Candidate genes for cannabis use disorders: findings, challenges and directions.

paper Cited Public

Authors: Agrawal, Arpana; Lynskey, Michael T
Year: 2009
Journal: Addiction (Abingdon, England)
PMID: 19335651
DOI: 10.1111/j.1360-0443.2009.02504.x
PMCID: PMC2703791

#	Section	Preview
40	Cannabinoid receptors (CNR1 and CNR2)	Given the modest number of studies in Table 2 of cannabis dependence , there is only limited…
41	Cannabinoid receptors (CNR1 and CNR2)	The gene encoding CB2 (CNR2) lies on chromosome 1p36.11. The 39.4kb gene has 2 exons and has been…
42	Fatty acid amide hydrolase (FAAH)	A candidate with considerable promise for association studies of cannabis use disorders is the gene…
43	Fatty acid amide hydrolase (FAAH)	Residing on human chromosome 1p35−34, the FAAH gene is 19.5kb in length and includes 15 exons. The…
44	Fatty acid amide hydrolase (FAAH)	more likely to be street drug users or to report problems with alcohol or drugs. The effects were…
45	Monoglyceride lipase (MGLL)	In addition to FAAH, monoglyceride lipase (MGL) is responsible for the hydrolysis of 2-AG and other…
46	The Transient Receptor Potential Vanilloid 1 (TRPV1)	AEA (anandamide) also activates the vanilloid receptor 1, a transient receptor potential cation…
47	Orphan cannabinoid receptor (GPR55)	Several animal models (CB1 −/− knockout) suggest that additional cannabinoid receptors may exist…
48	Non-specific genes of biological relevance	Genes encoding the major neurotransmitter systems could potentially influence the biological basis…
49	The GABAergic System – GABRA2	Gamma-amino butyric acid is one of the major inhibitory neurotransmitters in humans. Genes encoding…
50	The GABAergic System – GABRA2	Within the substance use literature, the most widely studied GABAergic gene is GABRA2 on chromosome…
51	The Dopaminergic System – DRD2	Studies suggest that THC increases dopamine firing release in several parts of the brain. Van der…
52	The Dopaminergic System – DRD2	Human association studies have found associations between DRD2 and cannabis use. Conner et al [113]…
53	The Opioidergic System – OPRM1	The endogenous opioid system consists of mu, delta and kappa receptors. The opioidergic system may…
54	The Opioidergic System – OPRM1	Given the primary importance of the mu-opioid receptors in cannabinoid-opioid interplay, the gene…
55	Challenges of genomic studies of cannabis use disorders	Despite the higher prevalence of cannabis use and cannabis use disorders than other illicit drug…
56	Challenges of genomic studies of cannabis use disorders — Biological mechanisms underlying genetic risk	Currently, our choice of candidate genes is driven by accumulating evidence from preclinical…
57	Challenges of genomic studies of cannabis use disorders — Gene-gene interactions	Cannabis and other substance use disorders are likely to be polygenic (i.e. to involve several genes…
58	Challenges of genomic studies of cannabis use disorders — Gene-environment interactions	Cannabis use disorders are multifactorial and these factors (genes and environment) interact to…
59	Challenges of genomic studies of cannabis use disorders — Definition of the Phenotype	Efforts are under way to improve existing DSM-IV criteria for cannabis use disorders, e.g. by the…

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In this knowledge base

Title	Year	PMID
Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.	2015	26595473
Cannabis controversies: how genetics can inform the study of comorbidity.	2014	24438181
Polygenic risk scores for smoking: predictors for alcohol and cannabis use?	2014	24450588
The Genetics, Neurogenetics and Pharmacogenetics of Addiction.	2014	25045619
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	2013	22823124
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.	2012	22745721
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	2012	22520967
No association of candidate genes with cannabis use in a large sample of Australian twin families.	2012	21507154
The co-occurring use and misuse of cannabis and tobacco: a review.	2012	22300456
The genetics of substance dependence.	2012	22703173
A genome-wide association study of DSM-IV cannabis dependence.	2011	21668797

External

Title	Authors	Journal	Year	Link
Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation.	Cordero AIH et al.	—	2025	→
Genetic Insights into Cannabis-induced Psychosis: Role of CNR1 Gene Mutation (rs1049353) and Implications- A Cross-sectional Study.	Sahoo S et al.	—	2025	→
Sex-Dependent Effects of <i>MAOA</i> Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.	Fite PJ et al.	—	2025	→
Amlodipine increases risk of primary open-angle glaucoma.	Lehrer S et al.	—	2024	→
Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of Action.	Alayoubi M et al.	—	2024	→
Integrative Analysis of Morphine-Induced Differential Circular RNAs and ceRNA Networks in the Medial Prefrontal Cortex.	Yang X et al.	—	2024	→
The Evolving Role of Cannabidiol-Rich Cannabis in People with Autism Spectrum Disorder: A Systematic Review.	Jawed B et al.	—	2024	→
Amlodipine increases risk of primary open angle glaucoma	Lehrer S et al.	—	2023	—
Cannabis Pharmacogenomics: A Path to Personalized Medicine.	Babayeva M et al.	—	2023	→
Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans.	Maliszewska K et al.	—	2023	→
Endocannabinoid System: Chemical Characteristics and Biological Activity.	Rezende B et al.	—	2023	→
The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder.	Sultan AA et al.	—	2023	→
Cannabis, Intraocular Pressure, and the Growth Arrest-Specific 7 (GAS7) Gene: A Retrospective Analysis.	Lehrer S et al.	—	2022	→
FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.	Vereczkei A et al.	—	2022	→
Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery.	Dasram MH et al.	—	2022	→
The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.	Verweij KJH et al.	—	2022	→
The systems medicine of cannabinoids in pediatrics: the case for more pediatric studies.	O'Dell CP et al.	—	2022	→
A systems omics-based approach to decode substance use disorders and neuroadaptations.	Veerappa A et al.	—	2021	→
CBD-enriched cannabis for autism spectrum disorder: an experience of a single center in Turkey and reviews of the literature.	Bilge S et al.	—	2021	→
Effects of Cannabis on Cardiovascular System: The Good, the Bad, and the Many Unknowns.	Dabiri AE et al.	—	2021	→
ELTD1-An Emerging Silent Actor in Cancer Drama Play.	Sevastre AS et al.	—	2021	→
A logical relationship for schizophrenia, bipolar, and major depressive disorder. Part 1: Evidence from chromosome 1 high density association screen.	Zhang Z et al.	—	2020	→
Cannabis as a Gateway Drug for Opioid Use Disorder.	Williams AR	—	2020	→
Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer's Disease.	Uddin MS et al.	—	2020	→
Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status.	Fantauzzi MF et al.	—	2020	→
ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.	Li J et al.	—	2019	→
Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception.	Gerra MC et al.	—	2019	→
<i>CNR1</i> and <i>FAAH</i> variation and affective states induced by marijuana smoking.	Palmer RHC et al.	—	2019	→
Neuropsychiatric implications of transient receptor potential vanilloid (TRPV) channels in the reward system.	Singh R et al.	—	2019	→
Predicting Substance Use Patterns Among Rural Adults: The Roles of Mothers, Fathers, and Parenthood.	Wong JJ et al.	—	2019	→
Priority Considerations for Medicinal Cannabis-Related Research.	Bonn-Miller MO et al.	—	2019	→
A comparative study of socio-demographic and substance use correlates in early-onset psychosis.	Paruk S et al.	—	2018	→
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.	Zou S et al.	—	2018	→
Cannabinoids for the treatment of rheumatic diseases - where do we stand?	Katz-Talmor D et al.	—	2018	→
Gender-specific association of functional <i>prodynorphin</i> 68 bp repeats with cannabis exposure in an African American cohort.	Yuferov V et al.	—	2018	→
Pharmacogenetics of Cannabinoids.	Hryhorowicz S et al.	—	2018	→
Psychosocial and pharmacological interventions for the treatment of cannabis use disorder.	Sabioni P et al.	—	2018	→
The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users.	Batalla A et al.	—	2018	→
Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.	Ashenhurst JR et al.	—	2017	→
Family-Related Stress versus External Stressors: Differential Impacts on Alcohol and Illicit Drug Use in Young Men.	Rougemont-Bücking A et al.	—	2017	→
Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma.	Serban F et al.	—	2017	→
The genetic basis of the comorbidity between cannabis use and major depression.	Hodgson K et al.	—	2017	→
Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.	Maple KE et al.	—	2016	→
Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction.	Cadoni C	—	2016	→
Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.	Melroy-Greif WE et al.	—	2016	→
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.	Stringer S et al.	—	2016	→
Keep off the grass? Cannabis, cognition and addiction.	Curran HV et al.	—	2016	→
Age, sex and personality in early cannabis use.	Muro I Rodríguez A	—	2015	→
Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.	Carey CE et al.	—	2015	→
Cannabis controversies: how genetics can inform the study of comorbidity.	Agrawal A et al.	—	2014	→
Have the genetics of cannabis involvement gone to pot?	Agrawal A et al.	—	2014	→
Moderators of the association between peer and target adolescent substance use.	Marschall-Lévesque S et al.	—	2014	→
Polygenic risk scores for smoking: predictors for alcohol and cannabis use?	Vink JM et al.	—	2014	→
The Genetics, Neurogenetics and Pharmacogenetics of Addiction.	Demers CH et al.	—	2014	→
Trajectory of adolescent cannabis use on addiction vulnerability.	Hurd YL et al.	—	2014	→
Transient receptor potential vanilloid type 1 channel may modulate opioid reward.	Nguyen TL et al.	—	2014	→
A longitudinal analysis of the effects of a DRD4 polymorphism on marijuana use.	Vaske J et al.	—	2013	→
Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.	Sim MS et al.	—	2013	→
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence.	Rotter A et al.	—	2013	→
ELTD1, a potential new biomarker for gliomas.	Towner RA et al.	—	2013	→
Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction.	Panlilio LV et al.	—	2013	→
Interaction of the TaqIA polymorphism and poor parental socialization on changes in adolescent marijuana use.	Vaske J	—	2013	→
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	Verweij KJ et al.	—	2013	→
Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.	Schacht JP et al.	—	2012	→
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.	Jutras-Aswad D et al.	—	2012	→
[Cannabis: Use and dependence].	Dervaux A et al.	—	2012	→
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	Han S et al.	—	2012	→
No association of candidate genes with cannabis use in a large sample of Australian twin families.	Verweij KJ et al.	—	2012	→
Orexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokers.	Rotter A et al.	—	2012	→
The co-occurring use and misuse of cannabis and tobacco: a review.	Agrawal A et al.	—	2012	→
The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential.	Finn DP et al.	—	2012	→
The genetics of addiction-a translational perspective.	Agrawal A et al.	—	2012	→
The genetics of substance dependence.	Wang JC et al.	—	2012	→
The interplay between parental monitoring and the dopamine D4 receptor gene in adolescent cannabis use.	Otten R et al.	—	2012	→
A genome-wide association study of DSM-IV cannabis dependence.	Agrawal A et al.	—	2011	→
Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation.	Farrimond JA et al.	—	2011	→
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.	Estrada G et al.	—	2011	→
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology.	Oshri A et al.	—	2011	→
DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study.	Creemers HE et al.	—	2011	→
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.	Nemoda Z et al.	—	2011	→
The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction.	Viveros MP et al.	—	2011	→
Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues.	Filbey FM et al.	—	2010	→
The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment.	André A et al.	—	2010	→
[Comorbidity of substance use disorders and attention-deficit hyperactivity disorders: pathogenesis and therapy].	Fallgatter AJ et al.	—	2009	→
Genetically informative studies of 'environment'.	Lynskey MT et al.	—	2009	→