Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.
paper
Primary
Public
- Authors
- Sherva, Richard; Wang, Qian; Kranzler, Henry; Zhao, Hongyu; Koesterer, Ryan; Herman, Aryeh; Farrer, Lindsay A; Gelernter, Joel
- Year
- 2016
- Journal
- JAMA psychiatry
- PMID
- 27028160
- DOI
- 10.1001/jamapsychiatry.2016.0036
- PMCID
- PMC4974817
IMPORTANCE: Cannabis dependence (CAD) is a serious problem worldwide and is of growing importance in the United States because cannabis is increasingly available legally. Although genetic factors contribute substantially to CAD risk, at present no well-established specific genetic risk factors for CAD have been elucidated. OBJECTIVE: To report findings for DSM-IV CAD criteria from association analyses performed in large cohorts of African American and European American participants from 3 studies of substance use disorder genetics. DESIGN, SETTING, AND PARTICIPANTS: This genome-wide association study for DSM-IV CAD criterion count was performed in 3 independent substance dependence cohorts (the Yale-Penn Study, Study of Addiction: Genetics and Environment [SAGE], and International Consortium on the Genetics of Heroin Dependence [ICGHD]). A referral sample and volunteers recruited in the community and from substance abuse treatment centers included 6000 African American and 8754 European American participants, including some from small families. Participants from the Yale-Penn Study were recruited from 2000 to 2013. Data were collected for the SAGE trial from 1990 to 2007 and for the ICGHD from 2004 to 2009. Data were analyzed from January 2, 2013, to November 9, 2015. MAIN OUTCOMES AND MEASURES: Criterion count for DSM-IV CAD. RESULTS: Among the 14 754 participants, 7879 were male, 6875 were female, and the mean (SD) age was 39.2 (10.2) years. Three independent regions with genome-wide significant single-nucleotide polymorphism associations were identified, considering the largest possible sample. These included rs143244591 (Ξ²β=β0.54, Pβ=β4.32βΓβ10-10 for the meta-analysis) in novel antisense transcript RP11-206M11.7;rs146091982 (Ξ²β=β0.54, Pβ=β1.33βΓβ10-9 for the meta-analysis) in the solute carrier family 35 member G1 gene (SLC35G1); and rs77378271 (Ξ²β=β0.29, Pβ=β2.13βΓβ10-8 for the meta-analysis) in the CUB and Sushi multiple domains 1 gene (CSMD1). Also noted was evidence of genome-level pleiotropy between CAD and major depressive disorder and for an association with single-nucleotide polymorphisms in genes associated with schizophrenia risk. Several of the genes identified have functions related to neuronal calcium homeostasis or central nervous system development. CONCLUSIONS AND RELEVANCE: These results are the first, to our knowledge, to identify specific CAD risk alleles and potential genetic factors contributing to the comorbidity of CAD with major depression and schizophrenia.
Regional Manhattan Plots of Association Results for DSM-IV Cannabis Dependence Criterion Count in 4 Genomic RegionsAssociation results from single-nucleotide polymorphisms (SNPs) in 4 regions. A, The 148.8- to 149.2-MB region encompassing RP11-206M11.7 on chromosome 3 in the Yale-Penn and Study of Addiction: Genetics and Environment (SAGE) African American participants. B, The 95.3- to 96-MB region encompassing SLC35G1 on chromosome 10 in the Yale-Penn and SAGE African American participants. C, The 2.8- to 4.8-MB region on chromosome 8 encompassing CSMD1 in the Yale-Penn, SAGE, and International Consortium on the Genetics of Heroin Dependence (ICGHD) African American and European American participants. D, The 25.07- to 25.43-MB region encompassing PI4K2B on chromosome 4 in the Yale-Penn, SAGE, and ICGHD African American and European American participants. In A and B, the SNPs are color coded according to the correlation coefficient (r2) in the 1000 Genomes African samples with the most significant SNP. In C and D, results from the African American and European American participants were combined, and no linkage disequilibrium information was displayed. The light purple circle represents the βlog10 P value for the most significant regional SNP in the meta-analysis of the discovery samples; the purple diamond, the result for that SNP after meta-analysis with the replication sample(s). The light blue line and right y-axis show the observed recombination rate.
| # | Section | Preview |
|---|---|---|
| 20 | Discussion β Effect of Exposure Status and Comorbidity | being protective) in every European American and African American population tested and became GWSβ¦ |
| 21 | Discussion β Ion Homeostasis and Addiction | The previously published GWAS of OD19 and CD20 in a subset of this sample each identified risk genesβ¦ |
| 22 | Discussion β Shared Risk for CAD and Other Psychiatric Disorders | Many previous studies7,8,45,46 have focused on the relationship between CAD and SCZ, whereas theβ¦ |
| 23 | Conclusions | This study provided the first GWS evidence to our knowledge for SNPs associated with CAD via GWAS in⦠|
β Prev
21β24 of 24
| Name | Type |
|---|---|
| African American | cohort |
| African American meta-analysis local | cohort |
| African American-specific SNPs local | variant |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| Alzheimer's disease | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| Australian ICGHD replication cohort local | cohort |
| autism spectrum disorder | phenotype |
| bipolar disorder | phenotype |
| CAD | drug |
| calcium | drug |
| cannabinoids | drug |
| cannabis dependence | phenotype |
| cannabis exposure local | drug |
| Cannabis-only users local | phenotype |
| cannabis use | phenotype |
| cannabis use disorder | phenotype |
| CD | phenotype |
| CD20 local | phenotype |
| cocaine | phenotype |
| Combined EA/AA sample local | cohort |
| coronary artery disease | phenotype |
| CR1 | gene |
| CSMD1 | gene |
| developing mammalian neurons local | anatomy |
| discovery phase local | cohort |
| discovery sample | cohort |
| DSM-IV CAD criteria local | phenotype |
| EA population | cohort |
| European American meta-analysis local | cohort |
| European ancestry | cohort |
| general population | cohort |
| growth cones of developing central nervous system neurons local | anatomy |
| heavy drinking | phenotype |
| ICGHD local | cohort |
| ICGHD data local | cohort |
| imputed minor allele dosage local | variant |
| International Consortium on the Genetics of Heroin Dependence local | cohort |
| lifetime CAD local | phenotype |
| major depressive disorder | phenotype |
| major psychiatric traits local | phenotype |
| MEF2C | gene |
| mood disorders | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| NRG1 | gene |
| OD | phenotype |
| OD19 local | phenotype |
| opioid dependence | phenotype |
| PI4K2B local | gene |
| polysubstance dependence | phenotype |
| POR local | gene |
| psychiatric disorders | phenotype |
| Psychiatric Genomics Consortium | cohort |
| replication phase local | cohort |
| replication sample | cohort |
| RIMS1 local | gene |
| RP11-206M11.7 local | gene |
| rs10954732 local | variant |
| rs142305709 local | variant |
| rs143244591 | variant |
| rs146091982 | variant |
| rs147170184 local | variant |
| rs186825689 local | variant |
| rs74823926 local | variant |
| rs77378271 | variant |
| S100B local | gene |
| SAGE | cohort |
| SAGE African American local | cohort |
| SAGE dataset | cohort |
| SAGE trial local | cohort |
| schizophrenia | phenotype |
| SCZ | phenotype |
| single-nucleotide polymorphisms | variant |
| SLC35G1 | gene |
| SNP in SLC35G1 local | variant |
| STIM1 local | gene |
| study cohort | cohort |
| Study of Addiction: Genetics and Environment | cohort |
| substance use | phenotype |
| Yale-Penn | cohort |
| Yale-Penn 1 local | cohort |
| Yale-Penn 2 local | cohort |
| Yale-Penn 3 local | cohort |
| Yale-Penn African American local | cohort |
| Yale-Penn cohort | cohort |
| Yale-Penn sample | cohort |
| Yale-Penn study | cohort |
| Ξ³-aminobutyric acid | drug |
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