Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence.
paper
Cited
Public
- Authors
- Mistry, Chetna J; Bawor, Monica; Desai, Dipika; Marsh, David C; Samaan, Zainab
- Year
- 2014
- Journal
- Current psychiatry reviews
- PMID
- 25242908
- DOI
- 10.2174/1573400510666140320000928
- PMCID
- PMC4155832
This narrative review aims to provide an overview of the impact of opioid dependence and the contribution of genetics to opioid dependence. Epidemiological data demonstrate that opioid dependence is a global trend with far-reaching effects on the social, economic, and health care systems. A review of classical genetic studies of opioid use suggests significant heritability of drug use behavior, however the evidence from molecular genetic studies is inconclusive. Nonetheless, certain genetic variants are important to consider given their role in the pathophysiology of addictive behavior. We undertook a literature review to identify the current state of knowledge regarding the role of genes in opioid dependence. Determining the association of genetic markers could change the current understanding of the various factors contributing to opioid dependence and therefore may improve recognition of individuals at risk for the disorder and prevention and treatment strategies.
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| 20 | INTERNAL PREPAREDNESS OR INTRINSIC VARIABLES | Therefore, it would be beneficial to monitor and assess behavioural patterns in order to identify⦠|
| 21 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Family and Twin Studies | Family, twin, and adoption studies have consistently reported that genetic factors contribute toβ¦ |
| 22 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Family and Twin Studies | Tsuang et al. [57] conducted a twin study including 3372 male twin pairs from the Vietnam Era Twinβ¦ |
| 23 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Family and Twin Studies | Using the same study population, the Harvard Twin Study of Substance Abuse that was conducted byβ¦ |
| 24 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Family and Twin Studies | The same research team investigated the genetic and environmental influences on transitions in drugβ¦ |
| 25 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Family and Twin Studies | The familial aggregation of substance use disorders was investigated in families of probands withβ¦ |
| 26 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors | Dopamine, a neurotransmitter widely distributed throughout the central nervous system (CNS), isβ¦ |
| 27 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β i. DRD2 | The D2 dopamine receptor is coded by the DRD2 gene located on chromosome 11q23 [62]. Polymorphismsβ¦ |
| 28 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β i. DRD2 | Hou et al. [64] investigated the association between the rs1800497polymorphism and heroinβ¦ |
| 29 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β i. DRD2 | In another study by Lawford et al. [63], the frequency of the rs1800497 A1 allele in 95 Caucasianβ¦ |
| 30 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β ii. DRD3 | The D3 dopamine receptors are coded by the DRD3 gene, which is found on chromosome 3q13.3 [66], andβ¦ |
| 31 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β ii. DRD3 | Duaux et al. [67] studied the BalI polymorphism in the DRD3 gene using a French Caucasian maleβ¦ |
| 32 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β iii. DRD4 | The dopamine D4 receptor is encoded by the DRD4 gene located on chromosome 11p15.5 [66]. The exonβ¦ |
| 33 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β iii. DRD4 | controls, providing evidence for an association with heroin dependence [68]. A study of DRD4 exonβ¦ |
| 34 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β iii. DRD4 | Kotler et al. [60] investigated the association between novelty seeking and long repeat alleles ofβ¦ |
| 35 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β A. Dopamine Receptors β iii. DRD4 | Similar findings were reported in a case-control study of Han Chinese subjects including 121β¦ |
| 36 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β B. Opioid Receptors | The ΞΌ, ΞΊ, and Ξ΄ opioid receptors belong to the class of G-protein coupled receptors that areβ¦ |
| 37 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β B. Opioid Receptors β i. OPRM1 | The opioid receptor ΞΌ 1 (OPRM1) gene, located on chromosome 6q24-q25 [72], is responsible forβ¦ |
| 38 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β B. Opioid Receptors β i. OPRM1 | In a study by Bond et al. [73], the investigators concluded that the most prevalent SNPs in theβ¦ |
| 39 | GENETIC SUSCEPTIBILITY TO OPIOID DEPENDENCE β Candidate Gene Studies β B. Opioid Receptors β i. OPRM1 | = 1, P = 0.054) [73]. Different patterns are observed in a group of American, Finish, and Nativeβ¦ |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome. | Borrego-Ruiz A et al. | β | 2025 | β |
| Genetic and Epigenetic Approaches to Opioid Use Disorder. | Ranadeva ND et al. | β | 2025 | β |
| Identification of variants from gene expression data of opioid-addicted patients. | Ajmeriya S et al. | β | 2025 | β |
| Opioid Use Disorders: Prevention, Diagnosis, and Treatment Strategies to Mitigate Addiction Risks. | Agarwal U et al. | β | 2025 | β |
| Predicting postoperative chronic opioid use with fair machine learning models integrating multi-modal data sources: a demonstration of ethical machine learning in healthcare. | Soley N et al. | β | 2025 | β |
| Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol. | Campbell M et al. | β | 2025 | β |
| Clinical characteristics associated with problematic pornography use among individuals seeking treatment for opioid use disorder. | Stefanovics EA et al. | β | 2024 | β |
| Evolutionary perspectives on substance and behavioural addictions: Distinct and shared pathways to understanding, prediction and prevention. | Hunt A et al. | β | 2024 | β |
| Impact of Prescription Opioid Detoxification on Quality of Life and Pain Levels. | Laubner SakalauskienΔ G et al. | β | 2024 | β |
| Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells. | Qian C et al. | β | 2024 | β |
| Molecular and Environmental Determinants of Addictive Substances. | Lorek M et al. | β | 2024 | β |
| Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome. | Radhakrishna U et al. | β | 2024 | β |
| Sex differences in comorbid pain and opioid use disorder: A scoping review. | DeVito EE et al. | β | 2024 | β |
| Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. | Conradt E et al. | β | 2023 | β |
| Caring for Our Patients With Opioid Use Disorder in the Perioperative Period: A Guide for the Anesthesiologist. | Barreveld AM et al. | β | 2023 | β |
| Does Morphine Exposure Before Gestation Change Anxiety-Like Behavior During Morphine Dependence in Male Wistar Rats? | Sabzevari S et al. | β | 2023 | β |
| Genetic Variants Associated With Opioid Use Disorder. | Freiermuth CE et al. | β | 2023 | β |
| The effects of childhood trauma and mental disorders on treatment engagement, contact with the criminal justice system, and mortality among people with opioid dependence. | Santo T et al. | β | 2023 | β |
| A qualitative assessment of perceptions and attitudes toward postoperative pain and opioid use in patients undergoing elective knee arthroscopy. | Anand A et al. | β | 2022 | β |
| The Mediating Role of Contextual Problems and Sensation Seeking in the Association between Substance Use and Mental Health in Adolescents from Northern Chile. | Caqueo-UrΓzar A et al. | β | 2022 | β |
| Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes. | Reed ZE et al. | β | 2022 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study. | Al-Eitan LN et al. | β | 2021 | β |
| Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. | Sherva R et al. | β | 2021 | β |
| Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences. | Chawar C et al. | β | 2021 | β |
| Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome. | Radhakrishna U et al. | β | 2021 | β |
| Reduced Opioid Prescription After Anterior Cruciate Ligament Reconstruction Does Not Affect Postoperative Pain or Prescription Refills: A Prospective, Surgeon-Blinded, Randomized, Controlled Trial. | Hartwell MJ et al. | β | 2021 | β |
| Sex and heredity are determinants of drug intake in a novel model of rat oral oxycodone self-administration. | Sharp BM et al. | β | 2021 | β |
| The Genomics of Opioid Addiction Longitudinal Study (GOALS): study design for a prospective evaluation of genetic and non-genetic factors for development of and recovery from opioid use disorder. | Heil J et al. | β | 2021 | β |
| American Civil War medical practice, the post-bellum opium crisis and modern comparisons. | Lande RG | β | 2020 | β |
| Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study. | Zhou H et al. | β | 2020 | β |
| Genome-wide association analysis of opioid use disorder: A novel approach using clinical data. | Song W et al. | β | 2020 | β |
| Genome-Wide Association Study of Opioid Cessation. | Cox JW et al. | β | 2020 | β |
| GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol. | Chawar C et al. | β | 2020 | β |
| Opioid-induced Somatic Activation: Prevalence in a Population of Patients With Chronic Pain. | Barbour A et al. | β | 2020 | β |
| Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic. | Balyan R et al. | β | 2020 | β |
| Pharmacotherapeutic management of co-morbid alcohol and opioid use. | Hood LE et al. | β | 2020 | β |
| The opioid crisis: a contextual, social-ecological framework. | Jalali MS et al. | β | 2020 | β |
| Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults. | Harbaugh CM et al. | β | 2019 | β |
| Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry. | Brick LA et al. | β | 2019 | β |
| Contribution of psychiatric diagnoses to extent of opioid prescription in the first year post-head and neck cancer diagnosis: A longitudinal study. | Henry M et al. | β | 2019 | β |
| Epidemiology of the U.S. opioid crisis: the importance of the vector. | Compton WM et al. | β | 2019 | β |
| Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West Virginia. | Kaski SW et al. | β | 2019 | β |
| Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. | Yang BZ et al. | β | 2019 | β |
| GWAS including 82,707 subjects identifies functional coding variant in <i>OPRM1</i> gene associated with opioid use disorder | Zhou H et al. | β | 2019 | β |
| High Prevalence of Misuse of Prescribed Opioid Analgesics in Patients with Chronic Non-Cancer Pain. | Eiden C et al. | β | 2019 | β |
| <i>OPRM1</i> A118G Polymorphisms and Its Role in Opioid Addiction: Implication on Severity and Treatment Approaches. | Taqi MM et al. | β | 2019 | β |
| Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. | Bao W et al. | β | 2019 | β |
| Pattern and probability of dispensing of prescription opioids and benzodiazepines among the new users in Australia: a retrospective cohort study. | Islam MM | β | 2019 | β |
| Trends in prescription opioid use and dose trajectories before opioid use disorder or overdose in US adults from 2006 to 2016: A cross-sectional study. | Wei YJ et al. | β | 2019 | β |
| Who is to blame for the opioid crisis? | Resnick B | β | 2019 | β |
| An association between latent toxoplasmosis and substance abuse: an Egyptian Center Study. | Elmorsy E et al. | β | 2018 | β |
| Drug Addiction: From Neuroscience to Ethics. | Farisco M et al. | β | 2018 | β |
| GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers. | Sun Y et al. | β | 2018 | β |
| Genetic association of human Corticotropin-Releasing Hormone Receptor 1 (CRHR1) with Internet gaming addiction in Korean male adolescents. | Park J et al. | β | 2018 | β |
| Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans. | Cheng Z et al. | β | 2018 | β |
| Implication of OPRM1 A118G Polymorphism in Opioids Addicts in Pakistan: In vitro and In silico Analysis. | Ahmed M et al. | β | 2018 | β |
| Opioid Initiation to Substance Use Treatment: "They Just Want to Feel Normal". | Wilson M et al. | β | 2018 | β |
| Use and Misuse of Opioids in Chronic Pain. | Volkow N et al. | β | 2018 | β |
| Association Between Initial Opioid Prescribing Patterns and Subsequent Long-Term Use Among Opioid-NaΓ―ve Patients: A Statewide Retrospective Cohort Study. | Deyo RA et al. | β | 2017 | β |
| Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran. | Sharafshah A et al. | β | 2017 | β |
| Analysis of morphine responses in mice reveals a QTL on Chromosome 7. | Crusio WE et al. | β | 2016 | β |
| Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese. | Xie X et al. | β | 2016 | β |
| Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies. | Volkow ND et al. | β | 2016 | β |
| Who Benefits from Chronic Opioid Therapy? Rethinking the Question of Opioid Misuse Risk. | Huber E et al. | β | 2016 | β |
| Adding Genetic Testing to Evidence-Based Guidelines to Determine the Safest and Most Effective Chronic Pain Treatment for Injured Workers. | Meshkin B et al. | β | 2015 | β |
| Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence. | Ali MA et al. | β | 2015 | β |
| Replication of ZNF804A gene variant associations with risk of heroin addiction. | Hancock DB et al. | β | 2015 | β |