Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.

paper Cited Public

Authors: Nielsen, David A; Ji, Fei; Yuferov, Vadim; Ho, Ann; He, Chunsheng; Ott, Jurg; Kreek, Mary Jeanne
Year: 2010
Journal: Psychiatric genetics
PMID: 20520587
DOI: 10.1097/YPG.0b013e32833a2106
PMCID: PMC3832188

#	Section	Preview
20	Results — Candidate gene association	All the variants in Table 5, except three, are located within the annotated genes listed. We found…
21	Discussion	We used a pooled DNA approach to identify single nucleotide polymorphisms associated with…
22	Discussion	In Caucasians, variant rs10494334, located on chromosome 1, had the smallest P values for…
23	Discussion	The variant with the next smallest P value in the Caucasians was in the T gene that encodes a…
24	Discussion	Three variants in close proximity in the RIMS2 gene were found in the 500 variants with the smallest…
25	Discussion	Several variants were found to be clustered in the cardiomyopathy associated 3 gene CMYA3 in the…
26	Discussion	A finding of particular interest in this study corroborated our earlier study using the 10K GeneChip…
27	Discussion	We recently reported an association of a haplotype of tryptophan hydroxylase 2 gene TPH2 with heroin…
28	Discussion	Other association studies of drug and alcohol addiction have used a similar DNA pooling approach.…
29	Discussion	Several linkage studies suggest the involvement of specific chromosomal regions in the vulnerability…
30	Discussion	the nearby marker D4S2394, which had nominal significance (point-wise P = 0.013) in the later Tsuang…
31	Discussion	There are two recent linkage studies on opioid dependence using single nucleotide polymorphisms…
32	Discussion	Future association studies in other cohorts of well-defined ethnicity and carefully defined…

Name	Type
A allele	cohort
addiction	phenotype
Affymetrix 50K Hind 240 array local	drug
Affymetrix 50K Xba 240 array local	drug
Affymetrix GeneChip Scanner 3000 local	drug
African American	cohort
African American group local	cohort
alcohol	phenotype
alcohol dependence	phenotype
autism	phenotype
autosomal variants local	variant
B probe local	drug
candidate genes	cohort
cannabis use	phenotype
cardiomyopathy	phenotype
cases	cohort
Caucasian	cohort
Caucasian (CEPH) population local	cohort
Caucasian cohort	cohort
Caucasian controls local	cohort
Caucasian former heroin addicts local	cohort
Caucasian group local	cohort
Caucasians	cohort
Chromosome 14q region local	variant
CMYA3 local	gene
controls	cohort
control subjects	cohort
CYMA3 local	gene
D17S785 local	variant
D4S1644 local	variant
D4S2394 local	variant
DNA microarrays	drug
DNA pools local	cohort
drug abuse vulnerability local	phenotype
DUSP27 local	gene
Eight variants (Gelernter) local	variant
European population	cohort
former severe heroin addicts local	cohort
Gelernter group local	cohort
Gelernter study local	cohort
GeneChip Mapping 100K Set local	drug
GeneChip Operating System (GCOS) local	drug
genetic factors	cohort
glutamate	drug
GRIN2A	gene
GRM8	gene
GRM8 intron 2 variant local	variant
GTYPE genotype Analysis Software local	drug
heavy drinking	phenotype
heroin addiction vulnerability local	phenotype
Hispanic	phenotype
holoprosencephaly local	phenotype
Kcna1	gene
Lachman Hispanic cohort local	cohort
marijuana	phenotype
Marijuana addiction local	phenotype
Methadone	drug
methamphetamine dependence	phenotype
NCAM1	gene
NCAM1 upstream variant local	variant
NetAffx Analysis Center local	drug
neural tube defects	phenotype
New York City cohort local	cohort
non-specific substance abuse local	phenotype
nucleus accumbens core	anatomy
OLIGO2 local	gene
opiates	drug
opioid dependence	phenotype
OPRM1	cohort
our study	cohort
Pde4b	gene
PDE4B variant local	variant
Pierre Robin sequence local	phenotype
PLA2G4F local	gene
preaxial polydactyly local	phenotype
Psychedelic addiction local	phenotype
Psychedelics local	drug
RIM2α local	drug
RIM2β local	drug
RIM2γ local	drug
RIMS2 local	gene
RIMS2 variant local	variant
rs1034576 local	variant
rs10492065 local	variant
rs10494334 local	variant
rs10506645 local	variant
rs10518620 local	variant
rs2180 local	variant
rs2280248 local	variant
rs2323218 local	variant
rs3749004 local	variant
rs3825786 local	variant
rs4766311 local	variant
rs6467108 local	variant
rs6517137 local	variant
rs9271 local	variant
rs950302 local	variant
schizophrenia	phenotype
Sedative addiction local	phenotype
sedatives	drug
severe heroin addicts local	cohort
Severe heroin addicts local	cohort
Shh	gene
SHH upstream variant 1Mb local	variant
SHH upstream variant 470kb local	variant
single nucleotide polymorphism	variant
Sox9	gene
SOX9 upstream variant 1.44Mb local	variant
stimulant dependence	phenotype
stimulants	drug
study cohort	cohort
T local	gene
TBXT local	gene
TIVS7-2 local	variant
TPH1	gene
TPH2	gene
Tsuang Chinese families local	cohort
Tsuang study local	cohort
unspecified gene local	gene
unspecified variant local	variant
variant	cohort
variant annotations local	drug
variants with no annotation local	variant
ventral tegmental area	anatomy
X chromosomal variants local	variant
Y chromosomal variants local	variant
Yoruba	cohort

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In this knowledge base

Title	Year	PMID
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.	2022	36207451
Human Genetics of Addiction: New Insights and Future Directions.	2018	29504045
KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.	2016	26202629
Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.	2015	25744370
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample.	2015	25637581
The genetics of substance dependence.	2012	22703173

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