Candidate genes for cannabis use disorders: findings, challenges and directions.

paper Cited Public

Authors: Agrawal, Arpana; Lynskey, Michael T
Year: 2009
Journal: Addiction (Abingdon, England)
PMID: 19335651
DOI: 10.1111/j.1360-0443.2009.02504.x
PMCID: PMC2703791

#	Section	Preview
20	Glossary of genetic terms — Multifactorial	The vulnerability to cannabis use disorders vary as a function of genes and environment…
21	Glossary of genetic terms — Polygenic	Cannabis use disorders are influenced by multiple genes of modest additive influence (non-Mendelian…
22	Glossary of genetic terms — Single Nucleotide Polymorphism (SNP)	A SNP is a change in a single base pair in a specific position along the genome that may or may not…
23	Glossary of genetic terms — Synonymous (or silent) mutation	A change in a basepair that does not cause the amino acid to change. This occurs due to redundancy…
24	Glossary of genetic terms — Trinucleotide repeats	a sequence of 3 basepairs (e.g. AAT) that is sequentially repeated a variable number of times.
25	Cannabis use disorders	Worldwide, the cumulative incidence of lifetime cannabis use ranges from 0.3% in China to 42% in the…
26	Heritability of cannabis use disorders	Over the last decade or so, twin studies have firmly established that additive genetic influences…
27	The next step: Genomic strategies	These twin studies have provided an important first step towards our comprehension of the etiology…
28	The next step: Genomic strategies	A review of gene identification strategies and initial findings in this area is accordingly timely.…
29	The next step: Genomic strategies	For (ii) and (iii), in addition to describing genomic methodologies and summarizing findings from…
30	The next step: Genomic strategies — Genomewide linkage analysis	In this family-based method, studies assess the likelihood that a genetic marker that is close to…
31	The next step: Genomic strategies — Genomewide linkage analysis	Linkage analysis rarely isolates a single gene. Rather, it narrows the investigator's search to a…
32	The next step: Genomic strategies — Genomewide linkage analysis	found to hydrolyze the endocannabinoids 2-arachidonoylethanolamide and 2-arachidonoylglycerol (two…
33	The next step: Genomic strategies — Genomewide linkage analysis	Thus, linkage studies have identified some novel candidate genes for future investigation. These…
34	The next step: Genomic strategies — Genomewide association studies (GWAS)	This is an exploratory method of study in which the genome is saturated with single nucleotide…
35	The next step: Genomic strategies — Candidate gene association analysis	This is a more targeted way to examine the extent to which SNPs in a gene that has been selected for…
36	Specific genes of biological relevance	The identification of genes that specifically relate to the action and metabolism of exogenous…
37	Cannabinoid receptors (CNR1 and CNR2)	Arguably the most likely candidate genes for cannabis use disorders are those encoding the…
38	Cannabinoid receptors (CNR1 and CNR2)	So far two cannabinoid receptors have been identified in humans: CB1, which is highly expressed in…
39	Cannabinoid receptors (CNR1 and CNR2)	The gene encoding CB1 (CNR1) is on human chromosome 6q14−15. It is a 25 kb gene with 4 exons, of…

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In this knowledge base

Title	Year	PMID
Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.	2015	26595473
Cannabis controversies: how genetics can inform the study of comorbidity.	2014	24438181
Polygenic risk scores for smoking: predictors for alcohol and cannabis use?	2014	24450588
The Genetics, Neurogenetics and Pharmacogenetics of Addiction.	2014	25045619
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	2013	22823124
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.	2012	22745721
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	2012	22520967
No association of candidate genes with cannabis use in a large sample of Australian twin families.	2012	21507154
The co-occurring use and misuse of cannabis and tobacco: a review.	2012	22300456
The genetics of substance dependence.	2012	22703173
A genome-wide association study of DSM-IV cannabis dependence.	2011	21668797

External

Title	Authors	Journal	Year	Link
Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation.	Cordero AIH et al.	—	2025	→
Genetic Insights into Cannabis-induced Psychosis: Role of CNR1 Gene Mutation (rs1049353) and Implications- A Cross-sectional Study.	Sahoo S et al.	—	2025	→
Sex-Dependent Effects of <i>MAOA</i> Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.	Fite PJ et al.	—	2025	→
Amlodipine increases risk of primary open-angle glaucoma.	Lehrer S et al.	—	2024	→
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action.	Alayoubi M et al.	—	2024	→
Integrative Analysis of Morphine-Induced Differential Circular RNAs and ceRNA Networks in the Medial Prefrontal Cortex.	Yang X et al.	—	2024	→
The Evolving Role of Cannabidiol-Rich Cannabis in People with Autism Spectrum Disorder: A Systematic Review.	Jawed B et al.	—	2024	→
Amlodipine increases risk of primary open angle glaucoma	Lehrer S et al.	—	2023	—
Cannabis Pharmacogenomics: A Path to Personalized Medicine.	Babayeva M et al.	—	2023	→
Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans.	Maliszewska K et al.	—	2023	→
Endocannabinoid System: Chemical Characteristics and Biological Activity.	Rezende B et al.	—	2023	→
The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder.	Sultan AA et al.	—	2023	→
Cannabis, Intraocular Pressure, and the Growth Arrest-Specific 7 (GAS7) Gene: A Retrospective Analysis.	Lehrer S et al.	—	2022	→
FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.	Vereczkei A et al.	—	2022	→
Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery.	Dasram MH et al.	—	2022	→
The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.	Verweij KJH et al.	—	2022	→
The systems medicine of cannabinoids in pediatrics: the case for more pediatric studies.	O'Dell CP et al.	—	2022	→
A systems omics-based approach to decode substance use disorders and neuroadaptations.	Veerappa A et al.	—	2021	→
CBD-enriched cannabis for autism spectrum disorder: an experience of a single center in Turkey and reviews of the literature.	Bilge S et al.	—	2021	→
Effects of Cannabis on Cardiovascular System: The Good, the Bad, and the Many Unknowns.	Dabiri AE et al.	—	2021	→
ELTD1-An Emerging Silent Actor in Cancer Drama Play.	Sevastre AS et al.	—	2021	→
A logical relationship for schizophrenia, bipolar, and major depressive disorder. Part 1: Evidence from chromosome 1 high density association screen.	Zhang Z et al.	—	2020	→
Cannabis as a Gateway Drug for Opioid Use Disorder.	Williams AR	—	2020	→
Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer's Disease.	Uddin MS et al.	—	2020	→
Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status.	Fantauzzi MF et al.	—	2020	→
ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.	Li J et al.	—	2019	→
Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception.	Gerra MC et al.	—	2019	→
<i>CNR1</i> and <i>FAAH</i> variation and affective states induced by marijuana smoking.	Palmer RHC et al.	—	2019	→
Neuropsychiatric implications of transient receptor potential vanilloid (TRPV) channels in the reward system.	Singh R et al.	—	2019	→
Predicting Substance Use Patterns Among Rural Adults: The Roles of Mothers, Fathers, and Parenthood.	Wong JJ et al.	—	2019	→
Priority Considerations for Medicinal Cannabis-Related Research.	Bonn-Miller MO et al.	—	2019	→
A comparative study of socio-demographic and substance use correlates in early-onset psychosis.	Paruk S et al.	—	2018	→
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.	Zou S et al.	—	2018	→
Cannabinoids for the treatment of rheumatic diseases - where do we stand?	Katz-Talmor D et al.	—	2018	→
Gender-specific association of functional <i>prodynorphin</i> 68 bp repeats with cannabis exposure in an African American cohort.	Yuferov V et al.	—	2018	→
Pharmacogenetics of Cannabinoids.	Hryhorowicz S et al.	—	2018	→
Psychosocial and pharmacological interventions for the treatment of cannabis use disorder.	Sabioni P et al.	—	2018	→
The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users.	Batalla A et al.	—	2018	→
Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.	Ashenhurst JR et al.	—	2017	→
Family-Related Stress versus External Stressors: Differential Impacts on Alcohol and Illicit Drug Use in Young Men.	Rougemont-Bücking A et al.	—	2017	→
Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma.	Serban F et al.	—	2017	→
The genetic basis of the comorbidity between cannabis use and major depression.	Hodgson K et al.	—	2017	→
Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.	Maple KE et al.	—	2016	→
Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction.	Cadoni C	—	2016	→
Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.	Melroy-Greif WE et al.	—	2016	→
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.	Stringer S et al.	—	2016	→
Keep off the grass? Cannabis, cognition and addiction.	Curran HV et al.	—	2016	→
Age, sex and personality in early cannabis use.	Muro I Rodríguez A	—	2015	→
Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.	Carey CE et al.	—	2015	→
Cannabis controversies: how genetics can inform the study of comorbidity.	Agrawal A et al.	—	2014	→
Have the genetics of cannabis involvement gone to pot?	Agrawal A et al.	—	2014	→
Moderators of the association between peer and target adolescent substance use.	Marschall-Lévesque S et al.	—	2014	→
Polygenic risk scores for smoking: predictors for alcohol and cannabis use?	Vink JM et al.	—	2014	→
The Genetics, Neurogenetics and Pharmacogenetics of Addiction.	Demers CH et al.	—	2014	→
Trajectory of adolescent cannabis use on addiction vulnerability.	Hurd YL et al.	—	2014	→
Transient receptor potential vanilloid type 1 channel may modulate opioid reward.	Nguyen TL et al.	—	2014	→
A longitudinal analysis of the effects of a DRD4 polymorphism on marijuana use.	Vaske J et al.	—	2013	→
Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.	Sim MS et al.	—	2013	→
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence.	Rotter A et al.	—	2013	→
ELTD1, a potential new biomarker for gliomas.	Towner RA et al.	—	2013	→
Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction.	Panlilio LV et al.	—	2013	→
Interaction of the TaqIA polymorphism and poor parental socialization on changes in adolescent marijuana use.	Vaske J	—	2013	→
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	Verweij KJ et al.	—	2013	→
Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.	Schacht JP et al.	—	2012	→
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.	Jutras-Aswad D et al.	—	2012	→
[Cannabis: Use and dependence].	Dervaux A et al.	—	2012	→
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	Han S et al.	—	2012	→
No association of candidate genes with cannabis use in a large sample of Australian twin families.	Verweij KJ et al.	—	2012	→
Orexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokers.	Rotter A et al.	—	2012	→
The co-occurring use and misuse of cannabis and tobacco: a review.	Agrawal A et al.	—	2012	→
The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential.	Finn DP et al.	—	2012	→
The genetics of addiction-a translational perspective.	Agrawal A et al.	—	2012	→
The genetics of substance dependence.	Wang JC et al.	—	2012	→
The interplay between parental monitoring and the dopamine D4 receptor gene in adolescent cannabis use.	Otten R et al.	—	2012	→
A genome-wide association study of DSM-IV cannabis dependence.	Agrawal A et al.	—	2011	→
Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation.	Farrimond JA et al.	—	2011	→
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.	Estrada G et al.	—	2011	→
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology.	Oshri A et al.	—	2011	→
DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study.	Creemers HE et al.	—	2011	→
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.	Nemoda Z et al.	—	2011	→
The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction.	Viveros MP et al.	—	2011	→
Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues.	Filbey FM et al.	—	2010	→
The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment.	André A et al.	—	2010	→
[Comorbidity of substance use disorders and attention-deficit hyperactivity disorders: pathogenesis and therapy].	Fallgatter AJ et al.	—	2009	→
Genetically informative studies of 'environment'.	Lynskey MT et al.	—	2009	→