Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.
paper
Primary
Public
- Authors
- Kamarajan, Chella; Rangaswamy, Madhavi; Tang, Yongqiang; Chorlian, David B; Pandey, Ashwini K; Roopesh, Bangalore N; Manz, Niklas; Saunders, Ramotse; Stimus, Arthur T; Porjesz, Bernice
- Year
- 2010
- Journal
- Journal of psychiatric research
- PMID
- 20035952
- DOI
- 10.1016/j.jpsychires.2009.11.019
- PMCID
- PMC2878886
OBJECTIVE: A dysfunctional neural reward system has been shown to be associated with alcoholism. The current study aims to examine reward processing in male alcoholics by using event-related potentials (ERPs) as well as behavioral measures of impulsivity and risk-taking. METHODS: Outcome-related negativity (ORN/N2) and positivity (ORP/P3) derived from a single outcome gambling task were analyzed using a mixed model procedure. Current density was compared across groups and outcomes using standardized low resolution electromagnetic tomography (sLORETA). Behavioral scores were also compared across groups. Correlations of ERP factors with behavioral and impulsivity factors were also analyzed. RESULTS: Alcoholics showed significantly lower amplitude than controls during all outcome conditions for the ORP component and decreased amplitude during the loss conditions for the ORN component. Within conditions, gain produced higher amplitudes than loss conditions. Topographically, both groups had an anterior focus during loss conditions and posterior maxima during gain conditions, especially for the ORN component. Decreased ORP current density at cingulate gyrus and less negative ORN current density at sensory and motor areas characterized the alcoholics. Alcoholics had higher levels of impulsivity and risk-taking features than controls. CONCLUSIONS: Deficient outcome/reward processing and increased impulsivity and risk-taking observed in alcoholics may be at least partly due to reward deficiency and/or dysfunctional reward circuitry in the brain, suggesting that alcoholism can be considered as part of the cluster of the reward deficiency syndrome (RDS).
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| Name | Type |
|---|---|
| -10 local | phenotype |
| -50 local | phenotype |
| Abnormal emotional traits local | phenotype |
| abstinence | phenotype |
| addiction | phenotype |
| Addictive-impulsive-compulsive spectrum local | phenotype |
| age | phenotype |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcohol/drug abuse | phenotype |
| Alcohol/Drug Dependent Individuals local | cohort |
| alcoholic group | cohort |
| alcoholism | phenotype |
| alcohol-related diseases | phenotype |
| Alcohol Use Disorder | phenotype |
| amplitude | phenotype |
| anterior cingulate cortex | anatomy |
| anterior region | anatomy |
| anticipation | phenotype |
| antisocial personality disorder | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| autonomic and endocrine systems local | anatomy |
| Behavioral risk-taking features local | phenotype |
| BIS | phenotype |
| BIS-11 score | phenotype |
| BIS impulsivity local | phenotype |
| brain | anatomy |
| Brain deficits local | phenotype |
| central | anatomy |
| choice stimulus (CS) local | phenotype |
| cingulate cortex | anatomy |
| clinical samples | cohort |
| cocaine | phenotype |
| cognitive aspects of decision making local | phenotype |
| cognitive control | phenotype |
| conduct disorder | phenotype |
| control | cohort |
| control group | cohort |
| controls | cohort |
| Corticalβstriatalβthalamic-cortical loops local | anatomy |
| Current density local | phenotype |
| Cz | anatomy |
| decision making | phenotype |
| Decreased current density in cingulate gyrus during ORP local | phenotype |
| disinhibition | phenotype |
| disinhibitory behaviors | phenotype |
| disinhibitory/externalizing spectrum local | phenotype |
| disulfiram | drug |
| dopamine | drug |
| Dopaminergic system | drug |
| dorsal (pregenual) ACC local | anatomy |
| dorsolateral prefrontal cortex | anatomy |
| drug | drug |
| drug dependence | phenotype |
| drug-seeking behavior | phenotype |
| Emotion | phenotype |
| emotional valence local | phenotype |
| ERP | phenotype |
| ERP factor 1 | phenotype |
| ERP factor 2 | phenotype |
| ERP factor 3 | phenotype |
| ERP factor 4 local | phenotype |
| ERP factors local | phenotype |
| ERP measures | phenotype |
| ERP recordings local | phenotype |
| ERP variables | phenotype |
| error monitoring local | phenotype |
| error-related negativity | phenotype |
| event-related brain oscillations | phenotype |
| event-related potential | phenotype |
| externalizing disorders | phenotype |
| family history of alcoholism | phenotype |
| frontal cortex | anatomy |
| frontosubcortical circuits local | anatomy |
| Frontosubcortical circuits local | anatomy |
| Fz | anatomy |
| GAIN | cohort |
| gain 10 (+10) local | phenotype |
| gain 50 (+50) local | phenotype |
| gain condition | phenotype |
| Gain condition (+10) local | phenotype |
| Gain condition (+50) local | phenotype |
| Gaining trend local | phenotype |
| Gambling Paradigm local | other |
| healthy controls | cohort |
| Healthy human subjects local | cohort |
| Healthy Male Controls local | cohort |
| healthy normals local | cohort |
| heavy drinking | phenotype |
| hostility | phenotype |
| Hyper-excitability during early processing at primary sensory and motor areas local | phenotype |
| hypodopaminergic trait local | phenotype |
| Impulse control disorders | phenotype |
| impulsivity | phenotype |
| inferior frontal gyrus | anatomy |
| insula | anatomy |
| Insula region local | anatomy |
| Iowa Gambling Task | phenotype |
| Kamarajan et al., 2009 local | cohort |
| large amount | phenotype |
| Large amount 50 local | phenotype |
| latency | phenotype |
| left temporal cortex | anatomy |
| limbic regions | anatomy |
| Losing trend local | phenotype |
| loss | phenotype |
| loss 10 (β10) local | phenotype |
| loss 50 (β50) local | phenotype |
| loss condition | phenotype |
| major medical disorders local | phenotype |
| Major Medical Disorders local | phenotype |
| Male alcoholics | phenotype |
| male participants | cohort |
| marijuana | phenotype |
| medial frontal cortex | anatomy |
| medial posterior local | anatomy |
| Medial posterior cortex local | anatomy |
| motor cortex | anatomy |
| motor response | phenotype |
| NaΓ―ve offspring local | cohort |
| Neural reward network local | anatomy |
| neurocognitive disinhibition local | phenotype |
| Neurocognitive dysfunction local | phenotype |
| nicotine | drug |
| non-planning | phenotype |
| Non-planning impulsivity | phenotype |
| novelty detection | phenotype |
| occipital cortex | anatomy |
| older alcoholics | phenotype |
| orbitofrontal cortex | anatomy |
| ORN | anatomy |
| ORN component | phenotype |
| ORN current density local | phenotype |
| ORP | phenotype |
| ORP amplitude | phenotype |
| ORP component | phenotype |
| ORP current density local | phenotype |
| outcome processing | phenotype |
| outcome-related negativity | phenotype |
| outcome stimulus (OS) local | phenotype |
| P3 amplitude | phenotype |
| P3/ORP component local | phenotype |
| parietal cortex | anatomy |
| pathological gambling | phenotype |
| performance monitoring local | phenotype |
| Performance variables local | phenotype |
| postcentral gyrus | anatomy |
| posterior cingulate area local | anatomy |
| Posterior cingulate area local | anatomy |
| posterior cingulate cortex | anatomy |
| Post-Traumatic Stress Disorder | phenotype |
| precentral gyrus | anatomy |
| predictability of outcome local | phenotype |
| prefrontal cortex | anatomy |
| Primary sensory and motor local | anatomy |
| Primary sensory and motor areas local | anatomy |
| Primary sensory area local | anatomy |
| psychiatric disorders | phenotype |
| Psychoactive Drugs local | drug |
| Pz | anatomy |
| reaction time | phenotype |
| Reduced negative ORN current density in postcentral, inferior frontal, precentral gyrus local | phenotype |
| response inhibition | phenotype |
| reward based decision making local | phenotype |
| reward deficiency syndrome | phenotype |
| reward processing | phenotype |
| reward processing deficiency local | phenotype |
| Reward processing deficiency local | phenotype |
| Reward Processing Deficiency local | phenotype |
| Reward processing dysfunction local | phenotype |
| reward sensitivity | phenotype |
| reward system | anatomy |
| right temporal cortex | anatomy |
| risk propensity local | phenotype |
| risk taking | phenotype |
| salience attribution local | phenotype |
| selection frequency | phenotype |
| Selection frequency for 10 after loss trend of previous 2 trials local | phenotype |
| Selection frequency for 50 after loss trend of previous 3 trials local | phenotype |
| Single Outcome Gambling (SOG) task local | other |
| Single Outcome Gambling (SOG) task local | phenotype |
| small amount | phenotype |
| Small amount 10 local | phenotype |
| social behavior regulation local | phenotype |
| subjects | cohort |
| substance-related addictive illnesses local | phenotype |
| Substance-Related Addictive Illnesses local | phenotype |
| substance use | phenotype |
| Total score of BIS local | phenotype |
| Touretteβs syndrome | phenotype |
| TRB | phenotype |
| TRB factor 1 | phenotype |
| TRB factor 2 | phenotype |
| TRB factor 3 | phenotype |
| TRB scores local | phenotype |
| Treatment-naive alcoholics local | cohort |
| working memory | phenotype |
| younger controls local | cohort |
| Younger controls local | cohort |
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