Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism.
- Authors
- Agrawal, Arpana; Tillman, Rebecca; Grucza, Richard A; Nelson, Elliot C; McCutcheon, Vivia V; Few, Lauren; Conner, Kenneth R; Lynskey, Michael T; Dick, Danielle M; Edenberg, Howard J; Hesselbrock, Victor M; Kramer, John R; Kuperman, Samuel; Nurnberger, John I; Schuckit, Marc A; Porjesz, Bernice; Bucholz, Kathleen K
- Year
- 2017
- Journal
- Journal of affective disorders
- PMID
- 28213124
- DOI
- 10.1016/j.jad.2016.12.060
- PMCID
- PMC5434702
BACKGROUND: Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. METHODS: The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. RESULTS: Ideation was related to 0.71-0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44-1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. LIMITATIONS: The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. CONCLUSION: Suicide attempts are associated with increased likelihood of onset of substance dependence.
No figures extracted from this document.
No entities extracted from this document yet.
No uploaded files.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Blood Alcohol Concentration in Finnish Suicide Deaths and Associated Risk Factors, 2016-2024. | Pokornyi T et al. | — | 2026 | → |
| Differentiating Transdiagnostic Roles of Psychological Pain and Depression on Suicide Attempt in Major Depressive Disorder, Bipolar Disorder and Substance Use Disorder. | Chen Y et al. | — | 2025 | → |
| Alcohol Dependence Among Adult Males in Chengalpattu District, South India: A Mixed Methods Study. | Baskaran G et al. | — | 2024 | → |
| Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations. | Paul SE et al. | — | 2024 | → |
| Intersection of adverse childhood experiences, suicide and overdose prevention. | Austin AE et al. | — | 2024 | → |
| Substance Use Disorder and Suicidal Ideation in Rural Maryland. | Ahuja M et al. | — | 2024 | → |
| Suicide ideation and psychotropic recreational drug use by adolescents: a systematic review and meta-analysis. | Oliveira Gracini CL et al. | — | 2024 | → |
| Mental Health and Smoking-Related Determinants of Alcohol Drinking Experience in Korean Adolescents. | Park SK et al. | — | 2023 | → |
| Shared genetic and environmental etiology between substance use disorders and suicidal behavior. | Edwards AC et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |
| Alcohol use disorder and non-fatal suicide attempt: findings from a Swedish National Cohort Study. | Edwards AC et al. | — | 2022 | → |
| Association between cannabis use and suicidal behavior: A systematic review of cohort studies. | Carvalho JV et al. | — | 2022 | → |
| Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence. | Kuhns L et al. | — | 2022 | → |
| Does cannabis use in adolescence predict self-harm or suicide? Results from a Finnish Birth Cohort Study. | Denissoff A et al. | — | 2022 | → |
| Roles of alcohol use disorder and resilience in risk of suicide attempt in men: A Swedish population-based cohort. | Lannoy S et al. | — | 2022 | → |
| Suicidal ideation among Canadian adults during the COVID-19 pandemic: the role of psychosocial factors and substance use behaviours. | Geda N et al. | — | 2022 | → |
| Early Age of Alcohol Initiation and its Association with Suicidal Behaviors. | Ahuja M et al. | — | 2021 | → |
| Relationship Between the Early Initiation of Substance Use and Attempted Suicide Among in-School Adolescents in Seven Low- or Middle-Income African Countries: An Analysis of the Global School-Based Student Health Survey Data. | Li L et al. | — | 2021 | → |
| Suicidal Ideation among Persons with Alcohol Use Disorder: A Cross-Sectional Study. | Rahoof FV et al. | — | 2021 | → |
| Alcohol use and risk of suicide: a systematic review and Meta-analysis. | Amiri S et al. | — | 2020 | → |
| Cannabis Use as a Risk Factor for Depression, Anxiety, and Suicidality: Epidemiological Associations and Implications for Nurses. | Halladay JE et al. | — | 2020 | → |
| National Trends in Mental Health Care for US Adolescents. | Mojtabai R et al. | — | 2020 | → |
| Neuroimmune signaling in alcohol use disorder. | Erickson EK et al. | — | 2019 | → |
| Is cannabis a risk factor for suicide attempts in men and women with psychotic illness? | Waterreus A et al. | — | 2018 | → |
| Major depressive disorder, suicidal thoughts and behaviours, and cannabis involvement in discordant twins: a retrospective cohort study. | Agrawal A et al. | — | 2017 | → |