Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

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Authors: Chen, Andrew C H; Tang, Yongqiang; Rangaswamy, Madhavi; Wang, Jen C; Almasy, Laura; Foroud, Tatiana; Edenberg, Howard J; Hesselbrock, Victor; Nurnberger, John; Kuperman, Samuel; O'Connor, Sean J; Schuckit, Marc A; Bauer, Lance O; Tischfield, Jay; Rice, John P; Bierut, Laura; Goate, Alison; Porjesz, Bernice
Year: 2009
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 18618593
DOI: 10.1002/ajmg.b.30818
PMCID: PMC2660384

#	Section	Preview
0	Introduction	Using diagnoses as the sole phenotypes may not be optimal for genetic dissection of complex…
1	Introduction	Event-related potentials (ERPs) provide a non-invasive tool to explore the characteristics of…
2	Introduction	Recent research suggests that ERPs are not unitary phenomena but are formed through the…
3	Introduction	The major neurochemical substrates contributing to theta and delta rhythms and P3 involve strong…
4	Introduction	In the present study, we investigated the potential associations between single nucleotide…
5	Methods — Subjects	The samples included in this study were recruited and tested as part of the Collaborative Study on…
6	Methods — Subjects	The families used in the analyses are taken from multiplex families recruited from alcoholic…
7	Methods — Subjects	A Caucasian-only subset of the sample comprising 209 families with 1049 individuals was used in the…
8	Methods — Subjects	Prior to administration of the neurophysiology test battery, alcoholic subjects had been detoxified…
9	Methods — Event-Related Potential Data Acquisition and Signal Analysis	Subjects were seated in a comfortable chair located in a dimly-lit sound-attenuated RF-shielded room…
10	Methods — Event-Related Potential Data Acquisition and Signal Analysis	and amplified 10,000 times using a set of amplifiers (Sensorium, Charlotte, VT). The continuous EEG…
11	Methods — Event-Related Potential Data Acquisition and Signal Analysis	Details of the visual oddball paradigm for eliciting event-related potentials employed in the…
12	Methods — ERO energy band computation	To obtain estimates of localized power of the generally non-stationary evoked potential time series,…
13	Methods — ERO energy band computation	regions of interest (TFROI’s) specified by frequency band ranges and time intervals (Lachaux and…
14	Methods — Genotyping	Publicly available databases, dbSNP (http://www.ncbi.nlm.nih.gov/SNP/) and HapMap…
15	Methods — Genetic Analyses	Family-Based Association Tests (FBAT, Rabinowitz and Laird 2000) were employed for genetic…
16	Methods — Genetic Analyses	In this study, a quantitative trait, theta band (4–5 Hz) amplitude of EROs, and a dichotomous…
17	Results	Table 1 summarizes the demography of the study subjects. Comorbid psychiatric disorders are…
18	Results	Among the 22 SNPs we genotyped, 8 SNPs had very low minor allele frequency (MAF), lower than 0.002.…
19	Results	Table 2 demonstrates p-values of the results of the FBAT with the theta band EROs as well as…

Name	Type
acamprosate	drug
Acute/chronic medical illness local	phenotype
affected offspring	phenotype
alcohol	phenotype
alcohol dependence	phenotype
alcohol dependence (ICD-10) local	phenotype
Alcohol dependence (ICD-10) local	phenotype
alcohol dependent group local	cohort
Alcoholic proband	cohort
alcoholism	phenotype
alcohol relapse behavior local	phenotype
alcohol self-administration	phenotype
animal models	cohort
antisocial personality disorder	phenotype
anxiolytic effect	phenotype
Attention-deficit hyperactive disorder local	phenotype
brain oscillations	phenotype
Bruker mass spectrometry workstation	drug
cannabis dependence	phenotype
cannabis use	phenotype
Caucasian-only subset local	cohort
Chi square tests local	drug
cholinergic	drug
cholinergic agonists	drug
CHRM2	gene
COGA criteria local	phenotype
cognitive processes	phenotype
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
comorbidity	phenotype
complex neuropsychiatric diseases local	phenotype
conduct disorder	phenotype
cortex	anatomy
Cortical glutamatergic sub-systems local	anatomy
craving	phenotype
cue-induced reinstatement	phenotype
delta band ERO	phenotype
Delta response local	phenotype
delta rhythm	phenotype
dentate gyrus	anatomy
depression	phenotype
Disinhibitory disorders	phenotype
Dopaminergic system	drug
DSM-IIIR criteria local	phenotype
EEG	phenotype
endophenotype	phenotype
epilepsy	phenotype
event related total amplitude response local	phenotype
eye movements local	phenotype
Feighner definite criteria local	phenotype
first-degree relatives	cohort
frontal cortex	anatomy
frontal midline	anatomy
Frontal theta activity local	phenotype
fronto-central region	anatomy
GABA	phenotype
genes	gene
glutamate	drug
GRM8	gene
GRM8 intron 6 SNP local	variant
GRM8 intron 7 SNP local	variant
GRM8 SNPs local	variant
group III mGluR agonist local	drug
group III mGlu receptor agonist local	drug
Head injury	phenotype
hepatic encephalopathy	phenotype
hippocampus	anatomy
HIV infection	phenotype
human subjects	cohort
hyperglutamatergic state	phenotype
Impulse control disorders	phenotype
intermediate phenotypes	phenotype
lateral perforant path local	anatomy
lateral reticular nucleus local	anatomy
Liver cirrhosis	phenotype
lower theta (4–5 Hz) TFROI local	phenotype
major depressive disorder	phenotype
MassEXTEND local	drug
MENDEL linkage computer programs local	drug
metabotropic glutamate receptors	drug
mGlu8 receptor agonist local	drug
multiplex families	cohort
neocortex	anatomy
neuroanatomical information local	anatomy
neurochemical information local	drug
Neurosurgical procedures local	phenotype
NMDA	drug
noradrenaline	drug
ORP	phenotype
P300 event related potential local	phenotype
P300 measures	phenotype
P3 component	phenotype
posterior region	anatomy
psychiatric disorders	phenotype
psychotropic medication	drug
retina	anatomy
rs10225567 local	variant
rs10487457 local	variant
rs10487459 local	variant
rs1361995 local	variant
rs17866780 local	variant
rs2234947 local	variant
rs2299495 local	variant
rs2302165 local	variant
rs769194 local	variant
rs769198 local	variant
rs769200 local	variant
rs769202 local	variant
scalp	anatomy
Sequenom MassArray local	drug
Sequenom SpectroTYPER software local	drug
shrimp alkaline phosphatase local	drug
social phobia	phenotype
SSAGA	cohort
stimulus processing	phenotype
Sub-cortical glutamatergic sub-systems local	anatomy
substance use	phenotype
target evoked theta ERO local	phenotype
TFROI	anatomy
thalamus	anatomy
theta band	phenotype
theta band (4–5 Hz) amplitude of EROs local	phenotype
theta band energy local	phenotype
Theta band ERO phenotype local	phenotype
theta band of EROs local	phenotype
theta ERO	phenotype
theta oscillations	phenotype
unaffected group	cohort
Unaffected subjects local	cohort
USERM13 local	drug

Citation	PMID	DOI	Status
Abecasis, GR et al., Bioinformatics, 2000, GOLD--graphical overview of linkage disequilibrium	10842743	10.1093/bioinformatics/16.2.182	Cited
Almasy, L et al., Am J Hum Genet, 1998, Multipoint quantitative-trait linkage analysis in general pedigrees	9545414	10.1086/301844	Cited
Almasy, L et al., Am J Med Genet, 1999, Heritability of event-related brain potentials in families with a history of alcoholism	10402506	—	Primary
Bachteler, D et al., Neuropsychopharmacology, 2005, The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat	15668725	10.1038/sj.npp.1300657	Cited
Backstrom, P et al., Eur J Pharmacol, 2005, Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG	16324694	10.1016/j.ejphar.2005.10.051	Cited
Backstrom, P et al., Neuropsychopharmacology, 2004, mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior	14735132	10.1038/sj.npp.1300381	Cited
Basar, E et al., IEEE Eng Med Biol Mag, 1999, Oscillatory brain theory: a new trend in neuroscience	10337564	10.1109/51.765190	Cited
Basar, E et al., Int J Psychophysiol, 2001, The selectively distributed theta system: functions	11163897	10.1016/s0167-8760(00)00141-0	Cited
Basar-Eroglu, C et al., Int J Psychophysiol, 1992, P300-response: possible psychophysiological correlates in delta and theta frequency channels. A review	1399755	10.1016/0167-8760(92)90055-g	Cited
Begleiter, H et al., Electroencephalogr Clin Neurophysiol, 1995, Event-related brain potentials differentiate priming and recognition to familiar and unfamiliar faces	7530638	10.1016/0013-4694(94)00240-l	Cited
Begleiter, H et al., Electroencephalogr Clin Neurophysiol, 1998, Quantitative trait loci analysis of human event-related brain potentials: P3 voltage	9607513	10.1016/s0168-5597(98)00002-1	Primary
Begleiter, H et al., Int J Psychophysiol, 2006, Genetics of human brain oscillations	16540194	10.1016/j.ijpsycho.2005.12.013	Primary
Benjamini, Y et al., Journal of the Royal Statistical Society Series B-Methodological, 1995, Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing	—	—	—
Boehnke, M, Am J Hum Genet, 1991, Allele frequency estimation from data on relatives	1985459	—	Cited
Bucholz, KK et al., J Stud Alcohol, 1994, A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA	8189735	10.15288/jsa.1994.55.149	Primary
Cornish, JL et al., J Neurosci, 2000, Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction	10899176	10.1523/JNEUROSCI.20-15-j0006.2000	Cited
Dahchour, A et al., Prog Neurobiol, 2000, Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate	10670704	10.1016/s0301-0082(99)00031-3	Cited
Duvoisin, RM et al., J Neurosci, 1995, A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb	7722646	10.1523/JNEUROSCI.15-04-03075.1995	Cited
Fellous, JM et al., Hippocampus, 2000, Cholinergic induction of oscillations in the hippocampal slice in the slow (0.5–2 Hz), theta (5–12 Hz), and gamma (35–70 Hz) bands	10791841	10.1002/(SICI)1098-1063(2000)10:2<187::AID-HIPO8>3.0.CO;2-M	Cited
Ferraguti, F et al., J Neurosci, 2005, Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus	16280590	10.1523/JNEUROSCI.2547-05.2005	Cited
Folstein, MF et al., J Psychiatr Res, 1975, "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician	1202204	10.1016/0022-3956(75)90026-6	Cited
Foroud, T et al., Alcohol Clin Exp Res, 2000, Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping	10923994	—	Primary
Gallinat, J et al., Psychopharmacology (Berl), 2006, Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing	16767420	10.1007/s00213-006-0397-0	Cited
Gottesman, II et al., Am J Psychiatry, 2003, The endophenotype concept in psychiatry: etymology and strategic intentions	12668349	10.1176/appi.ajp.160.4.636	Cited
Gruber, WR et al., Cereb Cortex, 2005, Alpha phase synchronization predicts P1 and N1 latency and amplitude size	15749980	10.1093/cercor/bhh139	Cited
Hesselbrock, M et al., Addiction, 1999, A validity study of the SSAGA--a comparison with the SCAN	10615721	10.1046/j.1360-0443.1999.94913618.x	Primary
Hesselbrock, V et al., J Biomed Sci, 2001, P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism	11173979	10.1007/BF02255974	Primary
Holter, SM et al., Pharmacol Biochem Behav, 2000, Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats	10837854	10.1016/s0091-3057(00)00196-9	Cited
J Clin Neurophysiol, 1991, American Electroencephalographic Society guidelines for standard electrode position nomenclature	2050819	—	Cited
Jones, KA et al., Behav Genet, 2006, A cholinergic receptor gene (CHRM2) affects event-related oscillations	16823639	10.1007/s10519-006-9075-6	Primary
Jones, KA et al., Int J Psychophysiol, 2004, Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition	15210286	10.1016/j.ijpsycho.2004.02.004	Primary
Kamarajan, C et al., Clin Neurophysiol, 2005, Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism	15826845	10.1016/j.clinph.2004.12.015	Primary
Karakas, S et al., Clin Neurophysiol, 2000, A new strategy involving multiple cognitive paradigms demonstrates that ERP components are determined by the superposition of oscillatory responses	11018485	10.1016/s1388-2457(00)00418-1	Cited
Katsanis, J et al., Psychophysiology, 1997, P300 event-related potential heritability in monozygotic and dizygotic twins	9009808	10.1111/j.1469-8986.1997.tb02415.x	Cited
Klimesch, W et al., Brain Res Cogn Brain Res, 2001, Theta synchronization during episodic retrieval: neural correlates of conscious awareness	11489606	10.1016/s0926-6410(01)00024-6	Cited
Krystal, JH et al., Pharmacol Ther, 2003, N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability	12804700	10.1016/s0163-7258(03)00054-8	Cited
Lachaux, JP et al., J Neurosci Methods, 2003, A simple measure of correlation across time, frequency and space between continuous brain signals	12606066	10.1016/s0165-0270(02)00358-8	Cited
Lukatch, HS et al., J Neurophysiol, 1997, Physiology, pharmacology, and topography of cholinergic neocortical oscillations in vitro	9163368	10.1152/jn.1997.77.5.2427	Cited
Makeig, S et al., Science, 2002, Dynamic brain sources of visual evoked responses	11809976	10.1126/science.1066168	Cited
Mann, K et al., Alcohol Clin Exp Res, 2004, The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis	14745302	10.1097/01.ALC.0000108656.81563.05	Cited
Nurnberger, JI et al., Arch Gen Psychiatry, 2004, A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands	15583116	10.1001/archpsyc.61.12.1246	Primary
O'Connor, S et al., Electroencephalogr Clin Neurophysiol, 1994, Heritable features of the auditory oddball event-related potential: peaks, latencies, morphology and topography	7511509	10.1016/0168-5597(94)90052-3	Cited
Olive, MF et al., Mol Pharmacol, 2005, The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism	15548766	10.1124/mol.104.003319	Cited
Palucha, A et al., Neuropharmacology, 2004, Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats	14680755	10.1016/j.neuropharm.2003.09.006	Cited
Polich, J et al., Int J Psychophysiol, 2006, Neuropsychology and neuropharmacology of P3a and P3b	16510201	10.1016/j.ijpsycho.2005.12.012	Cited
Porjesz, B et al., Alcohol Clin Exp Res, 1998, Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism	9756048	—	Primary
Porjesz, B et al., Clin Neurophysiol, 2005, The utility of neurophysiological markers in the study of alcoholism	15826840	10.1016/j.clinph.2004.12.016	Primary
Porjesz, B et al., Suppl Clin Neurophysiol, 2004, The genetics of oscillations in the human brain	16106644	10.1016/s1567-424x(09)70382-4	Cited
Pothecary, CA et al., Neuropharmacology, 2002, Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG	12213277	10.1016/s0028-3908(02)00077-1	Cited
Rabinowitz, D et al., Hum Hered, 2000, A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information	10782012	10.1159/000022918	Cited
Reich, T et al., Am J Med Genet, 1998, Genome-wide search for genes affecting the risk for alcohol dependence	9603606	—	Primary
Saugstad, JA et al., Mol Pharmacol, 1997, Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile	9016353	10.1124/mol.51.1.119	Cited
Schoepp, DD, J Pharmacol Exp Ther, 2001, Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system	11561058	—	Cited
Schutte, BC et al., Am J Med Genet, 1999, Microdeletions at chromosome bands 1q32–q41 as a cause of Van der Woude syndrome	10323740	10.1002/(sici)1096-8628(19990521)84:2<145::aid-ajmg11>3.0.co;2-l	Cited
Shigemoto, R et al., J Neurosci, 1997, Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus	9295396	10.1523/JNEUROSCI.17-19-07503.1997	Cited
Spanagel, R et al., Addiction, 2005, Addiction and its brain science	16367982	10.1111/j.1360-0443.2005.01260.x	Cited
Spielman, RS et al., Am J Hum Genet, 1996, The TDT and other family-based tests for linkage disequilibrium and association	8900224	—	Cited
Stockwell, R et al., IEEE Trans Signal Process, 1996, Localization of the complex spectrum: the S-transform	—	—	—
Storey, JD et al., Proc Natl Acad Sci U S A, 2003, Statistical significance for genomewide studies	12883005	10.1073/pnas.1530509100	Cited
Tsai, G et al., Annu Rev Med, 1998, The role of glutamatergic neurotransmission in the pathophysiology of alcoholism	9509257	10.1146/annurev.med.49.1.173	Cited
Tzschentke, TM et al., Crit Rev Neurobiol, 2000, Functional relationship among medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in locomotion and reward	11513242	—	Cited
Wang, JC et al., Hum Mol Genet, 2004, Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome	15229186	10.1093/hmg/ddh194	Primary

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Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

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