Genome-wide scan for self-rating of the effects of alcohol in American Indians.

paper Cited Public

Authors: Ehlers, Cindy L; Gizer, Ian R; Schuckit, Marc A; Wilhelmsen, Kirk C
Year: 2010
Journal: Psychiatric genetics
PMID: 20505555
DOI: 10.1097/YPG.0b013e32833add87
PMCID: PMC2933945

#	Section	Preview
0	Introduction	Individual sensitivity to alcohol has been demonstrated to be an inherited factor that affects the…
1	Introduction	by many, but not all, studies directly examining the reaction to alcohol among children of…
2	Introduction	Studies using similar alcohol challenge methodologies among groups at lower risk for alcoholism have…
3	Introduction	The estimated variation in response to a standard modest dose of alcohol has also been captured in…
4	Introduction	where direct tests of responses to alcohol drinking may not be feasible due to logistical factors,…
5	Introduction	Genetic studies of complex phenotypes, such as level of response to alcohol, often have advantages…
6	Introduction	The present report is part of a larger study exploring risk factors for substance dependence among…
7	Methods	Participants were recruited from eight geographically contiguous reservations, with a total…
8	Methods	To be included in the study, participants had to be an Indian indigenous to the catchment area, at…
9	Methods	Potential participants first met individually with research staff to have the study explained and…
10	Methods	disorder and psychiatric disorder diagnoses according to Diagnostic and Statistical Manual…
11	Methods	Level of response to alcohol was estimated using a retrospective report instrument the Self-Rating…
12	Methods	The score is generated by counting up the number of drinks reported in each time period (FIRST FIVE,…
13	Methods	One hundred and eighty-one pedigrees containing 1600 individuals were used in the genetic analyses.…
14	Methods	DNA was isolated from whole blood using an automated DNA extraction procedure, genotyping was done…
15	Methods	Genotypes were determined for 410 subjects. The PREST software program, which assesses degree of…
16	Methods	For linkage analysis, a variance components approach was used to calculate multipoint LOD scores at…
17	Results	Three hundred eighty-one participants out of a larger population of 620 had completed SRE…
18	Results	Analyses of multipoint variance component LOD scores, for the “FIRST FIVE” SRE phenotype,…
19	Discussion	The CNS effects of alcohol range from mild euphoria (high), to impaired coordination, to ataxia,…

Name	Type
African	cohort
African American	cohort
age	phenotype
agitation	phenotype
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
alcoholism	phenotype
alcohol metabolism	phenotype
alcohol-related problems	phenotype
alcohol sensitivity	phenotype
Alcohol Use	phenotype
ALDH2	gene
American Indians	cohort
antisocial personality disorder/conduct disorder phenotype local	phenotype
any drug dependence/regular tobacco use local	phenotype
Asian	cohort
Asian heritage individuals local	cohort
ASPD/CD phenotype local	phenotype
blood pressure	phenotype
body mass index	phenotype
Body sway	phenotype
body weight	phenotype
Breath alcohol level	phenotype
cannabis dependence	phenotype
Caucasian population	cohort
Caucasian sons of alcoholics local	cohort
children of alcoholics	cohort
chr9_11cM local	variant
Chromosome 10 local	gene
chromosome 12 region local	variant
CNS effects of alcohol local	phenotype
COGA dataset	cohort
COGA sample	cohort
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
Composite sensitivity measure local	phenotype
Composite Sensitivity Measure local	phenotype
Diaphoresis local	phenotype
drug	drug
EEG alpha power phenotype local	phenotype
ethanol consumption	phenotype
Family history negative for alcoholism local	cohort
Family history positive for alcoholism local	cohort
family members	cohort
first-degree relatives	cohort
FIRST FIVE SRE phenotype local	phenotype
FIVE phenotype local	phenotype
full cohort	cohort
Genetically informative families local	cohort
HD5 panel local	variant
Indian indigenous local	cohort
Indian population	cohort
Intoxication rating	phenotype
Irish Affected Sib Pair Study local	cohort
Jewish descent individuals local	cohort
Kcnma1	gene
linkage sample local	cohort
Low intensity response to alcohol local	phenotype
matched controls	cohort
maximum drinking phenotype local	phenotype
Men with positive family history local	cohort
Middle age women local	cohort
Midsouth Tobacco Family Study local	cohort
Military population local	cohort
Native American Heritage local	phenotype
Native American Indians local	cohort
Native American Mission Indians local	cohort
Native Americans	cohort
Native American sample local	cohort
non-Indian populations local	cohort
objective effects of alcohol local	phenotype
opioid	drug
opioid dependence	phenotype
OPRM1	cohort
OPRM1 SNPs	variant
other substances	phenotype
participants	cohort
participants with <50% Native American heritage local	cohort
participants with >=50% Native American heritage local	cohort
Pedigree cohort local	cohort
phenotype	phenotype
phenotype data	phenotype
Polygenic risk score for alcohol dependence	phenotype
Prior experience with alcohol local	phenotype
probands	cohort
Psychiatric disorder diagnoses local	phenotype
psychiatric disorders	phenotype
Pulse local	phenotype
Reservation cohort local	cohort
Retrospective Self-Report Measure local	phenotype
San Francisco Family Alcoholism study local	cohort
Scripps Research Institute local	cohort
Self-Rating of the Effects of Alcohol (SRE) measure local	phenotype
Self reported responses to alcohol local	phenotype
Self-Report of the Effects of Alcohol (SRE) local	phenotype
severity of alcohol dependence drinking symptomatology phenotype local	phenotype
sex	phenotype
sibling pairs	cohort
sibpairs local	cohort
small nuclear families local	cohort
smoking	phenotype
smoking phenotypes	phenotype
sons of alcoholic fathers	phenotype
South West Indian population local	cohort
Southwest Indian tribe local	cohort
SRE	phenotype
SRE FIRST FIVE local	phenotype
SRE FIRST FIVE phenotype local	phenotype
SRE scores	phenotype
SSAGA	cohort
study cohort	cohort
Subjective High Assessment Scale	phenotype
Subjective level of intoxication local	phenotype
subjective response to alcohol challenge local	phenotype
subjects	cohort
Substance dependence phenotypes local	phenotype
substance-related phenotypes local	phenotype
substance related traits local	phenotype
substance use	phenotype
tobacco use	phenotype
tolerance	phenotype
tremor	phenotype
Twin cohort	cohort

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In this knowledge base

Title	Year	PMID
A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.	2018	29623680
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	2015	26236574
Evidence for a genetic component for substance dependence in Native Americans.	2013	23377636
Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire.	2013	22980675
Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers.	2012	22235947

External

Title	Authors	Journal	Year	Link
Genetic influences on alcohol sensitivity: A critical review.	Yeung EW et al.	—	2024	→
Genomics and inclusion of Indigenous peoples in high income countries.	Gwynne K et al.	—	2023	→
Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.	Parker CC et al.	—	2020	→
Genome-wide association studies of the self-rating of effects of ethanol (SRE).	Lai D et al.	—	2020	→
A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.	Schuckit MA	—	2018	→
Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.	Edwards AC et al.	—	2018	→
Communicating about family health history: heredity, culture, iatrogenesis and the public good.	Parrott R	—	2015	→
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	Salvatore JE et al.	—	2015	→
A brief history of research on the genetics of alcohol and other drug use disorders.	Schuckit MA	—	2014	→
Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.	Ehlers CL et al.	—	2014	→
CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.	Criado JR et al.	—	2014	→
Curious cases: Altered dose-response relationships in addiction genetics.	Uhl GR et al.	—	2014	→
Evidence for a genetic component for substance dependence in Native Americans.	Ehlers CL et al.	—	2013	→
Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire.	Schuckit MA et al.	—	2013	→
Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders.	Criado JR et al.	—	2012	→
Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers.	Kalu N et al.	—	2012	→
Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study.	Schuckit MA et al.	—	2012	→
Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.	Ehlers CL et al.	—	2011	→