Genetic influences in emotional dysfunction and alcoholism-related brain damage.

paper Cited Public

Authors: Oscar-Berman, Marlene; Bowirrat, Abdalla
Year: 2005
Journal: Neuropsychiatric disease and treatment
PMID: 18568071
PMCID: PMC2416753

#	Section	Preview
20	Emotional dysfunction and brain damage in alcoholism	that alcoholics overestimated the intensity of all emotional expressions, misinterpreted emotional…
21	Emotional dysfunction and brain damage in alcoholism	A decoding deficit for anger and contempt also has been reported. In a recent study by Townshend and…
22	Emotional dysfunction and brain damage in alcoholism	Other considerations in alcoholics’ responses to emotional materials are length of sobriety and…
23	Emotional dysfunction and brain damage in alcoholism	To explain emotional dysfunction, theorists have made reference to participation of multiple regions…
24	Emotional dysfunction and brain damage in alcoholism — Cortical changes	Alcoholism-related changes in emotion, cognition, and behavior have been linked to extensive regions…
25	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	The frontal lobes are connected with all of the other lobes of the brain and they receive and send…
26	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	the frontal lobes exhibit impulsive aggression (Kuruoglu et al 1996; Deckel 1999; Blair and…
27	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	Prefrontal cortex is not functionally uniform. Major subdivisions are the dorsolateral prefrontal…
28	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	but the two systems are distinctly different. Primary OFC connections are with the medial thalamus…
29	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	Many studies have found the frontal lobes to be more susceptible to alcohol-related brain damage…
30	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	Magnetic resonance imaging studies have shown frontal lobe volume losses in alcoholic subjects…
31	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The frontal lobes	Frontal lobe blood flow (Nicolas et al 1993) and metabolism (Volkow et al 1992) may decrease in…
32	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Although the left and the right cerebral hemispheres are complementary in their functions, each half…
33	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Nonetheless, evidence from healthy adults and from brain-damaged patients has shown that the right…
34	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Right hemisphere dominance is usually very clear for negative emotions, but becomes less clear when…
35	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	1999; Narushima et al 2003). Patients with right frontal damage, however, are more likely to show…
36	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Rather than an opposite dominance of the right hemisphere for negative emotions and the left…
37	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Behavioral studies have shown that in healthy humans, the left side of the face is emotionally more…
38	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	As noted earlier, differences between the two cerebral hemispheres can be seen easily in cases of…
39	Emotional dysfunction and brain damage in alcoholism — Cortical changes — The right hemisphere	Findings from lesion studies and from neuroimaging studies in healthy subjects suggest that an…

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In this knowledge base

Title	Year	PMID
Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism.	2014	25307576
Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.	2010	20035952

External

Title	Authors	Journal	Year	Link
The Dopamine System in Mediating Alcohol Effects in Humans.	Beck A et al.	—	2025	→
Age as a potential modulator of alcohol-related deficits.	Nixon SJ et al.	—	2023	→
Clinical Outcomes of Severe Forms of Early Social Stress.	Berhe O et al.	—	2022	→
Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study.	Xu Y et al.	—	2021	→
Effective Connectivity for Default Mode Network Analysis of Alcoholism.	Khan DM et al.	—	2021	→
Proteomics Reveals Profound Metabolic Changes in the Alcohol Use Disorder Brain.	Enculescu C et al.	—	2019	→
The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.	Courtney KE et al.	—	2019	→
Alcohol-Mediated Organ Damages: Heart and Brain.	Obad A et al.	—	2018	→
Proteomics reveals profound metabolic changes in the alcohol use disorder brain	Enculescu C et al.	—	2018	—
Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism.	Rivas-Grajales AM et al.	—	2018	→
Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study.	Seitz J et al.	—	2017	→
Frontal lobe executive dysfunction and cerebral perfusion study in alcohol dependence syndrome.	Khanna P et al.	—	2017	→
Gender dimorphism of brain reward system volumes in alcoholism.	Sawyer KS et al.	—	2017	→
Brain activity classifies adolescents with and without a familial history of substance use disorders.	Qiao J et al.	—	2015	→
Gender effects in alcohol dependence: an fMRI pilot study examining affective processing.	Padula CB et al.	—	2015	→
Relationship between emotional processing, drinking severity and relapse in adults treated for alcohol dependence in Poland.	Kopera M et al.	—	2015	→
Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat.	Prins SA et al.	—	2014	→
Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism.	Oscar-Berman M et al.	—	2014	→
Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism.	Cservenka A et al.	—	2014	→
Midbrain-driven emotion and reward processing in alcoholism.	Müller-Oehring EM et al.	—	2013	→
The dopamine system in mediating alcohol effects in humans.	Charlet K et al.	—	2013	→
White matter damage is associated with memory decline in chronic alcoholics: a quantitative diffusion tensor tractography study.	Trivedi R et al.	—	2013	→
Function and dysfunction of prefrontal brain circuitry in alcoholic Korsakoff's syndrome.	Oscar-Berman M	—	2012	→
Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.	Kamarajan C et al.	—	2010	→
The effect of moderate to heavy alcohol consumption on neuropsychological performance as measured by the repeatable battery for the assessment of neuropsychological status.	Green A et al.	—	2010	→
Alcoholism and dampened temporal limbic activation to emotional faces.	Marinkovic K et al.	—	2009	→
Frontal brain dysfunction in alcoholism with and without antisocial personality disorder.	Oscar-Berman M et al.	—	2009	→
Structural and diffusional brain abnormality related to relatively low level alcohol consumption.	Sasaki H et al.	—	2009	→
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