Nominal association with CHRNA4 variants and nicotine dependence.

paper Cited Public

Authors: Kamens, H M; Corley, R P; McQueen, M B; Stallings, M C; Hopfer, C J; Crowley, T J; Brown, S A; Hewitt, J K; Ehringer, M A
Year: 2013
Journal: Genes, brain, and behavior
PMID: 23350800
DOI: 10.1111/gbb.12021
PMCID: PMC3727281

#	Section	Preview
0	INTRODUCTION	Smoking is the leading cause of self-induced morbidity and premature mortality, and 12.8% of the US…
1	INTRODUCTION	The most abundant nAChR found in the brain is the high affinity α4β2* receptor (where * indicates…
2	INTRODUCTION	Given this literature, early human genetic studies of the genes coding for nAChR subunits focused on…
3	INTRODUCTION	In contrast to the human genetics studies examining an association between CHRNB2 and ND, the work…
4	INTRODUCTION	The goal of the current study was to investigate the role of CHRNA4 and CHRNB2 in lifetime DSM-IV ND…
5	MATERIALS AND METHODS	We examined the association between genetic variation in the CHRNA4 and CHRNB2 genes and ND symptoms…
6	MATERIALS AND METHODS — Samples — Center on Antisocial Drug Dependence (CADD)	The Center on Antisocial Drug Dependence (CADD) sample was recruited as a longitudinal study…
7	MATERIALS AND METHODS — Samples — Center on Antisocial Drug Dependence (CADD)	same household as the proband were asked to participate in the study. The CADD is currently in its…
8	MATERIALS AND METHODS — Samples — Center on Antisocial Drug Dependence (CADD)	analysis, genotypic data from all available family members were included, but the phenotypic data…
9	MATERIALS AND METHODS — Samples — Genetics of Antisocial Drug Dependence (GADD)	The Genetics of Antisocial Drug Dependence (GADD) sample is a multisite research project that began…
10	MATERIALS AND METHODS — Samples — Genetics of Antisocial Drug Dependence (GADD)	Interview Schedule for Children (DISC; Shaffer et al. 2000) for those under 17 years of age. At wave…
11	MATERIALS AND METHODS — SNP Selection and Genotyping	Twenty SNPs in CHRNA4 and CHRNB2 were originally genotyped for this study. Polymorphisms were…
12	MATERIALS AND METHODS — SNP Selection and Genotyping	population (http://www.ncbi.nlm.nih.gov/SNP/) or had a minor allele frequency of > 0.01 in the CADD…
13	MATERIALS AND METHODS — SNP Selection and Genotyping	were excluded. All SNPs were genotyped in a subset of samples in replicate reactions to determine…
14	MATERIALS AND METHODS — Statistical Methods — SNP assessment	SNPs were assessed for linkage disequilibrium (LD) and conformity to Hardy-Weinberg equilibrium…
15	MATERIALS AND METHODS — Statistical Methods — Statistical Analyses	All seven DSM-IV ND symptoms were included. Briefly, an individual who endorsed one of the…
16	MATERIALS AND METHODS — Statistical Methods — Statistical Analyses	variable in a family-based association test carried out in the FBAT software package using an…
17	RESULTS — Hardy Weinberg Equilibrium (HWE) and Linkage disequilibrium (LD) of the SNPs	Using the threshold of p < 0.001 (Barrett et al. 2005), all SNPs conformed to HWE (Table 2 - 3). To…
18	RESULTS — SNPs in CHRNA4 are associated with ND	Genetic variation in the CHRNA4 gene, but not the CHRNB2 gene, showed nominal association with…
19	RESULTS — SNPs in CHRNA4 are associated with ND	In contrast to the results with CHRNA4, no SNPs in CHRNB2 were associated with DSM-IV ND symptoms…

Name	Type
abstinence rates	phenotype
acetylcholine	drug
Adolescent drug abuse local	phenotype
African American	cohort
Antisocial drug dependence local	phenotype
antisocial personality disorder	phenotype
CADD clinical sample local	cohort
CADD clinical subjects local	cohort
CADD community sample local	cohort
CADD Hispanic sample local	cohort
CADD non-Hispanic EA sample local	cohort
CADD sample local	cohort
Center on Antisocial Drug Dependence	cohort
Chinese males local	cohort
Chrna4	gene
Chrnb2	gene
CHRN SNPs local	gene
clinical population	cohort
Clinical probands local	cohort
Community based probands local	cohort
conditioned place aversion	phenotype
conditioned place preference	phenotype
conduct disorder	phenotype
control population	cohort
drug	drug
drug dependence	phenotype
drugs	drug
DSM-IV ND criteria local	phenotype
DSM-IV ND symptoms local	phenotype
DSM-IV nicotine dependence symptom count local	phenotype
DSM-IV nicotinic dependence symptoms local	phenotype
European ancestry	cohort
Fagerström Test for ND local	phenotype
family members	cohort
GADD local	cohort
GADD sample local	cohort
generalized anxiety disorder	phenotype
Genetics of Antisocial Drug Dependence local	cohort
Genetics of Antisocial Drug Dependence (GADD) sample local	cohort
Han et al 2011 local	cohort
HapMap	cohort
heavy smoking	phenotype
Hispanic	phenotype
Hispanic cohort local	cohort
Hispanic sample local	cohort
Hispanic sub-sample local	cohort
Lifetime DSM-IV ND symptoms local	phenotype
Lifetime DSM-IV nicotine dependence symptoms local	phenotype
lifetime major depression local	phenotype
lifetime ND symptoms local	phenotype
major depressive disorder	phenotype
ND symptom counts local	phenotype
ND symptoms local	phenotype
nicotine	drug
nicotine addiction	phenotype
nicotine dependence	phenotype
nicotine-induced hypothermia local	phenotype
nicotine reward	phenotype
nicotine self-administration	phenotype
nicotine sensitization local	phenotype
nicotine tolerance local	phenotype
nicotinic acetylcholine receptor	drug
non-Hispanic EA CADD sample local	cohort
non-Hispanic EA cohort local	cohort
offspring generation local	cohort
Plink	drug
regular smoking	phenotype
rs1044294 local	variant
rs1044394	variant
rs1044396	variant
rs1044397	variant
rs1127313 local	variant
rs1127314	variant
rs2072658	variant
rs2072660	variant
rs2072661	variant
rs3766927	variant
rs3787138	variant
rs3787140 local	variant
rs7543174 local	variant
self-identified Hispanics local	cohort
smoking behaviors	phenotype
smoking cessation	phenotype
smoking cessation treatment seekers local	cohort
smoking initiation	phenotype
smoking quantity	phenotype
smoking-related behaviors	phenotype
smoking status	phenotype
SNPs in CHRNA4 local	variant
SNPs in CHRNB2 local	variant
subjective effects	phenotype
substance use	phenotype
tobacco use	phenotype
United States	cohort
young adult clinical referral sample local	cohort
α4β2* nicotinic receptors local	drug

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In this knowledge base

Title	Year	PMID
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	2016	27166759
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.	2014	24687270

External

Title	Authors	Journal	Year	Link
Clinical, molecular, physiologic, and therapeutic feature of patients with CHRNA4 and CHRNB2 deficiency: A systematic review.	Jalaiei A et al.	—	2025	→
Directional associations between antisocial behavior and alcohol use disorder symptoms from adolescence through adulthood: A sibling comparison cross-lagged approach.	McCabe CJ et al.	—	2025	→
Executive functions as a mediator of childhood maltreatment on adult psychopathology: A longitudinal mediation analysis comparing maltreatment factor models.	Kent KR et al.	—	2022	→
The impact of adolescent stress on nicotine use and affective disorders in rodent models.	Mooney-Leber SM et al.	—	2022	→
Partial and full deletion of nicotinic acetylcholine receptor α4 and β2 subunits reduces sensitivity to acute nicotine administration and development of tolerance following chronic nicotine administration.	Marks MJ et al.	—	2020	→
Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence.	Garcia-Rivas V et al.	—	2019	→
Reduced α4 subunit expression in α4<sup>+-</sup> and α4<sup>+-</sup> /β2<sup>+-</sup> nicotinic acetylcholine receptors alters α4β2 subtype up-regulation following chronic nicotine treatment.	Moretti M et al.	—	2018	→
Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.	Melroy-Greif WE et al.	—	2017	→
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	Yang J et al.	—	2016	→
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.	Kamens HM et al.	—	2016	→
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use.	Melroy-Greif WE et al.	—	2016	→
Test for association of common variants in GRM7 with alcohol consumption.	Melroy-Greif WE et al.	—	2016	→
CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy.	Rocha Santos J et al.	—	2015	→
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.	Hancock DB et al.	—	2015	→
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The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype.	Eggert M et al.	—	2015	→
Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults.	Coon H et al.	—	2014	→
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.	Melroy WE et al.	—	2014	→
Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysis.	Vandenbergh DJ et al.	—	2014	→
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