Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

paper Cited Public

Authors: Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven; Andreasen, Nancy C
Year: 2011
Journal: Schizophrenia research
PMID: 21420833
DOI: 10.1016/j.schres.2011.02.021
PMCID: PMC3085576

#	Section	Preview
20	2. Patients and Methods — 2.6 Statistical analyses	Neurocognition-CNR1 relationships focused on SNPs where there were significant genotype-by-marijuana…
21	3. Results	Allele frequency and pair-wise LD between the 12 CNR1 tSNPs are summarized in Table 1. Several of…
22	3. Results — 3.1 Differences between patients with and without lifetime history of marijuana abuse/dependence	Compared to patients without prior heavy marijuana use, patients with lifetime history of marijuana…
23	3. Results — 3.1 Differences between patients with and without lifetime history of marijuana abuse/dependence	Patients with marijuana abuse/dependence had smaller frontal WM (Adjusted Mean=175.6 versus 180.6cc…
24	3. Results — 3.1 Differences between patients with and without lifetime history of marijuana abuse/dependence	Allele frequency distributions for CNR1 tSNPs also did not differ significantly between patients…
25	3. Results — 3.2 Relationships between CNR1 tSNPs and brain volumes across marijuana misuse groupings	After adjusting for multiple comparisons, the main effects of 3 CNR1 tSNPs on total cerebral WM…
26	3. Results — 3.2 Relationships between CNR1 tSNPs and brain volumes across marijuana misuse groupings	Follow-up analyses investigating the inter-relationships between these 3 CNR1 tSNPs on lobar WM…
27	3. Results — 3.3 Relationships between rs12720071 and neurocognition	There were significant rs12720071 genotype effects on Processing Speed/Attention and Problem Solving…
28	3. Results — 3.3 Relationships between rs12720071 and neurocognition	Because there was significantly more males among patients with marijuana misuse (92.3% versus 69.4%…
29	4. Discussion	In this study, we investigated 12 tSNPs representing much of the genetic variability surrounding the…
30	4. Discussion	CB1 is the primary brain receptor activated by marijuana. It is down-regulated in the brain in…
31	4. Discussion	terminals, neuronal cell bodies, and dendrites (Ong & Mackie, 1999). However, recent studies have…
32	4. Discussion	Previous schizophrenia-CNR1 genetic association studies, restricted mostly to two CNR1 variants,…
33	4. Discussion	Associations between CNR1 and substance misuse have also not been consistently replicated. The…
34	4. Discussion	Zhang et al., 2004) or with CNR1 SNPs (Heller et al., 2001; Herman, Kranzler, Cubells, Gelernter, &…
35	4. Discussion	SNPs may be functional in exerting their effects on disease phenotype if the variant either 1)…
36	4. Discussion	The three CNR1 SNPs implicated in our study (i.e. rs7766029, rs12720071, and rs9450898) are…
37	4. Discussion	altered CNR1 Exon 3 RNA levels in the human brain (Zhang et al., 2004) as well as with prefrontal…
38	4. Discussion	al., 2002; Sterneck & Johnson, 1998; Taubenfeld, Milekic, Monti, & Alberini, 2001). Thus, the A>G…
39	4. Discussion	The limitations of this study include our relatively small sample of patients with marijuana misuse…

Citation	PMID	DOI	Status
Agrawal, A et al., Am J Med Genet B Neuropsychiatr Genet, 2009, Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence	19016476	10.1002/ajmg.b.30881	Primary
Akira, S et al., Embo J, 1990, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family	2112087	10.1002/j.1460-2075.1990.tb08316.x	Cited
Alberini, CM et al., Cell, 1994, C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia	8137425	10.1016/0092-8674(94)90386-7	Cited
Andreasen, NC et al., Arch Gen Psychiatry, 1992, The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology	1637251	10.1001/archpsyc.1992.01820080023004	Cited
Andreasen, NC et al., J Comput Assist Tomogr, 1996, Automatic atlas-based volume estimation of human brain regions from MR images	8576490	10.1097/00004728-199601000-00018	Cited
Andreasen, NC et al., J Neuropsychiatry Clin Neurosci, 1993, Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging	8508032	10.1176/jnp.5.2.121	Cited
Andreasen, NC et al., JAMA, 1994, Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging	7966925	—	Cited
Andreasson, S et al., Lancet, 1987, Cannabis and schizophrenia. A longitudinal study of Swedish conscripts	2892048	10.1016/s0140-6736(87)92620-1	Cited
Arevalo-Martin, A et al., Eur J Neurosci, 2007, Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor 1 and cannabinoid receptor 2	17880390	10.1111/j.1460-9568.2007.05782.x	Cited
Arseneault, L et al., BMJ, 2002, Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study	12446537	10.1136/bmj.325.7374.1212	Cited
Ballon, N et al., Pharmacogenomics J, 2006, (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population	16314880	10.1038/sj.tpj.6500352	Cited
Barrett, JC et al., Bioinformatics, 2005, Haploview: analysis and visualization of LD and haplotype maps	15297300	10.1093/bioinformatics/bth457	Cited
Benjamini, Y et al., J Educ Behav Stat, 2000, On the Adaptive Control of the False Discovery Rate in Multiple Testing With Independent Statistics	—	—	—
Berrendero, F et al., Development, 1998, Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development	9671590	10.1242/dev.125.16.3179	Cited
Borner, C et al., Mol Pharmacol, 2008, Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes	18156315	10.1124/mol.107.042945	Cited
Breivogel, CS et al., J Neurochem, 1999, Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain	10582605	10.1046/j.1471-4159.1999.0732447.x	Cited
Cargill, M et al., Nat Genet, 1999, Characterization of single-nucleotide polymorphisms in coding regions of human genes	10391209	10.1038/10290	Cited
Cartegni, L et al., Nat Rev Genet, 2002, Listening to silence and understanding nonsense: exonic mutations that affect splicing	11967553	10.1038/nrg775	Cited
Chavarría-Siles, I et al., Am J Med Genet Part B: Neuropsychiatric Genet, 2008, Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia	18186055	10.1002/ajmg.b.30592	Cited
Chen, X et al., Arch Gen Psychiatry, 2008, Cannabinoid receptor 1 gene association with nicotine dependence	18606954	10.1001/archpsyc.65.7.816	Cited
Comings, DE et al., Mol Psychiatry, 1997, Cannabinoid receptor gene (CNR1): association with i.v. drug use	9106242	10.1038/sj.mp.4000247	Cited
Cortes-Canteli, M et al., J Biol Chem, 2002, CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells	11733516	10.1074/jbc.M108761200	Cited
Covault, J et al., Mol Psychiatry, 2001, Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence	11526463	10.1038/sj.mp.4000925	Cited
Degenhardt, L et al., Drug and Alcohol Dependence, 2003, Testing hypotheses about the relationship between cannabis use and psychosis	12821204	10.1016/s0376-8716(03)00064-4	Cited
DeLisi, LE, Curr Opin Psychiatry, 2008, The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?	18332661	10.1097/YCO.0b013e3282f51266	Cited
D’Souza, DC et al., Eur Arch Psychiatry Clin Neurosci, 2009, Cannabis and psychosis/schizophrenia: human studies	19609589	10.1007/s00406-009-0024-2	Cited
Eggan, SM et al., Cereb Cortex, 2007, Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis	16467563	10.1093/cercor/bhj136	Cited
Galve-Roperh, I et al., Eur Arch Psychiatry Clin Neurosci, 2009, The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders	19588184	10.1007/s00406-009-0028-y	Cited
Gardner, EL, Pharmacol Biochem Behav, 2005, Endocannabinoid signaling system and brain reward: emphasis on dopamine	15936806	10.1016/j.pbb.2005.01.032	Cited
Green, MF et al., Biol Psychiatry, 2004, Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria	15336511	10.1016/j.biopsych.2004.06.023	Cited
Haber, SN et al., Neuropsychopharmacology, 2009, The Reward Circuit: Linking Primate Anatomy and Human Imaging	19812543	10.1038/npp.2009.129	Cited
Harkany, T et al., Mol Cell Endocrinol, 2008, Endocannabinoid functions controlling neuronal specification during brain development	18394789	10.1016/j.mce.2008.02.011	Cited
Harris, G et al., J Comput Assist Tomogr, 1999, Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection	10050826	10.1097/00004728-199901000-00030	Cited
Heinemeyer, T et al., Nucleic Acids Res, 1998, Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL	9399875	10.1093/nar/26.1.362	Cited
Heller, D et al., Addict Biol, 2001, The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users	11341859	10.1080/13556210020040271	Cited
Henquet, C et al., BMJ, Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people	15574485	10.1136/bmj.38267.664086.63	Cited
Henquet, C et al., Psychological Medicine, 2008, Letter to the Editor: The coherence of the evidence linking cannabis with psychosis	18298878	10.1017/S0033291707002279	Cited
Henquet, C et al., Schizophr Bull, The environment and schizophrenia: the role of cannabis use	15976013	10.1093/schbul/sbi027	Cited
Herman, AI et al., Am J Med Genet B Neuropsychiatr Genet, 2006, Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence	16741937	10.1002/ajmg.b.30325	Cited
Hickman, M et al., Addiction, 2009, If cannabis caused schizophrenia - how many cannabis users may need to be prevented in order to prevent one case of schizophrenia? England and Wales calculations	19832786	10.1111/j.1360-0443.2009.02736.x	Cited
Hill, SK et al., Schizophr Res, 2004, Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia	15037339	10.1016/S0920-9964(03)00213-5	Cited
Ho, BC et al., Am J Psychiatry, 2003, Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia	12505813	10.1176/appi.ajp.160.1.142	Cited
Ho, BC et al., Arch Gen Psychiatry, Long-term Antipsychotic Treatment and Brain Volume: A Longitudinal Study of First-Episode Schizophrenia	21300943	10.1001/archgenpsychiatry.2010.199	Cited
Ho, BC et al., Schizophr Res, 2004, Validity of symptom assessment in psychotic disorders: information variance across different sources of history	15099611	10.1016/j.schres.2003.07.006	Cited
Hollingshead, AB et al., Social Class and Mental Illness: A Community Study, 1958	17895405	10.2105/ajph.97.10.1756	Cited
Hopfer, CJ et al., Am J Med Genet B Neuropsychiatr Genet, 2006, Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents	16917946	10.1002/ajmg.b.30378	Cited
Hutchison, KE et al., Arch Gen Psychiatry, 2008, The incentive salience of alcohol: translating the effects of genetic variant in CNR1	18606956	10.1001/archpsyc.65.7.841	Cited
Johnson, JP et al., Mol Psychiatry, 1997, Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential	9106243	10.1038/sj.mp.4000246	Cited
Kareken, DA et al., Neuropsychology, 1995, Cognitive functioning and neuroanatomic volume measures in schizophrenia	—	—	—
Kendler, KS et al., Am J Psychiatry, 2003, Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins	12668357	10.1176/appi.ajp.160.4.687	Cited
Kohn, Y et al., Mol Psychiatry, 2005, Excitement and confusion on chromosome 6q: the challenges of neuropsychiatric genetics in microcosm	16172614	10.1038/sj.mp.4001738	Cited
Kumra, S, Minn Med, 2007, Schizophrenia and cannabis use	17305103	—	Cited
Lahiri, DK et al., Nucleic Acids Res, 1991, A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies	1681511	10.1093/nar/19.19.5444	Cited
Laviolette, SR et al., Cell Mol Life Sci, 2006, The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction	16699809	10.1007/s00018-006-6027-5	Cited
Leroy, S et al., Am J Med Genet, 2001, Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1	11803524	10.1002/ajmg.10038	Cited
Lewis, DA et al., Int Rev Neurobiol, 2007, Deciphering the disease process of schizophrenia: the contribution of cortical GABA neurons	17349859	10.1016/S0074-7742(06)78004-7	Cited
Lewis, DA et al., Neuropsychopharmacology, 2008, Neuroplasticity of neocortical circuits in schizophrenia	17805309	10.1038/sj.npp.1301563	Cited
Li, T et al., Mol Psychiatry, 2000, No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population	10822338	10.1038/sj.mp.4000670	Cited
Magnotta, VA et al., Comput Med Imaging Graph, 2002, Structural MR image processing using the BRAINS2 toolbox	12074920	10.1016/s0895-6111(02)00011-3	Cited
Martinez-Gras, I et al., Eur Arch Psychiatry Clin Neurosci, 2006, (AAT)n repeat in the cannabinoid receptor gene, CNR1: association with schizophrenia in a Spanish population	16788767	10.1007/s00406-006-0665-3	Cited
Menard, C et al., Neuron, 2002, An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis	12441050	10.1016/s0896-6273(02)01026-7	Cited
Milev, P et al., Am J Psychiatry, 2005, Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up	15741466	10.1176/appi.ajp.162.3.495	Cited
Moldrich, G et al., Peptides, 2000, Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study	11090929	10.1016/s0196-9781(00)00324-7	Cited
Molina-Holgado, E et al., J Neurosci, 2002, Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling	12427829	10.1523/JNEUROSCI.22-22-09742.2002	Cited
Moore, TH et al., Lancet, 2007, Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review	17662880	10.1016/S0140-6736(07)61162-3	Cited
Murray, RM et al., Nat Rev Neurosci, 2007, Cannabis, the mind and society: the hash realities	17925811	10.1038/nrn2253	Cited
Ong, WY et al., Neuroscience, 1999, A light and electron microscopic study of the CB1 cannabinoid receptor in primate brain	10426477	10.1016/s0306-4522(99)00025-1	Cited
O’Shea, M et al., J Psychopharmacol, 2004, Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats	15582916	10.1177/026988110401800407	Cited
O’Shea, M et al., J Psychopharmacol, 2006, Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats	16714325	10.1177/0269881106065188	Cited
Pazos, MR et al., Pharmacol Biochem Behav, 2005, Functional neuroanatomy of the endocannabinoid system	15936805	10.1016/j.pbb.2005.01.030	Cited
Pertwee, RG, Pharmacol Ther, 1997, Pharmacology of cannabinoid CB1 and CB2 receptors	9336020	10.1016/s0163-7258(97)82001-3	Cited
Price, DA et al., J Neurochem, 2007, CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum	17250681	10.1111/j.1471-4159.2006.04383.x	Cited
Prokunina, L et al., Nat Genet, 2002, A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans	12402038	10.1038/ng1020	Cited
Rodriguez, JJ et al., J Neurosci, 2001, Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus	11157068	10.1523/JNEUROSCI.21-03-00823.2001	Cited
Romero, J et al., J Mol Neurosci, 1998, Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTP gamma S binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to delta 9-tetrahydrocannabinol	10096037	10.1385/JMN:11:2:109	Cited
Sabatti, C et al., Genetics, 2003, False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders	12807801	10.1093/genetics/164.2.829	Cited
Saykin, AJ et al., Arch Gen Psychiatry, 1994, Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia	7905258	10.1001/archpsyc.1994.03950020048005	Cited
Schmidt, LG et al., Drug Alcohol Depend, 2002, Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence	11841893	10.1016/s0376-8716(01)00164-8	Cited
Schneider, M et al., Eur Neuropsychopharmacol, 2007, The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion	16679004	10.1016/j.euroneuro.2006.03.009	Cited
Seifert, J et al., Neurosci Lett, 2007, No association of CNR1 gene variations with susceptibility to schizophrenia	17881126	10.1016/j.neulet.2007.08.008	Cited
Sewell, RA et al., Int Rev Psychiatry, 2009, Cannabinoids and psychosis	19367509	10.1080/09540260902782802	Cited
Stefanis, NC et al., Addiction, 2004, Early adolescent cannabis exposure and positive and negative dimensions of psychosis	15369572	10.1111/j.1360-0443.2004.00806.x	Cited
Sterneck, E et al., J Neurochem, 1998, CCAAT/enhancer binding protein beta is a neuronal transcriptional regulator activated by nerve growth factor receptor signaling	9603207	10.1046/j.1471-4159.1998.70062424.x	Cited
Sunyaev, S et al., Trends in Genetics, 2000, Towards a structural basis of human non-synonymous single nucleotide polymorphisms	10782110	10.1016/s0168-9525(00)01988-0	Cited
Talairach, J et al., Co-Planar Stereotaxic Atlas of the Human Brain, 1988	—	—	—
Taubenfeld, SM et al., Nat Neurosci, 2001, The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta	11477427	10.1038/90520	Cited
Tsai, SJ et al., Psychiatric Genetics, 2000, Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia	11204352	10.1097/00041444-200010030-00008	Cited
Tsuang, MT et al., Arch Gen Psychiatry, 1998, Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities	9819064	10.1001/archpsyc.55.11.967	Cited
Ujike, H et al., Mol Psychiatry, 2002, CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia	12082570	10.1038/sj.mp.4001029	Cited
van Os, J et al., Am J Epidemiol, 2002, Cannabis use and psychosis: a longitudinal population-based study	12181101	10.1093/aje/kwf043	Cited
Vinson, CR et al., Science, 1989, Scissors-grip model for DNA recognition by a family of leucine zipper proteins	2683088	10.1126/science.2683088	Cited
Wegener, N et al., Brain Res, 2009, Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment	19094973	10.1016/j.brainres.2008.11.081	Cited
Woods, RP et al., J Comput Assist Tomogr, 1992, Rapid automated algorithm for aligning and reslicing PET images	1629424	10.1097/00004728-199207000-00024	Cited
Young, SE et al., Behavior Genetics, 2006, Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?	16619135	10.1007/s10519-006-9066-7	Cited
Zammit, S et al., BMJ, 2002, Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study	12446534	10.1136/bmj.325.7374.1199	Cited
Zhang, PW et al., Mol Psychiatry, 2004, Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse	15289816	10.1038/sj.mp.4001560	Cited
Zuo, L et al., Biol Psychiatry, 2007, CNR1 variation modulates risk for drug and alcohol dependence	17509535	10.1016/j.biopsych.2006.12.004	Cited

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External

Title	Authors	Journal	Year	Link
Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders.	Kumar U	—	2024	→
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Association between formal thought disorder and cannabis use: a systematic review and meta-analysis.	Argote M et al.	—	2022	→
Biomarkers of the Endocannabinoid System in Substance Use Disorders.	Navarrete F et al.	—	2022	→
Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls.	Ferretjans R et al.	—	2022	→
Cannabis induced psychosis: A systematic review on the role of genetic polymorphisms.	Carvalho C et al.	—	2022	→
Gene-Environment Interactions in Schizophrenia: A Literature Review.	Wahbeh MH et al.	—	2021	→
Impact of Endocannabinoid System Manipulation on Neurodevelopmental Processes Relevant to Schizophrenia.	Zamberletti E et al.	—	2021	→
Receptor-Dependent and Independent Regulation of Voltage-Gated Ca<sup>2+</sup> Channels and Ca<sup>2+</sup>-Permeable Channels by Endocannabinoids in the Brain.	Boczek T et al.	—	2021	→
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G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans.	Rodríguez-Rodríguez I et al.	—	2019	→
Genetic variations in the dopamine reward system influence exercise reinforcement and tolerance for exercise intensity.	Flack K et al.	—	2019	→
Neuroimaging Studies in Patients With Mental Disorder and Co-occurring Substance Use Disorder: Summary of Findings.	Stoychev KR	—	2019	→
Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders.	Sami MB et al.	—	2018	→
Cannabinoids and glial cells: possible mechanism to understand schizophrenia.	de Almeida V et al.	—	2018	→
Gene variants and educational attainment in cannabis use: mediating role of DNA methylation.	Gerra MC et al.	—	2018	→
Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.	Misiak B et al.	—	2018	→
No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans.	Rodríguez-Rodríguez IA et al.	—	2018	→
Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis.	Ohtani T et al.	—	2018	→
Proteomics and Lipidomics in the Elucidation of Endocannabinoid Signaling in Healthy and Schizophrenia Brains.	Seabra G et al.	—	2018	→
The effect of interactions between genetics and cannabis use on neurocognition. A review.	Cosker E et al.	—	2018	→
The research evidence for schizophrenia as a neurodevelopmental disorder.	Rund BR	—	2018	→
Gene × Environment Interactions: From Molecular Mechanisms to Behavior.	Halldorsdottir T et al.	—	2017	→
Neuroimaging genomics in psychiatry-a translational approach.	Mufford MS et al.	—	2017	→
Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia.	Fakhoury M	—	2017	→
Schizophrenia and depression, two poles of endocannabinoid system deregulation.	Rodríguez-Muñoz M et al.	—	2017	→
THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons.	Obiorah IV et al.	—	2017	→
The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.	Gouvêa ES et al.	—	2017	→
Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.	Ayhan Y et al.	—	2016	→
Attitudes towards cannabis use and genetic testing for schizophrenia.	Schiffman J et al.	—	2016	→
Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial.	González-Ortega I et al.	—	2016	→
Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis.	Bioque M et al.	—	2016	→
Genetic and Environmental Factors Associated with Cannabis Involvement.	Bogdan R et al.	—	2016	→
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.	Sherva R et al.	—	2016	→
Human Laboratory Studies on Cannabinoids and Psychosis.	Sherif M et al.	—	2016	→
Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate.	Hill SY et al.	—	2016	→
Cannabis and creativity: highly potent cannabis impairs divergent thinking in regular cannabis users.	Kowal MA et al.	—	2015	→
[Frontal brain volume reduction due to antipsychotic drugs?].	Aderhold V et al.	—	2015	→
Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.	Yıldız M et al.	—	2015	→
Alcohol and Relatively Pure Cannabis Use, but Not Schizotypy, are Associated with Cognitive Attenuations.	Herzig DA et al.	—	2014	→
Cannabidiol as a potential treatment for psychosis.	Schubart CD et al.	—	2014	→
Genetic dissection of the psychotomimetic effects of cannabinoid exposure.	O'Tuathaigh CM et al.	—	2014	→
Gone to Pot - A Review of the Association between Cannabis and Psychosis.	Radhakrishnan R et al.	—	2014	→
Long-term consequences of adolescent cannabinoid exposure in adult psychopathology.	Renard J et al.	—	2014	→
Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders.	Rutter JL et al.	—	2014	→
The Cannabis Pathway to Non-Affective Psychosis may Reflect Less Neurobiological Vulnerability.	Løberg EM et al.	—	2014	→
What contributes to individual differences in brain structure?	Gu J et al.	—	2014	→
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence.	Malchow B et al.	—	2013	→
Cannabis use and brain structural alterations of the cingulate cortex in early psychosis.	Rapp C et al.	—	2013	→
Cannabis use and premorbid functioning as predictors of poorer neurocognition in schizophrenia spectrum disorder.	Ringen PA et al.	—	2013	→
Combined grey matter VBM and white matter TBSS analysis in young first episode psychosis patients with and without cannabis consumption.	Haller S et al.	—	2013	→
Endocannabinoids and endovanilloids: a possible balance in the regulation of the testicular GnRH signalling.	Chianese R et al.	—	2013	→
Gene x environment interactions in schizophrenia and bipolar disorder: evidence from neuroimaging.	Geoffroy PA et al.	—	2013	→
MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse.	Onwuameze OE et al.	—	2013	→
Modulation of cognitive and emotional processing by cannabidiol: the role of the anterior cingulate cortex.	Kowal MA et al.	—	2013	→
Peripheral endocannabinoid system dysregulation in first-episode psychosis.	Bioque M et al.	—	2013	→
Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings.	Batalla A et al.	—	2013	→
Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus.	Nicoll G et al.	—	2012	→
An fMRI Study of Neuronal Activation in Schizophrenia Patients with and without Previous Cannabis Use.	Løberg EM et al.	—	2012	→
Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.	Schacht JP et al.	—	2012	→
Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence.	Hillard CJ et al.	—	2012	→
Current world literature.	—	—	2012	→
Effect of long-term cannabis use on axonal fibre connectivity.	Zalesky A et al.	—	2012	→
Effects of cannabis use on human brain structure in psychosis: a systematic review combining in vivo structural neuroimaging and post mortem studies.	Rapp C et al.	—	2012	→
The endocannabinoid system and its role in schizophrenia: a systematic review of the literature.	Ferretjans R et al.	—	2012	→