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nicotine drug

Aliases
(-)-nicotine hydrogen tartrate, (−)-nicotine hydrogen tartrate salt, IV nicotine, NIC, acute nicotine administration, acute nicotinic administration, any illicit drugs, alcohol, or nicotine, chronic nicotine, cigarettes, nicotine, nicotine dependence, nicotine dose, nicotine hydrogen tartrate salt, nicotine spray, plasma nicotine, prenatal nicotine exposure, regular use of nicotine, saliva nicotine, tobacco
External links
DrugBank · PubChem
Evidence from: primary | all sources

Related entities (503)

SubjectRelationObjectp-valueEvidence
acetylcholine associated_with nicotine 1
addiction risk_factor_for nicotine 1
adolescent drinking risk_factor_for nicotine 1
adolescents associated_with nicotine 2
adolescents risk_factor_for nicotine 2
adolescent smoking associated_with nicotine 1
African-Americans associated_with nicotine 1
alcohol interacts_with nicotine 1
alcohol associated_with nicotine 5
alcohol dependence associated_with nicotine 4
alcoholism associated_with nicotine 1
Alcohol Use Disorder risk_factor_for nicotine 1
Alcohol Use Disorder associated_with nicotine 3
Alcohol Use Disorder interacts_with nicotine 1
AMPK interacts_with nicotine 1
amygdala associated_with nicotine 1
ANKK1 associated_with nicotine 1
ANKK1 risk_factor_for nicotine 2
Asian associated_with nicotine 1
Bdnf risk_factor_for nicotine 1
bipolar disorder associated_with nicotine 1
blacks associated_with nicotine 1
bupropion targets nicotine 1
candidate genes risk_factor_for nicotine 1
cannabis dependence associated_with nicotine 2
cannabis use risk_factor_for nicotine 1
cannabis use disorder associated_with nicotine 1
cannabis use disorder risk_factor_for nicotine 1
case-control sample associated_with nicotine 1
CB1 receptor risk_factor_for nicotine 1
cholinergic risk_factor_for nicotine 1
CHRNA risk_factor_for nicotine 1
CHRNA10 associated_with nicotine 1
CHRNA10 risk_factor_for nicotine 2
CHRNA2 risk_factor_for nicotine 1
Chrna3 associated_with nicotine 12
Chrna3 interacts_with nicotine 3
Chrna3 targets nicotine 1
Chrna3 risk_factor_for nicotine 8
Chrna4 risk_factor_for nicotine 4
Chrna4 associated_with nicotine 5
Chrna4 interacts_with nicotine 2
CHRNA5 interacts_with nicotine 4
CHRNA5 targets nicotine 1
CHRNA5 risk_factor_for nicotine 11
CHRNA5 associated_with nicotine 0.0001 16
CHRNA5 regulates nicotine 1
CHRNA5-CHRNA3-CHRNB4 cluster associated_with nicotine 3
Chrna6 risk_factor_for nicotine 3
Chrna6 associated_with nicotine 6
Chrna7 associated_with nicotine 3
Chrna7 risk_factor_for nicotine 2
CHRNA8 associated_with nicotine 1
CHRNA9 risk_factor_for nicotine 1
CHRNA9 associated_with nicotine 1
Chrnb1 associated_with nicotine 1
Chrnb1 risk_factor_for nicotine 1
Chrnb2 risk_factor_for nicotine 2
Chrnb2 associated_with nicotine 4
Chrnb3 associated_with nicotine 6
Chrnb3 risk_factor_for nicotine 3
Chrnb4 targets nicotine 1
Chrnb4 risk_factor_for nicotine 7
Chrnb4 associated_with nicotine 9
Chrnb4 interacts_with nicotine 3
CHRND associated_with nicotine 1
CHRNG risk_factor_for nicotine 1
CHRNG associated_with nicotine 1
cigarettes associated_with nicotine 3
cigarettes risk_factor_for nicotine 1
cigarettes interacts_with nicotine 1
cocaine associated_with nicotine 2
COGEND associated_with nicotine 7
Collaborative Study on the Genetics of Alcoholism (COGA) associated_with nicotine 1
common variants risk_factor_for nicotine 1
COMT Val158Met associated_with nicotine 1
COMT Val158Met interacts_with nicotine 1
controls protective_against nicotine 1
control subjects associated_with nicotine 1
corticotropin-releasing factor protective_against nicotine 1
cotinine biomarker_for nicotine 2
cotinine associated_with nicotine 2
COVID-19 pandemic risk_factor_for nicotine 1
CPD associated_with nicotine 1
CTNNA3 associated_with nicotine 2
CYP2A6 interacts_with nicotine 5
CYP2A6 protective_against nicotine 1
CYP2A6 regulates nicotine 3
CYP2A6 targets nicotine 1
CYP2A6 associated_with nicotine 1
CYP2B6 interacts_with nicotine 2
cytochrome P450 interacts_with nicotine 1
cytochrome P450 associated_with nicotine 1
DAT1 VNTR associated_with nicotine 1
dbGAP samples associated_with nicotine 1
DBH associated_with nicotine 1
DISC1 associated_with nicotine 1
Dnmt3b associated_with nicotine 1
dopamine associated_with nicotine 1
Dopamine D2 receptor associated_with nicotine 1
Dopamine D2 receptor risk_factor_for nicotine 2
Dopaminergic system risk_factor_for nicotine 1
DRD1 risk_factor_for nicotine 1
DRD3 risk_factor_for nicotine 1
DSM-IV associated_with nicotine 1
early initiation risk_factor_for nicotine 1
early substance use risk_factor_for nicotine 1
East Asian associated_with nicotine 1
endocannabinoid system risk_factor_for nicotine 1
endogenous opioids associated_with nicotine 1
endophenotype-general candidate SNPs associated_with nicotine 1
European ancestry associated_with nicotine 2
European population associated_with nicotine 1
Europeans associated_with nicotine 1
expectation interacts_with nicotine 1
externalizing behavior associated_with nicotine 1
Fagerström Test for Nicotine Dependence biomarker_for nicotine 1
Fagerström Test for Nicotine Dependence associated_with nicotine 2
Filipino associated_with nicotine 1
FTND associated_with nicotine 2
FTND score associated_with nicotine 1
FTND score biomarker_for nicotine 1
FTO associated_with nicotine 1
GABA associated_with nicotine 1
GABA risk_factor_for nicotine 2
GABAA receptor associated_with nicotine 1
GABAB receptor protective_against nicotine 1
GABAB receptor associated_with nicotine 1
Gabbr1 associated_with nicotine 1
Gabbr2 associated_with nicotine 2
Gabbr2 risk_factor_for nicotine 1
GABRA2 risk_factor_for nicotine 1
GABRA2 associated_with nicotine 2
genetic risk interacts_with nicotine 1
genetic risk risk_factor_for nicotine 1
glutamate targets nicotine 1
glutamatergic system risk_factor_for nicotine 1
GWAS & Sequencing Consortium of Alcohol and Nicotine use associated_with nicotine 1
habitual smoking risk_factor_for nicotine 1
heavy drinking associated_with nicotine 2
heavy smoking associated_with nicotine 1
hippocampus associated_with nicotine 1
Hispanic associated_with nicotine 1
Initial sensitivity associated_with nicotine 1
KCNN3 associated_with nicotine 1
Kendler et al. study associated_with nicotine 1
knockout mice associated_with nicotine 1
light smokers protective_against nicotine 1
major depressive disorder associated_with nicotine 1
maternal smoking associated_with nicotine 1
mice associated_with nicotine 1
Native Americans associated_with nicotine 1
Native Americans risk_factor_for nicotine 1
Native Hawaiians associated_with nicotine 1
negative mood risk_factor_for nicotine 1
NESARC associated_with nicotine 1
Netherlands Twin Register associated_with nicotine 1
neuroticism risk_factor_for nicotine 1
NHGRI-EBI GWAS catalog associated_with nicotine 1
nicotine interacts_with 5-HT 1
nicotine regulates 5-HT 1
nicotine interacts_with 5-HTTLPR 1
nicotine risk_factor_for abstinence 1
nicotine associated_with abstinence 1
nicotine interacts_with acoustic startle response 1
nicotine risk_factor_for addiction 1
nicotine associated_with addiction 2
nicotine regulates adipose tissue 1
nicotine associated_with adolescents 0.005 2
nicotine associated_with adults 1
nicotine associated_with African-Americans 2
nicotine associated_with alcohol 3
nicotine associated_with alcohol dependence 3
nicotine associated_with Alcohol Dependence Symptoms 1
nicotine associated_with alcohol self-administration 1
nicotine associated_with Alcohol Use Disorder 1
nicotine regulates AMPK 1
nicotine interacts_with AMPK 1
nicotine associated_with amygdala 1
nicotine associated_with angular gyrus 1
nicotine associated_with anorexia nervosa 1
nicotine associated_with anterior cingulate cortex 1
nicotine interacts_with antipsychotics 1
nicotine associated_with anxiety-like behavior 1
nicotine associated_with aversion 1
nicotine protective_against aversive response 1
nicotine regulates beta-endorphin 1
nicotine associated_with blood pressure 0.0001 1
nicotine associated_with body temperature 1
nicotine regulates body weight 2
nicotine interacts_with brain 1
nicotine associated_with brain 2
nicotine risk_factor_for brain development 1
nicotine interacts_with brainstem 1
nicotine risk_factor_for brain volume 1
nicotine regulates CAMKK2 1
nicotine risk_factor_for cancer 2
nicotine risk_factor_for cannabis use disorder 1
nicotine risk_factor_for cardiovascular disease 1
nicotine interacts_with central nervous system 1
nicotine regulates Chat 1
nicotine interacts_with CHRNA10 1
nicotine interacts_with CHRNA2 1
nicotine interacts_with Chrna3 4
nicotine interacts_with Chrna4 4
nicotine targets Chrna4 1
nicotine regulates Chrna4 1
nicotine targets CHRNA5 1
nicotine interacts_with CHRNA5 4
nicotine regulates Chrna6 1
nicotine interacts_with Chrna6 1
nicotine interacts_with Chrna7 2
nicotine interacts_with CHRNA9 1
nicotine interacts_with Chrnb2 6
nicotine regulates Chrnb2 2
nicotine targets Chrnb2 1
nicotine interacts_with Chrnb3 1
nicotine targets Chrnb4 1
nicotine interacts_with Chrnb4 4
nicotine risk_factor_for cigarettes 1
nicotine associated_with cigarettes 5
nicotine associated_with cingulate cortex 2
nicotine associated_with cocaine 2
nicotine associated_with COGEND 1
nicotine risk_factor_for cognition 1
nicotine associated_with cognition 1
nicotine associated_with cognitive flexibility 1
nicotine associated_with conditioned place aversion 1
nicotine associated_with conditioned taste aversion 2
nicotine protective_against conditioned taste aversion 1
nicotine associated_with controls 1
nicotine risk_factor_for COPD 2
nicotine expressed_in cortex 1
nicotine associated_with cotinine 1
nicotine associated_with craving 1
nicotine protective_against craving 2
nicotine associated_with current smoking 2
nicotine interacts_with current smoking 1
nicotine interacts_with CYP2A6 1
nicotine regulates CYP2E1 1
nicotine interacts_with CYP2E1 1
nicotine regulates DARPP-32 1
nicotine associated_with default mode network 1
nicotine interacts_with default mode network 1
nicotine associated_with dependence 1
nicotine associated_with depression 2
nicotine associated_with depressive symptoms 1
nicotine protective_against depressive symptoms 1
nicotine interacts_with dopamine 1
nicotine regulates dopamine 0.0001 5
nicotine targets Dopamine D2 receptor 1
nicotine regulates dopamine release 1
nicotine regulates dopaminergic neurons 0.05 1
nicotine interacts_with Dopaminergic system 1
nicotine targets DRD1 1
nicotine associated_with drug dependence 2
nicotine protective_against drug dependence 1
nicotine associated_with Drug Strength 1
nicotine regulates endogenous opioids 1
nicotine associated_with endophenotype 1
nicotine associated_with energy expenditure 0.01 1
nicotine regulates energy expenditure 0.05 1
nicotine associated_with energy homeostasis 1
nicotine regulates energy homeostasis 1
nicotine interacts_with ethanol group 1
nicotine associated_with European population 1
nicotine associated_with externalizing disorders 2
nicotine associated_with Fagerström Test for Nicotine Dependence 3
nicotine regulates FASN 1
nicotine regulates feeding 1
nicotine associated_with feeding 1
nicotine risk_factor_for fetal alcohol syndrome 1
nicotine associated_with food intake 1
nicotine regulates food intake 1
nicotine associated_with frontal cortex 1
nicotine associated_with fusiform gyrus 1
nicotine interacts_with fusiform gyrus 1
nicotine interacts_with GABA 1
nicotine interacts_with GABAB receptor 1
nicotine interacts_with glutamate 2
nicotine associated_with heart rate 0.0001 1
nicotine associated_with hippocampus 1
nicotine associated_with human brain 1
nicotine protective_against illness 1
nicotine interacts_with insula 1
nicotine regulates lateral amygdala 1
nicotine regulates lean body mass 1
nicotine associated_with licit drugs 1
nicotine interacts_with lingual gyrus 1
nicotine associated_with locomotion 1
nicotine regulates locomotor activity 1
nicotine risk_factor_for lung cancer 3
nicotine risk_factor_for major depressive disorder 1
nicotine associated_with major depressive disorder 2
nicotine regulates MAPK3 1
nicotine associated_with MAPK3 1
nicotine associated_with maxdrinks 1
nicotine associated_with men 1
nicotine associated_with mice 1
nicotine associated_with monkeys 1
nicotine protective_against mood disorders 1
nicotine associated_with motor activity 1
nicotine protective_against negative mood 1
nicotine associated_with network dysfunction 1
nicotine risk_factor_for neuropsychiatric disorders 1
nicotine associated_with nicotine 8
nicotine risk_factor_for nicotine 5
nicotine risk_factor_for nicotine addiction 3
nicotine associated_with nicotine addiction 2
nicotine associated_with nicotine reward 1
nicotine regulates nicotine self-administration 1
nicotine risk_factor_for nicotine self-administration 1
nicotine associated_with nicotine use 1
nicotine associated_with nicotine withdrawal 2
nicotine risk_factor_for nicotine withdrawal 1
nicotine protective_against nicotine withdrawal 1
nicotine interacts_with nicotinic acetylcholine receptor 1
nicotine targets nicotinic acetylcholine receptor 4
nicotine targets norepinephrine 1
nicotine regulates NPY 1
nicotine associated_with NPY 1
nicotine associated_with nucleus accumbens 1
nicotine interacts_with nucleus accumbens 5
nicotine interacts_with nucleus accumbens shell 1
nicotine risk_factor_for Offspring smoking 1
nicotine associated_with opioid 1
nicotine associated_with opioid dependence 1
nicotine associated_with orbitofrontal cortex 1
nicotine regulates orbitofrontal cortex 1
nicotine associated_with other substances 1
nicotine risk_factor_for physical dependence 1
nicotine risk_factor_for physiological dependence 1
nicotine associated_with pipe 1
nicotine regulates PKA 1
nicotine associated_with place preference 1
nicotine associated_with Pomc 1
nicotine regulates Pomc 1
nicotine associated_with positive reinforcement 1
nicotine interacts_with posterior cingulate cortex 1
nicotine regulates PPARGC1A 1
nicotine regulates PPARGC1B 1
nicotine associated_with precuneus 1
nicotine associated_with prefrontal cortex 3
nicotine associated_with psychiatric disorders 1
nicotine associated_with psychoactive substances 1
nicotine targets rats 1
nicotine associated_with rats 3
nicotine interacts_with rats 2
nicotine associated_with regular smoking 1
nicotine regulates reinstatement 1
nicotine associated_with relapse 1
nicotine risk_factor_for relapse 1
nicotine risk_factor_for respiratory depression 1
nicotine associated_with rewarding effects 1
nicotine interacts_with reward pathways 1
nicotine regulates reward system 1
nicotine associated_with reward system 1
nicotine associated_with rs1051730 1
nicotine associated_with rs1409568 0.003 1
nicotine associated_with SAGE 1
nicotine risk_factor_for schizophrenia 1
nicotine risk_factor_for sensorimotor region 1
nicotine interacts_with serotonin 2
nicotine regulates serotonin 1
nicotine interacts_with SLC6A4 1
nicotine associated_with smokeless tobacco 1
nicotine associated_with smoking 3
nicotine biomarker_for smoking abstinence 1
nicotine associated_with smoking behavior 1
nicotine associated_with smoking behaviors 1
nicotine risk_factor_for smoking cessation 1
nicotine associated_with smoking cessation 3
nicotine associated_with smoking frequency 1
nicotine associated_with smoking quantity 2
nicotine associated_with snus 1
nicotine risk_factor_for SP 1
nicotine protective_against stress 1
nicotine associated_with substance 1
nicotine biomarker_for substance use 1
nicotine risk_factor_for substance use 2
nicotine associated_with substance use 4
nicotine protective_against SUD 1
nicotine interacts_with suicide 1
nicotine risk_factor_for suicide 1
nicotine interacts_with thalamocortical projections 1
nicotine associated_with thalamus 1
nicotine interacts_with thalamus 1
nicotine regulates thermogenesis 1
nicotine risk_factor_for tobacco dependence 2
nicotine protective_against tobacco dependence 1
nicotine associated_with tobacco smoke 1
nicotine associated_with tobacco use 4
nicotine associated_with Twin cohort 2
nicotine regulates UCP1 1
nicotine associated_with users 1
nicotine interacts_with ventral striatum 1
nicotine interacts_with ventral tegmental area 1
nicotine targets ventral tegmental area 2
nicotine risk_factor_for visual attention 1
nicotine risk_factor_for visual region 1
nicotine interacts_with VMH 1
nicotine interacts_with VTA 1
nicotine associated_with weight loss 1
nicotine regulates weight loss 1
nicotine targets white matter 1
nicotine protective_against withdrawal 2
nicotine associated_with withdrawal 1
nicotine associated_with women 1
nicotine associated_with working memory 1
nicotine targets α4β2 nAChR 1
nicotine addiction associated_with nicotine 1
nicotine replacement therapy risk_factor_for nicotine 1
nicotine replacement therapy associated_with nicotine 1
nicotine self-administration associated_with nicotine 1
nicotine use risk_factor_for nicotine 1
nicotinic acetylcholine receptor interacts_with nicotine 2
nicotinic acetylcholine receptor associated_with nicotine 2
nicotinic acetylcholine receptor risk_factor_for nicotine 1
NMR biomarker_for nicotine 1
norepinephrine protective_against nicotine 1
novel variant risk_factor_for nicotine 1
NRT associated_with nicotine 1
NRXN1 associated_with nicotine 0.0001 2
NRXN3 associated_with nicotine 0.0001 2
NTR associated_with nicotine 1
NTRK2 risk_factor_for nicotine 1
nucleus accumbens associated_with nicotine 1
nucleus accumbens shell associated_with nicotine 1
opioid associated_with nicotine 1
opioid dependence associated_with nicotine 1
Opioid system risk_factor_for nicotine 1
OPRM1 targets nicotine 1
OPRM1 associated_with nicotine 2
OPRM1 biomarker_for nicotine 1
oxytocin protective_against nicotine 1
parental alcoholism risk_factor_for nicotine 1
PARK2 associated_with nicotine 1
participants associated_with nicotine 1
paternal alcoholism risk_factor_for nicotine 1
pathological gambling risk_factor_for nicotine 1
physical abuse risk_factor_for nicotine 1
positive reinforcement risk_factor_for nicotine 1
PPARA regulates nicotine 1
PPARA protective_against nicotine 1
P rats associated_with nicotine 1
prefrontal cortex associated_with nicotine 1
prenatal alcohol exposure risk_factor_for nicotine 1
problematic alcohol use associated_with nicotine 1
QIMR associated_with nicotine 1
rats associated_with nicotine 1
regular smoking risk_factor_for nicotine 1
regular smoking associated_with nicotine 1
rs1044396 associated_with nicotine 1
rs1044396 risk_factor_for nicotine 1
rs1051730 risk_factor_for nicotine 4
rs1051730 associated_with nicotine 6e-20 5
rs12914008 protective_against nicotine 0.022 1
rs12914008 risk_factor_for nicotine 0.035 1
rs13277524 associated_with nicotine 1
rs1344706 associated_with nicotine 1
rs16969968 associated_with nicotine 7
rs16969968 risk_factor_for nicotine 8
rs2036527 associated_with nicotine 1
rs2072660 associated_with nicotine 1
rs2072661 associated_with nicotine 1
rs2075572 associated_with nicotine 1
rs2236196 associated_with nicotine 1
rs3787138 associated_with nicotine 1
rs578776 risk_factor_for nicotine 1
rs578776 protective_against nicotine 7.09e-05 1
rs578776 associated_with nicotine 3
rs588765 protective_against nicotine 0.055 1
rs588765 associated_with nicotine 3
rs588765 risk_factor_for nicotine 1
rs6494212 associated_with nicotine 1
rs680244 associated_with nicotine 1
SAGE associated_with nicotine 2
s allele risk_factor_for nicotine 1
schizophrenia associated_with nicotine 1
Serotonergic system risk_factor_for nicotine 1
serotonin associated_with nicotine 1
SLCO3A1 associated_with nicotine 0.001 1
smoking risk_factor_for nicotine 1
smoking associated_with nicotine 3
smoking behavior associated_with nicotine 1
smoking initiation associated_with nicotine 1
SNP associated_with nicotine 3
subjects associated_with nicotine 1
substance use associated_with nicotine 1
tobacco dependence associated_with nicotine 1
tobacco dependence risk_factor_for nicotine 1
tobacco use associated_with nicotine 1
TTC12 associated_with nicotine 1
TTC12 risk_factor_for nicotine 1
Twin cohort associated_with nicotine 1
United States associated_with nicotine 1
varenicline interacts_with nicotine 1
VTA associated_with nicotine 1
whites risk_factor_for nicotine 1
whites associated_with nicotine 1
Yale-Penn associated_with nicotine 1
young adults risk_factor_for nicotine 1
α4β2 nAChR associated_with nicotine 1

Mentioned in (273)

Papers in which this entity is mentioned.

Merged raw entities (15)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name Type Papers Mentions
nicotine drug 271 1240
nic drug 4 5
nicotine dependence drug 1 2
nicotine hydrogen tartrate salt drug 1 1
acute nicotine administration drug
acute nicotinic administration drug
any illicit drugs, alcohol, or nicotine drug
chronic nicotine drug
iv nicotine drug
nicotine dose drug
(-)-nicotine hydrogen tartrate drug
(−)-nicotine hydrogen tartrate salt drug
plasma nicotine drug
regular use of nicotine drug
saliva nicotine drug