Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

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Authors: Chen, Andrew C H; Tang, Yongqiang; Rangaswamy, Madhavi; Wang, Jen C; Almasy, Laura; Foroud, Tatiana; Edenberg, Howard J; Hesselbrock, Victor; Nurnberger, John; Kuperman, Samuel; O'Connor, Sean J; Schuckit, Marc A; Bauer, Lance O; Tischfield, Jay; Rice, John P; Bierut, Laura; Goate, Alison; Porjesz, Bernice
Year: 2009
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 18618593
DOI: 10.1002/ajmg.b.30818
PMCID: PMC2660384

#	Section	Preview
20	Results	False discovery rate (FDR) was calculated to correct for multiple comparisons. We found 74…
21	Results	Figure 2 demonstrates that individuals with CC genotype for the rs1361995 SNP show significantly…
22	Discussion	GRM8 spans over 800 kb, and is composed of 10 exons (Shigemoto and others 1997). The present study…
23	Discussion	Intracellular actions of metabotropic glutamate receptors (mGluRs) are mediated by G-protein. mGluRs…
24	Discussion	terminals in the dentate gyrus (Shigemoto and others 1997). mGluR8-expressing nerve terminals have…
25	Discussion	Neural oscillatory responses have been attributed to various cognitive processes in the literature.…
26	Discussion	and frontal theta activity during stimulus processing (Gallinat and others 2006). The results…
27	Discussion	It is an interesting finding that 3 SNPs in the intron 6 region of GRM8 were significantly…
28	Discussion	We did not find any significant difference in distribution of comorbid psychiatric diagnoses between…
29	Discussion	In conclusion, our findings underscore the great potential to utilize the brain oscillations evoked…

Name	Type
acamprosate	drug
Acute/chronic medical illness local	phenotype
affected offspring	phenotype
alcohol	phenotype
alcohol dependence	phenotype
alcohol dependence (ICD-10) local	phenotype
Alcohol dependence (ICD-10) local	phenotype
alcohol dependent group local	cohort
Alcoholic proband	cohort
alcoholism	phenotype
alcohol relapse behavior local	phenotype
alcohol self-administration	phenotype
animal models	cohort
antisocial personality disorder	phenotype
anxiolytic effect	phenotype
Attention-deficit hyperactive disorder local	phenotype
brain oscillations	phenotype
Bruker mass spectrometry workstation	drug
cannabis dependence	phenotype
cannabis use	phenotype
Caucasian-only subset local	cohort
Chi square tests local	drug
cholinergic	drug
cholinergic agonists	drug
CHRM2	gene
COGA criteria local	phenotype
cognitive processes	phenotype
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
comorbidity	phenotype
complex neuropsychiatric diseases local	phenotype
conduct disorder	phenotype
cortex	anatomy
Cortical glutamatergic sub-systems local	anatomy
craving	phenotype
cue-induced reinstatement	phenotype
delta band ERO	phenotype
Delta response local	phenotype
delta rhythm	phenotype
dentate gyrus	anatomy
depression	phenotype
Disinhibitory disorders	phenotype
Dopaminergic system	drug
DSM-IIIR criteria local	phenotype
EEG	phenotype
endophenotype	phenotype
epilepsy	phenotype
event related total amplitude response local	phenotype
eye movements local	phenotype
Feighner definite criteria local	phenotype
first-degree relatives	cohort
frontal cortex	anatomy
frontal midline	anatomy
Frontal theta activity local	phenotype
fronto-central region	anatomy
GABA	phenotype
genes	gene
glutamate	drug
GRM8	gene
GRM8 intron 6 SNP local	variant
GRM8 intron 7 SNP local	variant
GRM8 SNPs local	variant
group III mGluR agonist local	drug
group III mGlu receptor agonist local	drug
Head injury	phenotype
hepatic encephalopathy	phenotype
hippocampus	anatomy
HIV infection	phenotype
human subjects	cohort
hyperglutamatergic state	phenotype
Impulse control disorders	phenotype
intermediate phenotypes	phenotype
lateral perforant path local	anatomy
lateral reticular nucleus local	anatomy
Liver cirrhosis	phenotype
lower theta (4–5 Hz) TFROI local	phenotype
major depressive disorder	phenotype
MassEXTEND local	drug
MENDEL linkage computer programs local	drug
metabotropic glutamate receptors	drug
mGlu8 receptor agonist local	drug
multiplex families	cohort
neocortex	anatomy
neuroanatomical information local	anatomy
neurochemical information local	drug
Neurosurgical procedures local	phenotype
NMDA	drug
noradrenaline	drug
ORP	phenotype
P300 event related potential local	phenotype
P300 measures	phenotype
P3 component	phenotype
posterior region	anatomy
psychiatric disorders	phenotype
psychotropic medication	drug
retina	anatomy
rs10225567 local	variant
rs10487457 local	variant
rs10487459 local	variant
rs1361995 local	variant
rs17866780 local	variant
rs2234947 local	variant
rs2299495 local	variant
rs2302165 local	variant
rs769194 local	variant
rs769198 local	variant
rs769200 local	variant
rs769202 local	variant
scalp	anatomy
Sequenom MassArray local	drug
Sequenom SpectroTYPER software local	drug
shrimp alkaline phosphatase local	drug
social phobia	phenotype
SSAGA	cohort
stimulus processing	phenotype
Sub-cortical glutamatergic sub-systems local	anatomy
substance use	phenotype
target evoked theta ERO local	phenotype
TFROI	anatomy
thalamus	anatomy
theta band	phenotype
theta band (4–5 Hz) amplitude of EROs local	phenotype
theta band energy local	phenotype
Theta band ERO phenotype local	phenotype
theta band of EROs local	phenotype
theta ERO	phenotype
theta oscillations	phenotype
unaffected group	cohort
Unaffected subjects local	cohort
USERM13 local	drug

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Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

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