A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.

paper Cited Public

Authors: Lind, Penelope A; Macgregor, Stuart; Vink, Jacqueline M; Pergadia, Michele L; Hansell, Narelle K; de Moor, Marleen H M; Smit, August B; Hottenga, Jouke-Jan; Richter, Melinda M; Heath, Andrew C; Martin, Nicholas G; Willemsen, Gonneke; de Geus, Eco J C; Vogelzangs, Nicole; Penninx, Brenda W; Whitfield, John B; Montgomery, Grant W; Boomsma, Dorret I; Madden, Pamela A F
Year: 2010
Journal: Twin research and human genetics : the official journal of the International Society for Twin Studies
PMID: 20158304
DOI: 10.1375/twin.13.1.10
PMCID: PMC3070599

#	Section	Preview
20	RESULTS — Genome-wide Association in the Australian Sample	The lowest p-values for ND, AD and comorbid AD/ND respectively were 4.43×10−8 (rs964170 in…
21	RESULTS — Genome-wide Association in the Australian Sample	The SNP rs964170 within ARHGAP10, which ranked number one for ND, also ranked number 11 for the…
22	RESULTS — Genome-wide Association in Dutch Samples	The top results of the Australian sample (rs964170 for ND and rs12761801 for AD) were not replicated…
23	RESULTS — Meta-analysis and Connectivity Diagram	Tables 6 and 7 list detailed results for the 30 most significant SNPs from the meta-analysis of AD…
24	DISCUSSION	We have used a GWAS strategy in a search for genes involved in AD, ND and comorbid AD/ND in samples…
25	DISCUSSION	The protein coded by ARHGAP10 is a member of the Rho GTPase activating protein (Rho-GAP) family…
26	DISCUSSION	patients with ASDs has been reported (Maussion et al., 2008). DDX6 lies at 121 cM on chromosome 11;…
27	DISCUSSION	Another interesting result is GRM3 (metabotropic glutamate 3 receptor gene) on chromosome 7. In…
28	DISCUSSION	These associations in the Australian sample did not replicate in the Dutch samples. Furthermore, a…
29	DISCUSSION	genes were grouped by their biological functions, cellular locations, and possible interactions of…
30	DISCUSSION	C. elegans (Davies et al., 2003). Because KCNMA1 has been implicated in nicotine- and…
31	DISCUSSION	Compared to the results of a GWA for smoking initiation and current smoking in the Dutch NESDA/NTR…
32	DISCUSSION	Our approach to discovery of genes affecting AD and ND has both strengths and limitations. The main…
33	DISCUSSION	second limitation is the comparatively small sample size, although we estimate that power would be…
34	DISCUSSION	CAGE criteria were used in the NTR sample. A fourth limitation may be that specific genetic effects…
35	DISCUSSION	that this is a study of alcohol and nicotine dependency versus non-dependency. As such, we did not…
36	DISCUSSION	In conclusion, we have identified a number of gene networks (ion-channels, cell adhesion molecules)…

Citation	PMID	DOI	Status
Alarcon, M et al., Am J Hum Genet, 2008, Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene	18179893	10.1016/j.ajhg.2007.09.005	Cited
Arking, DE et al., Am J Hum Genet, 2008, A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism	18179894	10.1016/j.ajhg.2007.09.015	Cited
Basseres, DS et al., Biochem Biophys Res Commun, 2002, ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein	12056806	10.1016/S0006-291X(02)00514-4	Cited
Bice, P et al., Alcohol Clin Exp Res, 2009, Genomewide SNP screen to detect quantitative trait Loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice	19120064	10.1111/j.1530-0277.2008.00866.x	Cited
Bierut, LJ et al., Hum Mol Genet, 2007, Novel genes identified in a high-density genome wide association study for nicotine dependence	17158188	10.1093/hmg/ddl441	Cited
Boomsma, DI et al., Eur J Hum Genet, 2008, Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects	18197199	10.1038/sj.ejhg.5201979	Cited
Boomsma, DI et al., Twin Res Hum Genet, 2006, Netherlands Twin Register: from twins to twin families	17254420	10.1375/183242706779462426	Cited
Brown, KM et al., Nat Genet, 2008, Common sequence variants on 20q11.22 confer melanoma susceptibility	18488026	10.1038/ng.163	Cited
Bucholz, KK et al., J Stud Alcohol, 1994, A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA	8189735	10.15288/jsa.1994.55.149	Primary
Butt, CM et al., Alcohol Clin Exp Res, 2003, A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol	12766617	10.1097/01.ALC.0000067973.41153.BC	Cited
Butt, CM et al., J Pharmacol Exp Ther, 2004, Interaction of the nicotinic cholinergic system with ethanol withdrawal	14610221	10.1124/jpet.103.059758	Cited
Caporaso, N et al., PLoS ONE, 2009, Genome-wide and candidate gene association study of cigarette smoking behaviors	19247474	10.1371/journal.pone.0004653	Cited
Chen, Q et al., Schizophr Res, 2005, A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population	15567072	10.1016/j.schres.2004.07.002	Cited
Cottler, LB et al., Br J Psychiatry, 1991, The CIDI-core substance abuse and dependence questions: cross-cultural and nosological issues. The WHO/ADAMHA Field Trial	1756341	10.1192/bjp.159.5.653	Cited
Davies, AG et al., Cell, 2003, A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans	14675531	10.1016/s0092-8674(03)00979-6	Cited
de Leon, J et al., Schizophr Res, 2002, Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders	12084419	10.1016/s0920-9964(01)00217-1	Cited
Drgon, T et al., Mol Med, 2009, Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers	19009022	10.2119/molmed.2008.00096	Cited
Egan, MF et al., Proc Natl Acad Sci U S A, 2004, Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia	15310849	10.1073/pnas.0405077101	Cited
Ewing, JA, Jama, 1984, Detecting alcoholism. The CAGE questionnaire	6471323	10.1001/jama.252.14.1905	Cited
Fallin, MD et al., Am J Hum Genet, 2005, Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios	16380905	10.1086/497703	Cited
Friedman, JI et al., Mol Psychiatry, 2008, CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy	17646849	10.1038/sj.mp.4002049	Cited
Fujii, Y et al., Psychiatr Genet, 2003, Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia	12782962	10.1097/01.ypg.0000056682.82896.b0	Cited
Gelernter, J et al., Biol Psychiatry, 2007, Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus	17081504	10.1016/j.biopsych.2006.08.023	Cited
Gelernter, J et al., Hum Genet, 2009, Genetics of alcohol dependence	19533172	10.1007/s00439-009-0701-2	Cited
Grant, BF et al., Arch Gen Psychiatry, 2004, Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions	15520358	10.1001/archpsyc.61.11.1107	Cited
Hansell, NK et al., Twin Res Hum Genet, 2008, Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence	18498207	10.1375/twin.11.3.287	Cited
Heath, AC et al., Psychol Med, 1997, Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men	9403910	10.1017/s0033291797005643	Cited
Heatherton, TF et al., Br J Addict, 1991, The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire	1932883	10.1111/j.1360-0443.1991.tb01879.x	Cited
Hettema, JM et al., Drug Alcohol Depend, 1999, A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins	10617315	10.1016/s0376-8716(99)00053-8	Cited
Hishimoto, A et al., Hum Mol Genet, 2007, Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms	17804423	10.1093/hmg/ddm247	Cited
Hu, G et al., PLoS ONE, 2009, Human disease-drug network based on genomic expression profiles	19657382	10.1371/journal.pone.0006536	Cited
Hurt, RD et al., Jama, 1996, Mortality following inpatient addictions treatment. Role of tobacco use in a community-based cohort	8601929	10.1001/jama.275.14.1097	Cited
Johnson, C et al., Am J Med Genet B Neuropsychiatr Genet, 2006, Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism	16894614	10.1002/ajmg.b.30346	Primary
Kenny, PJ et al., J Pharmacol Exp Ther, 2003, Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats	12805481	10.1124/jpet.103.052027	Cited
Knopik, VS et al., Psychol Med, 2004, Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors	15724882	10.1017/s0033291704002922	Cited
Koopmans, JR et al., Alcohol Clin Exp Res, 1997, Association between alcohol use and smoking in adolescent and young adult twins: a bivariate genetic analysis	9161615	—	Cited
Kuper, H et al., Int J Cancer, 2000, Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma	10699921	—	Cited
Lachman, HM et al., Hum Mol Genet, 2007, Genomewide suggestive linkage of opioid dependence to chromosome 14q	17409192	10.1093/hmg/ddm081	Cited
Lessov, CN et al., Psychol Med, 2004, Defining nicotine dependence for genetic research: evidence from Australian twins	15500307	10.1017/s0033291703001582	Cited
Li, CY et al., PLoS Comput Biol, 2008, Genes and (common) pathways underlying drug addiction	18179280	10.1371/journal.pcbi.0040002	Cited
Liechti, ME et al., J Neurosci, 2007, Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence	17715344	10.1523/JNEUROSCI.1766-07.2007	Cited
Liu, QR et al., Am J Med Genet B Neuropsychiatr Genet, 2006, Addiction molecular genetics: 639,401 SNP whole genome association identifies many “cell adhesion” genes	17099884	10.1002/ajmg.b.30436	Cited
Liu, YZ et al., Mol Psychiatry, 2009, Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15	19188921	10.1038/mp.2009.3	Cited
Loukola, A et al., Pharmacogenomics J, 2008, Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background	17549066	10.1038/sj.tpj.6500464	Cited
Macgregor, S et al., Nucleic Acids Res, 2006, Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates	16627870	10.1093/nar/gkl136	Cited
Macgregor, S et al., Nucleic Acids Res, 2008, Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays	18276640	10.1093/nar/gkm1060	Cited
Madden, PA et al., Alcohol Clin Exp Res, 1997, Smoking and intoxication after alcohol challenge in women and men: genetic influences	9438540	—	Cited
Madden, PA et al., Alcohol Clin Exp Res, 2002, Shared genetic vulnerability in alcohol and cigarette use and dependence	12500120	10.1097/01.ALC.0000040960.15151.30	Cited
Madden, PA et al., Alcohol Res Health, 2000, Smoking and the genetic contribution to alcohol-dependence risk	15986715	—	Cited
Madden, PA et al., Behav Genet, 1999, The genetics of smoking persistence in men and women: a multicultural study	10857247	10.1023/a:1021674804714	Cited
Madden, PA et al., Twin Res, 2004, The epidemiology and genetics of smoking initiation and persistence: crosscultural comparisons of twin study results	15053857	10.1375/13690520460741471	Cited
Marchini, J et al., Nat Genet, 2007, A new multipoint method for genome-wide association studies by imputation of genotypes	17572673	10.1038/ng2088	Cited
Marti, SB et al., Am J Med Genet, 2002, Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population	11840505	10.1002/ajmg.1624	Cited
Maussion, G et al., Hum Mol Genet, 2008, Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism	18492799	10.1093/hmg/ddn154	Cited
Melquist, S et al., Am J Hum Genet, 2007, Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms	17357082	10.1086/513320	Cited
Mossner, R et al., Eur Neuropsychopharmacol, 2008, Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia	18614340	10.1016/j.euroneuro.2008.05.007	Cited
Nature, 2003, The International HapMap Project	14685227	10.1038/nature02168	Cited
Norton, N et al., BMC Psychiatry, 2005, No evidence for association between polymorphisms in GRM3 and schizophrenia	15892884	10.1186/1471-244X-5-23	Cited
Novak, G et al., World J Biol Psychiatry, 2009, Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study	19658047	10.1080/15622970903079499	Cited
Owens, JC et al., Alcohol Clin Exp Res, 2003, Alpha4beta2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response	14691373	10.1097/01.ALC.0000102700.72447.0F	Cited
Papassotiropoulos, A et al., Science, 2006, Common Kibra alleles are associated with human memory performance	17053149	10.1126/science.1129837	Cited
Penninx, BW et al., Int J Methods Psychiatr Res, 2008, The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods	18763692	10.1002/mpr.256	Cited
Pergadia, ML et al., Am J Med Genet B Neuropsychiatr Genet, 2009, Genetic linkage findings for DSM-IV nicotine withdrawal in two populations	19180564	10.1002/ajmg.b.30924	Cited
Purcell, S et al., Am J Hum Genet, 2007, PLINK: a tool set for whole-genome association and population-based linkage analyses	17701901	10.1086/519795	Cited
Risch, N et al., Science, 1996, The future of genetic studies of complex human diseases	8801636	10.1126/science.273.5281.1516	Cited
Rosenberger, A et al., BMC Genet, 2005, Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association	16451667	10.1186/1471-2156-6-S1-S55	Cited
Saccone, SF et al., Am J Hum Genet, 2007, Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples	17436240	10.1086/513703	Cited
Saccone, SF et al., Bioinformatics, 2008, Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence	18565990	10.1093/bioinformatics/btn315	Primary
Schuckit, MA et al., Alcohol Clin Exp Res, 2005, Autosomal linkage analysis for the level of response to alcohol	16340454	10.1097/01.alc.0000187598.82921.27	Cited
Sham, P et al., Nat Rev Genet, 2002, DNA Pooling: a tool for large-scale association studies	12415316	10.1038/nrg930	Cited
Spinola, M et al., Cancer Lett, 2007, Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene	17223258	10.1016/j.canlet.2006.11.029	Cited
Steer, S et al., Genes Immun, 2007, Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis	17159887	10.1038/sj.gene.6364359	Cited
Sullivan, PF et al., Mol Psychiatry, 2009, Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo	19065144	10.1038/mp.2008.125	Cited
Terracciano, A et al., Mol Psychiatry, 2008, Genome-wide association scan for five major dimensions of personality	18957941	10.1038/mp.2008.113	Cited
Thorgeirsson, TE et al., Nature, 2008, A variant associated with nicotine dependence, lung cancer and peripheral arterial disease	18385739	10.1038/nature06846	Cited
Tochigi, M et al., Schizophr Res, 2006, No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population	16904291	10.1016/j.schres.2006.07.008	Cited
Treutlein, J et al., Arch Gen Psychiatry, 2009, Genome-wide association study of alcohol dependence	19581569	10.1001/archgenpsychiatry.2009.83	Cited
True, WR et al., Arch Gen Psychiatry, 1999, Common genetic vulnerability for nicotine and alcohol dependence in men	10401514	10.1001/archpsyc.56.7.655	Cited
Uhl, GR et al., Ann N Y Acad Sci, Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify “connectivity constellation” and drug target genes with pleiotropic effects	18991966	10.1196/annals.1441.018	Cited
Uhl, GR et al., Arch Gen Psychiatry, Molecular genetics of successful smoking cessation: convergent genome-wide association study results	18519826	10.1001/archpsyc.65.6.683	Cited
Uhl, GR et al., BMC Genet, 2007, Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs	17407593	10.1186/1471-2156-8-10	Cited
Vink, JM et al., Am J Hum Genet, 2009, Genome-wide association study of smoking initiation and current smoking	19268276	10.1016/j.ajhg.2009.02.001	Cited
Vink, JM et al., Behav Genet, 2005, Heritability of smoking initiation and nicotine dependence	15971021	10.1007/s10519-004-1327-8	Cited
Wang, K et al., Am J Hum Genet, 2007, Pathway-Based Approaches for Analysis of Genomewide Association Studies	17966091	10.1086/522374	Cited
Ye, H et al., Sheng Li Xue Bao, 2004, Effect of chronic cigarette smoking on large-conductance calcium-activated potassium channel and Kv1.5 expression in bronchial smooth muscle cells of rats	15497036	—	Cited

In this knowledge base

Title	Year	PMID
Human Genetics of Addiction: New Insights and Future Directions.	2018	29504045
A genome wide association study of fast beta EEG in families of European ancestry.	2017	28040410
The genetic epidemiology of substance use disorder: A review.	2017	28938182
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.	2015	26173477
Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.	2015	25542586
Genomic influences on alcohol problems in a population-based sample of young adults.	2015	25439982
Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.	2014	25129674
Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood.	2013	23282961
Genome-wide association studies of maximum number of drinks.	2013	23953852
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.	2013	23216389
Stress-response pathways are altered in the hippocampus of chronic alcoholics.	2013	23981442
Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice.	2012	22239914
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	2012	22488850
Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.	2012	22574115
Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.	2012	21818662
The genetic basis of addictive disorders.	2012	22640768
The genetics of alcohol dependence: advancing towards systems-based approaches.	2012	22854292
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	2011	21314694
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.	2011	21497796

External

Title	Authors	Journal	Year	Link
Human genetics and epigenetics of alcohol use disorder.	Zhou H et al.	—	2024	→
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN.	Monteil A et al.	—	2024	→
Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies.	Chang XW et al.	—	2022	→
Genome-wide associated variants of subclinical atherosclerosis among young people with HIV and gene-environment interactions.	He J et al.	—	2022	→
TrustGWAS: A full-process workflow for encrypted GWAS using multi-key homomorphic encryption and pseudorandom number perturbation.	Yang M et al.	—	2022	→
Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples.	Fan R et al.	—	2021	→
Genome-Wide Association Study of Opioid Cessation.	Cox JW et al.	—	2020	→
Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults.	Chang LH et al.	—	2019	→
Associations between polygenic risk for tobacco and alcohol use and liability to tobacco and alcohol use, and psychiatric disorders in an independent sample of 13,999 Australian adults.	Chang LH et al.	—	2019	→
Associations of <i>BRAP</i> polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test.	Kim JW et al.	—	2019	→
Cross-Sectional Study to Characterise Nicotine Dependence in Central Vietnamese Men.	Kõks G et al.	—	2019	→
GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.	Xiang B et al.	—	2019	→
National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies.	Cates HM et al.	—	2019	→
Human Genetics of Addiction: New Insights and Future Directions.	Hancock DB et al.	—	2018	→
Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions.	Klenowski PM et al.	—	2018	→
A genome wide association study of fast beta EEG in families of European ancestry.	Meyers JL et al.	—	2017	→
Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.	Xu H et al.	—	2017	→
CHN2 Promoter Methylation Change May Be Associated With Methamphetamine Dependence.	Hao L et al.	—	2017	→
Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.	Yeung EW et al.	—	2017	→
Genetic variation in the exome: Associations with alcohol and tobacco co-use.	Otto JM et al.	—	2017	→
The genetic epidemiology of substance use disorder: A review.	Prom-Wormley EC et al.	—	2017	→
The genetics of alcohol dependence and alcohol-related liver disease.	Stickel F et al.	—	2017	→
Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men.	Wu LS et al.	—	2016	→
Overview of the Genetics of Alcohol Use Disorder.	Tawa EA et al.	—	2016	→
An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila.	Sandhu S et al.	—	2015	→
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.	Nishizawa D et al.	—	2015	→
DAT1 and Alcohol Use: Differential Responses to Life Stress during Adolescence.	Stogner JM	—	2015	→
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.	Grotewiel M et al.	—	2015	→
Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.	McClintick JN et al.	—	2015	→
Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.	Pirastu N et al.	—	2015	→
Genomic influences on alcohol problems in a population-based sample of young adults.	Edwards AC et al.	—	2015	→
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila.	Morozova TV et al.	—	2015	→
Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population.	Pombar-Gomez M et al.	—	2015	→
Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry.	Palmer RH et al.	—	2015	→
The structure and function of NKAIN2-a candidate tumor suppressor.	Zhao SC et al.	—	2015	→
Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples.	Taylor A et al.	—	2014	→
Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.	McClintick JN et al.	—	2014	→
Genetics and genomics of alcohol sensitivity.	Morozova TV et al.	—	2014	→
Genetics of alcohol dependence: a review of clinical studies.	Samochowiec J et al.	—	2014	→
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.	Loukola A et al.	—	2014	→
Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau.	Jiang Y et al.	—	2014	→
Nematodes feel a craving--using Caenorhabditis elegans as a model to study alcohol addiction.	Zhu G et al.	—	2014	→
The sodium leak channel, NALCN, in health and disease.	Cochet-Bissuel M et al.	—	2014	→
A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity.	Wen Y et al.	—	2013	→
Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood.	Edwards AC et al.	—	2013	→
Association of a novel polymorphism of the β2-chimaerin gene (CHN2) with smoking.	Barrio-Real L et al.	—	2013	→
Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples.	Pan Y et al.	—	2013	→
Genetics and epigenetics of alcohol dependence.	Nieratschker V et al.	—	2013	→
Genome-wide association studies of maximum number of drinks.	Pan Y et al.	—	2013	→
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.	Zuo L et al.	—	2013	→
Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation.	Manzardo AM et al.	—	2013	→
Stress-response pathways are altered in the hippocampus of chronic alcoholics.	McClintick JN et al.	—	2013	→
The genetics of alcohol dependence.	Rietschel M et al.	—	2013	→
Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.	Vanderlinden LA et al.	—	2013	→
ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.	Wang KS et al.	—	2012	→
Association mapping of height and maturity across five environments using the sorghum mini core collection.	Upadhyaya HD et al.	—	2012	→
Association study of 45 candidate genes in nicotine dependence in Han Chinese.	Wei J et al.	—	2012	→
A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.	Verhagen M et al.	—	2012	→
Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice.	Bhandari P et al.	—	2012	→
CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity.	Onaivi ES et al.	—	2012	→
Convergence of genetic influences in comorbidity.	McEachin RC et al.	—	2012	→
Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.	Harmey D et al.	—	2012	→
Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.	Wang KS et al.	—	2012	→
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	Zuo L et al.	—	2012	→
Identification of SSR markers associated with height using pool-based genome-wide association mapping in sorghum	Wang YH et al.	—	2012	—
Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence.	Coller JK et al.	—	2012	→
Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.	Bettinger JC et al.	—	2012	→
Oral Nicotine Self-Administration in Rodents.	Collins AC et al.	—	2012	→
Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.	van Beek JH et al.	—	2012	→
The genetic basis of addictive disorders.	Ducci F et al.	—	2012	→
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks.	Morozova TV et al.	—	2012	→
The genetics of alcohol dependence: advancing towards systems-based approaches.	Palmer RH et al.	—	2012	→
The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects.	Lobo DS et al.	—	2012	→
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.	Wang KS et al.	—	2011	→
A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study.	Voisey J et al.	—	2011	→
Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.	Le-Niculescu H et al.	—	2011	→
Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study.	Wang KS et al.	—	2011	→
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS et al.	—	2011	→
Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.	Baik I et al.	—	2011	→
Genome-wide association studies of alcohol dependence and substance use disorders.	Treutlein J et al.	—	2011	→
Heritability of problem drinking and the genetic overlap with personality in a general population sample.	de Moor MH et al.	—	2011	→
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.	Zill P et al.	—	2011	→
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.	Li D et al.	—	2011	→
An integrated genome research network for studying the genetics of alcohol addiction.	Spanagel R et al.	—	2010	→