Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task.
- Authors
- Pandey, A K; Kamarajan, C; Tang, Y; Chorlian, D B; Roopesh, B N; Manz, N; Stimus, A; Rangaswamy, M; Porjesz, B
- Year
- 2012
- Journal
- Biological psychology
- PMID
- 22024409
- DOI
- 10.1016/j.biopsycho.2011.10.009
- PMCID
- PMC3245806
In alcoholism research, studies concerning time-locked electrophysiological aspects of response inhibition have concentrated mainly on the P3 component of the event-related potential (ERP). The objective of the present study was to investigate the N2 component of the ERP to elucidate possible brain dysfunction related to the motor response and its inhibition using a Go/NoGo task in alcoholics. The sample consisted of 78 abstinent alcoholic males and 58 healthy male controls. The N2 peak was compared across group and task conditions. Alcoholics showed significantly reduced N2 peak amplitudes compared to normal controls for Go as well as NoGo task conditions. Control subjects showed significantly larger NoGo than Go N2 amplitudes at frontal regions, whereas alcoholics did not show any differences between task conditions at frontal regions. Standardized low resolution electromagnetic tomography analysis (sLORETA) indicated that alcoholics had significantly lower current density at the source than control subjects for the NoGo condition at bilateral anterior prefrontal regions, whereas the differences between groups during the Go trials were not statistically significant. Furthermore, NoGo current density across both groups revealed significantly more activation in bilateral anterior cingulate cortical (ACC) areas, with the maximum activation in the right cingulate regions. However, the magnitude of this difference was much less in alcoholics compared to control subjects. These findings suggest that alcoholics may have deficits in effortful processing during the motor response and its inhibition, suggestive of possible frontal lobe dysfunction.
Illustration of Go/NoGo task, showing correct (1, 3) and incorrect (2, 4) response.
LLM interpretation
This figure is a schematic diagram illustrating four scenarios of a Go/NoGo task: two correct responses (1, 3) and two incorrect responses (2, 4). Each timeline details the sequence of stimuli and timing, including a 100 ms initial cue, varying response or inhibition windows (400 ms or 1100 ms), a 200 ms stimulus (dollar sign or 'X'), and a 1000 ms post-stimulus period. All trials conclude with a 100 ms marker and a total inter-trial interval of 2400 ms.
61 Electrode locations are illustrated and shown according to regional groupings. Electrodes selected for statistical analysis from each group included are highlighted.
LLM interpretation
This is a schematic diagram illustrating the placement of 61 EEG electrode locations on a human scalp. The electrodes are organized into five regional groupings: Frontal, Central, Parietal, Occipital, and Left/Right Temporal. Specific electrodes selected for statistical analysis are highlighted with grey shading, while others remain white.
(3a) Grand averaged ERP waveform of N2 components in control (green line) and alcoholic (red line) subjects during Go/NoGo task. Time is shown in milliseconds where stimulus onset was at 0 with a 125 ms prestimulus baseline, and (3b) 2-D maps of N2 peak surface potentials (ΞΌV) for the Go (alcoholic=254 ms, controls=242 ms) and NoGo (alcoholic=262 ms, controls=246 ms) task conditions in control and alcoholic subjects.
LLM interpretation
Figure 3 consists of ERP waveforms (3a) and 2-D topographic maps (3b) comparing control (green) and alcoholic (red) subjects during Go and NoGo tasks. The waveforms show voltage ($\mu$V) over time (ms) across four electrode sites (Fz, FCz, Cz, Pz), with the N2 component highlighted in the NoGo condition. The topographic maps visualize the surface potential distribution at the N2 peak, with a color scale ranging from -6 to 0 $\mu$V.
Least square means of N2 peak amplitudes for control and alcoholic subjects on the Go/NoGo task.
LLM interpretation
This figure consists of two grouped horizontal bar charts comparing the least square means of N2 peak amplitudes between Control (grey) and Alcoholic (black) groups across six brain regions for "Go" and "NoGo" tasks. In all regions and for both tasks, the Control group exhibits more negative peak amplitudes compared to the Alcoholic group. The x-axis represents the Least Square Means, ranging from 0 to -6, while the y-axis lists the brain regions: Rt-Temporal, Lt-Temporal, Occipital, Parietal, Central, and Frontal.
The sLORETA images showing statistical differences (Log of ratio of averages) between Go and NoGo task conditions for control (a, b) and alcoholic (c, d) subjects in the N2 time-range.
LLM interpretation
This figure presents sLORETA brain imaging maps showing statistical differences (log of ratio of averages) between Go and NoGo task conditions during the N2 time-range. Panels (a, b) display these differences for control subjects, while panels (c, d) show them for alcoholic subjects, with yellow-highlighted regions indicating areas of significant activation. The visualization includes axial, sagittal, and coronal views, with specific coordinates and p-values provided for the peak activation areas in the control and alcoholic groups.
The sLORETA images showing statistical differences (Log of ratio of averages) between groups for NoGo trials in the N2 time-range.
LLM interpretation
This figure presents sLORETA brain imaging results showing statistical differences (log of ratio of averages) between groups for NoGo trials during the N2 time-range. Panel (a) displays axial, sagittal, and coronal cross-sections of the brain with yellow clusters indicating areas of significant difference, specifically localized in the frontal region. Panel (b) provides multiple 3D surface renderings of the brain, highlighting the spatial distribution of these significant clusters across different perspectives.
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