Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
- Authors
- Salvatore, Jessica E; Aliev, Fazil; Bucholz, Kathleen; Agrawal, Arpana; Hesselbrock, Victor; Hesselbrock, Michie; Bauer, Lance; Kuperman, Samuel; Schuckit, Marc A; Kramer, John; Edenberg, Howard J; Foroud, Tatiana M; Dick, Danielle M
- Year
- 2015
- Journal
- Clinical psychological science : a journal of the Association for Psychological Science
- PMID
- 25821660
- DOI
- 10.1177/2167702614534211
- PMCID
- PMC4371857
In this project, we aimed to bring large-scale gene identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders-based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)-predicted externalizing disorders, subclinical externalizing behavior, and impulsivity-related traits adolescents (n = 248) and young adults (n = 207), and whether parenting and peer factors in adolescence moderated polygenic risk to predict externalizing disorders. Polygenic scores predicted externalizing disorders in adolescents and young adults, even after controlling for parental externalizing disorder history. Polygenic scores also predicted subclinical externalizing behavior and impulsivity traits in the adolescents and young adults. Adolescent parental monitoring and peer substance use moderated polygenic scores to predict externalizing disorders. This illustrates how state of the science genetics can be integrated with psychological science to identify how genetic risk contributes to the development of psychopathology.
Schematic of study sample. The Adult genome-wide association study (GWAS) subsample included adult participants who were 29 years of age and older at the time of their psychiatric interviews. The GWAS weights from the adult subsample were used to calculate polygenic scores in the Adolescent and Young Adult subsamples.
LLM interpretation
This figure is a schematic diagram illustrating the study sample structure derived from 118 European-American families in the COGA family-based sample. It shows three subsamples: an Adult GWAS subsample (n = 1,249), an Adolescent subsample (n = 248), and a Young Adult subsample (n = 207), each listing their respective gender distribution and assessment measures. Arrows indicate that GWAS weights from the adult subsample were used to calculate polygenic scores for the adolescent and young adult groups.
Association results from the GWAS of the externalizing disorder composite in the adult sample. On the x-axis are chromosomes 1-22. On the y-axis are inverse logarithms of the p-values for each SNP.
LLM interpretation
This is a Manhattan plot showing GWAS association results for an externalizing disorder composite. The x-axis represents chromosomes 1–22, and the y-axis represents the negative logarithm of the p-values (-log10(P)) for individual SNPs. No data points cross the horizontal genome-wide significance threshold line, indicating a lack of statistically significant associations.
Adolescent parental monitoring (Panel A) and perceived peer substance use (Panel B) moderate polygenic risk to predict the externalizing disorder composite.
LLM interpretation
This figure consists of two line graphs (Panels A and B) showing the interaction between polygenic risk scores and environmental factors on an externalizing disorder composite. Panel A shows that as parental monitoring increases, the externalizing disorder composite decreases for both high and low polygenic score groups, with a steeper decline for the high polygenic group. Panel B shows that as perceived peer substance use increases, the externalizing disorder composite increases for both groups, with a more pronounced increase for those with a high polygenic score.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations of polygenic scores and developmental trajectories of externalizing behaviors. | Sasia AB et al. | — | 2025 | → |
| Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors. | Su J et al. | — | 2025 | → |
| Polygenic risk and hostile environments: Links to stable and dynamic antisocial behaviors across adolescence. | Acland EL et al. | — | 2025 | → |
| Predicting Genetic Risk for Impulsivity and Substance Use in Adolescence | Wade NE et al. | — | 2025 | — |
| Sociodemographic, Clinical and Genetic Correlates of Aggressive and Auto-Aggressive Behaviour in Alcohol-Dependent Individuals - Preliminary Study. | Czarnecki D et al. | — | 2025 | → |
| Alcohol Use Disorder Polygenic Risk Scores and Trajectories of Early Adolescent Externalizing Behaviors: Examining the Role of Parenting and Family Conflict in the Racially/Ethnically Diverse ABCD Sample. | Trevino AD et al. | — | 2024 | → |
| Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples. | Elam KK et al. | — | 2024 | → |
| Gene-environment transactions between peer cigarette use, parental supervision, and Chinese adolescent cigarette smoking initiation. | Meyer Z et al. | — | 2024 | → |
| A Polygenic Risk Score Enhances Risk Prediction for Adolescents' Antisocial Behavior over the Combined Effect of 22 Extra-familial, Familial, and Individual Risk Factors in the Context of the Family Check-Up. | Wang FL et al. | — | 2023 | → |
| Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods. | Sterrett-Hong EM et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |
| The impact of dopamine receptor D4, temperamental negativity, and household chaos on young twins' externalizing behaviors. | Jamnik MR et al. | — | 2023 | → |
| Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry. | Zheng B et al. | — | 2022 | → |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | — | 2022 | → |
| Genetic variance in conscientiousness relates to youth psychopathology beyond executive functions. | Shields AN et al. | — | 2022 | → |
| Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use. | Elam KK et al. | — | 2022 | → |
| Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. | Akingbuwa WA et al. | — | 2022 | → |
| The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems. | Ksinan AJ et al. | — | 2022 | → |
| The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse. | Stephenson M et al. | — | 2022 | → |
| The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance. | Kuo SI et al. | — | 2022 | → |
| Case-control study on clinical characteristics of child and adolescent psychiatric outpatients with child-to-parent violence. | Sasaki Y et al. | — | 2021 | → |
| Prevalence and correlates of neurocognitive impairment and psychiatric disorders among schoolchildren in Wakiso District, Uganda: a cross-sectional study. | Nampijja M et al. | — | 2021 | → |
| Problems with Centrality Measures in Psychopathology Symptom Networks: Why Network Psychometrics Cannot Escape Psychometric Theory. | Hallquist MN et al. | — | 2021 | → |
| The Impact of Personality Pathology Across Three Generations: Evidence from the St. Louis Personality and Intergenerational Network Study. | Shields AN et al. | — | 2021 | → |
| Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study. | Cerniglia L et al. | — | 2020 | → |
| Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use. | Bares CB et al. | — | 2020 | → |
| Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: The complex role of genetic factors. | Ensink JBM et al. | — | 2020 | → |
| The Genetics of Externalizing Problems. | Barr PB et al. | — | 2020 | → |
| When is Parental Monitoring Effective? A Person-centered Analysis of the Role of Autonomy-supportive and Psychologically Controlling Parenting in Referred and Non-referred Adolescents. | Rodríguez-Meirinhos A et al. | — | 2020 | → |
| Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents. | Compton KS et al. | — | 2019 | → |
| FinnTwin12 Cohort: An Updated Review. | Rose RJ et al. | — | 2019 | → |
| Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression. | Elam KK et al. | — | 2019 | → |
| Genetic influences on antisocial behavior: recent advances and future directions. | Gard AM et al. | — | 2019 | → |
| Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. | Sadeh N et al. | — | 2019 | → |
| Neighborhood alcohol outlet density and genetic influences on alcohol use: evidence for gene-environment interaction. | Slutske WS et al. | — | 2019 | → |
| Parenting Interacts with Oxytocin Polymorphisms to Predict Adolescent Social Anxiety Symptom Development: A Novel Polygenic Approach. | Nelemans SA et al. | — | 2019 | → |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | — | 2019 | → |
| Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. | Meyers JL et al. | — | 2019 | → |
| The sampling precision of research in five major areas of psychology. | Trafimow D et al. | — | 2019 | → |
| Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?" | Dick DM | — | 2018 | → |
| Intergenerational Continuity in Substance Abuse: Does Offspring's Friendship Network Make a Difference? | Henry KL et al. | — | 2018 | → |
| Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use. | Elam KK et al. | — | 2018 | → |
| Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population. | Jansen PR et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. | Su J et al. | — | 2018 | → |
| Adolescent externalizing behaviour, psychological control, and peer rejection: Transactional links and dopaminergic moderation. | Janssens A et al. | — | 2017 | → |
| Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity. | Elam KK et al. | — | 2017 | → |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | — | 2017 | → |
| Biometric Modeling of Gene-Environment Interplay: The Intersection of Theory and Method and Applications for Social Inequality. | South SC et al. | — | 2017 | → |
| Developmental Etiologies of Alcohol Use and Their Relations to Parent and Peer Influences Over Adolescence and Young Adulthood: A Genetically Informed Approach. | Deutsch AR et al. | — | 2017 | → |
| Genes, Environments, and Sex Differences in Alcohol Research. | Salvatore JE et al. | — | 2017 | → |
| Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging. | Zald DH et al. | — | 2017 | → |
| Mediation of effects of the level of response to alcohol and impulsivity 15 years later in 36-year-old men: Implications for prevention efforts. | Schuckit MA et al. | — | 2017 | → |
| Parent and peer influences on emerging adult substance use disorder: A genetically informed study. | Bountress K et al. | — | 2017 | → |
| Parenting intervention effects on children's externalizing behavior: the moderating role of genotype and temperament. | Overbeek G | — | 2017 | → |
| Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems. | Wang FL et al. | — | 2017 | → |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | — | 2017 | → |
| The role of parental marital discord in the etiology of externalizing problems during childhood and adolescence. | Jarnecke AM et al. | — | 2017 | → |
| Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders. | Cho SB et al. | — | 2017 | → |
| Alcohol-related genes show an enrichment of associations with a persistent externalizing factor. | Ashenhurst JR et al. | — | 2016 | → |
| Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior. | Windhorst DA et al. | — | 2016 | → |
| Genetic influences on adolescent behavior. | Dick DM et al. | — | 2016 | → |
| Molecular genetic approaches to understanding the comorbidity of psychiatric disorders. | Gizer IR | — | 2016 | → |
| Polygenic Risk for Externalizing Psychopathology and Executive Dysfunction in Trauma-Exposed Veterans. | Sadeh N et al. | — | 2016 | → |
| Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict. | Elam KK et al. | — | 2016 | → |
| Sensation seeking, peer deviance, and genetic influences on adolescent delinquency: Evidence for person-environment correlation and interaction. | Mann FD et al. | — | 2016 | → |
| Subtyping of alcohol dependence in Indian males: A cluster analytic approach. | Malhotra S et al. | — | 2016 | → |
| 5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children. | Weeland J et al. | — | 2015 | → |
| Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. | Vrshek-Schallhorn S et al. | — | 2015 | → |
| Biological Risk for the Development of Problem Behavior in Adolescence: Integrating Insights from Behavioral Genetics and Neuroscience. | Harden KP et al. | — | 2015 | → |
| Gene-Environment Interplay: Where We Are, Where We Are Going. | Salvatore JE et al. | — | 2015 | → |
| Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. | Weeland J et al. | — | 2015 | → |