Accumbens functional connectivity during reward mediates sensation-seeking and alcohol use in high-risk youth.
paper
Cited
Public
- Authors
- Weiland, Barbara J; Welsh, Robert C; Yau, Wai-Ying Wendy; Zucker, Robert A; Zubieta, Jon-Kar; Heitzeg, Mary M
- Year
- 2013
- Journal
- Drug and alcohol dependence
- PMID
- 22958950
- DOI
- 10.1016/j.drugalcdep.2012.08.019
- PMCID
- PMC3546225
BACKGROUND: Differences in fronto-striatal connectivity in problem substance users have suggested reduced influence of cognitive regions on reward-salience regions. Youth with a family history of alcoholism (FH+) have disrupted ventral striatal processing compared with controls with no familial risk (FH-). As sensation-seeking represents an additional vulnerability factor, we hypothesized that functional connectivity during reward anticipation would differ by family history, and would mediate the relationship between sensation-seeking and drinking in high-risk subjects. METHODS: Seventy 18-22 year olds (49 FH+/21 FH-) performed a monetary incentive delay task during functional magnetic resonance imaging. Group connectivity differences for incentive (reward/loss) vs. neutral conditions were evaluated with psychophysiological interaction (PPI) analysis, seeded in nucleus accumbens (NAcc). Indirect effects of sensation-seeking on drinking volume through accumbens connectivity were tested. RESULTS: NAcc connectivity with paracentral lobule/precuneus and sensorimotor areas was decreased for FH- vs. increased for FH+ during incentive anticipation. In FH+, task-related functional coupling between left NAcc and supplementary sensorimotor area (SSMA) and right precuneus correlated positively with sensation-seeking and drinking volume and mediated their relationship. In FH-, left NAcc-SSMA connectivity correlated negatively with sensation-seeking but was not related to drinking. CONCLUSIONS: These results suggest preexisting differences in accumbens reward-related functional connectivity in high-risk subjects. NAcc coupling with SSMA, involved in attention and motor networks, and precuneus, a default mode structure, appear to mediate sensation-seeking's effect on drinking in those most at-risk. Differences in accumbens connectivity with attention/motor/default networks, rather than control systems, may influence the reward system's role in vulnerability for substance abuse.
A) Schematic illustration of the monetary incentive delay task performed by subjects in the fMRI scanner. B) Location of 5-mm diameter spherical nucleus accumbens mask at the ventromesial intersection of caudate and putamen (y=13 MNI). C) Activation in bilateral nucleus accumbens during reward and loss anticipation by family history groups. Error bars: Β± 1 Standard Error.
Regions with negative functional connectivity with NAcc during incentive including areas. FHβ controls have reduced task connectivity in regions which map onto default mode network resting state regions representing areas significantly decoupled during incentive processing. A) Functional connectivity for FHβ controls with left NAcc; B) functional connectivity for FHβ controls with right NAcc; C) Functional connectivity for FH+ with left NAcc; D) functional connectivity for FH+ with right NAcc. Data are displayed on the lateral and medial surfaces of the left hemisphere (Left), the dorsal surface (Center), and the lateral and medial surfaces of the right hemisphere (Right) for each NAcc. Connectivity maps are displayed at cluster-level p<0.05 corrected with the exception of D) which is displayed at cluster-level p<0.08 due to lack of significant clusters at the more stringent threshold.
Extracted task-related functional connectivity change with NAcc during Incentive>Neutral anticipatory processing by family history group. L, left; R, right; NAcc, nucleus accumbens; SSMA, supplementary sensoriomotor area; PoG, postcentral gyrus; SMA, supplementary motor area; OCC, occipital.
A) Statistical parametric maps identifying large cluster designated supplementary sensorimotor area (SSMA). B) Correlations between left NAccβSSMA incentive connectivity change and sensation-seeking by family history group. C) Correlations between left NAccβSSMA incentive connectivity change and transformed drinking volume for the past six months by family history group.
Meditation model of vulnerability with unstandardized coefficients testing indirect effect of connectivity on relationship of sensation-seeking on drinking volume.
| Name | Type |
|---|---|
| Acute medical illness local | phenotype |
| addiction | phenotype |
| Addictive substance use local | phenotype |
| alcohol | phenotype |
| alcoholism | phenotype |
| alcoholism risk | phenotype |
| Alcohol Use | phenotype |
| amount | phenotype |
| amygdala | anatomy |
| anterior cingulate cortex | anatomy |
| anticipation of incentive stimuli local | phenotype |
| Anticipatory striatal activation local | anatomy |
| anxiety | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| attention network | anatomy |
| auditory/phonology network local | anatomy |
| axis I disorder | phenotype |
| basal ganglia | anatomy |
| caudate nucleus | anatomy |
| Centrally active medications local | drug |
| cerebellum | anatomy |
| cerebral hemispheres | anatomy |
| Chronic health conditions | phenotype |
| chronic heroin users local | cohort |
| Cognitive control regions local | anatomy |
| conduct disorder | phenotype |
| connectivity change local | phenotype |
| control group | cohort |
| Control network local | anatomy |
| control subjects | cohort |
| cortex | anatomy |
| craving | phenotype |
| DD | phenotype |
| decision-making deficits | phenotype |
| default mode network | anatomy |
| depression | phenotype |
| DMN | anatomy |
| drinking | phenotype |
| drinking volume local | phenotype |
| Drinking volume local | phenotype |
| drug dependence | phenotype |
| DV | phenotype |
| early substance use | phenotype |
| externalizing disorders | phenotype |
| Familial liability local | phenotype |
| familial risk | cohort |
| familial risk for substance abuse local | phenotype |
| family history negative | phenotype |
| family history of alcoholism | phenotype |
| family history positive | phenotype |
| fetal alcohol syndrome | phenotype |
| FH | cohort |
| FH+ | drug |
| FHβ local | cohort |
| FH+ families local | cohort |
| FHβ families local | cohort |
| FH group local | cohort |
| FHN | cohort |
| FH+ subjects | cohort |
| FH- subjects local | cohort |
| FHβ subjects local | cohort |
| First 70 neuroimaging participants local | cohort |
| Food sensitivity local | phenotype |
| functional connectivity | phenotype |
| group | cohort |
| healthy controls | cohort |
| heavy drinking | phenotype |
| heroin users | phenotype |
| High-risk population local | cohort |
| high-risk subjects | cohort |
| High risk taking local | phenotype |
| hippocampus | anatomy |
| hostility | phenotype |
| Impulsive decision making | phenotype |
| incentive anticipation local | phenotype |
| incentive connectivity change local | phenotype |
| inferior parietal lobe | anatomy |
| inhibitory control deficits local | phenotype |
| insula | anatomy |
| lateral temporal lobe local | anatomy |
| left NAcc-right precuneus connectivity local | anatomy |
| Left NAcc-right precuneus connectivity local | phenotype |
| left NAcc-SSMA local | anatomy |
| Left NAcc-SSMA incentive connectivity local | phenotype |
| limbic regions | anatomy |
| loss | phenotype |
| loss anticipation | phenotype |
| low familial risk for substance abuse local | phenotype |
| medial orbitofrontal cortex | anatomy |
| medial prefrontal cortex | anatomy |
| medial SSMA local | anatomy |
| Michigan Longitudinal Study | cohort |
| midbrain | anatomy |
| Midline areas local | anatomy |
| midline regions | anatomy |
| MLS | cohort |
| motor network local | anatomy |
| Motor network local | anatomy |
| NAcc | anatomy |
| NAcc-SSMA connectivity local | anatomy |
| Neurological illness local | phenotype |
| neutral | phenotype |
| neutral condition | phenotype |
| Nonalcoholic families local | phenotype |
| novelty seeking | phenotype |
| nucleus accumbens | anatomy |
| obesity | phenotype |
| occipital cortex | anatomy |
| occipital regions local | anatomy |
| Occipital regions local | anatomy |
| orbitofrontal cortex | anatomy |
| other ROIs local | anatomy |
| overeating | phenotype |
| paracentral local | anatomy |
| paracentral lobule | anatomy |
| parental alcoholism | phenotype |
| parietal cortex | anatomy |
| participants | cohort |
| polysubstance abuse | phenotype |
| positive affect | phenotype |
| postcentral gyrus | anatomy |
| precentral gyrus | anatomy |
| precuneus | anatomy |
| premotor cortex | anatomy |
| problem substance users local | cohort |
| psychosis | phenotype |
| putamen | anatomy |
| reaction time | phenotype |
| regulation deficits local | phenotype |
| reward | phenotype |
| reward anticipation | phenotype |
| Rewardβrelated circuitry local | anatomy |
| Reward-related functional connectivity with the NAcc local | anatomy |
| reward system | anatomy |
| Reward task performance local | phenotype |
| right lingual gyrus | anatomy |
| right NAcc-SSMA local | anatomy |
| right NAcc-SSMA connectivity local | phenotype |
| Risk-related behaviors local | phenotype |
| saliency responses local | phenotype |
| schizophrenia | phenotype |
| sedatives | drug |
| self-referential network local | anatomy |
| Sensationβseeking local | phenotype |
| sensation-seeking personality local | phenotype |
| sensation-seeking score local | phenotype |
| sensorimotor cortex | anatomy |
| striatum | anatomy |
| substance abuse | phenotype |
| substance-dependent subjects local | cohort |
| substance use | phenotype |
| substantia nigra | anatomy |
| success rate | phenotype |
| superior temporal local | anatomy |
| supplemental motor area local | anatomy |
| supplementary sensorimotor area local | anatomy |
| Supplementary sensorimotor area local | anatomy |
| Target duration local | phenotype |
| task difficulty | phenotype |
| temporal lobe | anatomy |
| valence | phenotype |
| ventral/rostral anterior cingulate local | anatomy |
| ventral striatum | anatomy |
| ventral tegmental area | anatomy |
| visual network | anatomy |
| young adults | cohort |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth. | Elliott AS et al. | β | 2025 | β |
| Tangent space functional reconfigurations in individuals at risk for alcohol use disorder. | Moghaddam M et al. | β | 2025 | β |
| Unintended bias in the pursuit of collinearity solutions in fMRI analysis. | Mumford JA et al. | β | 2025 | β |
| How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms. | Ruge J et al. | β | 2024 | β |
| Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder. | Miller AP et al. | β | 2024 | β |
| Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events. | Assari S et al. | β | 2024 | β |
| Neural bases of reward anticipation in healthy individuals with low, mid, and high levels of schizotypy. | Carruzzo F et al. | β | 2023 | β |
| Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder | Miller AP et al. | β | 2023 | β |
| The age-varying effects of adolescent stress on impulsivity and sensation seeking. | Wasserman AM et al. | β | 2023 | β |
| A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood. | Kaiser A et al. | β | 2022 | β |
| Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward. | Del Giacco AC et al. | β | 2022 | β |
| Brain functional connectivity during and after imagery of gaming and alternative leisure activities in patients with internet gaming disorder. | Kim SJ et al. | β | 2022 | β |
| Effects of family history of substance use disorder on reward processing in adolescents with and without attention-deficit/hyperactivity disorder. | Paraskevopoulou M et al. | β | 2022 | β |
| Neural heterogeneity underlying late adolescent motivational processing is linked to individual differences in behavioral sensation seeking. | Demidenko MI et al. | β | 2022 | β |
| Functional connectivity in frontostriatal networks differentiate offspring of parents with substance use disorders from other high-risk youth. | Kwon E et al. | β | 2021 | β |
| Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration. | Bart CP et al. | β | 2021 | β |
| Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors andΒ Consequences From a Large Cohort Naturalistic Study. | Ivanov I et al. | β | 2021 | β |
| The externalizing and internalizing pathways to marijuana use initiation: Examining the synergistic effects of impulsiveness and sensation seeking. | Wasserman AM et al. | β | 2021 | β |
| The Human Basal Ganglia Mediate the Interplay between Reactive and Proactive Control of Response through Both Motor Inhibition and Sensory Modulation. | Criaud M et al. | β | 2021 | β |
| Ventral striatal resting-state functional connectivity in adolescents is associated with earlier onset of binge drinking. | Morales AM et al. | β | 2021 | β |
| Alcohol and Human Health: What Is the Evidence? | Hendriks HFJ | β | 2020 | β |
| Basolateral amygdala - nucleus accumbens circuitry regulates optimal cue-guided risk/reward decision making. | van Holstein M et al. | β | 2020 | β |
| Differences in the modulation of functional connectivity by self-talk tasks between people with low and high life satisfaction. | Kyeong S et al. | β | 2020 | β |
| Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse. | Ang YS et al. | β | 2020 | β |
| Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures. | Kamarajan C et al. | β | 2020 | β |
| The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk. | Amico E et al. | β | 2020 | β |
| The ups and downs of relating nondrug reward activation to substance use risk in adolescents. | Bjork JM | β | 2020 | β |
| Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence. | Vaidya JG et al. | β | 2019 | β |
| Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study. | Just AL et al. | β | 2019 | β |
| High sensation seeking is associated with behavioral and neural insensitivity to increased negative outcomes during decision-making under uncertainty. | Xu S et al. | β | 2019 | β |
| Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task. | Cao Z et al. | β | 2019 | β |
| Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings. | Crews FT et al. | β | 2019 | β |
| Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. | Le TM et al. | β | 2019 | β |
| Reward-related regions form a preferentially coupled system at rest. | Huckins JF et al. | β | 2019 | β |
| Sex Differences in the Effect of Nucleus Accumbens Volume on Adolescent Drinking: The Mediating Role of Sensation Seeking in the NCANDA Sample. | Morales AM et al. | β | 2019 | β |
| The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence. | Courtney KE et al. | β | 2019 | β |
| Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain. | Hong JY et al. | β | 2018 | β |
| Decreased Connection Between Reward Systems and Paralimbic Cortex in Depressive Patients. | Bai T et al. | β | 2018 | β |
| Human Striatal Response to Reward Anticipation Linked to Hippocampal Glutamate Levels. | Bossong MG et al. | β | 2018 | β |
| Individual differences in self-reported reward-approach tendencies relate to resting-state and reward-task-based fMRI measures. | Dong G et al. | β | 2018 | β |
| Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use. | Brown-Rice KA et al. | β | 2018 | β |
| Socioeconomic disadvantage and altered corticostriatal circuitry in urban youth. | Marshall NA et al. | β | 2018 | β |
| Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence. | Jones SA et al. | β | 2017 | β |
| Enhanced functional connectivity and volume between cognitive and reward centers of naΓ―ve rodent brain produced by pro-dopaminergic agent KB220Z. | Febo M et al. | β | 2017 | β |
| Executive functioning and substance use in adolescence: Neurobiological and behavioral perspectives. | Kim-Spoon J et al. | β | 2017 | β |
| Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. | Feldstein Ewing SW et al. | β | 2017 | β |
| Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders. | Zahr NM et al. | β | 2017 | β |
| Striatal activation and frontostriatal connectivity during non-drug reward anticipation in alcohol dependence. | Becker A et al. | β | 2017 | β |
| Age associations with neural processing of reward anticipation in adolescents with bipolar disorders. | UroΕ‘eviΔ S et al. | β | 2016 | β |
| Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults. | Joseph JE et al. | β | 2016 | β |
| Neurobiological phenotypes associated with a family history of alcoholism. | Cservenka A | β | 2016 | β |
| Nucleus accumbens functional connectivity discriminates medication-overuse headache. | Torta DM et al. | β | 2016 | β |
| Reduced Functional Connectivity within the Mesocorticolimbic System in Substance Use Disorders: An fMRI Study of Puerto Rican Young Adults. | Posner J et al. | β | 2016 | β |
| Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts. | Rosell-Negre P et al. | β | 2016 | β |
| Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression. | Schilbach L et al. | β | 2016 | β |
| Winning is not enough: ventral striatum connectivity during physical aggression. | Buades-Rotger M et al. | β | 2016 | β |
| Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism. | Cservenka A et al. | β | 2015 | β |
| Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents. | Karoly HC et al. | β | 2015 | β |
| Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks. | Weissman DG et al. | β | 2015 | β |
| Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders. | Holgate JY et al. | β | 2015 | β |
| Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls. | Cservenka A et al. | β | 2015 | β |
| Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior. | Joseph JE et al. | β | 2015 | β |
| National multi-cohort time trends in adolescent risk preference and the relation with substance use and problem behavior from 1976 to 2011. | Keyes KM et al. | β | 2015 | β |
| Neuroimaging Risk Markers for Substance Abuse: Recent Findings on Inhibitory Control and Reward System Functioning. | Heitzeg MM et al. | β | 2015 | β |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | β | 2015 | β |
| The association between alcohol, marijuana use, and new and emerging tobacco products in a young adult population. | Cohn A et al. | β | 2015 | β |
| The quality of adolescents' peer relationships modulates neural sensitivity to risk taking. | Telzer EH et al. | β | 2015 | β |
| Differential reward network functional connectivity in cannabis dependent and non-dependent users. | Filbey FM et al. | β | 2014 | β |
| Exploring the relationship of functional network connectivity to latent trajectories of alcohol use and risky sex. | Thayer RE et al. | β | 2014 | β |
| Functional connectivity in prenatally stressed rats with and without maternal treatment with ladostigil, a brain-selective monoamine oxidase inhibitor. | Goelman G et al. | β | 2014 | β |
| Mapping the development of the basal ganglia in children with attention-deficit/hyperactivity disorder. | Shaw P et al. | β | 2014 | β |
| Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults. | Forbes EE et al. | β | 2014 | β |
| Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance. | Weiland BJ et al. | β | 2014 | β |
| Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism. | Cservenka A et al. | β | 2014 | β |
| Risk perception, motives and behaviours in university students. | Salameh P et al. | β | 2014 | β |
| Sweet-liking is associated with transformation of heavy drinking into alcohol-related problems in young adults with high novelty seeking. | Kampov-Polevoy A et al. | β | 2014 | β |
| Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents. | Spadoni AD et al. | β | 2013 | β |
| What is a representative brain? Neuroscience meets population science. | Falk EB et al. | β | 2013 | β |