Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2.

paper Primary Public

Authors: Perry, Brea L; Pescosolido, Bernice A; Bucholz, Kathleen; Edenberg, Howard; Kramer, John; Kuperman, Samuel; Schuckit, Marc Alan; Nurnberger, John I
Year: 2013
Journal: Behavior genetics
PMID: 23974430
DOI: 10.1007/s10519-013-9607-9
PMCID: PMC4441044

#	Section	Preview
40	Discussion — Theoretical implications	In sum, as suggested by research on gender and addiction, the GxExE findings identified here may be…
41	Discussion — Methodological implications	It is noteworthy from a methodological standpoint that the complex nature of these findings emerged…
42	Discussion — Methodological implications	Evidence even for two-way interactions between gender and genotype has been slow to accumulate in…
43	Discussion — Methodological implications	full size reduces statistical power to detect significance, particularly when effects are small (as…
44	Discussion — Methodological implications	Introducing interaction terms to test group-specific effects overcomes many of the problems…
45	Discussion — Limitations	A number of limitations of GxE research using candidate genes (cGxE) have been identified (Duncan…
46	Discussion — Limitations	the GxE effect presented in this study and GxE effects in previous research (e.g. Dick et al. 2001,…
47	Discussion — Limitations	In addition, findings from these cross-sectional data are associational, and causality cannot be…
48	Discussion — Limitations	Also, the GxExE effects examined do not reflect the full complexity of either genetic or social…
49	Discussion — Limitations	and hassles were reported for the past week, improving accuracy of recall but introducing…
50	Conclusion	Despite a substantial body of literature underscoring the relevance of gendered etiological pathways…

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