Gender modulates the development of theta event related oscillations in adolescents and young adults.
- Authors
- Chorlian, David B; Rangaswamy, Madhavi; Manz, Niklas; Kamarajan, Chella; Pandey, Ashwini K; Edenberg, Howard; Kuperman, Samuel; Porjesz, Bernice
- Year
- 2015
- Journal
- Behavioural brain research
- PMID
- 26102560
- DOI
- 10.1016/j.bbr.2015.06.020
- PMCID
- PMC4705839
The developmental trajectories of theta band (4-7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. These tasks call upon attentional and working memory resources. Large differences in developmental rates between males and females were found; scalp location and task modality (visual or auditory) differences within males and females were small compared to gender differences. Trajectories of interregional and intermodal correlations between ERO power values exhibited increases with age in both genders, but showed a divergence in development between auditory and visual systems during ages 16 to 21. These results are consistent with previous electrophysiological and imaging studies and provide additional temporal detail about the development of neurophysiological indices of cognitive activity. Since measures of the P3 response has been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions.
Theta ERO total power trajectory means (s(t)) in auditory (left column) and visual (right column) modalities presented in three views: Top row: Development curves: log(s(t)). Middle row: Relative development curves:sΜ(t) = (log(s(t)) β mean(log(s(t))))/mean(log(s(t))). Values are shown as relative to the mean value of the trajectory over the entire age range of 12 to 25. Plots of relative values emphasize similarities and differences in overall shape, rather than in values. Bottom row: Rates of change of development curves: dlog(s(t))/dt = (ds(t)/dt)/s(t). Each line in this graph represents the slope of the corresponding line in the graph in the top row at the corresponding age. The y-axis is inverted in order to more clearly illustrate the decrease in absolute value of the slopes with time. All line styles and colors of the graphs follow the legends in the middle row.
Intramodal and Intermodal Phenotypic Correlations. Intramodal correlations in top panel: Left Columns: Auditory correlations; Right Columns: Visual Correlations. Intermodal correlations in bottom panel: Left Columns: Matching locations; Right Columns: Non-matching locations. (For non-matching locations the first electrode is the auditory, the second the visual.) Note that the scales are different between in the top and bottom panels.
| Name | Type |
|---|---|
| Acute/chronic medical illnesses affecting brain function | phenotype |
| ADHD | phenotype |
| adolescents | cohort |
| adulthood | cohort |
| adults | cohort |
| age | phenotype |
| age 12 | cohort |
| age 12-25 local | cohort |
| Age 15-18 local | cohort |
| age 16 | cohort |
| Age 16-21 local | cohort |
| age 17 local | phenotype |
| Age 18 local | cohort |
| Age 18-25 local | cohort |
| age 20 local | phenotype |
| Age 20 local | cohort |
| age 25 local | phenotype |
| age at initiation | phenotype |
| Age range 12-25 local | cohort |
| Ages 12-25 local | cohort |
| Ages 16-21 local | cohort |
| alcohol | phenotype |
| alcoholic families | cohort |
| Alcoholic proband | cohort |
| alcoholism | phenotype |
| anterior | anatomy |
| anterior cingulate cortex | anatomy |
| Auditory Cz local | anatomy |
| Auditory Cz β Visual Cz intermodal correlation local | phenotype |
| Auditory Cz β Visual Fz intermodal correlation local | phenotype |
| Auditory Cz β Visual Pz intermodal correlation local | phenotype |
| auditory Fz local | anatomy |
| Auditory Fz local | anatomy |
| Auditory Fz β Visual Cz intermodal correlation local | phenotype |
| Auditory Fz β Visual Fz intermodal correlation local | phenotype |
| auditory modality | anatomy |
| auditory oddball task local | phenotype |
| Auditory Pz local | anatomy |
| Auditory Pz β Visual Cz intermodal correlation local | phenotype |
| Auditory Pz β Visual Fz intermodal correlation local | phenotype |
| Auditory Pz β Visual Pz intermodal correlation local | phenotype |
| auditory system local | anatomy |
| Auditory system local | anatomy |
| brain development variables local | phenotype |
| brain networks | anatomy |
| central | anatomy |
| central (Cz) local | anatomy |
| COGA Prospective local | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| community | cohort |
| Community families local | cohort |
| conscious awareness | phenotype |
| cortex | anatomy |
| cortical anatomy local | phenotype |
| cortical thickness | phenotype |
| Cz | anatomy |
| Cz-Pz correlation local | phenotype |
| delta band ERO | phenotype |
| developmental rate curve local | phenotype |
| Developmental rates local | phenotype |
| developmental trajectory | phenotype |
| Developmental transition span local | phenotype |
| EEG | phenotype |
| epilepsy | phenotype |
| episodic memory | phenotype |
| ERO power | phenotype |
| event-related total power local | phenotype |
| externalizing disorders | phenotype |
| frontal cortex | anatomy |
| frontal (Fz) local | anatomy |
| frontal inhibitory control | phenotype |
| functional connectivity | phenotype |
| functional integration local | phenotype |
| functional neuroimaging brain development variables local | phenotype |
| Fz | anatomy |
| Fz-Cz correlation local | phenotype |
| Fz-Pz correlation local | phenotype |
| genetic variants | cohort |
| genetic variants (SNPs) local | variant |
| global brain anatomical features local | phenotype |
| global functional integration local | phenotype |
| gray matter | anatomy |
| Head injury | phenotype |
| hepatic encephalopathy | phenotype |
| Human immunodeficiency virus local | drug |
| Indiana University School of Medicine | cohort |
| insula | anatomy |
| intermodal correlations local | phenotype |
| Intermodal correlations local | phenotype |
| Intermodal power correlation local | phenotype |
| intramodal correlations local | phenotype |
| Intramodal correlations local | phenotype |
| Intramodal power correlation local | phenotype |
| intramodal power correlations local | phenotype |
| Intramodal power correlations local | phenotype |
| Liver cirrhosis | phenotype |
| locus coeruleus | anatomy |
| medication | drug |
| midline electrodes local | anatomy |
| Mini Mental State Examination score <25 | phenotype |
| neural synchrony | phenotype |
| Neurophysiological assessment local | phenotype |
| Neurosurgery | phenotype |
| oscillatory activity | phenotype |
| P3 amplitude | phenotype |
| P3 component | phenotype |
| P3 ERO local | phenotype |
| parietal (Pz) local | anatomy |
| posterior | anatomy |
| Prospective Study of the Collaborative Study on the Genetics of Alcoholism local | cohort |
| Psychoses | phenotype |
| Pz | anatomy |
| recognition memory | phenotype |
| regional brain anatomical features local | phenotype |
| relative frontal activity local | phenotype |
| resting state | phenotype |
| right-lateralized frontal region of ventral attention network | anatomy |
| right-lateralized temporoparietal region of ventral attention network | anatomy |
| schizophrenia | phenotype |
| sensory deficits | phenotype |
| sex | phenotype |
| sex differences | phenotype |
| spatial distribution changes with age local | phenotype |
| study cohort | cohort |
| Subjects age 8-20 local | cohort |
| substance use | phenotype |
| SUNY Downstate Medical Center | cohort |
| Supramodal development local | phenotype |
| supramodal functional integration local | phenotype |
| Supramodal functional integration local | phenotype |
| Supraregional development local | phenotype |
| task-related brain activity | phenotype |
| theta band | phenotype |
| Theta band event related oscillation (ERO) local | phenotype |
| theta ERO | phenotype |
| theta EROs | phenotype |
| Theta ERO trajectories local | phenotype |
| theta oscillations | phenotype |
| Theta power (auditory task) local | phenotype |
| Theta power (visual task) local | phenotype |
| total power in theta band local | phenotype |
| University of California at San Diego | cohort |
| University of Connecticut Health Center | cohort |
| University of Iowa | cohort |
| ventral attention network | anatomy |
| Visual Cz local | anatomy |
| Visual Fz local | anatomy |
| visual modality | anatomy |
| visual oddball task | phenotype |
| visual P3 response local | phenotype |
| visual Pz local | anatomy |
| Visual Pz local | anatomy |
| visual system | anatomy |
| Washington University School of Medicine in St. Louis | cohort |
| white matter | anatomy |
| young adults | cohort |
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In this knowledge base
External
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|---|---|---|---|---|
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