Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism.
paper
Cited
Public
- Authors
- Evans, Suzette M; Levin, Frances R
- Year
- 2011
- Journal
- Drug and alcohol dependence
- PMID
- 20888148
- DOI
- 10.1016/j.drugalcdep.2010.09.001
- PMCID
- PMC3017640
The present study determined whether: (1) the response to alcohol varied as a function of menstrual cycle phase and (2) women with a paternal history of alcoholism (FHP) were less sensitive to the effects of alcohol compared to women without a family history of alcoholism (FHN). The behavioral effects of alcohol (0.00, 0.25, and 0.75 g/kg) were evaluated in 21 FHN and 24 FHP women; each dose was tested during both the midfollicular and late luteal phases of the menstrual cycle. Baseline negative mood was increased during the luteal phase compared to the follicular phase (increased Beck Depression scores and decreased Vigor, Arousal, and Friendly scores). Alcohol increased ratings of Drug Liking and Good Drug Effect more in the luteal phase than the follicular phase. FHP women had greater negative mood during the luteal phase and some of these dysphoric effects were increased by alcohol more in FHP women than FHN women. Alcohol impaired performance, with no group or menstrual cycle differences. However, consistent with previous studies, FHP women were less impaired by alcohol than FHN women on the balance task. These data indicate that (1) the differences in response to alcohol across the menstrual cycle are subtle, although alcohol is liked more during the luteal phase; (2) increases in dysphoric mood during the luteal phase are more pronounced in FHP women compared to FHN women, particularly after alcohol; and (3) the differences observed in response to alcohol between FHP and FHN women are less pronounced than previously shown in men.
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| Name | Type |
|---|---|
| Absolute vodka local | drug |
| Abuse liability local | phenotype |
| age | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| Alcohol choice local | phenotype |
| alcohol dependence | phenotype |
| Alcohol (high dose) local | drug |
| alcoholism | phenotype |
| Alcohol pharmacokinetics local | phenotype |
| Alcohol Problems | phenotype |
| alcohol sensitivity | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use disorders | phenotype |
| anxiety | phenotype |
| Arousal scores local | phenotype |
| Bad Drug Effect cluster local | phenotype |
| Bad Effects | phenotype |
| balance scores local | phenotype |
| Balance scores local | phenotype |
| balance task local | phenotype |
| Balance task local | phenotype |
| Beck Depression Inventory | phenotype |
| Beck Depression scores local | phenotype |
| beer | drug |
| Behavioral effects of alcohol local | phenotype |
| behavioral response to alcohol local | phenotype |
| Behavioral response to alcohol local | phenotype |
| binge drinking | phenotype |
| Binge-drinking episode local | phenotype |
| Body sway | phenotype |
| Breath alcohol concentration | phenotype |
| caffeinated products local | drug |
| caffeine | drug |
| Canada Dry Tonic water local | drug |
| cannabinoids | drug |
| cigarettes | phenotype |
| coffee | drug |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| confusion | phenotype |
| Confusion-Bewilderment score local | phenotype |
| Decreased body sway local | phenotype |
| Delayed word recall local | phenotype |
| depression | phenotype |
| Depression-Dejection score local | phenotype |
| Depression-Dejection scores local | phenotype |
| Depression-Dejection subscale of the POMS local | phenotype |
| depression scores | phenotype |
| dextrose | drug |
| Digit Recall task local | phenotype |
| Digit Symbol Substitution Task local | phenotype |
| Digit Symbol Substitution Test local | phenotype |
| Divided Attention task local | phenotype |
| Drinking_days local | phenotype |
| drinks per week | phenotype |
| Drinks_per_week local | phenotype |
| drug | drug |
| drug dependence | phenotype |
| Drug Effect Questionnaire local | phenotype |
| drug_effect_strength local | phenotype |
| Drug Liking local | phenotype |
| Drug Liking rating local | phenotype |
| drugs | drug |
| Drug Strength | phenotype |
| Drug Strength rating local | phenotype |
| DSM-IV Axis I psychiatric disorders local | phenotype |
| DSST local | phenotype |
| dysphoric mood local | phenotype |
| Dysphoric mood local | phenotype |
| dysphoric mood changes local | phenotype |
| Early follicular local | phenotype |
| early follicular phase local | phenotype |
| Early follicular phase local | phenotype |
| Elevated Mood local | phenotype |
| Equal sweetener local | drug |
| estradiol | drug |
| Family density of alcoholism local | phenotype |
| Family histories of alcoholism and substance abuse local | phenotype |
| family history negative | phenotype |
| Family History Negative Alcoholism local | phenotype |
| Family History Negative (FHN) women local | cohort |
| Family history negative women local | cohort |
| Family History Negative women local | cohort |
| family history of alcoholism | phenotype |
| family history of alcoholism or substance abuse local | phenotype |
| family history positive | phenotype |
| Family History Positive Alcoholism local | phenotype |
| Family History Positive (FHP) women local | cohort |
| Family history positive women local | cohort |
| Family History Positive women local | cohort |
| Female college students local | cohort |
| Female pilots local | cohort |
| Female volunteers (with and without family history of alcoholism) local | cohort |
| FHN | cohort |
| FHN men local | phenotype |
| FHN women local | phenotype |
| FHP | cohort |
| FHP light drinkers local | cohort |
| FHP men local | cohort |
| FHP men local | phenotype |
| FHP moderate drinkers local | cohort |
| FHP women local | phenotype |
| First-degree family history of alcoholism local | cohort |
| first-degree relatives | cohort |
| Flight simulator performance local | phenotype |
| follicular phase local | phenotype |
| Follicular phase local | phenotype |
| Friendliness local | phenotype |
| Friendly score local | phenotype |
| Friendly scores local | phenotype |
| Friendly subscale of the POMS local | phenotype |
| future alcohol problems | phenotype |
| Good Drug Effect local | phenotype |
| Good Drug Effect ratings local | phenotype |
| healthy control women | cohort |
| heavy drinking | phenotype |
| Holdstock and de Wit (2000) study local | cohort |
| Hormone levels local | phenotype |
| human chorionic gonadotropin (hCG) local | drug |
| impaired performance | phenotype |
| intoxication | phenotype |
| Intoxication rating | phenotype |
| Lactose powder local | drug |
| Late follicular local | phenotype |
| Late follicular phase local | phenotype |
| Late luteal local | phenotype |
| late luteal phase local | phenotype |
| Late luteal phase local | phenotype |
| lifetime alcohol use | phenotype |
| Light drinker level local | phenotype |
| light drinkers | phenotype |
| liquor | drug |
| luteal phase local | phenotype |
| Luteal phase local | phenotype |
| luteinizing hormone | drug |
| major depressive disorder | phenotype |
| marijuana | phenotype |
| Maximum_drinks_per_occasion local | phenotype |
| Maximum Habitual Alcohol Intake | phenotype |
| medication | drug |
| men | cohort |
| Menstrual cycle local | phenotype |
| menstrual cycle phase local | phenotype |
| Menstrual cycle phase local | phenotype |
| Menstrual cycle phases local | phenotype |
| menstruation local | phenotype |
| midfollicular phase local | phenotype |
| Midfollicular phase local | phenotype |
| Midluteal local | phenotype |
| Midluteal phase local | phenotype |
| Moderate drinker level local | phenotype |
| moderate drinkers local | phenotype |
| Moderate drinkers local | cohort |
| Moderate drinkers local | phenotype |
| Moderate female drinking local | phenotype |
| mood changes | phenotype |
| mood disorders | phenotype |
| motor coordination | phenotype |
| negative consequences | phenotype |
| Negative outcomes of drinking local | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| no family history of alcoholism local | phenotype |
| Normal women local | cohort |
| Number of alcoholic relatives local | phenotype |
| Observer-rating scores local | phenotype |
| Ocean Spray Cranberry Juice Cocktail local | drug |
| oldest cohort of women local | cohort |
| opioid | drug |
| Ovulation kit local | drug |
| OvuQuick® local | drug |
| participants | cohort |
| paternal alcoholism | phenotype |
| Peppermint oil local | drug |
| Performance effects local | phenotype |
| Performance measures local | phenotype |
| personality traits | phenotype |
| Personality Traits cluster local | phenotype |
| physical symptoms | phenotype |
| Physical Symptoms cluster local | phenotype |
| placebo beverage | drug |
| Placebo capsules local | drug |
| PMDD local | phenotype |
| POMS subscales local | phenotype |
| Positive subjective effects local | phenotype |
| pregnancy | phenotype |
| Premenstrual dysphoric disorder local | phenotype |
| premenstrual symptoms local | phenotype |
| Premenstrual symptoms local | phenotype |
| present study | cohort |
| Profile of Mood States questionnaire local | phenotype |
| progesterone | drug |
| Reduced response to alcohol local | phenotype |
| Saccadic eye movement local | phenotype |
| sedatives | drug |
| Severe premenstrual symptoms local | phenotype |
| sex | phenotype |
| SHAS7 local | phenotype |
| Standard alcoholic beverage local | drug |
| State Anxiety scale local | phenotype |
| State Anxiety Scale local | phenotype |
| State-Trait Anxiety Inventory local | phenotype |
| subjective effects | phenotype |
| substance abuse | phenotype |
| Take Again rating local | phenotype |
| task performance | phenotype |
| telescoping local | phenotype |
| Tension-Anxiety scores local | phenotype |
| Tension-Anxiety subscale of the POMS local | phenotype |
| tobacco use | phenotype |
| Total Observer Rating score local | phenotype |
| urine | drug |
| Vigor scores local | phenotype |
| Visual Analog Scale local | phenotype |
| vital signs | phenotype |
| vodka | drug |
| WAS clusters local | phenotype |
| wine | drug |
| women | cohort |
| Women with a paternal history of alcoholism local | cohort |
| Women with premenstrual dysphoric disorder local | cohort |
| Word Recall and Recognition task local | phenotype |
| youngest cohort of women local | cohort |
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| Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone. | Eisenlohr-Moul TA et al. | — | 2015 | → |
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