Ni W et al. | β | 2024 | β |
| Exploring the shared genetic basis of major depressive disorder and frailty. | Fu W et al. | β | 2024 | β |
| Eye-brain connections revealed by multimodal retinal and brain imaging genetics. | Zhao B et al. | β | 2024 | β |
| Femoral neck width genetic risk score is a novel independent risk factor for hip fractures. | Tobias JH et al. | β | 2024 | β |
| Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. | Friligkou E et al. | β | 2024 | β |
| Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions. | Wang J et al. | β | 2024 | β |
| Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health. | Kouakou MR et al. | β | 2024 | β |
| Genetic analyses of the bidirectional associations between common mental disorders and asthma. | Yan Z et al. | β | 2024 | β |
| Genetic Analysis of Perceived Youthfulness Reveals Differences in How Men's and Women's Age Is Assessed. | Ingold N et al. | β | 2024 | β |
| Genetic and causal relationship between chronic gastrointestinal diseases and erectile dysfunction: a Mendelian randomization study. | Zeng X et al. | β | 2024 | β |
| Genetic and Phenotypic Features of Schizophrenia in the UK Biobank. | Legge SE et al. | β | 2024 | β |
| Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study. | Hegemann L et al. | β | 2024 | β |
| Genetic architecture of brain morphology and overlap with neuropsychiatric traits. | Ge YJ et al. | β | 2024 | β |
| Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology. | Madsen AL et al. | β | 2024 | β |
| Genetic architecture of the structural connectome. | Wainberg M et al. | β | 2024 | β |
| Genetic architecture reconciles linkage and association studies of complex traits. | Sidorenko J et al. | β | 2024 | β |
| Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits. | Ning C et al. | β | 2024 | β |
| Genetic association and causal effects between inflammatory bowel disease and conjunctivitis. | Chang S et al. | β | 2024 | β |
| Genetic association and causal relationship between multiple modifiable risk factors and autoimmune liver disease: a two-sample mendelian randomization study. | Gao W et al. | β | 2024 | β |
| Genetic association of inflammatory marker GlycA with lung function and respiratory diseases. | Guo Y et al. | β | 2024 | β |
| Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis. | Zheng X et al. | β | 2024 | β |
| Genetic associations between gut microbiota and type 2 diabetes mediated by plasma metabolites: a Mendelian randomization study. | Zheng X et al. | β | 2024 | β |
| Genetic associations between non-cognitive skills and academic achievement over development. | Malanchini M et al. | β | 2024 | β |
| Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders. | KΓ€mpe A et al. | β | 2024 | β |
| Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study. | Zhu G et al. | β | 2024 | β |
| Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk. | Yan M et al. | β | 2024 | β |
| Genetic correlation between smoking behavior and gastroesophageal reflux disease: insights from integrative multi-omics data. | Yan Z et al. | β | 2024 | β |
| Genetic correlations and causal relationships between cardio-metabolic traits and sepsis. | Zhang Z et al. | β | 2024 | β |
| Genetic drivers and cellular selection of female mosaic X chromosome loss. | Liu A et al. | β | 2024 | β |
| Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns. | Fu T et al. | β | 2024 | β |
| Genetic evidence for the causal effects of C-reactive protein on self-reported habitual sleep duration. | Iakunchykova O et al. | β | 2024 | β |
| Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits. | Galimberti M et al. | β | 2024 | β |
| Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression. | Zhukovsky P et al. | β | 2024 | β |
| Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. | Chen B et al. | β | 2024 | β |
| Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression. | Dybdahl Krebs M et al. | β | 2024 | β |
| Genetic liability to higher frailty index may increase the risk of ophthalmic disease. | Lin J et al. | β | 2024 | β |
| Genetic mapping across autoimmune diseases reveals shared associations and mechanisms. | Lincoln MR et al. | β | 2024 | β |
| Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity. | Chen Y et al. | β | 2024 | β |
| Genetic overlap between inflammatory bowel disease and iridocyclitis: insights from a genome-wide association study in a European population. | Liao W et al. | β | 2024 | β |
| Genetic predisposition to high BMI increases risk of early life respiratory infections and episodes of severe wheeze and asthma. | Jensen SK et al. | β | 2024 | β |
| Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. | Adebekun J et al. | β | 2024 | β |
| Genetic risk factors for COVID-19 and influenza are largely distinct. | Kosmicki JA et al. | β | 2024 | β |
| Genetic similarity between relatives provides evidence on the presence and history of assortative mating. | Sunde HF et al. | β | 2024 | β |
| Genetic variants for head size share genes and pathways with cancer. | Knol MJ et al. | β | 2024 | β |
| Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia. | Manzoni C et al. | β | 2024 | β |
| Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities. | Yang Y et al. | β | 2024 | β |
| Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. | Nievergelt CM et al. | β | 2024 | β |
| Genome-wide association analysis of hypertension and epigenetic aging reveals shared genetic architecture and identifies novel risk loci. | Li X et al. | β | 2024 | β |
| Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. | Zheng SL et al. | β | 2024 | β |
| Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits. | Zhen J et al. | β | 2024 | β |
| Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage. | Westergaard D et al. | β | 2024 | β |
| Genome-wide association studies for pelvic organ prolapse in the Japanese population. | Matsunami M et al. | β | 2024 | β |
| Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations. | Thorpe HHA et al. | β | 2024 | β |
| Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies. | Wei Y et al. | β | 2024 | β |
| Genome-wide association study of cardiometabolic multimorbidity in the UK Biobank. | Zhao C et al. | β | 2024 | β |
| Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population. | Strom NI et al. | β | 2024 | β |
| Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations. | Gelernter J et al. | β | 2024 | β |
| Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. | Jurgens SJ et al. | β | 2024 | β |
| Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy. | DeForest N et al. | β | 2024 | β |
| Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants. | Qi G et al. | β | 2024 | β |
| Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. | Salo V et al. | β | 2024 | β |
| Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. | Braun A et al. | β | 2024 | β |
| Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large-Scale Genome-Wide Cross-Trait Analysis. | Wang Q et al. | β | 2024 | β |
| Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis. | Wang Q et al. | β | 2024 | β |
| Genomic determinants, architecture, and constraints in drought-related traits in Corymbia calophylla. | Ahrens CW et al. | β | 2024 | β |
| Genomic insights into the shared and distinct genetic architecture of cognitive function and schizophrenia. | Wootton O et al. | β | 2024 | β |
| Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data. | Zhang Y et al. | β | 2024 | β |
| Global and regional genetic association analysis of ulcerative colitis and type 2 diabetes mellitus and causal validation analysis of two-sample two-way Mendelian randomization. | Hu YZ et al. | β | 2024 | β |
| GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing. | Kasher M et al. | β | 2024 | β |
| Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders. | Lee J et al. | β | 2024 | β |
| Heritability and genetic contribution analysis of structural-functional coupling in human brain. | Dai W et al. | β | 2024 | β |
| Human blood metabolites and gastric cancer: a Mendelian randomization analysis. | Zhang C et al. | β | 2024 | β |
| Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders. | Tesfaye M et al. | β | 2024 | β |
| Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors. | Ding K et al. | β | 2024 | β |
| Identifying BMI-associated genes via a genome-wide multi-omics integrative approach using summary data. | Tang J et al. | β | 2024 | β |
| iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images. | Xie Z et al. | β | 2024 | β |
| Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk. | Zhang D et al. | β | 2024 | β |
| Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure. | Cao G et al. | β | 2024 | β |
| Inherited infertility: Mapping loci associated with impaired female reproduction. | Ruotsalainen S et al. | β | 2024 | β |
| Insights from immunomics and metabolomics on the associations between prostatic diseases and coronavirus disease 2019. | Yang F et al. | β | 2024 | β |
| Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank. | CarriΓ³n-Castillo A et al. | β | 2024 | β |
| Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation. | ThΓ©riault S et al. | β | 2024 | β |
| Integrative Metabolomics Differentiate Coronary Artery Disease, Peripheral Artery Disease, and Venous Thromboembolism Risks. | Lee J et al. | β | 2024 | β |
| Interpreting population- and family-based genome-wide association studies in the presence of confounding. | Veller C et al. | β | 2024 | β |
| Investigating causal associations between pneumonia and lung cancer using a bidirectional mendelian randomization framework. | Song L et al. | β | 2024 | β |
| Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis. | Kirby A et al. | β | 2024 | β |
| Investigating shared genetic architecture between inflammatory bowel diseases and primary biliary cholangitis. | Huang W et al. | β | 2024 | β |
| Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis. | Chen Y et al. | β | 2024 | β |
| Investigating the shared genetic architecture between depression and subcortical volumes. | Liu M et al. | β | 2024 | β |
| Investigating the shared genetic architecture between frailty and insomnia. | Song Z et al. | β | 2024 | β |
| Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function. | Zhang S et al. | β | 2024 | β |
| Investigating the shared genetic architecture of osteoarthritis and frailty: a genome-wide cross-trait analysis. | Guo H et al. | β | 2024 | β |
| Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis. | Yuan W et al. | β | 2024 | β |
| Investigation of causal associations between cerebral cortical structure and Barrett's esophagus: insights from Mendelian randomization and meta-analysis. | Liu Q et al. | β | 2024 | β |
| Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults. | Liu Y et al. | β | 2024 | β |
| Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review. | Moore A et al. | β | 2024 | β |
| Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation. | Shen J et al. | β | 2024 | β |
| Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder. | Song J et al. | β | 2024 | β |
| Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults. | Deng YT et al. | β | 2024 | β |
| Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating. | Ma S et al. | β | 2024 | β |
| Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa). | D'Urso S et al. | β | 2024 | β |
| Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk. | Zhang R et al. | β | 2024 | β |
| Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer's disease. | Martin L et al. | β | 2024 | β |
| Mendelian randomization unraveled: gender-specific insights into obesity-related phenotypes and colorectal cancer susceptibility. | Chen X et al. | β | 2024 | β |
| Metabolome-wide Mendelian randomization reveals causal effects of betaine and N-acetylornithine on impairment of renal function. | Liu Y et al. | β | 2024 | β |
| mFusion: a multiscale fusion method bridging neuroimages to genes through neurotransmissions in mental health disorders. | Cao L et al. | β | 2024 | β |
| Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants. | Sysojev AΓ et al. | β | 2024 | β |
| MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures. | Zhang W et al. | β | 2024 | β |
| Multiome-wide Association Studies: Novel Approaches for Understanding Diseases. | Shao M et al. | β | 2024 | β |
| Multiomic profiling of transcription factor binding and function in human brain. | Loupe JM et al. | β | 2024 | β |
| Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine. | Sun X et al. | β | 2024 | β |
| Multi-trait GWAS for diverse ancestries: mapping the knowledge gap. | Troubat L et al. | β | 2024 | β |
| Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans. | Chakrabarty A et al. | β | 2024 | β |
| Multivariate genomic analysis of 5βmillion people elucidates the genetic architecture of shared components of the metabolic syndrome. | Park S et al. | β | 2024 | β |
| No bidirectional relationship between sleep phenotypes and risk of proliferative diabetic retinopathy: a two-sample Mendelian randomization study. | Liu H et al. | β | 2024 | β |
| Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping. | Nauffal V et al. | β | 2024 | β |
| Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: a Mendelian randomization study. | Chen S et al. | β | 2024 | β |
| Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities. | Zhu H et al. | β | 2024 | β |
| Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure. | Walle R et al. | β | 2024 | β |
| On network deconvolution for undirected graphs. | Lin Z et al. | β | 2024 | β |
| Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling. | Horwitz TB et al. | β | 2024 | β |
| PathGPS: discover shared genetic architecture using GWAS summary data. | Gao Z et al. | β | 2024 | β |
| Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample. | Salvatore JE et al. | β | 2024 | β |
| Pervasive biases in proxy genome-wide association studies based on parental history of Alzheimer's disease. | Wu Y et al. | β | 2024 | β |
| Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases. | OrtΓn Vela S et al. | β | 2024 | β |
| Phenotypic and genetic effect of carotid intima-media thickness on the risk of stroke. | Zhang W et al. | β | 2024 | β |
| Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants. | Chen Y et al. | β | 2024 | β |
| Pleiotropy, epistasis and the genetic architecture of quantitative traits. | Mackay TFC et al. | β | 2024 | β |
| Polygenic risk of social isolation behavior and its influence on psychopathology and personality. | Socrates AJ et al. | β | 2024 | β |
| Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events. | Heyne HO et al. | β | 2024 | β |
| Potential Causal Association Between Atrial Fibrillation/Flutter and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomisation Study. | Lee Y et al. | β | 2024 | β |
| Potential drug targets for osteoporosis identified: A Mendelian randomization study. | Zhao G et al. | β | 2024 | β |
| Predictive ability of multi-population genomic prediction methods of phenotypes for reproduction traits in Chinese and Austrian pigs. | Wang X et al. | β | 2024 | β |
| Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation. | Carey CE et al. | β | 2024 | β |
| Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics. | Dall'Aglio L et al. | β | 2024 | β |
| Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. | Meijsen J et al. | β | 2024 | β |
| Quantitative omnigenic model discovers interpretable genome-wide associations. | RuΕΎiΔkovΓ‘ N et al. | β | 2024 | β |
| Sarcopenia-related traits and 10 digestive system disorders: insight from genetic correlation and Mendelian randomization. | Yang T et al. | β | 2024 | β |
| Sex differences in shared genetic determinants between severe mental disorders and metabolic traits. | Pisanu C et al. | β | 2024 | β |
| Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. | He J et al. | β | 2024 | β |
| Sex-specific genetic architecture of blood pressure. | Yang ML et al. | β | 2024 | β |
| Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism. | Liley J et al. | β | 2024 | β |
| Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes. | Xie Y et al. | β | 2024 | β |
| Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue. | Li Y et al. | β | 2024 | β |
| Shared genetic architecture and causal relationship between sleep behaviors and lifespan. | Wu Y et al. | β | 2024 | β |
| Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis. | Yu X et al. | β | 2024 | β |
| Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases. | Gong T et al. | β | 2024 | β |
| Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis. | Liu R et al. | β | 2024 | β |
| Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis. | Wu KCH et al. | β | 2024 | β |
| Shared genetic architecture of non-viral cirrhosis with several pleiotropic traits: A nested case-control study in the UK Biobank. | Byun J et al. | β | 2024 | β |
| Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis. | Chen Z et al. | β | 2024 | β |
| Shared Genetic Architectures between Coronary Artery Disease and Type 2 Diabetes Mellitus in East Asian and European Populations. | Li X et al. | β | 2024 | β |
| Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis. | Wang J et al. | β | 2024 | β |
| Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis. | Qin C et al. | β | 2024 | β |
| Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants. | Chen Y et al. | β | 2024 | β |
| Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis. | Yu S et al. | β | 2024 | β |
| Shared genetic links between hypothyroidism and psychiatric disorders: evidence from a comprehensive genetic analysis. | Zhou J et al. | β | 2024 | β |
| Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease. | Di H et al. | β | 2024 | β |
| Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes. | Cordioli M et al. | β | 2024 | β |
| Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics. | Spargo TP et al. | β | 2024 | β |
| Structural models of genome-wide covariance identify multiple common dimensions in autism. | de Hoyos L et al. | β | 2024 | β |
| Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population. | Vanneste M et al. | β | 2024 | β |
| Task-Agnostic Machine-Learning-Assisted Inference. | Miao J et al. | β | 2024 | β |
| The causal relationship between type 2 diabetes mellitus and isolated REM sleep behavior disorder: results from multivariable and network Mendelian randomization analysis. | Zhang RY et al. | β | 2024 | β |
| The genetic architecture of biological age in nine human organ systems. | Wen J et al. | β | 2024 | β |
| The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals. | Gong T et al. | β | 2024 | β |
| The genetic architecture of multimodal human brain age. | Wen J et al. | β | 2024 | β |
| The genetic landscape of basal ganglia and implications for common brain disorders. | Bahrami S et al. | β | 2024 | β |
| The genetic landscape of neuro-related proteins in human plasma. | Repetto L et al. | β | 2024 | β |
| The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. | Cabrera-Mendoza B et al. | β | 2024 | β |
| The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis. | Liu Y et al. | β | 2024 | β |
| The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study. | Liu J et al. | β | 2024 | β |
| The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits. | Belbellaj W et al. | β | 2024 | β |
| The shared genetic etiology of antisocial behavior and psychiatric disorders: Insights from pleiotropy and causality analysis. | Wang S et al. | β | 2024 | β |
| Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability. | Suzuki Y et al. | β | 2024 | β |
| TransferGWAS of T1-weighted brain MRI data from UK Biobank. | Rakowski A et al. | β | 2024 | β |
| Two-sample Mendelian randomization studies revealed a causal relationship between insulin use and osteoporosis: An observational study. | Wang Z et al. | β | 2024 | β |
| Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease network. | Woerner J et al. | β | 2024 | β |
| Uncovering genetic loci and biological pathways associated with age-related cataracts through GWAS meta-analysis. | Diaz-Torres S et al. | β | 2024 | β |
| Uncovering the molecular networks of ferroptosis in the pathogenesis of type 2 diabetes and its complications: a multi-omics investigation. | Dong C et al. | β | 2024 | β |
| Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa. | Rajcsanyi LS et al. | β | 2024 | β |
| Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data. | Asgel Z et al. | β | 2024 | β |
| Unraveling the genetic and molecular landscape of sepsis and acute kidney injury: A comprehensive GWAS and machine learning approach. | Yang S et al. | β | 2024 | β |
| Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia. | Shen J et al. | β | 2024 | β |
| Unraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysis. | Luo YF et al. | β | 2024 | β |
| Unravelling the complex causal effects of substance use behaviours on common diseases. | Xue A et al. | β | 2024 | β |
| Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging. | Patel K et al. | β | 2024 | β |
| Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization. | Zheng X et al. | β | 2024 | β |
| Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives. | Guo J et al. | β | 2024 | β |
| Using Genetics to Investigate Relationships between Phenotypes: Application to Endometrial Cancer. | Bouttle K et al. | β | 2024 | β |
| Utilize proteomic analysis to identify potential therapeutic targets for combating sepsis and sepsis-related death. | Zhang T et al. | β | 2024 | β |
| Valid inference for machine learning-assisted genome-wide association studies. | Miao J et al. | β | 2024 | β |
| Widespread natural selection on metabolite levels in humans. | Timasheva Y et al. | β | 2024 | β |