New insights into the genetics of addiction.

paper Cited Public

Authors: Li, Ming D; Burmeister, Margit
Year: 2009
Journal: Nature reviews. Genetics
PMID: 19238175
DOI: 10.1038/nrg2536
PMCID: PMC2879628

#	Section	Preview
20	Murine behavioral studies — Knockout (KO) models of nAChR subunit genes	Genes encoding nAChRs mediate variability in many of the behavioral effects of nicotine. KO mice for…
21	Murine behavioral studies — Knockout (KO) models of nAChR subunit genes	KO mice of α574 and β475, as well as α3 KO heterozygous mice,76 show that each of the three genes…
22	Murine behavioral studies — Knockin (KI) model of α4 nAChR subunit in nicotine	To better understand the roles of α4-containing nAChRs, a KI approach was adopted with the goal of…
23	Murine behavioral studies — Mouse models of GABA genes in alcohol and other addictions	Rodent models of addiction have been studied for decades.79 QTL mapping of alcohol withdrawal…
24	Murine behavioral studies — Mouse models of GABA genes in alcohol and other addictions	Overall, many other mutants, KI, KO, and transgenic mice of various GABA subunit genes have…
25	Conclusions	Significant progress has been made in identifying susceptibility loci and genes for addictions.…
26	Conclusions	in other ethnic populations with different LD structure may be revealing. GWAS confirmation of…

Name	Type
Ability to quit smoking	phenotype
acetylcholine	drug
addiction	phenotype
ADH2	gene
ADH4	gene
ADH7	gene
ADH gene cluster	gene
African American	cohort
age	phenotype
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
alcoholism	phenotype
alcohol-related phenotypes	phenotype
alcohol sensitivity	phenotype
alcohol withdrawal	phenotype
ALDH2	gene
Alzheimer's disease	phenotype
American Indians	cohort
ANKK1	gene
ANKK1 variant local	variant
anxiety	phenotype
Asian	cohort
autism	phenotype
candidate genes	cohort
cannabis use	phenotype
Caucasian	cohort
Caucasians	cohort
Chinese men	cohort
CHRNA10	gene
CHRNA2	gene
Chrna3	gene
CHRNA3 SNP local	variant
Chrna4	gene
CHRNA5	gene
CHRNA5/A3 SNPs local	variant
CHRNA5 nonsynonymous polymorphism local	variant
Chrna6	gene
Chrna7	gene
CHRNA8	gene
CHRNA9	gene
Chrnb2	gene
Chrnb3	gene
Chrnb4	gene
cocaine	phenotype
cocaine-induced motor response local	phenotype
cocaine self-administration	phenotype
comorbid alcohol and drug dependence local	phenotype
continued use	phenotype
Cultural background local	phenotype
dependence	phenotype
dependent smokers local	cohort
dopamine release in ventral striatum local	phenotype
early-onset smokers local	cohort
Early response to alcoholism local	phenotype
early smoking	phenotype
education	phenotype
European ancestry	cohort
excessive ambulation local	phenotype
GABA	phenotype
GABA subunit genes local	gene
Gabbr2	gene
Gabra1	gene
GABRA2	gene
GABRA2 nonsynonymous variant local	variant
GABRB1	gene
Gabrb2	gene
heavy drinking	phenotype
heritability	phenotype
heterozygous Leu9′Ala KI mice local	cohort
heterozygous Leu9′Ser KI mice local	cohort
homozygous Leu9′Ala KI mice local	cohort
illicit drug use	phenotype
initiation	phenotype
Jewish Americans local	cohort
Leu9′Ala local	variant
Leu9′Ala KI mice local	cohort
Leu9′Ser local	variant
Leu9′Ser KI mice local	cohort
LOC123688	gene
locomotion-suppressant effects of nicotine local	phenotype
loss of righting reflex	phenotype
lung cancer	phenotype
Lung cancer susceptibility local	phenotype
motor learning impairment local	phenotype
multiple drugs	drug
multiple substances of abuse local	phenotype
nicotine	drug
nicotine dependence	phenotype
nicotine-induced seizures	phenotype
nicotine self-administration	phenotype
nicotine sensitivity	phenotype
NRXN1	gene
NRXN3	gene
opioid	drug
opioid dependence	phenotype
other addictions	phenotype
polysubstance abuse	phenotype
positive reinforcement	phenotype
problematic alcohol use	phenotype
psychiatric disorders	phenotype
reduced dopaminergic function local	phenotype
regular non-dependent smokers local	cohort
resistance to nicotine-induced seizures local	phenotype
reward	phenotype
Rodent models of addiction local	cohort
rs1044396	variant
rs16969968	variant
rs2072661	variant
rs2236196	variant
schizophrenia	phenotype
sedative dependence	phenotype
sedatives	drug
sensitization	phenotype
sex	phenotype
single substance local	phenotype
SLC6A11	gene
smoking	phenotype
smoking cessation	phenotype
smoking initiation	phenotype
smoking quantity	phenotype
socioeconomic status	phenotype
somatic signs of nicotine withdrawal local	phenotype
Southwest American Indians local	cohort
stimulant dependence	phenotype
stimulants	drug
subjective response to smoking local	phenotype
substance abuse	phenotype
tobacco dependence	phenotype
tobacco use	phenotype
tolerance	phenotype
Twin cohort	cohort
type 2 diabetes	phenotype
varenicline	drug
ventral striatum	anatomy
vulnerability to nicotine dependence local	phenotype
α3 KO heterozygous mice local	cohort
α4β2 nAChR	drug
α5 KO mice local	cohort
β4 KO mice local	cohort

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In this knowledge base

Title	Year	PMID
Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective.	2012	22261179
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.	2012	22006218
The genetics of substance dependence.	2012	22703173
Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).	2011	21145178
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.	2010	19859904
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.	2010	20808433
Breaking barriers in the genomics and pharmacogenetics of drug addiction.	2010	20981002

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Serotonin Receptor <i>HTR3A</i> Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality.	Suchanecka A et al.	—	2022	→
An ecological model of drug and alcohol use and related harms among Aboriginal and Torres Strait Islander Australians: A systematic review of the literature.	Snijder M et al.	—	2021	→
A randomized, double-blind, placebo-controlled trial of ondansetron for the treatment of cocaine use disorder with post hoc pharmacogenetic analysis.	Blevins D et al.	—	2021	→
A salience misattribution model for addictive-like behaviors.	Kalhan S et al.	—	2021	→
Bibliometric Insights in Genetic Factors of Substance-Related Disorders: Intellectual Developments, Turning Points, and Emerging Trends.	Wang K et al.	—	2021	→
Classical Psychedelics as Therapeutics in Psychiatry - Current Clinical Evidence and Potential Therapeutic Mechanisms in Substance Use and Mood Disorders.	Mertens LJ et al.	—	2021	→
Drug addiction: from bench to bedside.	Cheron J et al.	—	2021	→
Exposure to drugs of abuse induce effects that persist across generations.	Baratta AM et al.	—	2021	→
Genetic interactions with stressful environments in depression and addiction.	Burmeister M et al.	—	2021	→
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.	Sun Y et al.	—	2021	→
Alcohol Use Disorder and the Persistence/Recurrence of Major Depression: Le trouble de l'usage de l'alcool et la persistance/récurrence de la dépression majeure.	Onaemo VN et al.	—	2020	→
Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.	Chen J et al.	—	2020	→
Non-pharmacological care for opioid withdrawal in newborns.	Pahl A et al.	—	2020	→
ADGRL3 (LPHN3) variants predict substance use disorder.	Arcos-Burgos M et al.	—	2019	→
Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid.	Singh AK	—	2019	→
Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone.	Jones JD et al.	—	2019	→
Mini Review: Socio-Cultural Influences on the Link Between ADHD and SUD.	Slobodin O et al.	—	2019	→
NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference.	Li H et al.	—	2019	→
Robust genetic interaction analysis.	Wu M et al.	—	2019	→
Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.	Groh J et al.	—	2019	→
The epigenetic legacy of illicit drugs: developmental exposures and late-life phenotypes.	Wanner NM et al.	—	2019	→
The role of stress in drug addiction. An integrative review.	Ruisoto P et al.	—	2019	→
A little rein on addiction.	Mathuru AS	—	2018	→
Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach.	Hu Y et al.	—	2018	→
GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers.	Sun Y et al.	—	2018	→
Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence.	Yuanyuan J et al.	—	2018	→
Implication of Genes for the N-Methyl-D-Aspartate (NMDA) Receptor in Substance Addictions.	Chen J et al.	—	2018	→
Modeling Hybrid Traits for Comorbidity and Genetic Studies of Alcohol and Nicotine Co-Dependence.	Zhang H et al.	—	2018	→
Molecular Regulatory Pathways Link Sepsis With Metabolic Syndrome: Non-coding RNA Elements Underlying the Sepsis/Metabolic Cross-Talk.	Meydan C et al.	—	2018	→
Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran.	Soleimani Asl S et al.	—	2018	→
The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption.	Touchette JC et al.	—	2018	→
Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese.	Gao X et al.	—	2017	→
Daughters of Mothers Who Smoke: A Population-based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring.	Ncube CN et al.	—	2017	→
Genetic and Environmental Influences on Gambling: A Meta-Analysis of Twin Studies.	Xuan YH et al.	—	2017	→
GRONS: a comprehensive genetic resource of nicotine and smoking.	Fang Z et al.	—	2017	→
MAOA rs1137070 and heroin addiction interactively alter gray matter volume of the salience network.	Sun Y et al.	—	2017	→
Prevalence of Cigarette Smoking and Nicotine Dependence in Men and Women Residing in Two Provinces in China.	Ma Y et al.	—	2017	→
The association between the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.	Jeong JE et al.	—	2017	→
Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure.	Vassoler FM et al.	—	2017	→
Two novel candidate genes identified in adults from the Newfoundland population with addictive tendencies towards food.	Pedram P et al.	—	2017	→
A genome-wide investigation of food addiction.	Cornelis MC et al.	—	2016	→
A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.	Leng S et al.	—	2016	→
Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction.	Orsini CA et al.	—	2016	→
Epilepsy and tobacco smoking: a cross-sectional study.	Torriani O et al.	—	2016	→
Etiological theories of addiction: A comprehensive update on neurobiological, genetic and behavioural vulnerability.	Ouzir M et al.	—	2016	→
Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort.	Taylor M et al.	—	2016	→
Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment.	Cao J et al.	—	2016	→
Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence.	Azadeh S et al.	—	2016	→
Meta-Analysis Reveals Significant Association of the 3'-UTR VNTR in SLC6A3 with Alcohol Dependence.	Ma Y et al.	—	2016	→
Acute opioid administration induces hypothalamic-pituitary-adrenal activation and is mediated by genetic variation in interleukin (Il)1B.	Kershaw SG et al.	—	2015	→
A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction.	Liu M et al.	—	2015	→
Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging.	London ED et al.	—	2015	→
Common single nucleotide variants underlying drug addiction: more than a decade of research.	Bühler KM et al.	—	2015	→
Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence.	Tang X et al.	—	2015	→
Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.	Reyes-Gibby CC et al.	—	2015	→
Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders.	Liu C et al.	—	2015	→
Genome-wide association study of copy number variations (CNVs) with opioid dependence.	Li D et al.	—	2015	→
Pathways and networks-based analysis of candidate genes associated with nicotine addiction.	Liu M et al.	—	2015	→
Prioritizing Genes Related to Nicotine Addiction Via a Multi-source-Based Approach.	Liu X et al.	—	2015	→
The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers.	Su H et al.	—	2015	→
Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.	Ma Y et al.	—	2015	→
An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers.	Su H et al.	—	2014	→
Anticipated motivation for genetic testing among smokers, nonsmokers, and former smokers: an exploratory qualitative study of decision making.	Giordimaina AM et al.	—	2014	→
Association of genes involved in calcium and potassium pathways with opioid dependence.	Wang JC et al.	—	2014	→
Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris.	Quan C et al.	—	2014	→
Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.	Wang S et al.	—	2014	→
Lack of an association between SNPs within the cholinergic receptor genes and smoking behavior in a Czech post-MONICA study.	Hubacek JA et al.	—	2014	→
Neurobiology of adolescent substance use and addictive behaviors: treatment implications.	Hammond CJ et al.	—	2014	→
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.	Wang S et al.	—	2014	→
Testing the drug substitution switching-addictions hypothesis. A prospective study in a nationally representative sample.	Blanco C et al.	—	2014	→
Youth tobacco use type and associations with substance use disorders.	Cavazos-Rehg PA et al.	—	2014	→
A pilot study of genetic variants in dopamine regulators with indoor tanning and melanoma.	Flores KG et al.	—	2013	→
Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.	Beer B et al.	—	2013	→
BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study.	Greenwald MK et al.	—	2013	→
Capacity building and collaborative research on cross-national studies in the Asian region.	Hser YI et al.	—	2013	→
Exploring drug-target interaction networks of illicit drugs.	Atreya RV et al.	—	2013	→
High density of nicotinic receptors in the cingulo-insular network.	Picard F et al.	—	2013	→
Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in heroin-dependent patients.	Lee SY et al.	—	2013	→
Neuroadaptive changes associated with smoking: structural and functional neural changes in nicotine dependence.	Martin-Soelch C	—	2013	→
Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.	Biernacka JM et al.	—	2013	→
The dopamine receptor D1 gene is associated with the length of interval between first heroin use and onset of dependence in Chinese Han heroin addicts.	Peng S et al.	—	2013	→
Abuse and addiction: crack.	Associação Brasileira de Psiquiatria	—	2012	→
A common genetic network underlies substance use disorders and disruptive or externalizing disorders.	Arcos-Burgos M et al.	—	2012	→
Common and specific liability to addiction: approaches to association studies of opioid addiction.	Nielsen DA et al.	—	2012	→
Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective.	Vanyukov MM et al.	—	2012	→
Genetics of GABAergic signaling in nicotine and alcohol dependence.	Cui WY et al.	—	2012	→
Genetic variations in the dopaminergic system and alcohol use: a system-level analysis.	Chen C et al.	—	2012	→
Influence of brain-derived neurotrophic factor genetic polymorphisms on the ages of onset for heroin dependence in a Chinese population.	Meng C et al.	—	2012	→
Large scale association analysis for drug addiction: results from SNP to gene.	Guo X et al.	—	2012	→
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.	Yoon D et al.	—	2012	→
Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau().	Zhu W et al.	—	2012	→
Pharmacogenetically driven treatments for alcoholism: are we there yet?	Arias AJ et al.	—	2012	→
Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.	Müller DJ et al.	—	2012	→
The genetics of substance dependence.	Wang JC et al.	—	2012	→
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.	Zhang H et al.	—	2012	→
Associations among types of impulsivity, substance use problems and neurexin-3 polymorphisms.	Stoltenberg SF et al.	—	2011	→
Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour.	Rodriguez S et al.	—	2011	→
Genome-wide association studies of alcohol dependence and substance use disorders.	Treutlein J et al.	—	2011	→
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats.	Cao J et al.	—	2011	→
Next-generation DNA sequencing-based assay for measuring allelic expression imbalance (AEI) of candidate neuropsychiatric disorder genes in human brain.	Xu X et al.	—	2011	→
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking.	Johnson BA et al.	—	2011	→
Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese.	Gao F et al.	—	2011	→
Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence.	Jia W et al.	—	2011	→
Possible association between human blood types and opioid addiction.	Aflatoonian MR et al.	—	2011	→
Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).	Lopez-Quintero C et al.	—	2011	→
Statistical Analysis in Genetic Studies of Mental Illnesses.	Zhang H	—	2011	→
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.	Chen X et al.	—	2011	→
Active immunotherapy for the Treatment of Cocaine Dependence.	Kinsey BM et al.	—	2010	→
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.	Li MD et al.	—	2010	→
Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese.	Sato N et al.	—	2010	→
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.	Li MD et al.	—	2010	→
Breaking barriers in the genomics and pharmacogenetics of drug addiction.	Ho MK et al.	—	2010	→
Callosal microstructural abnormalities in Alzheimer's disease and alcoholism: same phenotype, different mechanisms.	Pitel AL et al.	—	2010	→
Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking.	Xu Q et al.	—	2010	→
Functional features, biological pathways, and protein interaction networks of addiction-related genes.	Sun J et al.	—	2010	→
Influence of brain-derived neurotrophic factor (val66met) genetic polymorphism on the ages of onset for heroin abuse in males.	Hou H et al.	—	2010	→
Measuring addiction propensity and severity: the need for a new instrument.	Conway KP et al.	—	2010	→
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice.	Changeux JP	—	2010	→
Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity.	Erlich PM et al.	—	2010	→
Schizophrenia gene networks and pathways and their applications for novel candidate gene selection.	Sun J et al.	—	2010	→
Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence.	Liu L et al.	—	2009	→
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.	Keskitalo K et al.	—	2009	→
Dopamine genes and nicotine dependence in treatment-seeking and community smokers.	Bergen AW et al.	—	2009	→
Genetic view on the phenomenon of combined diseases in man.	Puzyrev VP et al.	—	2009	→
Potential association of DRD2 and DAT1 genetic variation with heroin dependence.	Hou QF et al.	—	2009	→