The bigger picture of FTO: the first GWAS-identified obesity gene.

paper Cited Public

Authors: Loos, Ruth J F; Yeo, Giles S H
Year: 2014
Journal: Nature reviews. Endocrinology
PMID: 24247219
DOI: 10.1038/nrendo.2013.227
PMCID: PMC4188449

#	Section	Preview
0	Introduction	An estimated 40 to 70% of the variation in obesity susceptibility observed in the population is due…
1	Introduction	largest effect on body mass index (BMI) and obesity risk, most widely replicated with variety of…
2	I. The genetic epidemiology of FTO — The discovery of FTO as the first obesity susceptibility gene	In 2007, within a time period of three months, two studies claimed the discovery of FTO as the first…
3	I. The genetic epidemiology of FTO — The discovery of FTO as the first obesity susceptibility gene	Together, these studies firmly established FTO as the first gene with common variants that affect…
4	I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron	The two GWAS that first reported on FTO as an obesity susceptibility gene each identified a…
5	I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron	The cluster of BMI-associated FTO SNPs in East Asian populations is very similar to that of European…
6	I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron	However, in populations of African ancestry, the correlation between SNPs in FTO’s first intron is…
7	I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron	646kb-region at 16q12.2, encompassing FTO and the neighboring RPGRIP1L, were tested in more than…
8	I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron	Taken together, the BMI-associated FTO region, initially identified in European ancestry population,…
9	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	Since the discovery of FTO in 2007, at least 75 additional obesity-susceptibility loci have been…
10	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	Soon after the discovery of FTO in European ancestry populations, many replication efforts examined…
11	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	each additional minor allele,58 which is substantially less than in European ancestry populations…
12	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	Results of targeted replication of FTO in Africans and African Americans have been…
13	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	SNPs in FTO also show association with obesity-related traits in Hispanic/Latino populations74-77…
14	I. The genetic epidemiology of FTO — Effect size and explained variance across ancestries	Taken together, SNPs in FTO show association with obesity-related traits across many ancestries.…
15	I. The genetic epidemiology of FTO — FTO and obesity risk over the life course	Although FTO was first discovered as an obesity-susceptibility locus in adults,8-10 its associations…
16	I. The genetic epidemiology of FTO — FTO and obesity risk over the life course	While SNPs in FTO do not influence birth weight88-92, longitudinal studies have shown that they…
17	I. The genetic epidemiology of FTO — The role of lifestyle factors in the association between FTO and obesity-susceptibility	To gain insight in the potential mechanisms through which variation in FTO leads to increased risk…
18	I. The genetic epidemiology of FTO — The role of lifestyle factors in the association between FTO and obesity-susceptibility	The evidence supporting a role for FTO in the regulation of food intake is slowly growing. The…
19	I. The genetic epidemiology of FTO — The role of lifestyle factors in the association between FTO and obesity-susceptibility	Studies have consistently shown that FTO SNPs are not associated with physical activity…

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In this knowledge base

Title	Year	PMID
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.	2019	30940813
Endophenotype best practices.	2017	27473600

External

Title	Authors	Journal	Year	Link
2026 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.	Palaniappan LP et al.	—	2026	→
Differential Impact of BMI-Associated Genetic Variants on Breast Cancer Risk: Insights From Mediation Analysis.	Ando Y et al.	—	2026	→
Genetic and clinical determinants of neonatal jaundice and growth patterns in the Qingdao birth cohort: A genome-wide association study.	Chen X et al.	—	2026	→
Genome-wide cross-trait analyses reveal shared genetic architecture and causal links between attention-deficit/hyperactivity disorder and cardiovascular diseases.	Liu HY et al.	—	2026	→
Multidimensional risk impact of obesity on breast cancer incidence, treatment, and prognosis.	Liu Y et al.	—	2026	→
Precision medicine in low-income settings and small island developing states.	Saluja S et al.	—	2026	→
The Common <i>FTO</i> rs9939609 Polymorphism Interacts with Sleeping and Eating Windows to Affect Predisposition to Type 2 Diabetes.	Kazarnovsky Nahshan L et al.	—	2026	→
2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.	Martin SS et al.	—	2025	→
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.	Malone SG et al.	—	2025	→
ALKBH5 Promotes Breast Cancer Stemness Through Regulating Wnt/β-Catenin Signaling.	Wang K et al.	—	2025	→
A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid.	Zhao F et al.	—	2025	→
An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells.	Guang L et al.	—	2025	→
Association Analysis of the <i>FTO</i> Gene Polymorphisms with Growth and Carcass Traits of Heying Black Chicken and Tissue Expression Profile.	Ding H et al.	—	2025	→
Association Between Dietary Fiber Intake and Stroke Among US Adults: From NHANES and Mendelian Randomization Analysis.	Lai S et al.	—	2025	→
Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy.	Firneisz G et al.	—	2025	→
Association of homozygous fat mass and obesity-associated (FTO rs9939609) gene with body mass, body mass index (BMI), and the binge eating scale in women: A cross-sectional study.	Bressan Rente Ferreira Marum A et al.	—	2025	→
Associations Between <i>FTO</i> Polymorphisms and Neuroblastoma Risk in Chinese Children.	Liu P et al.	—	2025	→
Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice.	Steinwand S et al.	—	2025	→
DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues.	Fang MY et al.	—	2025	→
Exploring associations between the FTO rs9939609 genotype and plasma concentrations of appetite-related hormones in adults with obesity.	de Soysa AKH et al.	—	2025	→
Exploring the cecal microbial community associated with fat deposition in sheep and its possible pathways of action.	Cheng J et al.	—	2025	→
Familial Aggregation Patterns, Spousal Resemblance, and Family-Based Heritability of Adiposity-Related Traits: Insights from Tehran Cardiometabolic and Genetic Study (TCGS).	Riahi P et al.	—	2025	→
From Pregnancy to Breastfeeding: The Role of Maternal Exercise in Preventing Childhood Obesity.	Calcaterra V et al.	—	2025	→
FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion.	Zhou C et al.	—	2025	→
FTO rs9939609 polymorphism is associated with dietary quality in Korean females.	Kim M et al.	—	2025	→
Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.	Tejareh F et al.	—	2025	→
Genetic Landscape of Obesity in Children: Research Advances and Prospects.	Khusainova R et al.	—	2025	→
Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma.	Machado ME et al.	—	2025	→
Genetics of Common Obesity in Children and Adolescents.	León-Reyes G et al.	—	2025	→
Genetic studies on metabolic disorder-associated kidney diseases.	Imamura M et al.	—	2025	→
Identifying genetic variants associated with sugar intake and appraising the genetic correlations with cardiovascular outcomes.	Janzi S et al.	—	2025	→
Impact of high-protein, low-calorie diet on anthropometric indices, glycation, and inflammation associated with the fat mass and obesity (FTO) gene among individuals with overweight/obesity.	Hajira B et al.	—	2025	→
Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity.	Zhao QG et al.	—	2025	→
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.	Bjune JI et al.	—	2025	→
Lack of evidence for obesity paradox in patients with cardiovascular disease: A UK BioBank cohort study.	Yu W et al.	—	2025	→
m6A demethylase FTO/ALKBH5 promotes diabetes-induced endothelial cell dysfunction by negatively regulating lncRNA H19.	Luo Y et al.	—	2025	→
Mendelian randomization in SLEEP: avoiding pitfalls with MR-SLEEP guidelines.	Evans DS et al.	—	2025	→
Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight.	Sullivan AI et al.	—	2025	→
Multi-omic insights of preeclampsia and cardiovascular health outcomes.	Giesen EM et al.	—	2025	→
NGS Approaches in Clinical Diagnostics: From Workflow to Disease-Specific Applications.	Brancato D et al.	—	2025	→
Obesity genetic association prospective cohort utilizing single center real-world evidence data.	Bağci Ö et al.	—	2025	→
Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta-Analysis.	Guo F et al.	—	2025	→
Protein and total sugars intake modulate the rs9939609 single nucleotide polymorphism effect at the fat mass and obesity-associated gene on body composition.	Olmedo L et al.	—	2025	→
RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management.	Mohammadi A et al.	—	2025	→
Shared genetic architecture contributes to risk of major cardiovascular diseases.	Qiao J et al.	—	2025	→
Succinic acid-driven gut-fat axis orchestrates abdominal fat deposition in chickens via adipocyte-macrophage crosstalk.	Chen J et al.	—	2025	→
The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome.	Jiang L et al.	—	2025	→
The expanding landscape of genetic causes of obesity.	Semenova E et al.	—	2025	→
The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity.	Halder SK et al.	—	2025	→
The Microbiota and Evolution of Obesity.	Saad MJA et al.	—	2025	→
Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways.	Somala CS et al.	—	2025	→
The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance.	Rastogi A et al.	—	2025	→
Transcriptional control of brown adipocyte differentiation and function by NFIA: recent perspectives on deciphering metabolic diseases.	Hiraike Y	—	2025	→
Understanding and applying gene-environment interactions: a guide for nutrition professionals with an emphasis on integration in African research settings.	Nienaber-Rousseau C	—	2025	→
Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine.	Kunnathodi F et al.	—	2025	→
Visceral fat distribution: Interracial studies.	Banerjee S et al.	—	2025	→
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.	Martin SS et al.	—	2024	→
Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance-The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and <i>FTO</i> Gene Polymorphisms (rs9939609, rs1558902).	Czarnecka A et al.	—	2024	→
Association between body mass index trajectories and type 2 diabetes incidence over an 18-year follow-up in the Tehran Lipid and Glucose Study.	Hassanloo N et al.	—	2024	→
Association between FTO gene polymorphism and obesity in down syndrome children.	Mourad SA et al.	—	2024	→
Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture.	Kang J et al.	—	2024	→
Association of methylation risk score with incident type 2 diabetes mellitus: A nested case-control study.	Huo W et al.	—	2024	→
Associations Between rs9939609 FTO Polymorphism With Nutrient and Food Intake and Adherence to Dietary Patterns in an Urban Argentinian Population.	Olmedo L et al.	—	2024	→
Childhood Adiposity and Risk of Major Clinical Heart Diseases in Adulthood: A Mendelian Randomization Study.	Xiong Y et al.	—	2024	→
CRISPR/Cas9 Technology: A Novel Approach to Obesity Research.	Khademi Z et al.	—	2024	→
Current insights on m6A RNA modification in acute leukemia: therapeutic targets and future prospects.	Kaur P et al.	—	2024	→
Diabetes and obesity: leveraging heterogeneity for precision medicine.	Franks PW et al.	—	2024	→
Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use.	Cai W et al.	—	2024	→
Exploring the therapeutic mechanisms of millet in obesity through molecular docking, pharmacokinetics, and dynamic simulation.	Lakhani KG et al.	—	2024	→
Fine-Scale Haplotype Mapping Reveals an Association of the <i>FTO</i> Gene with Osteoporosis and Fracture Risk in Postmenopausal Women.	Greere D et al.	—	2024	→
From the reward network to whole-brain metrics: structural connectivity in adolescents and young adults according to body mass index and genetic risk of obesity.	Prunell-Castañé A et al.	—	2024	→
FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC.	Li R et al.	—	2024	→
FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque.	Sun J et al.	—	2024	→
FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.	Li G et al.	—	2024	→
Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population.	Vranceanu M et al.	—	2024	→
Genetic markers of cardiac autonomic neuropathy in the Kazakh population.	Bekenova N et al.	—	2024	→
Genetic studies of type 2 diabetes, and microvascular complications of diabetes.	Imamura M et al.	—	2024	→
Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.	Dashti HS et al.	—	2024	→
Influence of the Interaction between Genetic Factors and Breastfeeding on Children's Weight Status: A Systematic Review.	Yang Z et al.	—	2024	→
Integration of observational and causal evidence for the association between adiposity and 17 gastrointestinal outcomes: An umbrella review and meta-analysis.	Kim MS et al.	—	2024	→
Interaction between type 2 diabetes polygenic risk and physical activity on cardiovascular outcomes.	Lee CL et al.	—	2024	→
Maximal Fat Oxidation During Exercise in Healthy Individuals: Lack of Genetic Association with the <i>FTO</i> rs9939609 Polymorphism.	García-Pastor T et al.	—	2024	→
[One perspective of the genetic correlations between obesity, type 2 diabetes and cancer].	Bánhegyi RJ et al.	—	2024	→
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.	Xiao L et al.	—	2024	→
Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China.	Wang Y et al.	—	2024	→
Regulatory effects of natural products on N6-methyladenosine modification: A novel therapeutic strategy for cancer.	Mao-Mao et al.	—	2024	→
RNA modifications in gynecological cancer: current status and future directions.	He W et al.	—	2024	→
Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.	Yanasegaran K et al.	—	2024	→
Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population.	Vanneste M et al.	—	2024	→
The complex web of obesity: from genetics to precision medicine.	M JN et al.	—	2024	→
The evolving process of ferroptosis in thyroid cancer: Novel mechanisms and opportunities.	Yin L et al.	—	2024	→
The Genetics of Obesity.	Siddiqui J et al.	—	2024	→
The <i>FTO</i> variant conferring enhanced UCP1 expression is linked to human migration out of Africa.	Yin N et al.	—	2024	→
The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways<sup>TM</sup>) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial.	Pokushalov E et al.	—	2024	→
The interaction of breastfeeding and genetic factors on childhood obesity.	Danaie M et al.	—	2024	→
Translation of genome-wide association study: from genomic signals to biological insights.	Bruner WS et al.	—	2024	→
A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss.	He Y et al.	—	2023	→
Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.	Krishnan M et al.	—	2023	→
Body Adiposity Partially Mediates the Association between <i>FTO</i> rs9939609 and Lower Adiponectin Levels in Chilean Children.	Ochoa-Rosales C et al.	—	2023	→
Considerations of the Genetic Background of Obesity among Patients with Psoriasis.	Czarnecka A et al.	—	2023	→
Development of a Polygenic Risk Score for BMI to Assess the Genetic Susceptibility to Obesity and Related Diseases in the Korean Population.	Yoon N et al.	—	2023	→
Dietary approach to stop hypertension and healthy eating index 2015, modify the association between FTO polymorphisms and obesity phenotypes.	Hosseini-Esfahani F et al.	—	2023	→
Engineering m<sup>6</sup>A demethylation-activated DNAzyme for visually and sensitively sensing fat mass and obesity-associated protein.	Shi L et al.	—	2023	→
Fat mass and obesity-associated gene (FTO) rs9939609 (A/T) polymorphism and food preference in obese people with low-calorie intake and non-obese individuals with high-calorie intake.	Rahimlou M et al.	—	2023	→
FTO facilitates cancer metastasis by modifying the m<sup>6</sup>A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer.	Gao L et al.	—	2023	→
FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m6A methylation of TNIP1.	Zhou C et al.	—	2023	→
FTO gene variants (rs9939609, rs8050136 and rs17817449) and type 2 diabetes mellitus risk: A Meta-Analysis.	Amine Ikhanjal M et al.	—	2023	→
Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.	Valvi D et al.	—	2023	→
Genetic and epigenetic background of diabetic kidney disease.	Sandholm N et al.	—	2023	→
Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.	Kember RL et al.	—	2023	→
Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review.	van der Meer R et al.	—	2023	→
Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.	Tsao CW et al.	—	2023	→
Identification of four novel loci associated with psychotropic drug-induced weight gain in a Swiss psychiatric longitudinal study: A GWAS analysis.	Sjaarda J et al.	—	2023	→
Increased meso-striatal connectivity mediates trait impulsivity in <i>FTO</i> variant carriers.	Edwin Thanarajah S et al.	—	2023	→
Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.	Viljakainen H et al.	—	2023	→
Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis.	Lamichhane P et al.	—	2023	→
Linkage disequilibrium block single-nucleotide polymorphisms in FTO alpha ketoglutarate dependent dioxygenase gene inference with breast cancer and Type II diabetes in Pakistani female population.	Mansoor Q et al.	—	2023	→
Longitudinal effects of FTO gene polymorphism on body composition, cardiorespiratory fitness, physical activity, inflammatory markers, and cardiovascular risk in children and adolescents. "The UP & DOWN study".	Mier-Mota J et al.	—	2023	→
Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B.	Hu J et al.	—	2023	→
Mendelian randomization for cardiovascular diseases: principles and applications.	Larsson SC et al.	—	2023	→
Mendelian randomization reveals no associations of genetically-predicted obstructive sleep apnea with the risk of type 2 diabetes, nonalcoholic fatty liver disease, and coronary heart disease.	Ding X et al.	—	2023	→
Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing.	Gómez de Cedrón M et al.	—	2023	→
Minor alleles in the <i>FTO</i> SNPs contributed to the increased risk of obesity among Korean adults: meta-analysis from nationwide big data-based studies.	Kim OY et al.	—	2023	→
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.	Small AM et al.	—	2023	→
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.	Jing YX et al.	—	2023	→
N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism.	Zhang H et al.	—	2023	→
Novel insights regarding the role of noncoding RNAs in diabetes.	Macvanin MT et al.	—	2023	→
Sex and Race Differences in Obesity-Related Genetic Susceptibility and Risk of Cardiometabolic Disease in Older US Adults.	Yu H et al.	—	2023	→
The emergent role of mitochondrial RNA modifications in metabolic alterations.	Boughanem H et al.	—	2023	→
The genetic predisposition increases the chances of schoolchildren maintaining higher adiposity levels after three years.	Reuter ÉM et al.	—	2023	→
The rs1421085 variant within FTO promotes brown fat thermogenesis.	Zhang Z et al.	—	2023	→
Timing of Meals and Sleep in the Mediterranean Population: The Effect of Taste, Genetics, Environmental Determinants, and Interactions on Obesity Phenotypes.	Barragán R et al.	—	2023	→
Untargeted Metabolomics and Body Mass in Adolescents: A Cross-Sectional and Longitudinal Analysis.	Singh A et al.	—	2023	→
Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.	Lopdell TJ	—	2023	→
A genome-wide association study of mammographic texture variation.	Liu Y et al.	—	2022	→
Analysis of coding variants in the human FTO gene from the gnomAD database.	Souza Junior MLF et al.	—	2022	→
Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation.	San-Cristobal R et al.	—	2022	→
Association between fat mass and obesity-related variant and osteoarthritis risk: Integrated meta-analysis with bioinformatics.	Zhao K et al.	—	2022	→
Association of <i>GLP1R</i> variants rs2268641 and rs6923761 with obesity and other metabolic parameters in a Polish cohort.	Michałowska J et al.	—	2022	→
Associations between <i>FTO</i> rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults.	Mehrdad M et al.	—	2022	→
Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.	Lazarus E et al.	—	2022	→
CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue.	Bai N et al.	—	2022	→
Comprehensive mutations analyses of <i>FTO</i> (fat mass and obesity-associated gene) and their effects on FTO's substrate binding implicated in obesity.	Kumar R et al.	—	2022	→
Computational study of potential inhibitors for fat mass and obesity-associated protein from seaweed and plant compounds.	Prabhakar L et al.	—	2022	→
Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases.	Wu D et al.	—	2022	→
Development of a genetic risk score for obesity predisposition evaluation.	Damavandi N et al.	—	2022	→
Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma.	Ning J et al.	—	2022	→
Effects of Single Nucleotide Polymorphisms and Mediterranean Diet in Overweight or Obese Postmenopausal Women With Breast Cancer Receiving Adjuvant Hormone Therapy: A Pilot Randomized Controlled Trial.	Cho AR et al.	—	2022	→
Epigenetics and genetics of hepatoblastoma: Linkage and treatment.	Zhu LR et al.	—	2022	→
From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits.	Raben TG et al.	—	2022	→
FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial.	Santos KD et al.	—	2022	→
FTO and Anthropometrics: The Role of Modifiable Factors.	Evans C et al.	—	2022	→
FTO genotype was associated with breast cancer in HER2 negative patients.	Montazeri F et al.	—	2022	→
Genetic loci, rs17817449 and rs6567160, known for obesity and the risk of stroke events among middle-aged and older Chinese people.	Zhong QQ et al.	—	2022	→
Genetic polymorphisms are not associated with energy intake 1 year after Roux-en-Y gastric bypass in women.	Novais PFS et al.	—	2022	→
Genetic variation rs1121980 in the fat mass and obesity-associated gene (<i>FTO</i>) is associated with dietary intake in Koreans.	Goh Y et al.	—	2022	→
Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.	Tsao CW et al.	—	2022	→
Higher Waist Hip Ratio Genetic Risk Score Is Associated with Reduced Weight Loss in Patients with Severe Obesity Completing a Meal Replacement Programme.	Handley D et al.	—	2022	→
Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes.	Li X et al.	—	2022	→
<i>FTO</i> Common Obesity SNPs Interact with Actionable Environmental Factors: Physical Activity, Sugar-Sweetened Beverages and Wine Consumption.	Chermon D et al.	—	2022	→
Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.	Dashti HS et al.	—	2022	→
Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.	Yousuf AM et al.	—	2022	→
Maternal BMI and allergy in children until 3 years of age (JECS).	Hayashi D et al.	—	2022	→
Mechanisms of Weight Control by Primary Cilia.	Lee CH et al.	—	2022	→
Mediterranean Diet and Genetic Determinants of Obesity and Metabolic Syndrome in European Children and Adolescents.	Seral-Cortes M et al.	—	2022	→
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges.	Wang C et al.	—	2022	→
Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission.	Hazewinkel AD et al.	—	2022	→
Molecular mechanisms of transgenerational epigenetic inheritance.	Fitz-James MH et al.	—	2022	→
Multidisciplinary Progress in Obesity Research.	Lu X et al.	—	2022	→
Obesity, Bone Loss, and Periodontitis: The Interlink.	Zhao P et al.	—	2022	→
Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background.	VerHague M et al.	—	2022	→
Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.	Fabozzi G et al.	—	2022	→
Polygenic and socioeconomic risk for high body mass index: 69 years of follow-up across life.	Bann D et al.	—	2022	→
Potential Target Analysis of Triptolide Based on Transcriptome-Wide m<sup>6</sup>A Methylome in Rheumatoid Arthritis.	Fan D et al.	—	2022	→
Recruitment of CTCF to an <i>Fto</i> enhancer is responsible for transgenerational inheritance of BPA-induced obesity.	Jung YH et al.	—	2022	→
Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.	Saqlain M et al.	—	2022	→
Role of m6A writers, erasers and readers in cancer.	Fang Z et al.	—	2022	→
scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies.	Jia P et al.	—	2022	→
Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models.	Chen Y et al.	—	2022	→
Smooth muscle cell FTO regulates contractile function.	Luse MA et al.	—	2022	→
Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes.	Chailurkit LO et al.	—	2022	→
The genetics of obesity: from discovery to biology.	Loos RJF et al.	—	2022	→
The Influence of <i>FTO, FABP2, LEP, LEPR,</i> and <i>MC4R</i> Genes on Obesity Parameters in Physically Active Caucasian Men.	Maculewicz E et al.	—	2022	→
The interaction between genetic polymorphisms in FTO, MC4R and MTHFR genes and adherence to the Mediterranean Diet in relation to obesity.	Aoun C et al.	—	2022	→
The N6-Methyladenosine Modification and Its Role in mRNA Metabolism and Gastrointestinal Tract Disease.	Cai T et al.	—	2022	→
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits.	Hinney A et al.	—	2022	→
The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis.	Najd-Hassan-Bonab L et al.	—	2022	→
The role of RNA modification in hepatocellular carcinoma.	Feng Q et al.	—	2022	→
The roles of RNA N<sup>6</sup>-methyladenosine in esophageal cancer.	Teng C et al.	—	2022	→
The sex-specific influence of <i>FTO</i> genotype on exercise intervention for weight loss in adult with obesity.	Wang W et al.	—	2022	→
Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.	Bays HE et al.	—	2022	→
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.	Li CM et al.	—	2021	→
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.	Arslanian KJ et al.	—	2021	→
APOL1 renal risk variants are associated with obesity and body composition in African ancestry adults: An observational genotype-phenotype association study.	Nadkarni GN et al.	—	2021	→
Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea.	Hoang T et al.	—	2021	→
Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.	Dorling JL et al.	—	2021	→
Association between the <i>FTO</i> A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers.	Zmijewski P et al.	—	2021	→
Common and Unique Genetic Background between Attention-Deficit/Hyperactivity Disorder and Excessive Body Weight.	Dmitrzak-Weglarz M et al.	—	2021	→
Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.	Chalazan B et al.	—	2021	→
Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies.	Kumar SU et al.	—	2021	→
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study.	Seral-Cortes M et al.	—	2021	→
Epitranscriptomic modifications in acute myeloid leukemia: m<sup>6</sup>A and 2'-<i>O</i>-methylation as targets for novel therapeutic strategies.	Pauli C et al.	—	2021	→
Fat mass and obesity-associated protein regulates lipogenesis via m<sup>6</sup> A modification in fatty acid synthase mRNA.	Sun D et al.	—	2021	→
FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma.	Xiao F et al.	—	2021	→
Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?	Vrablik M et al.	—	2021	→
Genetics of Obesity: What We Have Learned Over Decades of Research.	Bouchard C	—	2021	→
Genetics of Sleep and Insights into Its Relationship with Obesity.	Dashti HS et al.	—	2021	→
Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity.	Liu Y et al.	—	2021	→
Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection.	Hu D et al.	—	2021	→
Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.	Virani SS et al.	—	2021	→
Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs.	Han T et al.	—	2021	→
Independent and combined associations between fast-food outlet exposure and genetic risk for obesity: a population-based, cross-sectional study in the UK.	Burgoine T et al.	—	2021	→
Intersecting Genetics of Frailty and Cardiovascular Disease.	Ahisar Y et al.	—	2021	→
Lesser Investigated Natural Ingredients for the Management of Obesity.	Majeed M et al.	—	2021	→
<i>FTO</i> gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population.	Isgin-Atici K et al.	—	2021	→
Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank.	Widen E et al.	—	2021	→
Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus.	Felisbino K et al.	—	2021	→
Obesity Management and Chronic Kidney Disease.	Chen Y et al.	—	2021	→
Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.	Li Y et al.	—	2021	→
Racial Disparities in Obesity Treatment Among Children and Adolescents.	Johnson VR et al.	—	2021	→
Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria.	Marchetti J et al.	—	2021	→
Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis.	Zhuang Z et al.	—	2021	→
Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population.	Janzi S et al.	—	2021	→
Targeting the RNA demethylase FTO for cancer therapy.	Zhou LL et al.	—	2021	→
The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.	Zhang X et al.	—	2021	→
The impact of late-career job loss and genetic risk on body mass index: Evidence from variance polygenic scores.	Schmitz LL et al.	—	2021	→
The interaction between FTO rs9939609 and physical activity is associated with a 2-fold reduction in the risk of obesity in Korean population.	Cho HW et al.	—	2021	→
The Phytochemical Rhein Mediates M<sup>6</sup>A-Independent Suppression of Adipocyte Differentiation.	Huang L et al.	—	2021	→
The role of genomics in global cancer prevention.	Ginsburg O et al.	—	2021	→
The role of the FTO gene in the relationship between depression and obesity. A systematic review.	Zarza-Rebollo JA et al.	—	2021	→
The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study.	Masip G et al.	—	2021	→
Transcriptome-wide association study identifies multiple genes associated with childhood body mass index.	Yao S et al.	—	2021	→
Understanding the appetite modulation pathways: The role of the FFA1 and FFA4 receptors.	Freitas RDS et al.	—	2021	→
Alteration of N<sup>6</sup>-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.	Li X et al.	—	2020	→
A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population.	Alathari BE et al.	—	2020	→
Are genes destiny? Exploring the role of intrauterine environment in moderating genetic influences on body mass.	Kim J	—	2020	→
Direct-to-Consumer Nutrigenetics Testing: An Overview.	Floris M et al.	—	2020	→
Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty.	Anguita-Ruiz A et al.	—	2020	→
Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observational Cohort Study.	Hawley NL et al.	—	2020	→
FTO - A Common Genetic Basis for Obesity and Cancer.	Lan N et al.	—	2020	→
Genetic predisposition in type 2 diabetes: A promising approach toward a personalized management of diabetes.	Sirdah MM et al.	—	2020	→
Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes.	Löfvenborg JE et al.	—	2020	→
Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.	Virani SS et al.	—	2020	→
Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study.	Man T et al.	—	2020	→
Identifying causal variants and genes using functional genomics in specialized cell types and contexts.	Liu B et al.	—	2020	→
Influence of FTO (Fat mass and obesity) gene and parental obesity on Brazilian children and adolescents adiposity.	Todendi PF et al.	—	2020	→
Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis.	Diels S et al.	—	2020	→
Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children.	Zhu Q et al.	—	2020	→
Investigating Mitonuclear Genetic Interactions Through Machine Learning: A Case Study on Cold Adaptation Genes in Human Populations From Different European Climate Regions.	Kalyakulina A et al.	—	2020	→
Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of <i>Annona muricata</i> Annonaceae: in silico and in vivo studies.	Elekofehinti OO et al.	—	2020	→
<i>SLC30A8, CDKAL1, TCF7L2, KCNQ1</i> and <i>IGF2BP2</i> are Associated with Type 2 Diabetes Mellitus in Iranian Patients.	Vatankhah Yazdi K et al.	—	2020	→
LMX1B rs10733682 Polymorphism Interacts with Macronutrients, Dietary Patterns on the Risk of Obesity in Han Chinese Girls.	Zhu Q et al.	—	2020	→
Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.	Elman I et al.	—	2020	→
No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males.	Dorling JL et al.	—	2020	→
Nutrigenetics/Nutrigenomics, Personalized Nutrition, and Precision Healthcare.	Marcum JA	—	2020	→
Precision Surgery for Obesity.	Dong Z et al.	—	2020	→
Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females.	Al Asoom LI et al.	—	2020	→
Replication of FTO Gene associated with lean mass in a Meta-Analysis of Genome-Wide Association Studies.	Ran S et al.	—	2020	→
Retrospective study of gene signatures and prognostic value of m6A regulatory factor in non-small cell lung cancer using TCGA database and the verification of FTO.	Shi H et al.	—	2020	→
The Effect Sizes of <i>PPARγ</i> rs1801282<i>, FTO</i> rs9939609, and <i>MC4R</i> rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study.	Bakhashab S et al.	—	2020	→
The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer.	Xu Y et al.	—	2020	→
The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood.	Schnurr TM et al.	—	2020	→
The obesity epidemic - Nature via nurture: A narrative review of high-income countries.	Jackson SE et al.	—	2020	→
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.	Zhao X et al.	—	2020	→
Acute Deletion of METTL14 in β-Cells of Adult Mice Results in Glucose Intolerance.	Men L et al.	—	2019	→
A genome-wide association study of bitter and sweet beverage consumption.	Zhong VW et al.	—	2019	→
Association of FTO Gene Variant (rs8050136) with Type 2 Diabetes and Markers of Obesity, Glycaemic Control and Inflammation.	Bego T et al.	—	2019	→
Association of <i>FTO</i> and <i>ADRB2</i> gene variation with energy restriction induced adaptations in resting energy expenditure and physical activity.	Camps SGJA et al.	—	2019	→
Clinical Insights into the Genetic Overlap Between Obesity Susceptibility and Food Choices.	Merino J	—	2019	→
Dynamic changes of muscle insulin sensitivity after metabolic surgery.	Gancheva S et al.	—	2019	→
Emotion-driven impulsiveness but not decision-making ability and cognitive inflexibility predicts weight status in adults.	Coumans JMJ et al.	—	2019	→
Environmental and Nutritional Effects Regulating Adipose Tissue Function and Metabolism Across Generations.	Sun W et al.	—	2019	→
Evidence for the association between <i>FTO</i> gene variants and vitamin B12 concentrations in an Asian Indian population.	Surendran S et al.	—	2019	→
Functional genomic characterization of the <i>FTO</i> locus in African Americans.	Gill R et al.	—	2019	→
Functions of RNA N6-methyladenosine modification in cancer progression.	Chen B et al.	—	2019	→
Functions of RNA N6-methyladenosine modification in cancer progression.	Chen B et al.	—	2019	→
Genetic determinants of beverage consumption: Implications for nutrition and health.	Cornelis MC	—	2019	→
Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.	González-Herrera L et al.	—	2019	→
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.	Kranzler HR et al.	—	2019	→
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.	Wang H et al.	—	2019	→
Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.	Benjamin EJ et al.	—	2019	→
Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity.	Wang Y et al.	—	2019	→
<i>FTO</i> Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population.	Hebbar P et al.	—	2019	→
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.	de Soysa AKH et al.	—	2019	→
Investigation of potential genomic biomarkers for obesity and personalized medicine.	Ergören MC et al.	—	2019	→
Media Multitasking Is Associated With Higher Body Mass Index in Pre-adolescent Children.	Lopez RB et al.	—	2019	→
MicroRNAs in Obesity and Related Metabolic Disorders.	Landrier JF et al.	—	2019	→
New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.	Hwang LD et al.	—	2019	→
Obesity: global epidemiology and pathogenesis.	Blüher M	—	2019	→
Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity.	Ferris E et al.	—	2019	→
Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traits	Shikov AE et al.	—	2019	—
Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years.	Manco L et al.	—	2019	→
Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice.	Rong B et al.	—	2019	→
Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.	de Marco G et al.	—	2019	→
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.	Salem ESB et al.	—	2019	→
The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes.	Guilherme JPLF et al.	—	2019	→
The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population.	Nasser FA et al.	—	2019	→
The FTO Gene and Measured Food Intake in 5- to 10-Year-Old Children Without Obesity.	Ranzenhofer LM et al.	—	2019	→
The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population.	Saber-Ayad M et al.	—	2019	→
The FTO rs9939609 "A" allele is associated with impaired fasting glucose and insulin resistance in Emirati population.	Saber-Ayad M et al.	—	2019	→
Unpacking the heritability of body mass index and other ratios.	Blomquist GE	—	2019	→
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.	Song T et al.	—	2019	→
Above the Epitranscriptome: RNA Modifications and Stem Cell Identity.	Morena F et al.	—	2018	→
Assessing effect of interaction between the <i>FTO</i> A/T polymorphism (rs9939609) and physical activity on obesity-related traits.	Leońska-Duniec A et al.	—	2018	→
[Association between copy number variations and risk of overweight/obesity among Han, Uyghur, and Kazak children].	Ainiwaer A et al.	—	2018	→
Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?	Al-Serri A et al.	—	2018	→
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.	Taira M et al.	—	2018	→
Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline.	Cornet C et al.	—	2018	→
Computational analyses of obesity associated loci generated by genome-wide association studies.	Cheng M et al.	—	2018	→
Critical Enzymatic Functions of FTO in Obesity and Cancer.	Deng X et al.	—	2018	→
Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity.	Olivo G et al.	—	2018	→
Drug development in the era of precision medicine.	Dugger SA et al.	—	2018	→
Effect of Obesity-Linked <i>FTO</i> rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women.	West NR et al.	—	2018	→
Fat mass and obesity-associated (FTO) rs9939609 polymorphism modifies the relationship between body mass index and affective symptoms through the life course: a prospective birth cohort study.	Koike S et al.	—	2018	→
Fat mass and obesity-associated gene rs9939609 polymorphism is a potential biomarker of recurrent venous thromboembolism in male but not in female patients.	Ahmad A et al.	—	2018	→
FTO affects food cravings and interacts with age to influence age-related decline in food cravings.	Dang LC et al.	—	2018	→
FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells.	Chen A et al.	—	2018	→
Genes associated with Type 2 Diabetes and vascular complications.	Montesanto A et al.	—	2018	→
Genetical genomics of growth in a chicken model.	Johnsson M et al.	—	2018	→
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association.	Benjamin EJ et al.	—	2018	→
Identification of Natural Compound Radicicol as a Potent FTO Inhibitor.	Wang R et al.	—	2018	→
<i>FTO</i> genotype, dietary protein intake, and body weight in a multiethnic population of young adults: a cross-sectional study.	Merritt DC et al.	—	2018	→
Impact of Genetic Variants on the Individual Potential for Body Fat Loss.	Cha S et al.	—	2018	→
Influence of <i>FTO</i> rs9939609 polymorphism on appetite, ghrelin, leptin, IL6, TNFα levels, and food intake of women with morbid obesity.	Magno FCCM et al.	—	2018	→
Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease.	Zhang Q et al.	—	2018	→
Kernel machine SNP set analysis provides new insight into the association between obesity and polymorphisms located on the chromosomal 16q.12.2 region: Tehran Lipid and Glucose Study.	Javanrouh N et al.	—	2018	→
Late effects in survivors of childhood acute lymphoblastic leukemia in the context of selected gene polymorphisms.	Kwiecinska K et al.	—	2018	→
Mouse models of peripheral metabolic disease.	da Silva Xavier G et al.	—	2018	→
Nutritional Genomics and Direct-to-Consumer Genetic Testing: An Overview.	Guasch-Ferré M et al.	—	2018	→
Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women.	Groth SW et al.	—	2018	→
Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.	Kodama S et al.	—	2018	→
Relationship between fat mass and obesity-associated gene expression and type 2 diabetes mellitus severity.	Wang Q et al.	—	2018	→
RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N<sup>6</sup> -methyladenosine (m<sup>6</sup> A).	Tan B et al.	—	2018	→
Splicing QTL of human adipose-related traits.	Ma L et al.	—	2018	→
<sup>1</sup>H, <sup>15</sup>N, <sup>13</sup>C backbone resonance assignment of human Alkbh5.	Purslow JA et al.	—	2018	→
The FTO variant is associated with chronic complications of diabetes mellitus in Czech population.	Hubacek JA et al.	—	2018	→
The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.	Kobayashi M et al.	—	2018	→
Women-specific risk factors for heart failure: A genetic approach.	van der Kemp J et al.	—	2018	→
A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.	Kim HS et al.	—	2017	→
Association analysis of FTO gene polymorphisms with obesity in Greek adults.	Goutzelas Y et al.	—	2017	→
C57BL/6J mice as a polygenic developmental model of diet-induced obesity.	Chu DT et al.	—	2017	→
Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial.	Celis-Morales C et al.	—	2017	→
Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS).	Han TS et al.	—	2017	→
Current Scope and Challenges in Phenome-Wide Association Studies.	Verma A et al.	—	2017	→
Endophenotype best practices.	Iacono WG et al.	—	2017	→
Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies.	Wagner R et al.	—	2017	→
Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position.	Heffernan SM et al.	—	2017	→
Fat mass and obesity-associated gene variations are related to fatty liver disease in HIV-infected patients.	Núñez-Torres R et al.	—	2017	→
FTO associations with obesity and telomere length.	Zhou Y et al.	—	2017	→
FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population.	Oyeyemi BF et al.	—	2017	→
FTO gene polymorphisms (rs9939609 and rs17817449) as predictors of Type 2 Diabetes Mellitus in obese Iraqi population.	Younus LA et al.	—	2017	→
Genetic and neural predictors of behavioral weight loss treatment: A preliminary study.	Chen EY et al.	—	2017	→
Genetics of fat intake in the determination of body mass.	Chmurzynska A et al.	—	2017	→
Genetic variation in the obesity gene FTO is not associated with decreased fat oxidation: the NEO study.	Blauw LL et al.	—	2017	→
Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence?	Goodyear K et al.	—	2017	→
Higher prevalence of FTO gene risk genotypes AA rs9939609, CC rs1421085, and GG rs17817449 and saliva containing Staphylococcus aureus in obese women in Croatia.	Huđek A et al.	—	2017	→
Impact of FTO SNPs <i>rs9930506</i> and <i>rs9939609</i> in Prostate Cancer Severity in a Cohort of Puerto Rican Men.	Salgado-Montilla JL et al.	—	2017	→
Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism.	Arif W et al.	—	2017	→
Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies	Jafari Nedooshan J et al.	—	2017	→
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.	Aas A et al.	—	2017	→
Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues.	Nowacka-Woszuk J et al.	—	2017	→
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.	Sharma A et al.	—	2017	→
Post-transcriptional gene regulation by mRNA modifications.	Zhao BS et al.	—	2017	→
Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome.	de Toro-Martín J et al.	—	2017	→
Prioritising Causal Genes at Type 2 Diabetes Risk Loci.	Grotz AK et al.	—	2017	→
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.	Rathjen T et al.	—	2017	→
Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.	McCaffery JM et al.	—	2017	→
Role of microRNAs in obesity and obesity-related diseases.	Iacomino G et al.	—	2017	→
rs9939609 FTO genotype associations with FTO methylation level influences body mass and telomere length in an Australian rural population.	Zhou Y et al.	—	2017	→
Systems biology of personalized nutrition.	van Ommen B et al.	—	2017	→
Television food advertisement exposure and FTO rs9939609 genotype in relation to excess consumption in children.	Gilbert-Diamond D et al.	—	2017	→
The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.	Say YH et al.	—	2017	→
The contribution of genetics and environment to obesity.	Albuquerque D et al.	—	2017	→
The FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals.	Yu JH et al.	—	2017	→
Variation in the Sweet Taste Receptor Gene and Dietary Intake in a Swedish Middle-Aged Population.	Habberstad C et al.	—	2017	→
What Twin Studies Tell Us About Brain Responses to Food Cues.	Schur E et al.	—	2017	→
A clinical perspective of obesity, metabolic syndrome and cardiovascular disease.	Han TS et al.	—	2016	→
Advances in Exercise, Fitness, and Performance Genomics in 2015.	Sarzynski MA et al.	—	2016	→
A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery.	Bandstein M et al.	—	2016	→
A Novel Inhibitor of the Obesity-Related Protein FTO.	Qiao Y et al.	—	2016	→
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.	Çağlayan AO et al.	—	2016	→
Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy.	Martins MC et al.	—	2016	→
A thrifty variant in CREBRF strongly influences body mass index in Samoans.	Minster RL et al.	—	2016	→
Beyond BMI: Conceptual Issues Related to Overweight and Obese Patients.	Müller MJ et al.	—	2016	→
Changes in Physical Activity Following a Genetic-Based Internet-Delivered Personalized Intervention: Randomized Controlled Trial (Food4Me).	Marsaux CF et al.	—	2016	→
Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study.	Iacomino G et al.	—	2016	→
Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study.	Labayen I et al.	—	2016	→
Five-Factor Model Personality Traits and the Objective and Subjective Experience of Body Weight.	Sutin AR et al.	—	2016	→
FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.	Xiang L et al.	—	2016	→
FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention.	Sailer C et al.	—	2016	→
FTO modulates fibrogenic responses in obstructive nephropathy.	Wang CY et al.	—	2016	→
FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?	Landgraf K et al.	—	2016	→
Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening.	Xia P et al.	—	2016	→
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study.	Silventoinen K et al.	—	2016	→
Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology.	Schnurr TM et al.	—	2016	→
Genetics of Insulin Resistance and the Metabolic Syndrome.	Brown AE et al.	—	2016	→
Genetic variants influencing effectiveness of exercise training programmes in obesity - an overview of human studies.	Leońska-Duniec A et al.	—	2016	→
Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men.	Hubacek JA et al.	—	2016	→
Genome-wide association study for the interaction between BMR and BMI in obese Korean women including overweight.	Lee M et al.	—	2016	→
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.	Kilpeläinen TO et al.	—	2016	→
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.	Heni M et al.	—	2016	→
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.	Young AI et al.	—	2016	→
N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.	Zou S et al.	—	2016	→
N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.	Wu R et al.	—	2016	→
N(6)-Methyladenosine Methyltransferases and Demethylases: New Regulators of Stem Cell Pluripotency and Differentiation.	Wu Y et al.	—	2016	→
N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.	Maity A et al.	—	2016	→
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study.	Celis-Morales C et al.	—	2016	→
Relationships between <i>FTO</i> rs9939609, <i>MC4R</i> rs17782313, and <i>PPARγ</i> rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study.	Rotter I et al.	—	2016	→
Resting-State Brain and the FTO Obesity Risk Allele: Default Mode, Sensorimotor, and Salience Network Connectivity Underlying Different Somatosensory Integration and Reward Processing between Genotypes.	Olivo G et al.	—	2016	→
Sex-Specific Association between Longitudinal Changes in Adiposity, FTO rs9939609 Polymorphism, and Leukocyte Telomere Length.	Shin C et al.	—	2016	→
The Elevated Susceptibility to Diabetes in India: An Evolutionary Perspective.	Wells JC et al.	—	2016	→
The genetic architecture of body mass index from infancy to adulthood modified by parental education.	Silventoinen K et al.	—	2016	→
Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them.	Mbarek H et al.	—	2016	→
Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population.	Zeng X et al.	—	2015	→
Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice.	van Norren K et al.	—	2015	→
Contributions of maternal and paternal adiposity and smoking to adult offspring adiposity and cardiovascular risk: the Midspan Family Study.	Han TS et al.	—	2015	→
Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.	Albuquerque D et al.	—	2015	→
Developmental biology. A Me6Age for pluripotency.	Stunnenberg HG et al.	—	2015	→
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.	Qi Q et al.	—	2015	→
Epigenetics of obesity: beyond the genome sequence.	Cordero P et al.	—	2015	→
FTO influences adipogenesis by regulating mitotic clonal expansion.	Merkestein M et al.	—	2015	→
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.	Wang CY et al.	—	2015	→
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.	Claussnitzer M et al.	—	2015	→
Genetics in child and adolescent psychiatry: methodological advances and conceptual issues.	Hohmann S et al.	—	2015	→
Genome-wide association studies of human adiposity: Zooming in on synapses.	Sandholt CH et al.	—	2015	→
Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO).	He W et al.	—	2015	→
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.	Tomei S et al.	—	2015	→
Relation of the multilocus genetic composite reflecting high dopamine signaling capacity to future increases in BMI.	Yokum S et al.	—	2015	→
Ribonucleic acid (RNA) biosynthesis in human cancer.	Hajjawi OS	—	2015	→
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.	Yue Y et al.	—	2015	→
Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.	Manning S et al.	—	2015	→
Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.	Liu X et al.	—	2015	→
The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors.	Äijälä M et al.	—	2015	→
The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.	Speakman JR	—	2015	→
The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients.	Bandstein M et al.	—	2015	→
[Bardet-Biedl syndrome: cilia and obesity - from genes to integrative approaches].	Chennen K et al.	—	2014	→
Changes in gene expression associated with FTO overexpression in mice.	Merkestein M et al.	—	2014	→
Effect of the FTO rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort.	Coto E et al.	—	2014	→
Epigenetics in health and disease: heralding the EWAS era.	Murphy TM et al.	—	2014	→
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.	Zhao X et al.	—	2014	→
FTO-genotype affects postprandial neuronal responses to visual food cues.	Ott V et al.	—	2014	→
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.	Pineda-Tenor D et al.	—	2014	→
Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss.	Goni L et al.	—	2014	→
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.	Batista PJ et al.	—	2014	→
Methyltransferases modulate RNA stability in embryonic stem cells.	Lin S et al.	—	2014	→
Obesity and FTO: Changing Focus at a Complex Locus.	Tung YCL et al.	—	2014	→
Poor ability to resist tempting calorie rich food is linked to altered balance between neural systems involved in urge and self-control.	He Q et al.	—	2014	→
Role of RNA methyltransferases in tissue renewal and pathology.	Blanco S et al.	—	2014	→
The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.	Yeo GS	—	2014	→