Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
paper
Primary
Public
- Authors
- Gelernter, J; Kranzler, H R; Sherva, R; Almasy, L; Koesterer, R; Smith, A H; Anton, R; Preuss, U W; Ridinger, M; Rujescu, D; Wodarz, N; Zill, P; Zhao, H; Farrer, L A
- Year
- 2014
- Journal
- Molecular psychiatry
- PMID
- 24166409
- DOI
- 10.1038/mp.2013.145
- PMCID
- PMC4165335
We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery and replication was 16β087 subjects, the largest sample for AD GWAS to date. Numerous genome-wide significant (GWS) associations were identified, many novel. Most associations were population specific, but in several cases were GWS in EAs and AAs for different SNPs at the same locus,showing biological convergence across populations. We confirmed well-known risk loci mapped to alcohol-metabolizing enzyme genes, notably ADH1B (EAs: Arg48His, P=1.17 Γ 10(-31); AAs: Arg369Cys, P=6.33 Γ 10(-17)) and ADH1C in AAs (Thr151Thr, P=4.94 Γ 10(-10)), and identified novel risk loci mapping to the ADH gene cluster on chromosome 4 and extending centromerically beyond it to include GWS associations at LOC100507053 in AAs (P=2.63 Γ 10(-11)), PDLIM5 in EAs (P=2.01 Γ 10(-8)), and METAP in AAs (P=3.35 Γ 10(-8)). We also identified a novel GWS association (1.17 Γ 10(-10)) mapped to chromosome 2 at rs1437396, between MTIF2 and CCDC88A, across all of the EA and AA cohorts, with supportive gene expression evidence, and population-specific GWS for markers on chromosomes 5, 9 and 19. Several of the novel associations implicate direct involvement of, or interaction with, genes previously identified as schizophrenia risk loci. Confirmation of known AD risk loci supports the overall validity of the study; the novel loci are worthy of genetic and biological follow-up. The findings support a convergence of risk genes (but not necessarily risk alleles) between populations, and, to a lesser extent, between psychiatric traits.
Chromosome 4 regional Manhattan plots. (a) European-Americans: regional Manhattan plot for the ADH gene cluster and adjacent regions on chromosome 4 showing the adjusted symptom count meta-analysis P-values from the discovery sample EAs, as well as points for the meta-analysis results after including our replication sample (diamonds). The points are colored based on degree of LD with rs1229984. Square points indicate genotyped SNPs and round points indicate imputed SNPs. All SNPs in the replication sample were genotyped. Data include the GCD sample plus SAGE, and GCD and German replication samples (diamonds). (b) African-Americans: regional Manhattan plot for the ADH gene cluster and adjacent regions on chromosome 4 showing the adjusted symptom count meta-analysis P-values from AAs in the discovery sample, as well as points for the meta-analysis result after inclusion of our replication sample (diamonds). The points are colored based on degree of LD with rs2066702. Square points indicate genotyped SNPs and round points indicate imputed SNPs. All SNPs in the replication sample were genotyped. Data include the GCD sample plus SAGE and the GCD replication sample (diamonds). AA, African-American; EA, European-American; LD, linkage disequilibrium; SAGE, study of addiction: genetics and environment.
(a) Chromosome 2 regional Manhattan plot in European-Americans: regional Manhattan plot for the 136.70β136.90 MB region on chromosome 2 showing the adjusted symptom count meta-analysis P-values from EAs in the discovery sample. The points are colored based on the LD with rs925966. Square points indicate genotyped SNPs and round points indicate imputed SNPs. Data include the GCD sample plus SAGE. (b) Chromosome 4 PDLIM5 region in EAs: regional Manhattan plot for the 95.27β95.69 MB region containing PDLIM5 on chromosome 4 showing the adjusted symptom count meta-analysis P-values from EAs in the discovery sample. The points are colored based on the LD with rs10031423. Square points indicate genotyped SNPs and round points indicate imputed SNPs. Data include the GCD sample plus SAGE. (c) Chromosome 5 regional Manhattan plot in African-Americans: regional Manhattan plot for the 3.98β4.18 MB region on chromosome 5 showing the adjusted symptom count meta-analysis P-values from AAs in the discovery sample. The points are colored based on degree of LD with rs1493464. Square points indicate genotyped SNPs and round points indicate imputed SNPs. Data include the GCD sample plus SAGE. AA, African-American; EA, European-American; LD, linkage disequilibrium; SAGE, study of addiction: genetics and environment.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| SNP-based prediction of schizophrenia using machine learning. | Ramazanova Z et al. | β | 2026 | β |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | β | 2025 | β |
| Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. | Pathak GA et al. | β | 2025 | β |
| Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing. | Liu L et al. | β | 2025 | β |
| Genotype-by-sex interaction analyses for alcohol use disorder across biobanks. | Zhou H et al. | β | 2025 | β |
| Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries. | Wang L et al. | β | 2025 | β |
| Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample. | Jinwala Z et al. | β | 2025 | β |
| The interaction between candidate SNPs and social factors significantly influences the prevalence of alcohol use disorder in Chinese young male adults. | Ju N et al. | β | 2025 | β |
| The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity. | Ehlers CL et al. | β | 2025 | β |
| A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. | Gupta P et al. | β | 2024 | β |
| A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives. | Deng WQ et al. | β | 2024 | β |
| A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. | Jennings MV et al. | β | 2024 | β |
| Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits. | Hartwell EE et al. | β | 2024 | β |
| Association patterns of antisocial personality disorder across substance use disorders. | Low A et al. | β | 2024 | β |
| Depressive symptoms, avoidant coping, and alcohol use: differences based on gender and posttraumatic stress disorder in emerging adults. | Danielson CK et al. | β | 2024 | β |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | β | 2024 | β |
| Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. | Koyanagi YN et al. | β | 2024 | β |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | β | 2024 | β |
| Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm. | Elam KK et al. | β | 2024 | β |
| Modifiable lifestyle factors influencing psychiatric disorders mediated by plasma proteins: A systemic Mendelian randomization study. | Chen Z et al. | β | 2024 | β |
| Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. | Toikumo S et al. | β | 2024 | β |
| Nicotine Motivated Behavior in <i>C. elegans</i>. | Salim C et al. | β | 2024 | β |
| Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes. | McKay L et al. | β | 2024 | β |
| What Are the Genetic Building Blocks of Alcohol-Related Behaviors? | Gelernter J et al. | β | 2024 | β |
| Alcohol Consumption and Alcohol Use Disorder: Exposing an Increasingly Shared Genetic Architecture. | White JD et al. | β | 2023 | β |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach. | Gentry AE et al. | β | 2023 | β |
| Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. | Wang JQ et al. | β | 2023 | β |
| Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. | Bountress KE et al. | β | 2023 | β |
| Genetic influences on alcohol flushing in East Asian populations. | Cho Y et al. | β | 2023 | β |
| Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations. | Chen WC et al. | β | 2023 | β |
| Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information. | Gedik H et al. | β | 2023 | β |
| Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. | Zhou H et al. | β | 2023 | β |
| Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample. | Kember RL et al. | β | 2023 | β |
| Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study. | Elam KK et al. | β | 2023 | β |
| Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. | Stiltner B et al. | β | 2023 | β |
| Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. | Na P et al. | β | 2023 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| The association between the <i>CCDC88A</i> gene polymorphism at rs1437396 and alcohol use disorder, with or without major depression disorder. | Bonea M et al. | β | 2023 | β |
| A Genome-Wide Association Study Reveals a <i>BDNF</i>-Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures. | Levchenko A et al. | β | 2022 | β |
| Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. | Tsermpini EE et al. | β | 2022 | β |
| An investigation into DNA methylation patterns associated with risk preference in older individuals. | Smyth LJ et al. | β | 2022 | β |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | β | 2022 | β |
| Association of Predicted Expression and Multimodel Association Analysis of Substance Abuse Traits. | Bost DM et al. | β | 2022 | β |
| A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse. | de Marco A et al. | β | 2022 | β |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach | Gentry AE et al. | β | 2022 | β |
| Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies. | Chang XW et al. | β | 2022 | β |
| FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. | Bowen MT et al. | β | 2022 | β |
| Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. | Lai D et al. | β | 2022 | β |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | β | 2022 | β |
| Genetic variants associated with circulating liver injury markers in Mexican Americans, a population at risk for non-alcoholic fatty liver disease. | Sabotta CM et al. | β | 2022 | β |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. | Parker CC et al. | β | 2022 | β |
| Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders. | Gunturkun MH et al. | β | 2022 | β |
| Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. | Deak JD et al. | β | 2022 | β |
| Genome-wide meta-analysis of alcohol use disorder in East Asians. | Zhou H et al. | β | 2022 | β |
| Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations. | Zhu T et al. | β | 2022 | β |
| Long Non-Coding RNAs: The New Frontier into Understanding the Etiology of Alcohol Use Disorder. | Denham AN et al. | β | 2022 | β |
| Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression. | Schaschl H et al. | β | 2022 | β |
| Understanding Anhedonia from a Genomic Perspective. | Bondy E et al. | β | 2022 | β |
| Associations of CB1 cannabinoid receptor (CNR1) gene polymorphisms with risk for alcohol dependence: Evidence from meta-analyses of genetic and genome-wide association studies. | Pabalan N et al. | β | 2021 | β |
| Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population. | Wu YY et al. | β | 2021 | β |
| Dimensional Phenotypes in Psychiatric Genetics: Lessons from Genome-Wide Association Studies of Alcohol Use Phenotypes. | Mallard TT et al. | β | 2021 | β |
| DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma. | Huang JC et al. | β | 2021 | β |
| Epigenetic and non-coding regulation of alcohol abuse and addiction. | Farris SP et al. | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury. | Hakim A et al. | β | 2021 | β |
| Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. | Lai D et al. | β | 2021 | β |
| Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges. | Vornholt E et al. | β | 2021 | β |
| Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population. | Peng Q et al. | β | 2021 | β |
| Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. | Polimanti R et al. | β | 2021 | β |
| Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study. | Bountress KE et al. | β | 2021 | β |
| Predicting alcohol use disorder remission: a longitudinal multimodal multi-featured machine learning approach. | Kinreich S et al. | β | 2021 | β |
| Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study. | Kinreich S et al. | β | 2021 | β |
| Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. | Luo X et al. | β | 2021 | β |
| The impact of removing former drinkers from genome-wide association studies of AUDIT-C. | Dao C et al. | β | 2021 | β |
| The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses. | Li W et al. | β | 2021 | β |
| Whole Genome Interpretation for a Family of Five. | Corpas M et al. | β | 2021 | β |
| A Family-Based Genome Wide Association Study of Externalizing Behaviors. | Barr PB et al. | β | 2020 | β |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and geneβenvironment interaction | Sun J et al. | β | 2020 | β |
| Alcohol Induced Depression: Clinical, Biological and Genetic Features. | FarrΓ© A et al. | β | 2020 | β |
| Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. | Drake J et al. | β | 2020 | β |
| Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population. | Huang YH et al. | β | 2020 | β |
| Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study. | Zhou H et al. | β | 2020 | β |
| A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia. | Liu L et al. | β | 2020 | β |
| Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations. | Cole JB et al. | β | 2020 | β |
| Differentiating Types of Self-Reported Alcohol Abstinence. | Gordon KS et al. | β | 2020 | β |
| Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use. | Bares CB et al. | β | 2020 | β |
| Genetic variants associated with alcohol dependence co-ordinate regulation of ADH genes in gastrointestinal and adipose tissues. | Hibberd R et al. | β | 2020 | β |
| Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. | Zhou H et al. | β | 2020 | β |
| GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits. | Matoba N et al. | β | 2020 | β |
| Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. | Thapa KS et al. | β | 2020 | β |
| On the path towards personalized medicine: Implications of pharmacogenetic studies of alcohol use disorder medications. | Nieto SJ et al. | β | 2020 | β |
| Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. | Maruvada P et al. | β | 2020 | β |
| Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health. | Marees AT et al. | β | 2020 | β |
| Prefrontal cortex eQTLs/mQTLs enriched in genetic variants associated with alcohol use disorder and other diseases. | Lin H et al. | β | 2020 | β |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | β | 2020 | β |
| Recent advances in genetic studies of alcohol use disorders. | Gupta I et al. | β | 2020 | β |
| Translational Molecular Approaches in Substance Abuse Research. | Fulton SL et al. | β | 2020 | β |
| Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. | Kapoor M et al. | β | 2019 | β |
| Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. | Averill LA et al. | β | 2019 | β |
| Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk. | Bach P et al. | β | 2019 | β |
| Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder. | Salvatore JE et al. | β | 2019 | β |
| Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data. | Mignogna KM et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents. | Compton KS et al. | β | 2019 | β |
| Genetic associations with suicide attempt severity and genetic overlap with major depression. | Levey DF et al. | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Genetic evidence for assortative mating on alcohol consumption in the UK Biobank. | Howe LJ et al. | β | 2019 | β |
| Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction. | Peng Q et al. | β | 2019 | β |
| Genetics of Alcoholism. | Edenberg HJ et al. | β | 2019 | β |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | β | 2019 | β |
| Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria. | Lai D et al. | β | 2019 | β |
| Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. | Wetherill L et al. | β | 2019 | β |
| Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. | Sanchez-Roige S et al. | β | 2019 | β |
| Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. | Kranzler HR et al. | β | 2019 | β |
| Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | β | 2019 | β |
| Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20Β 328 research participants of European ancestry. | Sanchez-Roige S et al. | β | 2019 | β |
| Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. | Gelernter J et al. | β | 2019 | β |
| Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. | Montalvo-Ortiz JL et al. | β | 2019 | β |
| GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network. | Xiang B et al. | β | 2019 | β |
| GWAS of Behavioral Traits. | Mehta D et al. | β | 2019 | β |
| Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Self-Reported Drinking Urge and Implicit Attentional Bias for Alcohol: A Human Laboratory Study. | Kim J et al. | β | 2019 | β |
| Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians. | Zaso MJ et al. | β | 2019 | β |
| Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. | Meda SA et al. | β | 2019 | β |
| Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment. | Pang TY et al. | β | 2019 | β |
| On entropy and information in gene interaction networks. | Wallace ZS et al. | β | 2019 | β |
| Pharmacogenetics of alcohol use disorder treatments: an update. | Hartwell EE et al. | β | 2019 | β |
| Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence. | Rosato AJ et al. | β | 2019 | β |
| Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry. | Brick LA et al. | β | 2019 | β |
| The etiology of DSM-5 alcohol use disorder: Evidence of shared and non-shared additive genetic effects. | Palmer RHC et al. | β | 2019 | β |
| The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial. | Kuo SI et al. | β | 2019 | β |
| "Why did I get that part of you?" Understanding addiction genetics through family history. | Dingel MJ et al. | β | 2019 | β |
| ADH1B: From alcoholism, natural selection, and cancer to the human phenome. | Polimanti R et al. | β | 2018 | β |
| A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. | Polimanti R et al. | β | 2018 | β |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | β | 2018 | β |
| Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students. | Thomas NS et al. | β | 2018 | β |
| A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. | Levran O et al. | β | 2018 | β |
| Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. | Trajanoska K et al. | β | 2018 | β |
| Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia. | Zai CC et al. | β | 2018 | β |
| AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations. | Justice AC et al. | β | 2018 | β |
| Conflict-related medial frontal theta as an endophenotype for alcohol use disorder. | Harper J et al. | β | 2018 | β |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | β | 2018 | β |
| Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. | Su J et al. | β | 2018 | β |
| Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. | Chen G et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | β | 2018 | β |
| Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. | Tylee DS et al. | β | 2018 | β |
| Genetic influences on conduct disorder. | Salvatore JE et al. | β | 2018 | β |
| Genome-wide association study identifies a novel locus for cannabis dependence. | Agrawal A et al. | β | 2018 | β |
| Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. | Gelernter J et al. | β | 2018 | β |
| Genome-wide meta-analysis of copy number variations with alcohol dependence. | Sulovari A et al. | β | 2018 | β |
| Human Genetics of Addiction: New Insights and Future Directions. | Hancock DB et al. | β | 2018 | β |
| Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses. | Luo J et al. | β | 2018 | β |
| Modeling of Human Hepatic and Gastrointestinal Ethanol Metabolism with Kinetic-Mechanism-Based Full-Rate Equations of the Component Alcohol Dehydrogenase Isozymes and Allozymes. | Chi YC et al. | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. | Feitosa MF et al. | β | 2018 | β |
| Patterns of shared signatures of recent positive selection across human populations. | Johnson KE et al. | β | 2018 | β |
| Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. | Bogdan R et al. | β | 2018 | β |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | β | 2018 | β |
| Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. | Almli LM et al. | β | 2018 | β |
| Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. | Smith AH et al. | β | 2018 | β |
| Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. | Sloan ME et al. | β | 2018 | β |
| Shared genetic etiology between alcohol dependence and major depressive disorder. | Foo JC et al. | β | 2018 | β |
| The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders. | Rabinowitz JA et al. | β | 2018 | β |
| The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption. | Sloan ME et al. | β | 2018 | β |
| Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. | Montalvo-Ortiz JL et al. | β | 2018 | β |
| What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics. | Nurnberger JI et al. | β | 2018 | β |
| A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study. | Vaht M et al. | β | 2017 | β |
| Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes. | Xu H et al. | β | 2017 | β |
| Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage. | Neuman MG et al. | β | 2017 | β |
| Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice. | Baker JA et al. | β | 2017 | β |
| Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV-1-Positive Individuals. | Wolf JM et al. | β | 2017 | β |
| An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. | Chen G et al. | β | 2017 | β |
| A National Swedish Longitudinal Twin-Sibling Study of alcohol use disorders among males. | Long EC et al. | β | 2017 | β |
| Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. | Polimanti R et al. | β | 2017 | β |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | β | 2017 | β |
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | Jensen KP et al. | β | 2017 | β |
| Are Alcohol Trajectories a Useful Way of Identifying At-Risk Youth? A Multiwave Longitudinal-Epidemiologic Study. | Vachon DD et al. | β | 2017 | β |
| Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors. | Li JJ | β | 2017 | β |
| Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. | Peng Q et al. | β | 2017 | β |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | β | 2017 | β |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | β | 2017 | β |
| Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. | Clark SL et al. | β | 2017 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| Genetic and Epigenetic Profile of Patients With Alcoholic Liver Disease. | Boccuto L et al. | β | 2017 | β |
| Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. | Treutlein J et al. | β | 2017 | β |
| Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era. | Do C et al. | β | 2017 | β |
| Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. | Wang Q et al. | β | 2017 | β |
| Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. | Zhou H et al. | β | 2017 | β |
| Genetics of addictive behavior: the example of nicotine dependence. | Gorwood P et al. | β | 2017 | β |
| Genetics of alcohol consumption in Drosophila melanogaster. | Fochler S et al. | β | 2017 | β |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | β | 2017 | β |
| Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. | Way MJ et al. | β | 2017 | β |
| Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112β117). | Clarke TK et al. | β | 2017 | β |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | β | 2017 | β |
| Genome-wide association study of body mass index in subjects with alcohol dependence. | Polimanti R et al. | β | 2017 | β |
| Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. | Smith AH et al. | β | 2017 | β |
| Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics. | Chartier KG et al. | β | 2017 | β |
| Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies. | Kong X et al. | β | 2017 | β |
| Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students. | Webb BT et al. | β | 2017 | β |
| Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. | Andersen AM et al. | β | 2017 | β |
| Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. | Owusu D et al. | β | 2017 | β |
| Review: DNA methylation and alcohol use disorders: Progress and challenges. | Zhang H et al. | β | 2017 | β |
| Review: Genetic and environmental risk factors for alcohol use disorders in American Indians and Alaskan Natives. | Enoch MA et al. | β | 2017 | β |
| Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications. | Dick DM et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| The genetics of alcohol dependence and alcohol-related liver disease. | Stickel F et al. | β | 2017 | β |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | β | 2017 | β |
| The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. | Polimanti R et al. | β | 2017 | β |
| Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. | Justice AC et al. | β | 2017 | β |
| ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer. | Li D et al. | β | 2016 | β |
| Analysis of high-order SNP barcodes in mitochondrial D-loop for chronic dialysis susceptibility. | Yang CH et al. | β | 2016 | β |
| Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. | Degenhardt F et al. | β | 2016 | β |
| A Review of Genome-Wide Association Studies of Stimulant and Opioid Use Disorders. | Jensen KP | β | 2016 | β |
| Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. | Schwantes-An TH et al. | β | 2016 | β |
| A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies. | Samek DR et al. | β | 2016 | β |
| Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. | Wang KS et al. | β | 2016 | β |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | β | 2016 | β |
| Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study. | Vu KN et al. | β | 2016 | β |
| DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample. | Fudalej S et al. | β | 2016 | β |
| DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. | Wang F et al. | β | 2016 | β |
| Evidence of CNIH3 involvement in opioid dependence. | Nelson EC et al. | β | 2016 | β |
| Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort. | Taylor M et al. | β | 2016 | β |
| Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. | Galinsky KJ et al. | β | 2016 | β |
| Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. | Stein MB et al. | β | 2016 | β |
| Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. | Sherva R et al. | β | 2016 | β |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | β | 2016 | β |
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | β | 2016 | β |
| Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. | Agrawal A et al. | β | 2016 | β |
| Molecular mechanisms underlying alcohol-drinking behaviours. | Ron D et al. | β | 2016 | β |
| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | β | 2016 | β |
| Overview of the Genetics of Alcohol Use Disorder. | Tawa EA et al. | β | 2016 | β |
| Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. | Polimanti R et al. | β | 2016 | β |
| Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. | Clarke TK et al. | β | 2016 | β |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | β | 2016 | β |
| Transplantation in alcohol-induced liver diseases-a kind of gene therapy for addictive behaviour? | Hillemacher T et al. | β | 2016 | β |
| Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? | Hart AB et al. | β | 2016 | β |
| [A genetic view of addiction]. | Ramoz N et al. | β | 2015 | β |
| Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. | Hart AB et al. | β | 2015 | β |
| An Effective Method to Identify Heritable Components from Multivariate Phenotypes. | Sun J et al. | β | 2015 | β |
| A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups. | Gong Q et al. | β | 2015 | β |
| A New Genomewide Association Meta-Analysis of Alcohol Dependence. | Zuo L et al. | β | 2015 | β |
| Association of GABAA receptor Ξ±2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. | Strac DS et al. | β | 2015 | β |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | β | 2015 | β |
| Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use. | Clark SL et al. | β | 2015 | β |
| Commentary: sex differences in the pathways to symptoms of alcohol use disorder: a study of opposite-sex twin pairs. | Kapoor M et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| Dissecting ancestry genomic background in substance dependence genome-wide association studies. | Polimanti R et al. | β | 2015 | β |
| Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. | Finegersh A et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Eye color: A potential indicator of alcohol dependence risk in European Americans. | Sulovari A et al. | β | 2015 | β |
| FKBP5 variation is associated with the acute and chronic effects of nicotine. | Jensen KP et al. | β | 2015 | β |
| Gene-Environment Interplay: Where We Are, Where We Are Going. | Salvatore JE et al. | β | 2015 | β |
| Genetics of complex traits in psychiatry. | Gelernter J | β | 2015 | β |
| Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. | Way M et al. | β | 2015 | β |
| Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. | Wang KS et al. | β | 2015 | β |
| Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. | Xu K et al. | β | 2015 | β |
| Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. | Derringer J et al. | β | 2015 | β |
| Genome-wide association study of copy number variations (CNVs) with opioid dependence. | Li D et al. | β | 2015 | β |
| Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. | Gelernter J et al. | β | 2015 | β |
| Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| Genomic influences on alcohol problems in a population-based sample of young adults. | Edwards AC et al. | β | 2015 | β |
| Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land? | Blum K et al. | β | 2015 | β |
| Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. | Repunte-Canonigo V et al. | β | 2015 | β |
| Pharmacotherapy for alcohol dependence: A stratified approach. | Thompson A et al. | β | 2015 | β |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | β | 2015 | β |
| Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology. | Agrawal A et al. | β | 2015 | β |
| Testing for polygenic effects in genome-wide association studies. | Pan W et al. | β | 2015 | β |
| The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. | Mbarek H et al. | β | 2015 | β |
| The neurometabolic fingerprint of excessive alcohol drinking. | Meinhardt MW et al. | β | 2015 | β |
| The pharmacogenetics of alcohol use disorder. | Jones JD et al. | β | 2015 | β |
| The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. | Grant JD et al. | β | 2015 | β |
| XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. | Juraeva D et al. | β | 2015 | β |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | β | 2014 | β |
| Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. | Peng Q et al. | β | 2014 | β |
| Cognitive mediators and disparities in the relation between teen depressiveness and smoking. | Mistry R et al. | β | 2014 | β |
| Data use under the NIH GWAS data sharing policy and future directions. | Paltoo DN et al. | β | 2014 | β |
| Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. | Zhang H et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes. | Richardson TG et al. | β | 2014 | β |
| Genetic factors for alcohol dependence and schizophrenia: common and rare variants. | Wang K et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Genome-wide association discoveries of alcohol dependence. | Zuo L et al. | β | 2014 | β |
| Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. | Kapoor M et al. | β | 2014 | β |
| Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. | Zhang H et al. | β | 2014 | β |
| Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. | Kos MZ et al. | β | 2014 | β |
| Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. | Salvatore JE et al. | β | 2014 | β |
| Protective variant associated with alcohol dependence in a Mexican American cohort. | Norden-Krichmar TM et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men. | Sartor CE et al. | β | 2014 | β |
| The Ξ±-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. | Jensen KP et al. | β | 2014 | β |