The influence of gene-environment interactions on the development of alcoholism and drug dependence.
paper
Cited
Public
- Authors
- Enoch, Mary-Anne
- Year
- 2012
- Journal
- Current psychiatry reports
- PMID
- 22367454
- DOI
- 10.1007/s11920-011-0252-9
- PMCID
- PMC3470472
Alcoholism and drug dependence are common psychiatric disorders with a heritability of about 50%; therefore genetic and environmental influences are equally important. Early-life stress is a predictor of adolescent problem drinking/drug use and alcohol/drug dependence in adulthood, but moderating factors governing the availability of alcohol/drug are important. The risk-resilience balance for addiction may be due in part to the interaction between genetic variation and environment stressors (G × E); this has been confirmed by twin studies of inferred genetic risk. Measured genotype studies to detect G × E effects have used a range of alcohol consumption and diagnostic phenotypes and stressors ranging from early-life to adulthood past year life events. In this article, the current state of the field is critically reviewed and suggestions are put forth for future research.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Coenzyme Q10 as an adjunctive treatment for substance use disorders: a preclinical review. | Adabi R et al. | — | 2025 | → |
| Embodied cognition driven Qigong: a cross-sectional study and a pilot randomized controlled trial on managing depression and preventing relapse in substance dependence. | Sun C et al. | — | 2024 | → |
| Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. | Hilal FF et al. | — | 2024 | → |
| GxE interaction effects of <i>HCRTR2</i> single nucleotide polymorphism and adverse childhood experiences on methamphetamine use disorder. | Chen KT et al. | — | 2024 | → |
| Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study. | Hsu TW et al. | — | 2024 | → |
| Perceived social support impacts on exercise adherence in patients with chronic low back pain. | Roberts KE et al. | — | 2024 | → |
| Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth. | Avramescu RG et al. | — | 2024 | → |
| The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females. | Castle ME et al. | — | 2024 | → |
| Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task. | Elton A et al. | — | 2023 | → |
| An Umbrella Review of the Links Between Adverse Childhood Experiences and Substance Misuse: What, Why, and Where Do We Go from Here? | Grummitt L et al. | — | 2022 | → |
| Association and Effects of Trauma, Displacement, and Illicit Drug Use on Psychiatric Illnesses in Khyber Pakhtunkhwa, Pakistan. | Wazir MNK et al. | — | 2022 | → |
| Association between platelet MAO activity and lifetime drug use in a longitudinal birth cohort study. | Sakala K et al. | — | 2022 | → |
| Family Function Impacts Relapse Tendency in Substance Use Disorder: Mediated Through Self-Esteem and Resilience. | Xia Y et al. | — | 2022 | → |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | — | 2022 | → |
| Parenting styles in relation to childhood obesity, smoking and drinking: A gene-environment interaction study. | Ji M et al. | — | 2022 | → |
| Positive lifestyle behaviours and emotional health factors are associated with low back pain resilience. | Roberts KE et al. | — | 2022 | → |
| Risky Gambling Behaviors: Associations with Mental Health and a History of Adverse Childhood Experiences (ACEs). | Bristow LA et al. | — | 2022 | → |
| Chronic stress in adolescence differentially affects cocaine vulnerability in adulthood in a selectively bred rat model of individual differences: role of accumbal dopamine signaling. | Aydin C et al. | — | 2021 | → |
| Early childhood trauma, substance use and complex concurrent disorders among adolescents. | Cabanis M et al. | — | 2021 | → |
| Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. | Hikida T et al. | — | 2020 | → |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction | Sun J et al. | — | 2020 | → |
| Alcohol Consumption in China Before and During COVID-19: Preliminary Results From an Online Retrospective Survey. | Wang Y et al. | — | 2020 | → |
| Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. | Hollander JA et al. | — | 2020 | → |
| Dibutyl phthalate exposure during gestation and lactation in C57BL/6 mice: Maternal behavior and neurodevelopment in pups. | Lee SM et al. | — | 2020 | → |
| Environmental Enrichment as a Strategy to Confront Social Isolation Under the COVID-19 Pandemic. | Davim A et al. | — | 2020 | → |
| Interaction Between the 5-Hydroxytryptamine Transporter-Linked Polymorphic Region (5-HTTLPR) and Negative Life Events in Adolescent Heavy Drinking. | Kim J et al. | — | 2020 | → |
| [Youth and Alcohol : A survey with a view to the situation in Austria]. | Skala K | — | 2020 | → |
| Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain). | Navarro-Mateu F et al. | — | 2019 | → |
| Drugs of Abuse Induced-Subversion of the Peripheral Immune Response and Central Glial Activity: Focus on Novel Therapeutic Approaches. | Magrone T et al. | — | 2019 | → |
| Endocannabinoids and Fear-Related Behavior in Mice Selectively Bred for High or Low Alcohol Preference. | Kirchhoff AM et al. | — | 2019 | → |
| Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. | Sadeh N et al. | — | 2019 | → |
| Neurocognitive Precursors of Substance Misuse Corresponding to Risk, Resistance, and Resilience Pathways: Implications for Prevention Science. | Rose EJ et al. | — | 2019 | → |
| Possible involvement of nucleus accumbens D1-like dopamine receptors in the morphine-induced condition place preference in the offspring of morphine abstinent rats. | Sadat-Shirazi MS et al. | — | 2019 | → |
| The role of genetics in stress effects on health and addiction. | Buchanan TW et al. | — | 2019 | → |
| A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. | Zhang J et al. | — | 2018 | → |
| A comparative study of the effectiveness of group-based cognitive behavioral therapy and dialectical behavioral therapy in reducing depressive symptoms in Iranian women substance abusers. | Sahranavard S et al. | — | 2018 | → |
| A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults. | Kim J et al. | — | 2018 | → |
| Early-life adversity selectively impairs α2-GABA<sub>A</sub> receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine. | Mitchell SJ et al. | — | 2018 | → |
| Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth. | Hulvershorn L et al. | — | 2018 | → |
| High times for cannabis: Epigenetic imprint and its legacy on brain and behavior. | Szutorisz H et al. | — | 2018 | → |
| Neuroscience of Addiction: Relevance to Prevention and Treatment. | Volkow ND et al. | — | 2018 | → |
| Prenatal stress and genetic risk: How prenatal stress interacts with genetics to alter risk for psychiatric illness. | Abbott PW et al. | — | 2018 | → |
| Research Review: What have we learned about adolescent substance use? | Gray KM et al. | — | 2018 | → |
| Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms. | Egervari G et al. | — | 2018 | → |
| The effects of early life stress on reward processing. | Novick AM et al. | — | 2018 | → |
| An exploration of addiction in adults experiencing early-life stress: a metasynthesis. | Teixeira CAB et al. | — | 2017 | → |
| DNA methylation signatures of chronic alcohol dependence in purified CD3<sup>+</sup> T-cells of patients undergoing alcohol treatment. | Brückmann C et al. | — | 2017 | → |
| Inhibiting social support from massage-like stroking increases morphine dependence. | Bates MLS et al. | — | 2017 | → |
| Opioid addiction: Who are your real friends? | Eitan S et al. | — | 2017 | → |
| Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications. | Dick DM et al. | — | 2017 | → |
| Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice. | Holgate JY et al. | — | 2017 | → |
| The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. | Granholm L et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| A Population-Based Study of Four Genes Associated with Heroin Addiction in Han Chinese. | Li Y et al. | — | 2016 | → |
| A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. | Munn-Chernoff MA et al. | — | 2016 | → |
| Commentary: A Gene-Based Association Method for Mapping Traits Using Reference Transcriptome Data. | Ghitza UE | — | 2016 | → |
| Compulsivity in obsessive-compulsive disorder and addictions. | Figee M et al. | — | 2016 | → |
| Effect of alcohol consumption on peripheral blood Alu methylation in Korean men. | Kim DS et al. | — | 2016 | → |
| Excessive Sensory Stimulation during Development Alters Neural Plasticity and Vulnerability to Cocaine in Mice. | Ravinder S et al. | — | 2016 | → |
| Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats. | Romano-López A et al. | — | 2016 | → |
| Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood. | Berardo LR et al. | — | 2016 | → |
| Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. | Yorgason JT et al. | — | 2016 | → |
| Two-year prognosis after residential treatment for patients with alcohol dependence: three chief guidelines for sobriety in Japan. | Cho T et al. | — | 2016 | → |
| Developmental pathways from child maltreatment to adolescent marijuana dependence: Examining moderation by FK506 binding protein 5 gene (FKBP5). | Handley ED et al. | — | 2015 | → |
| Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders. | Holgate JY et al. | — | 2015 | → |
| Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice. | Moriya Y et al. | — | 2015 | → |
| The role of childhood maltreatment in the altered trait and global expression of personality in cocaine addiction. | Brents LK et al. | — | 2015 | → |
| The role of serotonin in drug use and addiction. | Müller CP et al. | — | 2015 | → |
| Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. | Sweeney FF et al. | — | 2014 | → |
| Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. | Flagel SB et al. | — | 2014 | → |
| Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache. | Cargnin S et al. | — | 2014 | → |
| Development of impulse control circuitry in children of alcoholics. | Hardee JE et al. | — | 2014 | → |
| Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance? | Gapp K et al. | — | 2014 | → |
| Epigenetic and pharmacological regulation of 5HT3 receptors controls compulsive ethanol seeking in mice. | Barker JM et al. | — | 2014 | → |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | — | 2014 | → |
| Homosexual inclinations and the passions: A Thomistic theory of the psychogenesis of same-sex attraction disorder. | Kinney RL | — | 2014 | → |
| Human alcohol-related neuropathology. | de la Monte SM et al. | — | 2014 | → |
| Maternal isolation during the first two postnatal weeks affects novelty-induced responses and sensitivity to ethanol-induced locomotor activity during infancy. | Fernández M et al. | — | 2014 | → |
| Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures. | Bühler KM et al. | — | 2014 | → |
| Acquisition of Rater Agreement for the Stressful Life Events Schedule. | James LM et al. | — | 2013 | → |
| Addictive behaviors and addiction-prone personality traits: associations with a dopamine multilocus genetic profile. | Davis C et al. | — | 2013 | → |
| Adolescence and Alcohol: a review of the literature. | Skala K et al. | — | 2013 | → |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | — | 2013 | → |
| Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. | Yorgason JT et al. | — | 2013 | → |
| Genetic influences on the development of alcoholism. | Enoch MA | — | 2013 | → |
| Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. | MacKillop J | — | 2013 | → |
| The functional anatomy of impulse control disorders. | Probst CC et al. | — | 2013 | → |
| Use of psychoactive substances by adolescents: current panorama. | Lopes GM et al. | — | 2013 | → |
| Commentary on Durkee et al. (2012): adolescents in a webbed world. | Odlaug BL et al. | — | 2012 | → |
| Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats. | Romano-López A et al. | — | 2012 | → |