Genetics of alcohol dependence.
paper
Cited
Public
- Authors
- Gelernter, Joel; Kranzler, Henry R
- Year
- 2009
- Journal
- Human genetics
- PMID
- 19533172
- DOI
- 10.1007/s00439-009-0701-2
- PMCID
- PMC3773848
Alcohol dependence (AD), a genetically influenced phenotype, is extremely costly to individuals and to society in the United States and throughout the world, contributing to morbidity and mortality and a host of economic, interpersonal, and societal problems. Although until recently the only genes established to affect risk for AD were those encoding several alcohol metabolizing enzymes, there are now several other genes that can be regarded as confirmed risk loci, discovered through linkage and candidate gene association studies. While the mechanism of action of the effects of alcohol-metabolizing enzymes on AD risk is thought to be well understood, we are still in the early stages of understanding the physiology of other risk loci. Further, it is clear that only a small number of the many genes that influence risk for AD have been identified. Newer methodologies (e.g., genomewide association, study of copy number variation, and deep sequencing of candidate loci to identify rare risk variants) that have improved our understanding of other complex traits hold the promise of identifying a greater set of AD susceptibility loci.
No figures extracted from this document.
1–20 of 36
Next →
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity. | Ehlers CL et al. | — | 2025 | → |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | — | 2024 | → |
| Genetic Influences on Fetal Alcohol Spectrum Disorder. | Sambo D et al. | — | 2023 | → |
| The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence? | Kim Y et al. | — | 2022 | → |
| Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. | Ray LA et al. | — | 2021 | → |
| Diverse types of genomic evidence converge on alcohol use disorder risk genes. | Dai Y et al. | — | 2020 | → |
| Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures. | Lieberman R et al. | — | 2020 | → |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | — | 2020 | → |
| Genetic, Psychological, and Personal Network Factors Associated With Changes in Binge Drinking Over 2 Years Among Mexican Heritage Adolescents in the USA. | Song S et al. | — | 2019 | → |
| Examining the effects of alcohol on GABA<sub>A</sub> receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. | Lieberman R et al. | — | 2018 | → |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | — | 2018 | → |
| Genome-wide meta-analysis of copy number variations with alcohol dependence. | Sulovari A et al. | — | 2018 | → |
| Implication of Genes for the N-Methyl-D-Aspartate (NMDA) Receptor in Substance Addictions. | Chen J et al. | — | 2018 | → |
| Sex and β-Endorphin Influence the Effects of Ethanol on Limbic <i>Gabra2</i> Expression in a Mouse Binge Drinking Model. | Rhinehart EM et al. | — | 2018 | → |
| Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. | D'Addario C et al. | — | 2017 | → |
| Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. | Owusu D et al. | — | 2017 | → |
| Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women. | Wehby GL et al. | — | 2015 | → |
| Dissecting ancestry genomic background in substance dependence genome-wide association studies. | Polimanti R et al. | — | 2015 | → |
| GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. | Lieberman R et al. | — | 2015 | → |
| Rsu1 regulates ethanol consumption in Drosophila and humans. | Ojelade SA et al. | — | 2015 | → |
| S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. | Acevedo SF et al. | — | 2015 | → |
| Testing for polygenic effects in genome-wide association studies. | Pan W et al. | — | 2015 | → |
| Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples. | Taylor A et al. | — | 2014 | → |
| Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder. | Li D et al. | — | 2014 | → |
| Association of the HTR2A gene with alcohol and heroin abuse. | Cao J et al. | — | 2014 | → |
| EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior. | King IF et al. | — | 2014 | → |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | — | 2014 | → |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | — | 2014 | → |
| Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. | Wang S et al. | — | 2014 | → |
| Long-lasting, experience-dependent alcohol preference in Drosophila. | Peru Y Colón de Portugal RL et al. | — | 2014 | → |
| Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. | Gubner NR et al. | — | 2013 | → |
| Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2. | Otto JM et al. | — | 2013 | → |
| Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. | Cao J et al. | — | 2013 | → |
| Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence. | Fenton MC et al. | — | 2013 | → |
| Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. | Kos MZ et al. | — | 2013 | → |
| DSM-5 criteria for substance use disorders: recommendations and rationale. | Hasin DS et al. | — | 2013 | → |
| Genetic influences on the development of alcoholism. | Enoch MA | — | 2013 | → |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | — | 2013 | → |
| Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. | Han S et al. | — | 2013 | → |
| Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder. | Cao J et al. | — | 2013 | → |
| Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila. | Chen J et al. | — | 2013 | → |
| NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. | Zuo L et al. | — | 2013 | → |
| Opioid system genes in alcoholism: a case-control study in Croatian population. | Cupic B et al. | — | 2013 | → |
| Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans. | Han S et al. | — | 2013 | → |
| The Impact of ADH1B Alleles and Educational Status on Levels and Modes of Alcohol Consumption in Russian Male Individuals. | Borinskaya SA et al. | — | 2013 | → |
| Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol. | Wilhelm CJ et al. | — | 2012 | → |
| Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. | Peru Y Colón de Portugal RL et al. | — | 2012 | → |
| Direct-to-consumer genetic testing for addiction susceptibility: a premature commercialisation of doubtful validity and value. | Mathews R et al. | — | 2012 | → |
| Genetics of GABAergic signaling in nicotine and alcohol dependence. | Cui WY et al. | — | 2012 | → |
| Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. | Zhang H et al. | — | 2012 | → |
| Personalized treatment of alcohol dependence. | Kranzler HR et al. | — | 2012 | → |
| Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. | Li D et al. | — | 2012 | → |
| The genetic effect of copy number variations on the risk of alcoholism in a Korean population. | Bae JS et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. | Ray LA et al. | — | 2012 | → |
| Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene. | Flory JD et al. | — | 2011 | → |
| Alcohol, psoriasis, liver disease, and anti-psoriasis drugs. | Cassano N et al. | — | 2011 | → |
| A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. | Wang KS et al. | — | 2011 | → |
| An overview of the genetic susceptibility to alcoholism. | Buscemi L et al. | — | 2011 | → |
| Biological mechanisms in alcohol dependence--new perspectives. | Hillemacher T | — | 2011 | → |
| Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. | Olvera RL et al. | — | 2011 | → |
| Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. | Wang KS et al. | — | 2011 | → |
| Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. | Porcu P et al. | — | 2011 | → |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | — | 2011 | → |
| Individual vulnerability to addiction. | Swendsen J et al. | — | 2011 | → |
| Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study. | Gizer IR et al. | — | 2011 | → |
| Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse. | Lasek AW et al. | — | 2011 | → |
| Mast cells and ethanol consumption: interactions in the prostate, epididymis and testis of UChB rats. | Mendes LO et al. | — | 2011 | → |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | — | 2011 | → |
| Repetitive transcranial magnetic stimulation and drug addiction. | Barr MS et al. | — | 2011 | → |
| The genetic basis of delay discounting and its genetic relationship to alcohol dependence. | Mitchell SH | — | 2011 | → |
| A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. | Lind PA et al. | — | 2010 | → |
| Alcoholism and alternative splicing of candidate genes. | Sasabe T et al. | — | 2010 | → |
| Confirmation and generalization of an alcohol-dependence locus on chromosome 10q. | Panhuysen CI et al. | — | 2010 | → |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | — | 2010 | → |
| Genetics of drug dependence. | Gelernter J et al. | — | 2010 | → |
| Heritability of MMPI-2 scales in the UCSF family alcoholism study. | Gizer IR et al. | — | 2010 | → |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | — | 2010 | → |
| Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference. | Pelkonen A et al. | — | 2010 | → |
| Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. | Liu L et al. | — | 2009 | → |
| Genetics and the brain: many pathways to enlightenment. | O'Donovan MC et al. | — | 2009 | → |