Genetics and alcoholism.
paper
Primary
Public
- Authors
- Edenberg, Howard J; Foroud, Tatiana
- Year
- 2013
- Journal
- Nature reviews. Gastroenterology & hepatology
- PMID
- 23712313
- DOI
- 10.1038/nrgastro.2013.86
- PMCID
- PMC4056340
Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.
Major pathway of alcohol metabolism.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1. | Janesha UGS et al. | β | 2026 | β |
| Do Patients With Alcoholic Cirrhosis Accurately Recognize Their Alcohol Tolerance? A Study Comparing Self-Perception and ALDH2/ADH1B Genotype. | Tadokoro T et al. | β | 2026 | β |
| Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations. | Sahu P et al. | β | 2025 | β |
| Alcohol Use Disorder Associated Gene <i>FNDC4</i> Alters Glutamatergic and GABAergic Neurogenesis | Zhu X et al. | β | 2025 | β |
| Antisocial personality disorder:Failure to balance excitation/inhibition? | Lesch KP et al. | β | 2025 | β |
| Associations between sleep medication use and alcohol consumption over 36 years in Finnish twins. | Helaakoski V et al. | β | 2025 | β |
| Clinical profile of alcohol dependent paintents according to Lesch Typology one year after the Covid-19 pandemic-comparative study. | Kuljancic D et al. | β | 2025 | β |
| Development of a liquid chromatography-tandem mass spectrometry method for the analysis of plasma naltrexone and its active metabolite in patients with AUD. | Shen PT et al. | β | 2025 | β |
| Genetic and epigenetic determinants of fetal alcohol spectrum disorders: Toward a precision medicine approach. | Sessa F et al. | β | 2025 | β |
| Global burden and trends of high alcohol use-related injuries from 1990 to 2030: a comprehensive assessment of self-harm and interpersonal violence, transport injuries, and unintentional injuries using global burden of disease 2021. | Yuan Q et al. | β | 2025 | β |
| Is Alcohol Consumption Pattern Dependent on Prenatal Sex-Steroids? A Digit Ratio (2D:4D) Study Among University Students. | Εlawski B et al. | β | 2025 | β |
| Low Alanine Aminotransferase Levels in Alcohol Consuming Male Subjects, Carriers of the Common ALDH2 Deficient Variant, ALDH2*2. | Seike T et al. | β | 2025 | β |
| Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis. | Tu W et al. | β | 2025 | β |
| The combined effect between environmental exposure and oxidative stress-related susceptible gene polymorphisms on human semen quality. | Wu S et al. | β | 2025 | β |
| The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity. | Ehlers CL et al. | β | 2025 | β |
| Unveiling binge drinking trends and triggers among army personnel: a cross sectional study. | Jayasinghe LV et al. | β | 2025 | β |
| Alcohol Consumption and Cardiovascular Disease: A Narrative Review of Evolving Perspectives and Long-Term Implications. | Georgescu OS et al. | β | 2024 | β |
| Alcohol intake and endogenous sex hormones in women: Meta-analysis of cohort studies and Mendelian randomization. | Tin Tin S et al. | β | 2024 | β |
| Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis. | Veerappa A et al. | β | 2024 | β |
| Genetic and environmental influence on alcohol intent and alcohol sips among U.S. children-Effects across sex, race, and ethnicity. | Puga T et al. | β | 2024 | β |
| Human adaptations to diet: Biological and cultural coevolution. | Jelenkovic A et al. | β | 2024 | β |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | β | 2024 | β |
| The genetical genomic path to understanding why rats and humans consume too much alcohol. | Tabakoff B et al. | β | 2024 | β |
| The TMEM132B-GABA<sub>A</sub> receptor complex controls alcohol actions in the brain. | Wang G et al. | β | 2024 | β |
| Understanding Alcohol Relapse in Liver Transplant Patients With Alcohol-Related Liver Disease: A Comprehensive Review. | Shinde SS et al. | β | 2024 | β |
| Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders. | Cui Y et al. | β | 2023 | β |
| Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults. | Zhou T et al. | β | 2023 | β |
| Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | Γzkan-KotiloΔlu S et al. | β | 2023 | β |
| Family history of substance use disorder and likelihood of prescription drug misuse in adults 50 and older. | Schepis TS et al. | β | 2023 | β |
| Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease. | Seike T et al. | β | 2023 | β |
| Neuropharmacology of Alcohol Addiction with Special Emphasis on Proteomic Approaches for Identification of Novel Therapeutic Targets. | Ray SK et al. | β | 2023 | β |
| Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. | Kamarajan C et al. | β | 2023 | β |
| The association between the <i>CCDC88A</i> gene polymorphism at rs1437396 and alcohol use disorder, with or without major depression disorder. | Bonea M et al. | β | 2023 | β |
| Were the scale of excitability a circle: Tracing the roots of the disease theory of alcoholism through Brunonian stimulus dependence. | Perkins-McVey M | β | 2023 | β |
| Association Analysis of GSTP1-rs1695 Polymorphism with the Risk of Oral Cancer: A Literature Review, an Updated Meta- Analysis, and a Structural Assessment. | Baghaei A et al. | β | 2022 | β |
| Association between family history of alcohol use disorder and catamenial epilepsy. | Herzog AG | β | 2022 | β |
| Examining Social Influences on Why We Drink: Perceived Drinking Motives in the Social Network Impact Individuals' Own Drinking Motives and Alcohol Use. | Bartel SJ et al. | β | 2022 | β |
| FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. | Flippo KH et al. | β | 2022 | β |
| GABA<sub>A</sub> subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample. | Moe JS et al. | β | 2022 | β |
| Inactivation of the Lateral Hypothalamus Attenuates Methamphetamine-Induced Conditioned Place Preference through Regulation of Kcnq3 Expression. | Liu M et al. | β | 2022 | β |
| Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents. | Scholl JL et al. | β | 2022 | β |
| MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease. | Zhou K et al. | β | 2022 | β |
| Prenatal alcohol exposure and offspring subsequent alcohol use: A systematic review. | Duko B et al. | β | 2022 | β |
| Review of Ethanol Intoxication Sensing Technologies and Techniques. | Paprocki S et al. | β | 2022 | β |
| The alcohol flushing response is associated with the risk of depression. | Jeon S et al. | β | 2022 | β |
| Yohimbine as a pharmacological probe for alcohol research: a systematic review of rodent and human studies. | Curley DE et al. | β | 2022 | β |
| Alcohol in Psoriasis-From Bench to Bedside. | Szentkereszty-KovΓ‘cs Z et al. | β | 2021 | β |
| Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. | Rao X et al. | β | 2021 | β |
| Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke. | Lin CH et al. | β | 2021 | β |
| Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population. | Wu YY et al. | β | 2021 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Epigenetic modification in alcohol use disorder and alcoholic cardiomyopathy: From pathophysiology to therapeutic opportunities. | Wu L et al. | β | 2021 | β |
| Higher-Order Language Dysfunctions in Individuals with Alcohol Use Disorder. | Karabanowicz E et al. | β | 2021 | β |
| Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population. | Peng Q et al. | β | 2021 | β |
| Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway. | Mohankumar K et al. | β | 2021 | β |
| Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation. | Lee KM et al. | β | 2021 | β |
| Understanding the genetics and neurobiological pathways behind addiction (Review). | Popescu A et al. | β | 2021 | β |
| Alcohol-preferring P rats exhibit aversion-resistant drinking of alcohol adulterated with quinine. | Timme NM et al. | β | 2020 | β |
| Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases. | Crabb DW et al. | β | 2020 | β |
| Evaluation of COMT (rs4680), CNR2 (rs2501432), CNR2 (rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants in synthetic cannabinoid use disorder patients. | Pehlivan S et al. | β | 2020 | β |
| Flying Together: <i>Drosophila</i> as a Tool to Understand the Genetics of Human Alcoholism. | Lathen DR et al. | β | 2020 | β |
| Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. | Thapa KS et al. | β | 2020 | β |
| Recent advances in genetic studies of alcohol use disorders. | Gupta I et al. | β | 2020 | β |
| Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance. | Radcliffe RA et al. | β | 2020 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Alcohol sedation in adult <i>Drosophila</i> is regulated by <i>Cysteine proteinase-1</i>Β in cortex glia. | Lee KM et al. | β | 2019 | β |
| Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk. | Bach P et al. | β | 2019 | β |
| Collateral damage from college drinking: A conceptual framework for alcohol's harms to others among US college students. | Trangenstein P et al. | β | 2019 | β |
| Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500β000 men and women in China. | Millwood IY et al. | β | 2019 | β |
| Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease. | Yamamoto K et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction. | Peng Q et al. | β | 2019 | β |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | β | 2019 | β |
| Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder. | Petrelli B et al. | β | 2019 | β |
| Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance. | Adhikari P et al. | β | 2019 | β |
| Prevalence and Factors Associated With Hazardous Alcohol Consumption Among Motorcycle Taxi Riders in Kinondoni District, Dar-Es-Salaam, Tanzania: A Cross-Sectional Study. | Kitua DW et al. | β | 2019 | β |
| Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'. | Engel GL et al. | β | 2019 | β |
| Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. | Shabtai Y et al. | β | 2018 | β |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | β | 2018 | β |
| Competition between ethanol clearance and retinoic acid biosynthesis in the induction of fetal alcohol syndrome. | Shabtai Y et al. | β | 2018 | β |
| Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population. | HubΓ‘Δek JA et al. | β | 2018 | β |
| Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster. | Signor S et al. | β | 2018 | β |
| Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. | GΓ³mez GI et al. | β | 2018 | β |
| Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity. | Balan I et al. | β | 2018 | β |
| The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. | Gonzalez DA et al. | β | 2018 | β |
| Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. | Lusk R et al. | β | 2018 | β |
| A Combination of NaltrexoneΒ +Β Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking. | Froehlich JC et al. | β | 2017 | β |
| Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. | PinzΓ³n JH et al. | β | 2017 | β |
| Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV-1-Positive Individuals. | Wolf JM et al. | β | 2017 | β |
| Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. | Rinker JA et al. | β | 2017 | β |
| Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | β | 2017 | β |
| Genetics of alcohol consumption in Drosophila melanogaster. | Fochler S et al. | β | 2017 | β |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | β | 2017 | β |
| Hepatoprotective effect of Gan Kang Yuan against chronic liver injury induced by alcohol. | Guo Y et al. | β | 2017 | β |
| New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. | Orellana JA et al. | β | 2017 | β |
| Perceived parental alcohol problems and drinking patterns in youth: A cross-sectional study of 69,030 secondary education students in Denmark. | Pisinger VSC et al. | β | 2017 | β |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | β | 2017 | β |
| Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives. | Pang J et al. | β | 2017 | β |
| The Antioxidant Cofactor Alpha-Lipoic Acid May Control Endogenous Formaldehyde Metabolism in Mammals. | Shindyapina AV et al. | β | 2017 | β |
| ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer. | Li D et al. | β | 2016 | β |
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | β | 2016 | β |
| Atp1a2 contributes modestly to alcohol-related behaviors. | Gritz SM et al. | β | 2016 | β |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | β | 2016 | β |
| Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. | Galinsky KJ et al. | β | 2016 | β |
| MAOA expression predicts vulnerability for alcohol use. | Cervera-Juanes R et al. | β | 2016 | β |
| Mendelian randomisation suggests no beneficial effect of moderate alcohol consumption on the severity of nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2016 | β |
| Preliminary characterizations, antioxidant and hepatoprotective activity of polysaccharide from Cistanche deserticola. | Guo Y et al. | β | 2016 | β |
| Regulation of neuronal migration, an emerging topic in autism spectrum disorders. | Reiner O et al. | β | 2016 | β |
| The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease. | Oniki K et al. | β | 2016 | β |
| A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. | Buch S et al. | β | 2015 | β |
| AUTS2 is a potential therapeutic target for pancreatic cancer patients with liver metastases. | Han Y et al. | β | 2015 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| Dendrobium huoshanense polysaccharide prevents ethanol-induced liver injury in mice by metabolomic analysis. | Wang XY et al. | β | 2015 | β |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | β | 2015 | β |
| Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons. | Xiang Y et al. | β | 2015 | β |
| The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation. | Jurnak F | β | 2015 | β |
| Translating Alcohol Research: Opportunities and Challenges. | Batman AM et al. | β | 2015 | β |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD. | Smith SM et al. | β | 2014 | β |
| Protective variant associated with alcohol dependence in a Mexican American cohort. | Norden-Krichmar TM et al. | β | 2014 | β |
| Single-nucleotide polymorphisms interact to affect ADH7 transcription. | Jairam S et al. | β | 2014 | β |
| Alcoholism and liver disease in Mexico: genetic and environmental factors. | Roman S et al. | β | 2013 | β |