Associations among GABRG1, level of response to alcohol, and drinking behaviors.
- Authors
- Ray, Lara A; Hutchison, Kent E
- Year
- 2009
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 19426171
- DOI
- 10.1111/j.1530-0277.2009.00968.x
- PMCID
- PMC2965732
BACKGROUND: Recent studies of the genetics of alcoholism have focused on a cluster of genes encoding for gamma-aminobutyric acid (GABA(A)) receptor subunits, which is thought to play a role in the expression of addiction phenotypes. This study examined allelic associations between 2 single nucleotide polymorphisms (SNPs) of the GABRG1 gene (rs1391166 and rs1497571) and alcohol phenotypes, namely level of response to alcohol, alcohol use patterns, and alcohol-related problems. METHOD: Participants were non-treatment-seeking seeking hazardous drinkers (n = 124) who provided DNA samples, participated in a face-to-face interview for level of response to alcohol, and completed a series of drinking and individual differences measures. RESULTS: Analyses revealed that a SNP of the GABRG1 gene (rs1497571) was associated with level of response to alcohol and drinking patterns in this subclinical sample. Follow-up mediational analyses were also conducted to examine putative mechanisms underlying these associations. DISCUSSION: These findings replicate and extend recent research suggesting that genetic variation at the GABRG1 locus may underlie the expression of alcohol phenotypes, including level of response to alcohol.
No figures extracted from this document.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Multi-omics and electrophysiological examination of GABA<sub>A</sub> receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder. | Granchi J et al. | — | 2026 | → |
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | — | 2025 | → |
| Sex differences in GABA<sub>A</sub> receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver. | Ashton MK et al. | — | 2022 | → |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | — | 2021 | → |
| Genome-wide detection of signatures of selection in three Valdostana cattle populations. | Mastrangelo S et al. | — | 2020 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | — | 2018 | → |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | — | 2017 | → |
| Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research. | Bujarski S et al. | — | 2016 | → |
| Subjective Response to Alcohol as a Research Domain Criterion. | Ray LA et al. | — | 2016 | → |
| Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. | Kosobud AE et al. | — | 2015 | → |
| Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. | Reyes-Gibby CC et al. | — | 2015 | → |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | — | 2015 | → |
| Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients. | Spagnolo PA et al. | — | 2014 | → |
| Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples. | Pan Y et al. | — | 2013 | → |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | — | 2013 | → |
| Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. | Liu J et al. | — | 2013 | → |
| Effects of tetrahydropalmatine on post-traumatic stress disorder-induced changes in rat brain gene expression. | Ceremuga TE et al. | — | 2013 | → |
| Selection for drinking in the dark alters brain gene coexpression networks. | Iancu OD et al. | — | 2013 | → |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | — | 2013 | → |
| Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study. | Plawecki MH et al. | — | 2013 | → |
| Alcohol Dependence and Genes Encoding α2 and γ1 GABAA Receptor Subunits: Insights from Humans and Mice. | Borghese CM et al. | — | 2012 | → |
| GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects. | Grzywacz A et al. | — | 2012 | → |
| Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder. | Norman SB et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. | Li SM et al. | — | 2012 | → |
| Genetic association of recovery from eating disorders: the role of GABA receptor SNPs. | Bloss CS et al. | — | 2011 | → |
| Genetics of alcohol dependence. | Kimura M et al. | — | 2011 | → |
| GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. | Onori N et al. | — | 2010 | → |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | — | 2010 | → |