Genome-wide association studies in diverse populations.
paper
Cited
Public
- Authors
- Rosenberg, Noah A; Huang, Lucy; Jewett, Ethan M; Szpiech, Zachary A; Jankovic, Ivana; Boehnke, Michael
- Year
- 2010
- Journal
- Nature reviews. Genetics
- PMID
- 20395969
- DOI
- 10.1038/nrg2760
- PMCID
- PMC3079573
Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.
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| # | Section | Preview |
|---|---|---|
| 40 | Highlighted references | 50 This simulation study argues that fine mapping of causal variants is improved by joint analysis⦠|
| 41 | Highlighted references | 69 This article and the article that precedes it provide detailed analyses of genotype imputation in⦠|
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| Name | Type |
|---|---|
| 1000 Genomes Project | cohort |
| admixed population | cohort |
| African | cohort |
| Alzheimerβs disease | phenotype |
| ancestral African populations local | cohort |
| apoE | gene |
| APOE-Ξ΅4 | gene |
| Australia | cohort |
| Canada | cohort |
| cardiomyopathy | phenotype |
| causal variants | cohort |
| CEPH European collection local | cohort |
| common variants | cohort |
| disease | phenotype |
| disease-allele local | variant |
| Disease-risk variation local | variant |
| disease variation local | phenotype |
| diverse populations | cohort |
| European ancestry | cohort |
| European population | cohort |
| Europeans | cohort |
| Finland | cohort |
| genetically intermediate populations local | cohort |
| Genetically intermediate populations local | cohort |
| Genetic resource local | cohort |
| GWA discoveries local | phenotype |
| GWA study | cohort |
| HapMap | cohort |
| HapMap CEU | cohort |
| HapMap reference panels local | cohort |
| Iceland | cohort |
| imputation accuracy | drug |
| Indian subcontinent local | cohort |
| indigenous populations local | cohort |
| intermediate-LD indigenous populations local | cohort |
| intermediate population local | cohort |
| International Haplotype Map project | cohort |
| Kcnq1 | gene |
| Known variants local | variant |
| low-LD populations local | cohort |
| marker ascertainment local | drug |
| mixture panels local | cohort |
| mixture strategy local | drug |
| multiple populations local | cohort |
| MYBPC3 | gene |
| MYBPC3 risk variant local | variant |
| non-European ancestry | cohort |
| Other European populations local | cohort |
| parental populations | cohort |
| phenotype | phenotype |
| phenotypic variation | phenotype |
| population | cohort |
| population-genetic data local | cohort |
| population-genetic modeling local | cohort |
| population structure local | drug |
| rare disease-risk variant local | variant |
| rare risk alleles local | variant |
| rare variant | cohort |
| reference groups local | cohort |
| reference panel | cohort |
| reference population | cohort |
| risk allele | cohort |
| Risk-variant local | variant |
| Sardinia | cohort |
| separate association study local | cohort |
| small population local | cohort |
| SNP | cohort |
| study cohort | cohort |
| sub-Saharan African populations local | cohort |
| tag-SNP portability local | drug |
| tag-SNP portability local | phenotype |
| tag SNPs | cohort |
| target population | cohort |
| TCF7L2 | gene |
| type 2 diabetes | phenotype |
| United States | cohort |
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| Racial Disparities in Poverty Account for Mortality Differences in US Medicare Beneficiaries. | Kimmel PL et al. | β | 2016 | β |
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| Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake. | Mathias RA et al. | β | 2014 | β |
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| On the threshold from genome-wide association studies to whole-genome sequencing. Looking for signal in all the right places. | Hansel NN et al. | β | 2014 | β |
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| Personalized medicine, availability, and group disparity: an inquiry into how physicians perceive and rate the elements and barriers of personalized medicine. | Petersen KE et al. | β | 2014 | β |
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| Transethnic replication of association of CTG18.1 repeat expansion of TCF4 gene with Fuchs' corneal dystrophy in Chinese implies common causal variant. | Xing C et al. | β | 2014 | β |
| Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI. | Bailey SD et al. | β | 2014 | β |
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| Addressing human variability in next-generation human health risk assessments of environmental chemicals. | Zeise L et al. | β | 2013 | β |
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| Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. | Deo R et al. | β | 2013 | β |
| Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations. | Barzan D et al. | β | 2013 | β |
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| Dissecting genome-wide association signals for loss-of-function phenotypes in sorghum flavonoid pigmentation traits. | Morris GP et al. | β | 2013 | β |
| Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. | Walsh KM et al. | β | 2013 | β |
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| Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs. | Huson HJ et al. | β | 2012 | β |
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| Common roots: a contextual review of HIV epidemics in black men who have sex with men across the African diaspora. | Millett GA et al. | β | 2012 | β |
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| C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. | Doumatey AP et al. | β | 2012 | β |
| Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation. | Nakagome S et al. | β | 2012 | β |
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| Genetic architecture in a marine hybrid zone: comparing outlier detection and genomic clines analysis in the bivalve Macoma balthica. | Luttikhuizen PC et al. | β | 2012 | β |
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