Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.

paper Primary Public

Authors: Dick, Danielle M; Barr, Peter B; Cho, Seung Bin; Cooke, Megan E; Kuo, Sally I-Chun; Lewis, Tenesha J; Neale, Zoe; Salvatore, Jessica E; Savage, Jeanne; Su, Jinni
Year: 2018
Journal: Genes, brain, and behavior
PMID: 29227573
DOI: 10.1111/gbb.12447
PMCID: PMC5876087

#	Section	Preview
20	Post-GWAS Areas of Exploration from a Developmental Perspective — Mapping Phenotypic Risk Across Development	One preliminary example of how genetic markers have been associated with different phenotypes across…
21	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	Not only can genetic influence change in importance for an outcome across time, genetic associations…
22	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	in childhood and later alcohol use (Dick et al., 2013), indicative of the multiple potential…
23	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	in high school students and demonstrated a reduction in future alcohol outcomes. These studies (and…
24	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	These examples are specific to alcohol, but the idea of heterogeneous genetically-influenced…
25	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	that gene influences the phenotype (Geschwind & Flint, 2015, Mackay et al., 2009). For example, one…
26	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	Studies have already begun to use GWAS results to inform our understanding of etiological…
27	Post-GWAS Areas of Exploration from a Developmental Perspective — Understanding Mechanism	al., 2013), functional differences in brain reward systems (Heitzeg et al., 2014), and personality…
28	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	There is increasing recognition that genetic and environmental influences for many outcomes are…
29	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	In the area of substance use, twin studies yield consistent evidence for GxE effects associated with…
30	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	(reflecting neighborhood instability) were associated with greater genetic influences on alcohol…
31	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	Genetic liability can also play a role in shaping the individual’s environment, in the sense that…
32	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	Candidate gene-by-environment research has been controversial (Duncan and Keller, 2011; Dick et al.,…
33	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	Other studies have focused on aggregate measures of genetic risk, testing for moderation of risk…
34	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	Continued exploration of the environmental conditions that moderate genetic influences on substance…
35	Post-GWAS Areas of Exploration from a Developmental Perspective — Characterizing Gene Environment Interplay	us to eventually provide aggregate measures of both environmental and genetic risk, which could…
36	Post-GWAS Areas of Exploration from a Developmental Perspective — Mapping Pathways of Risk in Males and Females	There is currently a strong push from the National Institutes of Health to more carefully examine…
37	Post-GWAS Areas of Exploration from a Developmental Perspective — Mapping Pathways of Risk in Males and Females	or different genes. In view of the challenges associated with gene identification, and the massive…
38	Post-GWAS Areas of Exploration from a Developmental Perspective — Mapping Pathways of Risk in Males and Females	alcohol consumption in the UKBioBank sample (Clarke et al., 2017) largely replicated this conclusion…
39	Post-GWAS Areas of Exploration from a Developmental Perspective — Mapping Pathways of Risk in Males and Females	Identifying whether GxE effects are sex-specific is a natural extension of this work. In the area of…

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In this knowledge base

Title	Year	PMID
Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?".	2018	28735446

External

Title	Authors	Journal	Year	Link
Genetics to Improve Outcomes in Schizophrenia (GENios): A within-case molecular genetic study protocol.	Smart SE et al.	—	2026	→
Addressing artifactual bias in large, automated MRI analyses of brain development.	Elyounssi S et al.	—	2025	→
Integrative approaches to m6A and m5C RNA modifications in autism spectrum disorder revealing potential causal variants.	Jan SM et al.	—	2025	→
Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.	Su J et al.	—	2023	→
Examining the shared etiology of psychopathology with genome-wide association studies.	Mallard TT et al.	—	2023	→
General <i>v</i>. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study.	Waszczuk MA et al.	—	2023	→
Genomic analysis of firework fear and noise reactivity in standard poodles.	Handegård KW et al.	—	2023	→
Multiverse analyses of fear acquisition and extinction retention in posttraumatic stress disorder.	Lewis MW et al.	—	2023	→
Taking a lifespan approach to polygenic scores.	Freitag EW et al.	—	2023	→
Building causal knowledge in behavior genetics.	Madole JW et al.	—	2022	→
Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.	Dick DM et al.	—	2022	→
Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment.	Su J et al.	—	2022	→
Modern lifestyle risks associated with alcohol consumption and cigarette smoking in Ukraine.	Linskiy IV et al.	—	2022	→
The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems.	Ksinan AJ et al.	—	2022	→
Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood.	Elam KK et al.	—	2021	→
Applications and Challenges of Machine Learning Methods in Alzheimer's Disease Multi-Source Data Analysis.	Li X et al.	—	2021	→
Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.	Roffman JL et al.	—	2021	→
A systematic review of gene-by-intervention studies of alcohol and other substance use.	Neale ZE et al.	—	2021	→
Genetic contributions to anxiety disorders: where we are and where we are heading.	Ask H et al.	—	2021	→
Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking.	Adjangba C et al.	—	2021	→
Psychological and social risk factors associated with development of psychopathology, controlling for biological influence.	Isaksson J et al.	—	2021	→
Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.	Sanchez-Roige S et al.	—	2020	→
Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.	Schlomer GL et al.	—	2019	→
Polygenic risk for alcohol misuse is moderated by romantic partnerships.	Barr PB et al.	—	2019	→
Polygenic Risk for Alcohol Misuse is Moderated by Romantic Partnerships: Primarily in Men	Bar PB et al.	—	2019	—
Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity.	Ksinan AJ et al.	—	2019	→
Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"	Dick DM	—	2018	→
Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies.	Odintsova VV et al.	—	2018	→
G2B reviews: Epigenetics, epitranscriptomics, microRNAs and more: Emerging approaches to the study of genes, brain and behavior.	Holmes A	—	2018	→
Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample.	Lemery-Chalfant K et al.	—	2018	→
Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept.	Dick DM	—	2018	→