Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies.
paper
Cited
Public
- Authors
- Verweij, Karin J H; Zietsch, Brendan P; Lynskey, Michael T; Medland, Sarah E; Neale, Michael C; Martin, Nicholas G; Boomsma, Dorret I; Vink, Jacqueline M
- Year
- 2010
- Journal
- Addiction (Abingdon, England)
- PMID
- 20402985
- DOI
- 10.1111/j.1360-0443.2009.02831.x
- PMCID
- PMC2858354
BACKGROUND: Because cannabis use is associated with social, physical and psychological problems, it is important to know what causes some individuals to initiate cannabis use and a subset of those to become problematic users. Previous twin studies found evidence for both genetic and environmental influences on vulnerability, but due to considerable variation in the results it is difficult to draw clear conclusions regarding the relative magnitude of these influences. METHODS: A systematic literature search identified 28 twin studies on cannabis use initiation and 24 studies on problematic cannabis use. The proportion of total variance accounted for by genes (A), shared environment (C) and unshared environment (E) in (i) initiation of cannabis use and (ii) problematic cannabis use was calculated by averaging corresponding A, C and E estimates across studies from independent cohorts and weighting by sample size. RESULTS: For cannabis use initiation, A, C and E estimates were 48%, 25% and 27% in males and 40%, 39% and 21% in females. For problematic cannabis use A, C and E estimates were 51%, 20% and 29% for males and 59%, 15% and 26% for females. Confidence intervals of these estimates are considerably narrower than those in the source studies. CONCLUSIONS: Our results indicate that vulnerability to both cannabis use initiation and problematic use was influenced significantly by A, C and E. There was a trend for a greater C and lesser A component for cannabis use initiation compared to problematic use for females.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors. | Hamaoui J et al. | β | 2026 | β |
| Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals. | Thorpe HHA et al. | β | 2026 | β |
| Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk. | Poore HE et al. | β | 2026 | β |
| Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming. | Kim Y et al. | β | 2026 | β |
| Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming. | Kim Y et al. | β | 2026 | β |
| Topic Trends in Sibling Research in the Journal of Social and Personal Relationships. | Cahill KM et al. | β | 2026 | β |
| Absolute Risk Prediction for Cannabis Use Disorder in Adolescence and Early Adulthood Using Bayesian Machine Learning. | Wang T et al. | β | 2025 | β |
| Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria. | SooHoo JF et al. | β | 2025 | β |
| A Systematic Investigation of the Common Genetic Architecture of Substance Use Traits and the Relationship with Mental Health. | Pasman JA et al. | β | 2025 | β |
| Cannabis use patterns and different phenotypes in relation to other drugs use: latent class analyses from the Sao Paulo Megacity Mental Health Survey. | Silveira CM et al. | β | 2025 | β |
| Identifying predictors of Australian workers' illicit substance use: A nationally representative study. | Di Censo G et al. | β | 2025 | β |
| Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents. | Cupertino RB et al. | β | 2025 | β |
| Intergenerational Transmission of Cannabis Use: Testing Genetic Risk and the Mitigating Influences of Parent Positive Behavior Support in Early Childhood. | Ostner SG et al. | β | 2025 | β |
| Peer Victimization in Childhood and Timing of Substance Use Initiation: Evidence from a Twin Study. | Yu LH et al. | β | 2025 | β |
| Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth. | Sosnowski DW et al. | β | 2025 | β |
| The association between cannabis use and suicidal intensity in psychiatric inpatients. | Oladunjoye AF et al. | β | 2025 | β |
| The influence of genetics on the endocannabinoid system gene expression and relevance for targeting reproductive conditions. | Tanaka K et al. | β | 2025 | β |
| The relationship between recreational cannabis use, psychotic-like experiences, and the salience network in adolescent and young adult twins. | Atmaca-Turan H et al. | β | 2025 | β |
| Amygdala volume and depression symptoms in young adolescents who use cannabis. | Wallace AL et al. | β | 2024 | β |
| Cannabis and Psychosis: Weeding Out Fact from Fiction. | Johnson EC et al. | β | 2024 | β |
| Cannabis use disorder: from neurobiology to treatment. | Le Foll B et al. | β | 2024 | β |
| Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders. | Kember RL et al. | β | 2024 | β |
| Evidence for sex differences in the impact of cytochrome P450 genotypes on early subjective effects of cannabis. | Davis CN et al. | β | 2024 | β |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | β | 2024 | β |
| The genetic landscape of substance use disorders. | Gerring ZF et al. | β | 2024 | β |
| The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies. | Austin-Zimmerman I et al. | β | 2024 | β |
| The influence of transformations in supply on methamphetamine initiation among people injecting opioids in the United States. | Mars S et al. | β | 2024 | β |
| A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders. | Poore HE et al. | β | 2023 | β |
| Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans. | Rabinowitz JA et al. | β | 2023 | β |
| Does parental separation moderate the heritability of health risk behavior among adolescents? | Dierker P et al. | β | 2023 | β |
| Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics. | Greco LA et al. | β | 2023 | β |
| Genetic and Cultural Transmission of Alcohol Use Disorder in Swedish Twin Pedigrees. | Maes HH et al. | β | 2023 | β |
| Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study. | Hillmer A et al. | β | 2023 | β |
| Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene Γ environment moderation and mediation. | Elkrief L et al. | β | 2023 | β |
| MR-DoC2: Bidirectional Causal Modeling with Instrumental Variables and Data from Relatives. | Castro-de-Araujo LFS et al. | β | 2023 | β |
| Prospective, longitudinal study to isolate the impacts of marijuana use on neurocognitive functioning in adolescents. | Ren W et al. | β | 2023 | β |
| Research Review: Siblings matter. A multi-level meta-analysis on the association between cannabis use among adolescent siblings. | Defoe IN et al. | β | 2023 | β |
| Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence. | Buzzi B et al. | β | 2023 | β |
| The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study. | Cheng W et al. | β | 2023 | β |
| Transcriptome-wide association study by different approaches reveals candidate causal genes for cannabis use disorder. | Gao J et al. | β | 2023 | β |
| A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders | Poore HE et al. | β | 2022 | β |
| Association between <i>ABCB1</i> rs2235048 Polymorphism and THC Pharmacokinetics and Subjective Effects following Smoked Cannabis in Young Adults. | Matheson J et al. | β | 2022 | β |
| Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts. | Barr PB et al. | β | 2022 | β |
| Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits. | Toikumo S et al. | β | 2022 | β |
| Neurogenetic and Epigenetic Aspects of Cannabinoids. | Dennen CA et al. | β | 2022 | β |
| Predicting Adolescent Electronic Cigarette Use: Differences by Never, Ever, and Current Users. | Enlow PT et al. | β | 2022 | β |
| Prenatal alcohol and tobacco exposures and the risk of cannabis use in offspring: Findings from a population-based cohort study. | Duko B et al. | β | 2022 | β |
| The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems. | Ksinan AJ et al. | β | 2022 | β |
| The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond. | Verweij KJH et al. | β | 2022 | β |
| Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes. | Reed ZE et al. | β | 2022 | β |
| Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies. | Schaefer JD et al. | β | 2021 | β |
| Associations between the CADM2 gene, substance use, risky sexual behavior, and self-control: A phenome-wide association study. | Arends RM et al. | β | 2021 | β |
| Cannabis and Depression. | Feingold D et al. | β | 2021 | β |
| Cannabis Use and Brain Volume in Adolescent and Young Adult Cannabis Users: Effects Moderated by Sex and Aerobic Fitness. | Sullivan RM et al. | β | 2021 | β |
| Cannabis use and cannabis use disorder. | Connor JP et al. | β | 2021 | β |
| Cannabis use in college: Genetic predispositions, peers, and activity participation. | Thomas NS et al. | β | 2021 | β |
| Detection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters. | Oyaci Y et al. | β | 2021 | β |
| Genetic basis of cannabis use: a systematic review. | Hillmer A et al. | β | 2021 | β |
| Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization. | Hatoum AS et al. | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Genomic and Personalized Medicine Approaches for Substance Use Disorders (SUDs) Looking at Genome-Wide Association Studies. | Cozzoli D et al. | β | 2021 | β |
| The heritability of reading and reading-related neurocognitive components: A multi-level meta-analysis. | Andreola C et al. | β | 2021 | β |
| The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry. | Brick LA et al. | β | 2021 | β |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum. | Krueger RF et al. | β | 2021 | β |
| Which came first: Cannabis use or deficits in impulse control? | Rinehart L et al. | β | 2021 | β |
| Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. | AshaRani PV et al. | β | 2021 | β |
| Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models. | Dunn AL et al. | β | 2020 | β |
| Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples. | Zellers SM et al. | β | 2020 | β |
| A large-scale genome-wide association study meta-analysis of cannabis use disorder. | Johnson EC et al. | β | 2020 | β |
| Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators. | Sullivan RM et al. | β | 2020 | β |
| Association between polygenic liability for schizophrenia and substance involvement: A nationwide population-based study in Taiwan. | Wang SH et al. | β | 2020 | β |
| Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality. | Soler Artigas M et al. | β | 2020 | β |
| Cannabis use, depression and self-harm: phenotypic and genetic relationships. | Hodgson K et al. | β | 2020 | β |
| Deconstructing the neurobiology of cannabis use disorder. | Ferland JN et al. | β | 2020 | β |
| Development of a Vaping Machine for the Sampling of THC and CBD Aerosols Generated by Two Portable Dry Herb Cannabis Vaporisers. | Carrara L et al. | β | 2020 | β |
| Exploring Phenotypic and Genetic Overlap Between Cannabis Use and Schizotypy. | Vaissiere J et al. | β | 2020 | β |
| Genetic determinants of cannabis use: a systematic review protocol. | Hillmer A et al. | β | 2020 | β |
| Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. | Osborne AJ et al. | β | 2020 | β |
| Illicit drug use and the genetic overlap with Cannabis use. | Vink JM et al. | β | 2020 | β |
| Investigating the genetic and causal relationship between initiation or use of alcohol, caffeine, cannabis and nicotine. | Chang LH et al. | β | 2020 | β |
| Modeling the Comorbidity of Cannabis Abuse and Conduct Disorder/Conduct Problems from a Cognitive Neuroscience Perspective. | Blair RJ | β | 2020 | β |
| Onset of regular cannabis use and young adult insomnia: an analysis of shared genetic liability. | Winiger EA et al. | β | 2020 | β |
| Substance use: Interplay between polygenic risk and neighborhood environment. | Pasman JA et al. | β | 2020 | β |
| The Genetics of Externalizing Problems. | Barr PB et al. | β | 2020 | β |
| Determining Risks for Cannabis Use Disorder in the Face of Changing Legal Policies. | Taylor M et al. | β | 2019 | β |
| Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies. | Davis CN et al. | β | 2019 | β |
| Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception. | Gerra MC et al. | β | 2019 | β |
| Genetic Predisposition vs Individual-Specific Processes in the Association Between Psychotic-like Experiences and Cannabis Use. | Karcher NR et al. | β | 2019 | β |
| Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use. | Allegrini AG et al. | β | 2019 | β |
| Genome-wide association study implicates CHRNA2 in cannabis use disorder. | Demontis D et al. | β | 2019 | β |
| Onset of regular cannabis use and adult sleep duration: Genetic variation and the implications of a predictive relationship. | Winiger EA et al. | β | 2019 | β |
| Several clock genes polymorphisms are meaningful risk factors in the development and severity of cannabis addiction. | Saffroy R et al. | β | 2019 | β |
| Addressing Adolescents' and Young Adults' Substance Use Disorders. | Chadi N et al. | β | 2018 | β |
| Cannabinoids for the treatment of rheumatic diseases - where do we stand? | Katz-Talmor D et al. | β | 2018 | β |
| Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence. | Hiemstra M et al. | β | 2018 | β |
| Gene variants and educational attainment in cannabis use: mediating role of DNA methylation. | Gerra MC et al. | β | 2018 | β |
| Genome-wide association meta-analysis of age at first cannabis use. | MinicΔ CC et al. | β | 2018 | β |
| Genome-wide association study identifies a novel locus for cannabis dependence. | Agrawal A et al. | β | 2018 | β |
| GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. | Pasman JA et al. | β | 2018 | β |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | β | 2018 | β |
| Polygenic Score Γ Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth. | Musci RJ et al. | β | 2018 | β |
| Testing associations between cannabis use and subcortical volumes in two large population-based samples. | Gillespie NA et al. | β | 2018 | β |
| The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study. | Chang LH et al. | β | 2018 | β |
| The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity. | Struik D et al. | β | 2018 | β |
| Whole genome sequence study of cannabis dependence in two independent cohorts. | Gizer IR et al. | β | 2018 | β |
| Cannabis and Depression: A Twin Model Approach to Co-morbidity. | Smolkina M et al. | β | 2017 | β |
| Cannabis and development of dual diagnoses: A literature review. | Hanna RC et al. | β | 2017 | β |
| Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood. | Ashenhurst JR et al. | β | 2017 | β |
| Evidence for the Risks and Consequences of Adolescent Cannabis Exposure. | Levine A et al. | β | 2017 | β |
| Genetic and Environmental Contributions to the Association Between Cannabis Use and Psychotic-Like Experiences in Young Adult Twins. | NesvΓ₯g R et al. | β | 2017 | β |
| Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. | Brouwer RM et al. | β | 2017 | β |
| Heritability of lifetime ecstasy use. | Verweij KJH et al. | β | 2017 | β |
| Longitudinal Studies on the Etiology of Cannabis Use Disorder: A Review. | Courtney KE et al. | β | 2017 | β |
| Major depressive disorder, suicidal thoughts and behaviours, and cannabis involvement in discordant twins: a retrospective cohort study. | Agrawal A et al. | β | 2017 | β |
| Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. | Mason BL et al. | β | 2017 | β |
| Phenotypic and familial associations between childhood maltreatment and cannabis initiation and problems in young adult European-American and African-American women. | Grant JD et al. | β | 2017 | β |
| Short communication: Genetic association between schizophrenia and cannabis use. | Verweij KJ et al. | β | 2017 | β |
| The genetic basis of the comorbidity between cannabis use and major depression. | Hodgson K et al. | β | 2017 | β |
| Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis. | Richmond-Rakerd LS et al. | β | 2016 | β |
| A Longitudinal Adoption Study of Substance Use Behavior in Adolescence. | Huibregtse BM et al. | β | 2016 | β |
| Attentional dysfunction in abstinent long-term cannabis users with and without schizophrenia. | Rentzsch J et al. | β | 2016 | β |
| Birth Cohorts Analysis of Adolescent Cigarette Smoking and Subsequent Marijuana and Cocaine Use. | Keyes KM et al. | β | 2016 | β |
| Cannabinoids: Medical implications. | Schrot RJ et al. | β | 2016 | β |
| Cannabis Involvement and Nonsuicidal Self-Injury: A Discordant Twin Approach. | Few LR et al. | β | 2016 | β |
| Genetic and Environmental Factors Associated with Cannabis Involvement. | Bogdan R et al. | β | 2016 | β |
| Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. | Melroy-Greif WE et al. | β | 2016 | β |
| Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. | Stringer S et al. | β | 2016 | β |
| Heritability of compulsive Internet use in adolescents. | Vink JM et al. | β | 2016 | β |
| Heritability of high sugar consumption through drinks and the genetic correlation with substance use. | Treur JL et al. | β | 2016 | β |
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | β | 2016 | β |
| Keep off the grass? Cannabis, cognition and addiction. | Curran HV et al. | β | 2016 | β |
| Prenatal, perinatal, and adolescent exposure to marijuana: Relationships with aggressive behavior. | Barthelemy OJ et al. | β | 2016 | β |
| Role of overlapping genetic and environmental factors in the relationship between early adolescent conduct problems and substance use in young adulthood. | Verweij KJ et al. | β | 2016 | β |
| Targeting the Endocannabinoid System in Psychiatric Illness. | Katzman MA et al. | β | 2016 | β |
| The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter? | Olivares EL et al. | β | 2016 | β |
| The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings. | Agrawal A et al. | β | 2016 | β |
| A longitudinal study of cannabis use initiation among high school students: Effects of social anxiety, expectancies, peers and alcohol. | Schmits E et al. | β | 2015 | β |
| Dissociation between implicit and explicit expectancies of cannabis use in adolescence. | Schmits E et al. | β | 2015 | β |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | β | 2015 | β |
| Genetic contribution to the variance of blood pressure and heart rate: a systematic review and meta-regression of twin studies. | Wang B et al. | β | 2015 | β |
| Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset. | MinicΔ CC et al. | β | 2015 | β |
| Internalizing and externalizing psychopathology as predictors of cannabis use disorder onset during adolescence and early adulthood. | Farmer RF et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. | Yohn NL et al. | β | 2015 | β |
| Parental transmission of risk for cannabis use disorders to offspring. | Kosty DB et al. | β | 2015 | β |
| Psychotic experiences are linked to cannabis use in adolescents in the community because of common underlying environmental risk factors. | Shakoor S et al. | β | 2015 | β |
| The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study. | Giordano GN et al. | β | 2015 | β |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | β | 2015 | β |
| The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives. | Kandel D et al. | β | 2015 | β |
| The pharmacogenetics of alcohol use disorder. | Jones JD et al. | β | 2015 | β |
| The relationship between cannabis involvement and suicidal thoughts and behaviors. | Delforterie MJ et al. | β | 2015 | β |
| Cannabis and psychosis: Neurobiology. | Shrivastava A et al. | β | 2014 | β |
| Cannabis controversies: how genetics can inform the study of comorbidity. | Agrawal A et al. | β | 2014 | β |
| COMBINING META- AND MEGA- ANALYTIC APPROACHES FOR MULTI-SITE DIFFUSION IMAGING BASED GENETIC STUDIES: FROM THE ENIGMA-DTI WORKING GROUP. | Jahanshad N et al. | β | 2014 | β |
| Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study. | Kubarych TS et al. | β | 2014 | β |
| DSM-5 cannabis use disorder: a phenotypic and genomic perspective. | Agrawal A et al. | β | 2014 | β |
| Genetic and environmental contributions to social anxiety across different ages: a meta-analytic approach to twin data. | Scaini S et al. | β | 2014 | β |
| Genetic predisposition to schizophrenia associated with increased use of cannabis. | Power RA et al. | β | 2014 | β |
| Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders. | Few LR et al. | β | 2014 | β |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | β | 2014 | β |
| Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system. | Buisman-Pijlman FT et al. | β | 2014 | β |
| Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling. | Kochunov P et al. | β | 2014 | β |
| Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. | George O et al. | β | 2014 | β |
| Polygenic risk scores for smoking: predictors for alcohol and cannabis use? | Vink JM et al. | β | 2014 | β |
| Predicting cannabis abuse screening test (CAST) scores: a recursive partitioning analysis using survey data from Czech Republic, Italy, the Netherlands and Sweden. | Blankers M et al. | β | 2014 | β |
| The relationship between cannabis outcome expectancies and cannabis refusal self-efficacy in a treatment population. | Connor JP et al. | β | 2014 | β |
| A genetic perspective on the proposed inclusion of cannabis withdrawal in DSM-5. | Verweij KJ et al. | β | 2013 | β |
| A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears. | Van Houtem CM et al. | β | 2013 | β |
| Changes in cannabis use among young people: impact on mental health. | Copeland J et al. | β | 2013 | β |
| Is the relationship between early-onset cannabis use and educational attainment causal or due to common liability? | Verweij KJ et al. | β | 2013 | β |
| Long-term CBβ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids. | Tambaro S et al. | β | 2013 | β |
| Mental health differences between frequent cannabis users with and without dependence and the general population. | van der Pol P et al. | β | 2013 | β |
| Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. | Jahanshad N et al. | β | 2013 | β |
| The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation. | Verweij KJ et al. | β | 2013 | β |
| Use of psychoactive substances by adolescents: current panorama. | Lopes GM et al. | β | 2013 | β |
| Using Mendelian randomisation to infer causality in depression and anxiety research. | Gage SH et al. | β | 2013 | β |
| What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. | Kendler KS | β | 2013 | β |
| An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology. | Lynskey MT et al. | β | 2012 | β |
| Borderline personality traits and substance use: genetic factors underlie the association with smoking and ever use of cannabis, but not with high alcohol consumption. | Distel MA et al. | β | 2012 | β |
| [Cannabis: Use and dependence]. | Dervaux A et al. | β | 2012 | β |
| Genetic and environmental contributions to separation anxiety: a meta-analytic approach to twin data. | Scaini S et al. | β | 2012 | β |
| Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies. | Blokland GA et al. | β | 2012 | β |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | β | 2012 | β |
| Heritability of preferences for multiple cues of mate quality in humans. | Zietsch BP et al. | β | 2012 | β |
| No association of candidate genes with cannabis use in a large sample of Australian twin families. | Verweij KJ et al. | β | 2012 | β |
| State of the art treatments for cannabis dependence. | Danovitch I et al. | β | 2012 | β |
| The co-occurring use and misuse of cannabis and tobacco: a review. | Agrawal A et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Age moderates non-genetic influences on the initiation of cannabis use: a twin-sibling study in Dutch adolescents and young adults. | Distel MA et al. | β | 2011 | β |
| The Dutch Cannabis Dependence (CanDep) study on the course of frequent cannabis use and dependence: objectives, methods and sample characteristics. | van der Pol P et al. | β | 2011 | β |