Genome-wide association scan for five major dimensions of personality.

paper Cited Public

Authors: Terracciano, A; Sanna, S; Uda, M; Deiana, B; Usala, G; Busonero, F; Maschio, A; Scally, M; Patriciu, N; Chen, W-M; Distel, M A; Slagboom, E P; Boomsma, D I; Villafuerte, S; Sliwerska, E; Burmeister, M; Amin, N; Janssens, A C J W; van Duijn, C M; Schlessinger, D; Abecasis, G R; Costa, P T
Year: 2010
Journal: Molecular psychiatry
PMID: 18957941
DOI: 10.1038/mp.2008.113
PMCID: PMC2874623

#	Section	Preview
0	Introduction	Behavior genetic studies reveal that personality traits, like psychiatric disorders, have a genetic…
1	Introduction	small effect size. To detect such small genetic effects, there is a growing interest in high…
2	Introduction	Personality profiles assessed with the NEO-PI-R questionnaire can be conveniently summarized by five…
3	Introduction	on Neuroticism and Agreeableness (18), and with younger people generally scoring higher on…
4	Introduction	The present study provides the first GWA results for all five dimensions of personality, as measured…
5	Introduction	Here we report associations of the five personality factors with 362,129 SNPs in 3,972 Sardinians.…
6	Method — Sample description	We recruited 6,148 individuals, about 62% of the population aged 14 to 102 years, from a cluster of…
7	Method — Personality assessment	Personality traits were assessed using the Italian version of the Revised NEO Personality Inventory…
8	Method — Genotyping and imputation	DNA was extracted from blood samples. In the Sardinian cohort, 3,329 and 1,412 individuals were…
9	Method — Genotyping and imputation	carried by each individual (based on the genotypes of family members) and assigned each individual a…
10	Method — GWA analysis	Of the combined 500K and 10K Mapping array sets, the association analyses focused on 362,129 SNPs…
11	Method — GWA analysis	Our analytical approach considers all observed or estimated genotypes (rather than focusing on…
12	Method — GWA analysis	To evaluate association on the X chromosome, we modeled a polygenic variance component shared…
13	Method — Meta-Analysis	We use meta-analysis to summarize the results from the Sardinia and replication samples. The overall…
14	Method — Replication samples	We attempted to replicate six top signals for each of the five factors in two independent samples.…
15	Method — Replication samples	The results from the GWA analyses and the two replication samples prompted us to examine a single…
16	Results	We present the results of a GWA scan for five broad personality factors in a founder population from…
17	Results	SNPs with P-values lower or equal to 10−5 are presented in supplementary Table A (45 SNPs…
18	Results — Neuroticism	Of the SNPs that showed the strongest association with Neuroticism, rs362584 (P = 5.03 × 10−5) is…
19	Results — Neuroticism	several psychiatric disorders for which Neuroticism is an intermediate phenotype/endophenotype. In…

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GWA meta-analysis of personality in Korean cohorts.	Kim BH et al.	—	2015	→
Heritability estimates of the Big Five personality traits based on common genetic variants.	Power RA et al.	—	2015	→
Pathway analysis of genome-wide association datasets of personality traits.	Kim HN et al.	—	2015	→
The use of agomelatine in OCD: effects on the motivational aspects and dysregulated circadian rhythms.	Perugi G et al.	—	2015	→
Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.	Mõttus R et al.	—	2015	→
Clock gene modulates roles of OXTR and AVPR1b genes in prosociality.	Ci H et al.	—	2014	→
Gene-environment interaction.	Manuck SB et al.	—	2014	→
Genetic and environmental continuity in personality development: a meta-analysis.	Briley DA et al.	—	2014	→
Genetic influences on brain gene expression in rats selected for tameness and aggression.	Heyne HO et al.	—	2014	→
Genome-wide association study of medication adherence in chronic diseases in the korean population.	Seo I et al.	—	2014	→
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.	van den Berg SM et al.	—	2014	→
High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice.	Parker CC et al.	—	2014	→
Personality and risk of Alzheimer's disease: new data and meta-analysis.	Terracciano A et al.	—	2014	→
Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction.	Bjornsdottir G et al.	—	2014	→
Sardinians genetic background explained by runs of homozygosity and genomic regions under positive selection.	Di Gaetano C et al.	—	2014	→
Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met allele.	De Beaumont L et al.	—	2013	→
Anxiety genetics - findings from cross-species genome-wide approaches.	Sokolowska E et al.	—	2013	→
Biological pathways and genetic mechanisms involved in social functioning.	Ordoñana JR et al.	—	2013	→
Circadian regulation of renal function and potential role in hypertension.	Bonny O et al.	—	2013	→
CNTNAP2 is significantly associated with schizophrenia and major depression in the Han Chinese population.	Ji W et al.	—	2013	→
Epigenetic Modulation of Mood Disorders.	Archer T et al.	—	2013	→
Genetics of impulsive behaviour.	Bevilacqua L et al.	—	2013	→
Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.	Terracciano A et al.	—	2013	→
Genome-wide association study of personality traits in the long life family study.	Bae HT et al.	—	2013	→
Genome-wide association study of the five-factor model of personality in young Korean women.	Kim HN et al.	—	2013	→
Heritability and linkage analysis of personality in bipolar disorder.	Greenwood TA et al.	—	2013	→
Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks.	Rivero O et al.	—	2013	→
Personality factors and suicide risk in a representative sample of the German general population.	Blüml V et al.	—	2013	→
Personality pathways of successful ageing.	Srivastava K et al.	—	2013	→
Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes.	Moya PR et al.	—	2013	→
Shared environmental influences on personality: a combined twin and adoption approach.	Matteson LK et al.	—	2013	→
Sphingolipids in psychiatric disorders and pain syndromes.	Mühle C et al.	—	2013	→
The genetics of alcohol dependence.	Rietschel M et al.	—	2013	→
The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.	Strohmaier J et al.	—	2013	→
TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.	Aragam N et al.	—	2013	→
A genome-wide linkage study of individuals with high scores on NEO personality traits.	Amin N et al.	—	2012	→
Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.	Chojnicka I et al.	—	2012	→
Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders.	Pełka-Wysiecka J et al.	—	2012	→
BDNF and DYRK1A are variable and inversely correlated in lymphoblastoid cell lines from Down syndrome patients.	Tlili A et al.	—	2012	→
Broad bandwidth or high fidelity? Evidence from the structure of genetic and environmental effects on the facets of the five factor model.	Briley DA et al.	—	2012	→
Cadherins and neuropsychiatric disorders.	Redies C et al.	—	2012	→
Cadherins in brain morphogenesis and wiring.	Hirano S et al.	—	2012	→
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion.	Vinkhuyzen AA et al.	—	2012	→
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	Hart AB et al.	—	2012	→
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.	Greenwood TA et al.	—	2012	→
Genomic structural variation in psychiatric disorders.	Rucker JJ et al.	—	2012	→
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.	Webb BT et al.	—	2012	→
Meta-analysis of genome-wide association studies for personality.	de Moor MH et al.	—	2012	→
Neurotrophic gene polymorphisms and response to psychological therapy.	Lester KJ et al.	—	2012	→
Opportunities for bioinformatics in the classification of behavior and psychiatric disorders.	Chesler EJ et al.	—	2012	→
Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.	Wang KS et al.	—	2012	→
Sex ratio dynamics and fluctuating selection on personality.	Del Giudice M	—	2012	→
Sleep disturbances and circadian CLOCK genes in borderline personality disorder.	Fleischer M et al.	—	2012	→
Targeted pharmacogenetic analysis of antipsychotic response in the CATIE study.	Liu Q et al.	—	2012	→
The implications of genotype-environment correlation for establishing causal processes in psychopathology.	Jaffee SR et al.	—	2012	→
The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.	Montag C et al.	—	2012	→
Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.	Tielbeek JJ et al.	—	2012	→
A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families.	Li X et al.	—	2011	→
Compulsion or chronobiology? A case of severe obsessive-compulsive disorder treated with cognitive-behavioral therapy augmented with chronotherapy.	Coles ME et al.	—	2011	→
Dissecting the genetic architecture of human personality.	Munafò MR et al.	—	2011	→
Does variance in drinking motives explain the genetic overlap between personality and alcohol use disorder symptoms? A twin study of young women.	Littlefield AK et al.	—	2011	→
Effects of BDNF polymorphisms on brain function and behavior in health and disease.	Hong CJ et al.	—	2011	→
Frequent nightmares in children: familial aggregation and associations with parent-reported behavioral and mood problems.	Li SX et al.	—	2011	→
Heritability of problem drinking and the genetic overlap with personality in a general population sample.	de Moor MH et al.	—	2011	→
Hostility in adolescents and adults: a genome-wide association study of the Young Finns.	Merjonen P et al.	—	2011	→
Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.	Terracciano A et al.	—	2011	→
Personality is reflected in the brain's intrinsic functional architecture.	Adelstein JS et al.	—	2011	→
Personality Measurement and Assessment in Large Panel Surveys*	Roberts B et al.	—	2011	→
SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.	Guerini FR et al.	—	2011	→
Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity.	Bergman O et al.	—	2011	→
Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy.	Basoglu C et al.	—	2011	→
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.	Middeldorp CM et al.	—	2011	→
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.	Verweij KJ et al.	—	2010	→
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.	Lind PA et al.	—	2010	→
An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model.	McCrae RR et al.	—	2010	→
An association between Epac-1 gene variants and anxiety and depression in two independent samples.	Middeldorp CM et al.	—	2010	→
Attitudes and cardiovascular disease.	Tindle H et al.	—	2010	→
BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.	Terracciano A et al.	—	2010	→
Evolutionary genomics of animal personality.	van Oers K et al.	—	2010	→
Genetic advances in the study of speech and language disorders.	Newbury DF et al.	—	2010	→
Genome-wide association scan of trait depression.	Terracciano A et al.	—	2010	→
Molecular genetics of attention-deficit/hyperactivity disorder: an overview.	Banaschewski T et al.	—	2010	→
Morningness propensity in young adults born prematurely: the Helsinki study of very low birth weight adults.	Strang-Karlsson S et al.	—	2010	→
[Neurobiology and genetics of addiction].	Kiefer F	—	2010	→
Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits.	Terracciano A et al.	—	2010	→
Prevalence and correlates of frequent nightmares: a community-based 2-phase study.	Li SX et al.	—	2010	→
Recent advances in the genetics of language impairment.	Newbury DF et al.	—	2010	→
Brain-derived neurotrophic factor: role in depression and suicide.	Dwivedi Y	—	2009	→
Facets of personality linked to underweight and overweight.	Terracciano A et al.	—	2009	→
Genome-wide association study of smoking initiation and current smoking.	Vink JM et al.	—	2009	→
Genotype imputation.	Li Y et al.	—	2009	→
[Personality disorders in childhood and adolescence].	Jucksch V et al.	—	2009	→
Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.	Le Hellard S et al.	—	2009	→
Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples.	Terracciano A et al.	—	2009	→
Visual perspective and genetics: a commentary on Lemogne and colleagues.	Sutin AR	—	2009	→