Genetic influences on conduct disorder.
paper
Primary
Public
- Authors
- Salvatore, Jessica E; Dick, Danielle M
- Year
- 2018
- Journal
- Neuroscience and biobehavioral reviews
- PMID
- 27350097
- DOI
- 10.1016/j.neubiorev.2016.06.034
- PMCID
- PMC5183514
Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist. Studies of gene-environment interplay show that CD genetic predispositions also contribute to selection into higher-risk environments, and that environmental factors can alter the importance of CD genetic factors and differentially methylate CD candidate genes. The field's understanding of CD etiology will benefit from larger, adequately powered studies in gene identification efforts; the incorporation of polygenic approaches in gene-environment interplay studies; attention to the mechanisms of risk from genes to brain to behavior; and the use of genetically informative data to test quasi-causal hypotheses about purported risk factors.
No figures extracted from this document.
← Prev
41–57 of 57
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Brain Functional Connectivity Mediates the Association Between Adverse Childhood Experiences and Conduct Problems. | Liu P et al. | — | 2026 | → |
| Antisocial personality disorder:Failure to balance excitation/inhibition? | Lesch KP et al. | — | 2025 | → |
| Behavior choices amongst grooming, feeding and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs. | Ladd CE et al. | — | 2025 | → |
| Brain Responses During Face Processing in Conduct Disorder: Considering Sex and Callous-Unemotional Traits. | De Brito SA et al. | — | 2025 | → |
| Environmental Risk Factors of Conduct Disorder: An Overview of Meta-Analyses. | Salmanian M et al. | — | 2025 | → |
| Externalizing behaviors in children living near coal-fired power plants. | Zierold KM et al. | — | 2025 | → |
| Investigation of Relationship with God among Adolescents with Conduct Disorder: A Qualitative Content Analysis. | Salmanian M et al. | — | 2025 | → |
| The power of parenting: mitigating conduct problems among adolescents carrying genetic risk. | Choi M et al. | — | 2025 | → |
| Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. | Gao Y et al. | — | 2024 | → |
| Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study. | Frach L et al. | — | 2024 | → |
| Reciprocal relations between interparental aggression and symptoms of oppositional defiant and conduct disorders: a seven-wave cohort study of within-family effects from preschool to adolescence. | Nobakht HN et al. | — | 2024 | → |
| Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis. | Meijer M et al. | — | 2023 | → |
| Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood. | Vrantsidis DM et al. | — | 2023 | → |
| Genetics and epigenetics of human aggression. | Odintsova VV et al. | — | 2023 | → |
| Resting heart rate and antisocial behaviour: a Mendelian randomisation study. | Karwatowska L et al. | — | 2023 | → |
| DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence. | Noble AJ et al. | — | 2022 | → |
| Serotonin 5-HT<sub>2A</sub> receptor polymorphisms are associated with irritability and aggression in conduct disorder. | Nedic Erjavec G et al. | — | 2022 | → |
| The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors. | Chiocchetti AG et al. | — | 2022 | → |
| Trends in the prevalence of conduct disorder from 1990 to 2019: Findings from the Global Burden of Disease Study 2019. | Wu J et al. | — | 2022 | → |
| An Introduction to the Special Issue: Developmental Behavior Genetics and Externalizing Psychopathology. | Elam KK et al. | — | 2021 | → |
| Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis. | Luo M et al. | — | 2021 | → |
| Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention. | Elam KK et al. | — | 2021 | → |
| Psychopathy in women: insights from neuroscience and ways forward for research. | Tully J et al. | — | 2021 | → |
| SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study. | Farrow E et al. | — | 2021 | → |
| Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. | Podobnik J et al. | — | 2020 | → |
| DNA methylation analysis of amplicons from individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence | Noble AJ et al. | — | 2020 | — |
| Genetic and environmental contributions to psychopathological symptoms in adulthood: Clarifying the role of individual and parental risk factors. | Kim AR et al. | — | 2020 | → |
| Modeling the Comorbidity of Cannabis Abuse and Conduct Disorder/Conduct Problems from a Cognitive Neuroscience Perspective. | Blair RJ | — | 2020 | → |
| The Genetics of Externalizing Problems. | Barr PB et al. | — | 2020 | → |
| Biological explanations of criminal behavior. | Ling S et al. | — | 2019 | → |
| Conduct disorder. | Fairchild G et al. | — | 2019 | → |
| Cultures and Persons: Characterizing National and Other Types of Cultural Difference Can Also Aid Our Understanding and Prediction of Individual Variability. | Smith PB et al. | — | 2019 | → |
| Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. | Odintsova VV et al. | — | 2019 | → |
| Parenting and prenatal risk as moderators of genetic influences on conduct problems during middle childhood. | Marceau K et al. | — | 2019 | → |
| Psychiatric Genetics, Epigenetics, and Cellular Models in Coming Years. | Liu C et al. | — | 2019 | → |
| Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors. | Musci RJ et al. | — | 2019 | → |
| A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder. | Barker ED et al. | — | 2018 | → |
| MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder. | Sun X et al. | — | 2018 | → |
| Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study. | Cecil CAM et al. | — | 2018 | → |
| Imaging genetics in neurodevelopmental psychopathology. | Klein M et al. | — | 2017 | → |
| Oppositional defiant disorder: current insight. | Ghosh A et al. | — | 2017 | → |
| Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents. | Chang H et al. | — | 2017 | → |