Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

A heatmap depicting LDSC genome-wide genetic correlations between psychiatric and immune-related conditions such that red reflects more positive correlation coefficients while blue reflects more negative coefficients. Correlation coefficients are provided within each cell, with full details provided in Supplementary Table 2. Correlations reaching trend-level significance (0.05 < uncorrected p < 0.10) are depicted as colored panels, while relationships surpassing uncorrected p < 0.05 are additionally denoted with *, and relationships surpassing BH-p < 0.05 (for the total number of tests depicted in the figure) are denoted with **. The rows and columns of the heatmap are hierarchically clustered based on correlation coefficients. Abbreviations: Attention deficit-hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD).

This figure depicts the HESS local genetic correlation data with respect to the genome and previously reported genome-wide association signals for respective disorders. A model genome using HG19 coordinates is depicted in grey. Moving outward from the center of the plot, the first track containing a red histogram depicts loci significantly associated with SZ (GWAS p < 5×10−8), with larger peaks indicating more significance (plotted as -log(p-value)). The second track (labeled SZ-CD) depicts regions of genetic correlation between SZ and CD, such that blue reflects uncorrected p < 0.05 and red reflects BH corrected p < 0.05. The next track (labeled CD Hits) contains a histogram depicting CD GWAS signal as described previously. The next pair of tracks depict genetic correlations for SZ-PBC and PBC GWAS signal, respectively. The third pair of tracks depicts this information for SZ-SLE (with SLE GWAS signal). The fourth pair of tracks depicts this information for SZ-UC and UC GWAS signal, respectively. In the center of the plot, we identify several GWAS candidate genes using colored text and arrows to indicate the pertinent locus; colored text and arrows are used to indicate the relevant phenotype-pairs, such that green = SZ-CD, orange = SZ-PBC, yellow = SZ-SLE, brown = SZ-PBC/SLE, and purple = SZ/BD-CD/PBC/UC.