Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

paper Cited Public

Authors: Lüscher, Christian; Slesinger, Paul A
Year: 2010
Journal: Nature reviews. Neuroscience
PMID: 20389305
DOI: 10.1038/nrn2834
PMCID: PMC3052907

#	Section	Preview
20	A macromolecular signaling complex for GIRK channels	of hippocampal neurons110, which has been confirmed by cell-attached patch-clamp recordings111. In…
21	A macromolecular signaling complex for GIRK channels	Future immunoelectron or super-resolution microscopy studies may reveal additional details on the…
22	Reducing excitability: physiological roles for GIRK channels	The physiological activation of GIRK channels can shape the neuronal network behavior in many areas…
23	Reducing excitability: physiological roles for GIRK channels — Neuronal self-inhibition	Some neurons release a neurotransmitter to activate Gi/o-coupled receptors and in turn GIRK channels…
24	Reducing excitability: physiological roles for GIRK channels — Neuron-to-neuron inhibition	Activation of postsynaptic GABAB receptors115, D2 receptors116 and group II metabotropic glutamate…
25	Reducing excitability: physiological roles for GIRK channels — Neuron-to-neuron inhibition	limited by the speed of G protein activation. The reuptake/degradation of the neurotransmitter and…
26	Reducing excitability: physiological roles for GIRK channels — Network-level inhibition	The regulation of ambient levels of several endogenous GPCR agonists (e.g. adenosine, somatostatin)…
27	Reducing excitability: physiological roles for GIRK channels — Network-level inhibition	predominantly extrasynaptic DA autoreceptors on DA axons and heteroreceptors on neighboring cells.…
28	Moving channels to modulate GIRK	Recently, a plasticity of the slow IPSCs in response to GABAB and D2 receptor activation has been…
29	Moving channels to modulate GIRK	In contrast, activation of dopamine D2 receptors causes a long-term depression (LTD) of the…
30	Moving channels to modulate GIRK	Taken together, GIRK channels play a key role in many types of neuronal communication and, as will…
31	GIRK channels in pain perception and analgesia	GIRK channels have been implicated in pain perception. This notion is based on studies with mice…
32	GIRK channels in pain perception and analgesia	GIRK channels were first implicated in pain perception when opioid analgesia was tested in weaver…
33	GIRK channels in pain perception and analgesia	Subsequent studies have taken advantage of GIRK channel knockout mice (see Table 1). In GIRK2−/−…
34	GIRK channels in pain perception and analgesia	Knockout studies also suggest that GIRK channels may account for gender difference in nociception.…
35	GIRK channels in pain perception and analgesia	The periaqueductal grey (PAG), a small nucleus in the brain stem, has a crucial role in central…
36	GIRK channels in pain perception and analgesia	GIRK channels have also been implicated in opioid tolerance and dependence due to adaptive changes…
37	GIRK channels in pain perception and analgesia	An alternate role of GIRK channels in opioid dependence is suggested by the following observations.…
38	GIRK channels in pain perception and analgesia	Taken together these data suggest that GIRKs have a role in pain perception under specific…
39	Altered excitability and dying neurons: GIRK channels in disease	GIRK channels are implicated in the pathophysiology of several diseases, including epilepsy,…

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In this knowledge base

Title	Year	PMID
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.	2023	36207584
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	2018	29897633
A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.	2017	27993610
Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.	2017	28676630
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.	2014	24811384
Understanding alcohol use disorders with neuroelectrophysiology.	2014	25307587
Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.	2011	22098295

External

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A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons.	Liu X et al.	—	2026	→
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Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives.	Incontro S et al.	—	2025	→
Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.	Handklo-Jamal R et al.	—	2025	→
New insights into the role of solute carriers in response to salinity stress in the Manila clam (Ruditapes philippinarum).	Lin Z et al.	—	2025	→
Polystyrene modulation of perfluorooctanoic acid toxicity in zebrafish: Transcriptomic and toxicological insights.	Zhao Y et al.	—	2025	→
Rapid purification of brain protein complexes containing active and inactive forms of the G protein Gαo.	Yadav S et al.	—	2025	→
Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.	Pachenari N et al.	—	2025	→
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The structural basis of the G protein-coupled receptor and ion channel axis.	Luo Y et al.	—	2025	→
Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine.	Koita O et al.	—	2025	→
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A critical review of ethanol effects on neuronal firing: A metabolic perspective.	Popova D et al.	—	2024	→
Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons.	Choi Y et al.	—	2024	→
Central Channelopathies in Obesity.	Li AH et al.	—	2024	→
Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.	Nguyen H et al.	—	2024	→
Direct modulation of TRPC ion channels by Gα proteins.	Kang H et al.	—	2024	→
GABA<sub>B</sub> receptor-mediated modulation in the developing dorsal nucleus of the lateral lemniscus.	Javadova A et al.	—	2024	→
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Selectivity filter mutations shift ion permeation mechanism in potassium channels.	Mironenko A et al.	—	2024	→
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Unraveling the Interplay of Dopamine, Carbon Monoxide, and Heme Oxygenase in Neuromodulation and Cognition.	Bauer N et al.	—	2024	→
Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons.	Prytkova I et al.	—	2024	→
5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.	Gameiro-Ros I et al.	—	2023	→
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.	Popova D et al.	—	2023	→
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A muscarinic, GIRK channel-mediated inhibition of inspiratory-related XII nerve motor output emerges in early postnatal development in mice.	Rudy SL et al.	—	2023	→
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Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior.	Dong D et al.	—	2023	→
De Novo Variant in the <i>KCNJ9</i> Gene as a Possible Cause of Neonatal Seizures.	Kochetkova TO et al.	—	2023	→
Effects of GABA<sub>B</sub> receptor blockade on lateral habenula glutamatergic neuron activity following morphine injection in the rat: an electrophysiological study.	Amohashemi E et al.	—	2023	→
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.	Colombo S et al.	—	2023	→
Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance.	Rahman MM et al.	—	2023	→
Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits.	Park JC et al.	—	2023	→
GABAergic signaling as a potential therapeutic target in cancers.	Yang Y et al.	—	2023	→
Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways.	Seldeslachts A et al.	—	2023	→
Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson's Disease via Bioinformatics Analysis.	Zhou Y et al.	—	2023	→
Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade	Contreras A et al.	—	2023	—
Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade.	Contreras A et al.	—	2023	→
Increased GIRK channel activity prevents arrhythmia in mice with heart failure by enhancing ventricular repolarization.	An X et al.	—	2023	→
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy?	Löscher W	—	2023	→
Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.	Jiao Y et al.	—	2023	→
Multiple potassium channel tetramerization domain (KCTD) family members interact with Gβγ, with effects on cAMP signaling.	Sloan DC et al.	—	2023	→
Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear-potentiated startle.	Boyle CA et al.	—	2023	→
Neuronal primary cilia integrate peripheral signals with metabolic drives.	DeMars KM et al.	—	2023	→
Neuropharmacology of Alcohol Addiction with Special Emphasis on Proteomic Approaches for Identification of Novel Therapeutic Targets.	Ray SK et al.	—	2023	→
Opioid Receptors Modulate Firing and Synaptic Transmission in the Paraventricular Nucleus of the Thalamus.	Hou G et al.	—	2023	→
Perampanel as precision therapy in rare genetic epilepsies.	Nissenkorn A et al.	—	2023	→
Potassium Channels in Parkinson's Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment.	Chen X et al.	—	2023	→
Prostaglandin E<sub>2</sub> Induces Long-Lasting Inhibition of Noradrenergic Neurons in the Locus Coeruleus and Moderates the Behavioral Response to Stressors.	Mukai Y et al.	—	2023	→
Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids.	Cibulsky SM et al.	—	2023	→
Serotonergic regulation of appetite and sodium appetite.	Shin Y et al.	—	2023	→
Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors.	Hosseinzadeh Sahafi O et al.	—	2023	→
Soluble amyloid-β precursor peptide does not regulate GABA<sub>B</sub> receptor activity.	Rem PD et al.	—	2023	→
The collaborative study on the genetics of alcoholism: Genetics.	Johnson EC et al.	—	2023	→
The influence of dopamine autoreceptors on temperament and addiction risk.	Zald DH	—	2023	→
The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control.	Hernandez CC et al.	—	2023	→
The W101C <i>KCNJ5</i> Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes.	Kayser A et al.	—	2023	→
Activation of D1/D5 receptors ameliorates decreased intrinsic excitability of hippocampal neurons induced by neonatal blockade of N-methyl-d-aspartate receptors.	Griego E et al.	—	2022	→
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells.	Zheng F et al.	—	2022	→
Alcohol Use Disorder: Neurobiology and Therapeutics.	Yang W et al.	—	2022	→
Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.	Choudhury SP et al.	—	2022	→
AsKC11, a Kunitz Peptide from <i>Anemonia sulcata</i>, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels.	An D et al.	—	2022	→
ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (Ca<sub>V</sub> 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABA<sub>B</sub> receptor activation.	Yousuf A et al.	—	2022	→
Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology.	Brust TF	—	2022	→
Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K<sup>+</sup> channels.	Pelzmann B et al.	—	2022	→
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Dual action of ketamine confines addiction liability.	Simmler LD et al.	—	2022	→
Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy.	Akyuz E et al.	—	2022	→
Exploring the Mystery of Osteoarthritis using Bioinformatics Analysis of Cartilage Tissue.	Wang B et al.	—	2022	→
GABA-B receptors enhance GABA-A receptor currents by modulation of membrane trafficking in dentate gyrus granule cells.	Li N et al.	—	2022	→
GIRK2 Channels in Down Syndrome and Alzheimer's Disease.	Kleschevnikov A	—	2022	→
GIRK3 deletion facilitates kappa opioid signaling in chondrocytes, delays vascularization and promotes bone lengthening in mice.	Taylor EL et al.	—	2022	→
GIRK channel as a versatile regulator of neurotransmitter release via L-type Ca<sup>2+</sup> channel-dependent mechanism in the neuromuscular junction.	Tsentsevitsky AN et al.	—	2022	→
GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders.	Kotajima-Murakami H et al.	—	2022	→
G<sub>i/o</sub> protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na<sup>+</sup>/K<sup>+</sup> ATPase activation.	Dickerson MT et al.	—	2022	→
Histamine H<sub>3</sub> Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at Ca<sub>V</sub>2.1 (P/Q-Type) Calcium Channels and GIRK (K<sub>IR</sub>3) Potassium Channels.	Vázquez-Vázquez H et al.	—	2022	→
Hyperexcitable arousal circuits drive sleep instability during aging.	Li SB et al.	—	2022	→
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.	Yan S et al.	—	2022	→
Ionic signalling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear-potentiated startle response in the basolateral amygdala.	Boyle CA et al.	—	2022	→
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity.	Victor MB et al.	—	2022	→
Mechanisms and Regulation of Neuronal GABA<sub>B</sub> Receptor-Dependent Signaling.	Rose TR et al.	—	2022	→
Nanoscale alterations in GABA<sub>B</sub> receptors and GIRK channel organization on the hippocampus of APP/PS1 mice.	Martín-Belmonte A et al.	—	2022	→
Neural Subtype-dependent Cholinergic Modulation of Neural Activities by Activation of Muscarinic 2 Receptors and G Protein-activated Inwardly Rectifying Potassium Channel in Rat Periaqueductal Gray Neurons.	Sugawara S et al.	—	2022	→
Optical tools to study the subcellular organization of GPCR neuromodulation.	Jullié D et al.	—	2022	→
Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.	Zhang WW et al.	—	2022	→
Presynaptic mechanisms underlying GABA<sub>B</sub>-receptor-mediated inhibition of spontaneous neurotransmitter release.	Alten B et al.	—	2022	→
ProBDNF and Brain-Derived Neurotrophic Factor Prodomain Differently Modulate Acetylcholine Release in Regenerating and Mature Mouse Motor Synapses.	Bogacheva PO et al.	—	2022	→
Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APP<sub>Sw,Ind</sub> J9 Alzheimer's Disease Mouse Model.	Temprano-Carazo S et al.	—	2022	→
Spike-Dependent Dynamic Partitioning of the Locus Coeruleus Network through Noradrenergic Volume Release in a Simulation of the Nucleus Core.	Baral S et al.	—	2022	→
The pathophysiology of opioid-induced respiratory depression.	Montandon G	—	2022	→
The Relevance of GIRK Channels in Heart Function.	Campos-Ríos A et al.	—	2022	→
Transcriptome Analyses Provide Insights into the Auditory Function in <i>Trachemys scripta elegans</i>.	Lu N et al.	—	2022	→
TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G<sub>q/11</sub>-G<sub>i/o</sub> coincidence signals of variable strengths.	Tian JB et al.	—	2022	→
Activation of V<sub>1a</sub> vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels.	Lei S et al.	—	2021	→
A double bilayer to study the nonequilibrium environmental response of GIRK2 in complex states.	Weng J et al.	—	2021	→
Advances in Targeting GIRK Channels in Disease.	Zhao Y et al.	—	2021	→
A Gain-of-Function Variant in Dopamine D2 Receptor and Progressive Chorea and Dystonia Phenotype.	van der Weijden MCM et al.	—	2021	→
Altered Expression of Ion Channels in White Matter Lesions of Progressive Multiple Sclerosis: What Do We Know About Their Function?	Boscia F et al.	—	2021	→
A photoswitchable GPCR-based opsin for presynaptic inhibition.	Copits BA et al.	—	2021	→
Are ion channels potential therapeutic targets for Parkinson's disease?	Daniel NH et al.	—	2021	→
Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior.	Vo BN et al.	—	2021	→
Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying K<sup>+</sup> Channels.	Anderson A et al.	—	2021	→
Discovery, synthesis and biological characterization of a series of <i>N</i>-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1<i>H</i>-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.	Sharma S et al.	—	2021	→
Dopamine D<sub>4</sub> Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum.	Rivera A et al.	—	2021	→
Encephalopathy-causing mutations in Gβ<sub>1</sub> (<i>GNB1</i>) alter regulation of neuronal GIRK channels.	Reddy HP et al.	—	2021	→
Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions.	Qiao P et al.	—	2021	→
G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.	Djebari S et al.	—	2021	→
Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.	Enyeart JJ et al.	—	2021	→
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.	Korlatowicz A et al.	—	2021	→
Infralimbic cortex pyramidal neuron GIRK signaling contributes to regulation of cognitive flexibility but not affect-related behavior in male mice.	Anderson EM et al.	—	2021	→
Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.	Cui M et al.	—	2021	→
Metabotropic Modulation of Potassium Channels During Synaptic Plasticity.	Fernández-Fernández D et al.	—	2021	→
Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.	Jiang C et al.	—	2021	→
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.	Weaver CD et al.	—	2021	→
Optogenetic Modulation of Ion Channels by Photoreceptive Proteins.	Tsukamoto H et al.	—	2021	→
Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities.	Ehrlich AT et al.	—	2021	→
Reduced activity of GIRK1-containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory.	Mett A et al.	—	2021	→
RNA-binding proteins balance brain function in health and disease.	Schieweck R et al.	—	2021	→
Structural insights into GIRK2 channel modulation by cholesterol and PIP<sub>2</sub>.	Mathiharan YK et al.	—	2021	→
The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.	Alfaro-Ruiz R et al.	—	2021	→
The neural G protein Gαo tagged with GFP at an internal loop is functional in Caenorhabditis elegans.	Kumar S et al.	—	2021	→
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system.	Jeremic D et al.	—	2021	→
The role of peripheral opioid receptors in orofacial pain.	Liu Q et al.	—	2021	→
Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson's disease.	Lyu Y et al.	—	2021	→
Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells.	Parga Becerra A et al.	—	2021	→
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons.	Rodgers J et al.	—	2021	→
WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels.	An D et al.	—	2021	→
α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability.	Dagra A et al.	—	2021	→
Absence of methamphetamine-induced conditioned place preference in weaver mutant mice.	Ikekubo Y et al.	—	2020	→
A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors.	Berlin S et al.	—	2020	→
An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABA<sub>B</sub>/GIRK Signaling.	Druart M et al.	—	2020	→
Antinociceptive effect of selective G protein-gated inwardly rectifying K+ channel agonist ML297 in the rat spinal cord.	Kimura M et al.	—	2020	→
Functional characterization of 5-HT<sub>1A</sub> and 5-HT<sub>1B</sub> serotonin receptor signaling through G-protein-activated inwardly rectifying K<sup>+</sup> channels in a fluorescence-based membrane potential assay.	Gadgaard C et al.	—	2020	→
GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.	Lippiello P et al.	—	2020	→
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.	Anderson A et al.	—	2020	→
G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury.	Lyu C et al.	—	2020	→
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.	Pfeil EM et al.	—	2020	→
Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity.	Sánchez-Rodríguez I et al.	—	2020	→
Histamine, histamine receptors, and neuropathic pain relief.	Obara I et al.	—	2020	→
Identification of a G-Protein-Independent Activator of GIRK Channels.	Zhao Y et al.	—	2020	→
Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy.	Akyüz E et al.	—	2020	→
Low-Frequency (20 kHz) Ultrasonic Modulation of Drug Action.	Abramavičius S et al.	—	2020	→
Mechanisms of ammonium-induced neurotoxicity. Neuroprotective effect of alpha-2 adrenergic agonists.	Gaidin SG et al.	—	2020	→
Melatonin promotes sleep by activating the BK channel in <i>C. elegans</i>.	Niu L et al.	—	2020	→
Oxytocin receptors excite lateral nucleus of central amygdala by phospholipase Cβ- and protein kinase C-dependent depression of inwardly rectifying K<sup>+</sup> channels.	Hu B et al.	—	2020	→
PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity.	Zhao D et al.	—	2020	→
Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry.	Brullo C et al.	—	2020	→
Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators.	Walsh KB	—	2020	→
Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels.	Patel D et al.	—	2020	→
The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A<sub>1</sub> Receptor.	Spanoghe J et al.	—	2020	→
The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.	Xu Y et al.	—	2020	→
Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCα/Nrf2/p53 signaling pathways.	Wang C et al.	—	2020	→
Voltage modulates the effect of μ-receptor activation in a ligand-dependent manner.	Ruland JG et al.	—	2020	→
Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.	Abney KK et al.	—	2019	→
Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism.	Rønnekleiv OK et al.	—	2019	→
Artificial Signal Transduction across Membranes.	Vanuytsel S et al.	—	2019	→
Axonal projection-specific differences in somatodendritic α2 autoreceptor function in locus coeruleus neurons.	Wagner-Altendorf TA et al.	—	2019	→
Calcium, Dopamine and Neuronal Calcium Sensor 1: Their Contribution to Parkinson's Disease.	Catoni C et al.	—	2019	→
Cellular and Network Mechanisms May Generate Sparse Coding of Sequential Object Encounters in Hippocampal-Like Circuits.	Trinh AT et al.	—	2019	→
Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels.	Bukiya AN et al.	—	2019	→
Cholinergic Transmission at Muscarinic Synapses in the Striatum Is Driven Equally by Cortical and Thalamic Inputs.	Mamaligas AA et al.	—	2019	→
Conduction through a narrow inward-rectifier K<sup>+</sup> channel pore.	Bernsteiner H et al.	—	2019	→
Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells.	Soriano S et al.	—	2019	→
Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.	Kozek KA et al.	—	2019	→
Disease Associated Mutations in K<sub>IR</sub> Proteins Linked to Aberrant Inward Rectifier Channel Trafficking.	Zangerl-Plessl EM et al.	—	2019	→
Electrophysiological Actions of N/OFQ.	Winters BL et al.	—	2019	→
Emerging Diversity in Lipid-Protein Interactions.	Corradi V et al.	—	2019	→
Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.	Pati D et al.	—	2019	→
GABA is a modulator, rather than a classical transmitter, in the medial nucleus of the trapezoid body-lateral superior olive sound localization circuit.	Fischer AU et al.	—	2019	→
GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A.	Schratter G et al.	—	2019	→
Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.	Carver CM et al.	—	2019	→
L-DOPA-quinone Mediated Recovery from GIRK Channel Firing Inhibition in Dopaminergic Neurons.	Bizzarri BM et al.	—	2019	→
Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.	Tabak G et al.	—	2019	→
Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective.	Bazzari AH et al.	—	2019	→
Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement.	Morel C et al.	—	2019	→
Novel and Potent Dopamine D<sub>2</sub> Receptor Go-Protein Biased Agonists.	Bonifazi A et al.	—	2019	→
Novel Approaches to Persistent Pain Therapy.	Sisignano M et al.	—	2019	→
On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer.	Li D et al.	—	2019	→
Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands.	Acosta-Ruiz A et al.	—	2019	→
[Pain inhibition by opioids-new concepts].	Stein C	—	2019	→
[Pain inhibition by opioids-new concepts].	Stein C	—	2019	→
Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid-<i>β</i> Pathology.	Sánchez-Rodríguez I et al.	—	2019	→
Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel.	Kano H et al.	—	2019	→
Adenosine A<sub>1</sub> receptor activates background potassium channels and modulates information processing in olfactory bulb mitral cells.	Rotermund N et al.	—	2018	→
Alleviation by GABA<sub>B</sub> Receptors of Neurotoxicity Mediated by Mitochondrial Permeability Transition Pore in Cultured Murine Cortical Neurons Exposed to N-Methyl-D-aspartate.	Kinjo T et al.	—	2018	→
A mechanistic review on GNAO1-associated movement disorder.	Feng H et al.	—	2018	→
Analysis of natural product regulation of opioid receptors in the treatment of human disease.	Badal S et al.	—	2018	→
Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior.	Cannady R et al.	—	2018	→
Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells.	Gonzalez JC et al.	—	2018	→
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K<sup>+</sup> currents in adult murine atria.	Nobles M et al.	—	2018	→
DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K<sup>+</sup> Channels.	Kurokawa T et al.	—	2018	→
Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype.	Horvath GA et al.	—	2018	→
Genes linked to species diversity in a sexually dimorphic communication signal in electric fish.	Smith GT et al.	—	2018	→
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	Prytkova I et al.	—	2018	→
Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation.	Tateyama M et al.	—	2018	→
GPCR regulation of secretion.	Yim YY et al.	—	2018	→
G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1.	Carrington SJ et al.	—	2018	→
G<sub>i/o</sub> protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN.	Philippart F et al.	—	2018	→
G<sub>i</sub> protein functions in thalamic neurons to decrease orofacial nociceptive response.	Strand J et al.	—	2018	→
Inhibition of Pyramidal Neurons in the Basal Amygdala Promotes Fear Learning.	Tipps M et al.	—	2018	→
Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7.	Ostrovskaya OI et al.	—	2018	→
Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.	Krebs KM et al.	—	2018	→
Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex.	Radnikow G et al.	—	2018	→
Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury.	Stötzner P et al.	—	2018	→
New concepts in opioid analgesia.	Stein C	—	2018	→
New opioid receptor modulators and agonists.	Kaye AD et al.	—	2018	→
Nociceptin/Orphanin-FQ Inhibits Gonadotropin-Releasing Hormone Neurons via G-Protein-Gated Inwardly Rectifying Potassium Channels.	Constantin S et al.	—	2018	→
Peptide YY (3-36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons.	Domingues MF et al.	—	2018	→
Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease.	Chen X et al.	—	2018	→
Prohedonic properties of gamma-hydroxybutyrate are associated with changes in limbic resting-state functional connectivity.	Bosch OG et al.	—	2018	→
Reversal of dopamine-mediated firing inhibition through activation of the dopamine transporter in substantia nigra pars compacta neurons.	Aversa D et al.	—	2018	→
Rhodol-based thallium sensors for cellular imaging of potassium channel activity.	Dutter BF et al.	—	2018	→
Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D<sub>2</sub> Dopamine Receptor.	Chun LS et al.	—	2018	→
The Effect of Histamine on Inward and Outward Currents in Mouse Retinal Amacrine Cells.	Horio K et al.	—	2018	→
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease.	Liu H et al.	—	2018	→
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.	Chao PK et al.	—	2017	→
Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology.	Sánchez-Rodríguez I et al.	—	2017	→
A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.	Kamarajan C et al.	—	2017	→
Applications of optogenetic and chemogenetic methods to seizure circuits: Where to go next?	Forcelli PA	—	2017	→
Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.	Bukiya AN et al.	—	2017	→
Collision coupling in the GABA<sub>B</sub> receptor-G protein-GIRK signaling cascade.	Kahanovitch U et al.	—	2017	→
Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.	Wieting JM et al.	—	2017	→
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.	Möller D et al.	—	2017	→
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.	Chen SR et al.	—	2017	→
Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.	Glaaser IW et al.	—	2017	→
Dynamic monitoring of G<sub>i/o</sub>-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors.	Storch U et al.	—	2017	→
Dynamic role of the tether helix in PIP<sub>2</sub>-dependent gating of a G protein-gated potassium channel.	Lacin E et al.	—	2017	→
Enhancement of μ-opioid receptor desensitization by orexin-A in rat locus coeruleus neurons.	Mohammad Ahmadi Soleimani S et al.	—	2017	→
Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats.	Guatteo E et al.	—	2017	→
Functional perturbation of forebrain principal neurons reveals differential effects in novel and well-learned tasks.	Stoneham ET et al.	—	2017	→
Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.	Brust TF et al.	—	2017	→
Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.	Llamosas N et al.	—	2017	→
Inhibition of 17-beta-estradiol on neuronal excitability via enhancing GIRK1-mediated inwardly rectifying potassium currents and GIRK1 expression.	Zhang Y et al.	—	2017	→
Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking.	Cook JB et al.	—	2017	→
KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.	Fritzius T et al.	—	2017	→
Lithium reduces the span of G protein-activated K<sup>+</sup> (GIRK) channel inhibition in hippocampal neurons.	Dascal N et al.	—	2017	→
Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate.	Li WC et al.	—	2017	→
N-(2-methoxyphenyl) benzenesulfonamide, a novel regulator of neuronal G protein-gated inward rectifier K<sup>+</sup> channels.	Walsh KB et al.	—	2017	→
Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.	Baculis BC et al.	—	2017	→
Relationship in Pacemaker Neurons Between the Long-Term Correlations of Membrane Voltage Fluctuations and the Corresponding Duration of the Inter-Spike Interval.	Rubfiaro AS et al.	—	2017	→
Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders.	Dobbs LK et al.	—	2017	→
Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs).	Li Y et al.	—	2017	→
Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.	Marron Fernandez de Velasco E et al.	—	2017	→
The metal and metalloprotein profile of human plasma as biomarkers for stroke diagnosis.	Nahan KS et al.	—	2017	→
Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.	Govindpani K et al.	—	2017	→
Tuning of Neuronal Interactions in the Lateral Ventral Tegmental Area by Dopamine Sensitivity.	van der Velden L et al.	—	2017	→
α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.	Lieberman OJ et al.	—	2017	→
δ-Subunit Containing GABA<sub>A</sub> Receptors Modulate Respiratory Networks.	Montandon G et al.	—	2017	→
Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels.	Lu Y et al.	—	2016	→
A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.	Munoz MB et al.	—	2016	→
Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.	Montandon G et al.	—	2016	→
Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease.	Duda J et al.	—	2016	→
Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry.	Kammerer S et al.	—	2016	→
Development- and experience-dependent plasticity in the dorsomedial habenula.	Koppensteiner P et al.	—	2016	→
Distinct expression patterns of inwardly rectifying potassium currents in developing cerebellar granule cells of the hemispheres and the vermis.	Brandalise F et al.	—	2016	→
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.	Psichas A et al.	—	2016	→
Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons.	Saloman JL et al.	—	2016	→
G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids.	Montandon G et al.	—	2016	→
G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward.	Tipps ME et al.	—	2016	→
G Protein-Gated K<sup>+</sup> Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning.	Victoria NC et al.	—	2016	→
Hyperplasia in glands with hormone excess.	Marx SJ	—	2016	→
Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel.	Joshi K et al.	—	2016	→
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.	Yan R et al.	—	2016	→
Ion Channels in Neurological Disorders.	Kumar P et al.	—	2016	→
Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system.	Kawada H et al.	—	2016	→
KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients.	Kammerer S et al.	—	2016	→
Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways.	Krasnova IN et al.	—	2016	→
Opioid Receptors.	Stein C	—	2016	→
Optical control of GIRK channels using visible light.	Trads JB et al.	—	2016	→
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO).	Barber DM et al.	—	2016	→
Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner.	Rezania S et al.	—	2016	→
P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction.	Guzman SJ et al.	—	2016	→
Potassium Channels and Human Epileptic Phenotypes: An Updated Overview.	Villa C et al.	—	2016	→
Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice.	Lecca S et al.	—	2016	→
Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.	Mamaligas AA et al.	—	2016	→
Striatal dopamine neurotransmission: regulation of release and uptake.	Sulzer D et al.	—	2016	→
The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability.	Ang R et al.	—	2016	→
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.	Huang YJ et al.	—	2015	→
Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus.	Mayordomo-Cava J et al.	—	2015	→
A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.	Yakubovich D et al.	—	2015	→
A spinal opsin controls early neural activity and drives a behavioral light response.	Friedmann D et al.	—	2015	→
A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.	Jiang P et al.	—	2015	→
Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.	Mayfield J et al.	—	2015	→
Changes in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure.	Choi SJ et al.	—	2015	→
Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.	Poetschke C et al.	—	2015	→
Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior.	Llamosas N et al.	—	2015	→
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	Masuho I et al.	—	2015	→
Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels.	Dragicevic E et al.	—	2015	→
GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.	Herman MA et al.	—	2015	→
GIRK Channel Plasticity and Implications for Drug Addiction.	Marron Fernandez de Velasco E et al.	—	2015	→
GIRK Channels: A Potential Link Between Learning and Addiction.	Tipps ME et al.	—	2015	→
GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin.	Hablitz LM et al.	—	2015	→
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.	Lyu C et al.	—	2015	→
Gα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later.	Brust TF et al.	—	2015	→
Intrinsic plasticity: an emerging player in addiction.	Kourrich S et al.	—	2015	→
Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.	Masotti A et al.	—	2015	→
Localization and Targeting of GIRK Channels in Mammalian Central Neurons.	Luján R et al.	—	2015	→
Mechanisms of fast desensitization of GABA(B) receptor-gated currents.	Raveh A et al.	—	2015	→
NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3.4) channels.	Kienitz MC et al.	—	2015	→
New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.	Brust TF et al.	—	2015	→
Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor.	Huynh TG et al.	—	2015	→
Oxidative modulation of K+ channels in the central nervous system in neurodegenerative diseases and aging.	Peers C et al.	—	2015	→
Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.	Montalbano A et al.	—	2015	→
Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex.	Amaral AC et al.	—	2015	→
Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function.	De Zeeuw CI et al.	—	2015	→
Regulation of neuronal communication by G protein-coupled receptors.	Huang Y et al.	—	2015	→
RGS Redundancy and Implications in GPCR-GIRK Signaling.	Doupnik CA	—	2015	→
Sex differences in GABA(B)R-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex.	Marron Fernandez de Velasco E et al.	—	2015	→
The GIRK2 subunit is involved in IS-like seizures induced by GABA(B) receptor agonists.	Blichowski M et al.	—	2015	→
The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels.	Dascal N et al.	—	2015	→
Tonic firing rate controls dendritic Ca2+ signaling and synaptic gain in substantia nigra dopamine neurons.	Hage TA et al.	—	2015	→
Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.	Langford DJ et al.	—	2015	→
[Activation of cerebellar B-type γ-aminobutyric acid receptor modulates optokinetic reflex adaptation].	Shirai Y et al.	—	2014	→
Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics.	Bodhinathan K et al.	—	2014	→
A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation.	Jia L et al.	—	2014	→
Analysis of G-protein-activated inward rectifying K(+) (GIRK) channel currents upon GABAB receptor activation in rat supraoptic neurons.	Harayama N et al.	—	2014	→
Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder.	Gomez L et al.	—	2014	→
Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization.	Turecek R et al.	—	2014	→
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.	Schmitt N et al.	—	2014	→
Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.	Dragicevic E et al.	—	2014	→
Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol.	Soeda F et al.	—	2014	→
Development of a novel screening system for allatostatin receptor agonists in search of new candidate insect growth regulators.	Na J et al.	—	2014	→
Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes.	Kienitz MC et al.	—	2014	→
Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.	Wen W et al.	—	2014	→
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.	Cheng MF et al.	—	2014	→
Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.	Kirizs T et al.	—	2014	→
Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.	Farhy Tselnicker I et al.	—	2014	→
Electrophysiology of arcuate neurokinin B neurons in female Tac2-EGFP transgenic mice.	Cholanian M et al.	—	2014	→
Fractal-like correlations of the fluctuating inter-spike membrane potential of a Helix aspersa pacemaker neuron.	Seseña-Rubfiaro A et al.	—	2014	→
GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization.	Adelfinger L et al.	—	2014	→
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease.	Nava-Mesa MO et al.	—	2014	→
GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia.	Gaillard S et al.	—	2014	→
Inhibitory plasticity dictates the sign of plasticity at excitatory synapses.	Wang L et al.	—	2014	→
Inward rectifier potassium (Kir) current in dopaminergic periglomerular neurons of the mouse olfactory bulb.	Borin M et al.	—	2014	→
Kir3 channel signaling complexes: focus on opioid receptor signaling.	Nagi K et al.	—	2014	→
Lipid signaling cascades of orexin/hypocretin receptors.	Kukkonen JP	—	2014	→
Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.	Wydeven N et al.	—	2014	→
Membrane channels as integrators of G-protein-mediated signaling.	Inanobe A et al.	—	2014	→
Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?	Gomez-Sanchez CE et al.	—	2014	→
Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling.	Lee PT et al.	—	2014	→
New insights into the therapeutic potential of Girk channels.	Luján R et al.	—	2014	→
Obesity attenuates D2 autoreceptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons.	Koyama S et al.	—	2014	→
Orexin/hypocretin receptor signalling cascades.	Kukkonen JP et al.	—	2014	→
Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle.	Chung MK et al.	—	2014	→
Phasic dopamine release drives rapid activation of striatal D2-receptors.	Marcott PF et al.	—	2014	→
Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system.	Wang W et al.	—	2014	→
Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.	Kahanovitch U et al.	—	2014	→
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.	Wydeven N et al.	—	2014	→
RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.	Ostrovskaya O et al.	—	2014	→
Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain.	Subramaniam M et al.	—	2014	→
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.	Munoz MB et al.	—	2014	→
Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels.	Hablitz LM et al.	—	2014	→
Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.	Bagriantsev SN et al.	—	2014	→
The role of D2-autoreceptors in regulating dopamine neuron activity and transmission.	Ford CP	—	2014	→
Uncoupling of secretion from growth in some hormone secretory tissues.	Marx SJ	—	2014	→
Understanding alcohol use disorders with neuroelectrophysiology.	Rangaswamy M et al.	—	2014	→
Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.	Langford DJ et al.	—	2014	→
Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse.	Nava-Mesa MO et al.	—	2013	→
Conductance properties of the inwardly rectifying channel, Kir3.2: molecular and Brownian dynamics study.	Hilder TA et al.	—	2013	→
Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.	Richard-Lalonde M et al.	—	2013	→
Differential maturation of GIRK2-expressing neurons in the mouse cerebellum.	Aguado C et al.	—	2013	→
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.	Ramos-Hunter SJ et al.	—	2013	→
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.	Wen W et al.	—	2013	→
Dual effects of L-DOPA on nigral dopaminergic neurons.	Guatteo E et al.	—	2013	→
G protein modulation of K2P potassium channel TASK-2 : a role of basic residues in the C terminus domain.	Añazco C et al.	—	2013	→
Identification of the mechanism mediating genioglossus muscle suppression in REM sleep.	Grace KP et al.	—	2013	→
In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.	Butko MT et al.	—	2013	→
Ion channels in the central regulation of energy and glucose homeostasis.	Sohn JW	—	2013	→
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.	Kaufmann K et al.	—	2013	→
Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase.	Treiber F et al.	—	2013	→
Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels.	Bodhinathan K et al.	—	2013	→
Neuronal circuits that regulate feeding behavior and metabolism.	Sohn JW et al.	—	2013	→
Noradrenaline stimulates cell proliferation by suppressing potassium channels via G(i/o) -protein-coupled α(1B) -adrenoceptors in human osteoblasts.	Kodama D et al.	—	2013	→
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.	Kukkonen JP	—	2013	→
Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.	Murthy R et al.	—	2013	→
Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.	Balana B et al.	—	2013	→
Role of GIRK channels on the noradrenergic transmission in vivo: an electrophysiological and neurochemical study on GIRK2 mutant mice.	Torrecilla M et al.	—	2013	→
Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety.	Asan E et al.	—	2013	→
Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease.	Michel PP et al.	—	2013	→
Structural biology: Ion channel twists to open.	Reuveny E	—	2013	→
Synaptic and cellular profile of neurons in the lateral habenula.	Meye FJ et al.	—	2013	→
The Concise Guide to PHARMACOLOGY 2013/14: ion channels.	Alexander SP et al.	—	2013	→
The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.	Khan SM et al.	—	2013	→
The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia.	Nockemann D et al.	—	2013	→
Variable dendritic integration in hippocampal CA3 pyramidal neurons.	Makara JK et al.	—	2013	→
X-ray structure of the mammalian GIRK2-βγ G-protein complex.	Whorton MR et al.	—	2013	→
A fluorescent screening assay for identifying modulators of GIRK channels.	Vazquez M et al.	—	2012	→
Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population.	Yamada K et al.	—	2012	→
Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion.	Sladek CD et al.	—	2012	→
Double and triple in situ hybridization for coexpression studies: combined fluorescent and chromogenic detection of neuropeptide Y (NPY) and serotonin receptor subtype mRNAs expressed at different abundance levels.	Bonn M et al.	—	2012	→
GIRK channel modulation by assembly with allosterically regulated RGS proteins.	Zhou H et al.	—	2012	→
GPCR mediated regulation of synaptic transmission.	Betke KM et al.	—	2012	→
K(+) channels: function-structural overview.	González C et al.	—	2012	→
Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.	Vidal V et al.	—	2012	→
Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.	Padgett CL et al.	—	2012	→
Multiple pharmacological actions of centrally acting antitussives--Do they target G protein-coupled inwardly rectifying K⁺ (GIRK) channels?	Takahama K	—	2012	→
Neurobiology of resilience.	Russo SJ et al.	—	2012	→
Neuropeptide transmission in brain circuits.	van den Pol AN	—	2012	→
Opiate drug use and the pathophysiology of neuroAIDS.	Hauser KF et al.	—	2012	→
RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo.	Chuang HH et al.	—	2012	→
SDF and GABA interact to regulate axophilic migration of GnRH neurons.	Casoni F et al.	—	2012	→
Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.	Wydeven N et al.	—	2012	→
The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line.	Oki K et al.	—	2012	→
The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias.	Ang R et al.	—	2012	→
Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice.	Cooper A et al.	—	2012	→
Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders.	Han MH et al.	—	2012	→
Voltage-dependent open-channel block of G protein-gated inward-rectifying K(+) (GIRK) current in rat atrial myocytes by tamoxifen.	Vanheiden S et al.	—	2012	→
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.	Howard RJ et al.	—	2011	→
Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro.	Littwitz C et al.	—	2011	→
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.	Whorton MR et al.	—	2011	→
Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.	Fernández-Alacid L et al.	—	2011	→
Dopamine receptors and Parkinson's disease.	Hisahara S et al.	—	2011	→
Function and mechanism of axonal targeting of voltage-sensitive potassium channels.	Gu C et al.	—	2011	→
Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants.	Kobayashi T et al.	—	2011	→
Interactions of cations with the cytoplasmic pores of inward rectifier K(+) channels in the closed state.	Inanobe A et al.	—	2011	→
In vivo ethanol experience increases D(2) autoinhibition in the ventral tegmental area.	Perra S et al.	—	2011	→
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.	Balana B et al.	—	2011	→
Modulation of peripheral sensory neurons by the immune system: implications for pain therapy.	Stein C et al.	—	2011	→
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.	Yow TT et al.	—	2011	→
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons.	Mazei-Robison MS et al.	—	2011	→
Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.	Sohn JW et al.	—	2011	→
Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	Kao L et al.	—	2011	→
Targeting GIRK Channels for the Development of New Therapeutic Agents.	Walsh KB	—	2011	→
The physiology, signaling, and pharmacology of dopamine receptors.	Beaulieu JM et al.	—	2011	→
The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes.	Sahlholm K	—	2011	→
Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.	Berlin S et al.	—	2011	→
A structural determinant for the control of PIP2 sensitivity in G protein-gated inward rectifier K+ channels.	Inanobe A et al.	—	2010	→
G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels.	Styer AM et al.	—	2010	→
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.	Nassirpour R et al.	—	2010	→
The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.	Zylbergold P et al.	—	2010	→